Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells.
- 2012-11
- FEMS Immunology & Medical Microbiology 66(2)
- - M. Karlsson
  - N. Scherbak
  - H. Khalaf
  - P. Olsson
  - J. Jass
- PubMed: 22620976
- DOI: 10.1111/j.1574-695X.2012.00994.x
1 Insight on
- Improved Immune Response
- Low evidence
Dietary supplements for benign prostatic hyperplasia: an overview of systematic reviews.
- 2012-11
- Review
- Maturitas 73(3)
- - Tae-Hun Kim
  - Hyun-Ja Lim
  - Myung-Sunny Kim
  - Myeong Soo Lee
- PubMed: 22883375
- DOI: 10.1016/j.maturitas.2012.07.007
2 Insights on
- Improved Benign Prostatic Hyperplasia Symptoms
- Improved Urinary Flow Measure
- Low evidence
Protective effect of Bacillus subtilis ANSB060 on egg quality, biochemical and histopathological changes in layers exposed to aflatoxin B1.
- 2012-11
- Clinical Trial
- Poultry Science 91(11)
- - Q. Ma
  - X. Gao
  - T. Zhou
  - L. H. Zhao
  - Y. Fan
  - X. Y. Li
  - Y. Lei
  - C. Ji
  - J. Zhang
- PubMed: 23091142
- DOI: 10.3382/ps.2012-02474
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Yeasts in table olive processing: desirable or spoilage microorganisms?
- 2012-11
- International Journal of Food Microbiology 160(1)
- - F. N. Arroyo-López
  - V. Romero-Gil
  - J. Bautista-Gallego
  - F. Rodríguez-Gómez
  - R. Jiménez-Díaz
  - P. García-García
  - A. Querol
  - A. Garrido-Fernández
- PubMed: 23141644
- DOI: 10.1016/j.ijfoodmicro.2012.08.003
5 Insights on
- Low evidence
- Highly Cited
High-velocity intermittent running: effects of beta-alanine supplementation.
- 2012-10
- RCT · n = 26
- Journal of strength and conditioning research 26(10)
- - Abbie E Smith-Ryan
  - David H Fukuda
  - Jeffrey R Stout
  - Kristina L Kendall
  - Kristina L Kendall
- PubMed: 22797003
- DOI: 10.1519/jsc.0b013e318267922b
3 Insights on
- High evidence
Probiotics reduce gut microbial translocation and improve adult atopic dermatitis.
- 2012-10
- RCT
- Journal of clinical gastroenterology 46
- - Enrico Iemoli
  - Daria Trabattoni
  - Serena Parisotto
  - Linda Borgonovo
  - Marco Toscano
  - Giuliano Rizzardini
  - Mario Clerici
  - Elena Ricci
  - Alessandra Fusi
  - Elena De Vecchi
  - Stefania Piconi
  - Lorenzo Drago
- PubMed: 22955355
- DOI: 10.1097/mcg.0b013e31826a8468
6 Insights on
- High evidence
Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice
- 2012-10
- Clinical Trial
- Gut Pathogens 4(1)
- - L. Fitzpatrick
  - Jeffrey S. Small
  - W. Greene
  - Kelly Karpa
  - S. Farmer
  - D. Keller
- PubMed: 23088680
- DOI: 10.1186/1757-4749-4-13
5 Insights on
- Low evidence
- Animal Study
Yogurt containing bioactive molecules produced by Lactobacillus acidophilus La-5 exerts a protective effect against enterohemorrhagic Escherichia coli in mice.
- 2012-10
- Clinical Trial
- Journal of Food Protection 75(10)
- - M. Zeinhom
  - M. Zeinhom
  - A. Tellez
  - V. Delcenserie
  - A. El-kholy
  - S. El-Shinawy
  - M. Griffiths
- PubMed: 23043828
- DOI: 10.4315/0362-028X.JFP-11-508
2 Insights on
- Reduced Tumor Necrosis Factor Alpha Production
- Reduced Severity of EHEC Infection
- Low evidence
- Animal Study
Effects of dietary probiotic (Pediococcus acidilactici) supplementation on performance, nutrient digestibility, egg traits, egg yolk cholesterol, and fatty acid profile in laying hens.
- 2012-10
- RCT · n = 222
- Poultry Science 91(10)
- - D. Mikulski
  - J. Jankowski
  - Jakub Naczmański
  - M. Mikulska
  - V. Demey
- PubMed: 22991559
- DOI: 10.3382/PS.2012-02370
12 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Effects of probiotic, Clostridium butyricum, on growth performance, immune function, and cecal microflora in broiler chickens.
- 2012-09
- RCT · n = 450
- Poultry Science 91(9)
- - C. M. Yang
  - G. Cao
  - P. Ferket
  - Tao Liu
  - L. Zhou
  - L. Zhang
  - Y. Xiao
  - A. Chen
- PubMed: 22912445
- DOI: 10.3382/ps.2011-02131
3 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Polypodium leucotomos extract in atopic dermatitis: a randomized, double-blind, placebo-controlled, multicenter trial.
- 2012-09
- RCT · n = 105
- Actas dermo-sifiliograficas 103(7)
- - A Ramírez-Bosca
  - P Zapater
  - I Betlloch
  - F Albero
  - A Martínez
  - J Díaz-Alperi
  - J F Horga
- PubMed: 22560125
- DOI: 10.1016/j.ad.2012.01.008
2 Insights on
- Reduced Topical Corticosteroid Use
- Reduced Oral Antihistamine Use
- High evidence
- Large Human Trial
Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals.
- 2012-09
- RCT · n = 100
- Journal of Dairy Science 95(9)
- - S. Wang
  - H. Zhu
  - C. Lu
  - Z. Kang
  - Y. Luo
  - L. Feng
  - X. Lu
- PubMed: 22916885
- DOI: 10.3168/jds.2012-5426
3 Insights on
- High evidence
- Highly Cited
In vitro evaluation of Lactobacillus crispatus K313 and K243: high-adhesion activity and anti-inflammatory effect on Salmonella braenderup infected intestinal epithelial cell.
- 2012-09
- Veterinary Microbiology 159(1-2)
- - Zhilan Sun
  - Lihua Huang
  - J. Kong
  - Shumin Hu
  - Xiao-Wan Zhang
  - W. Kong
- PubMed: 22542524
- DOI: 10.1016/j.vetmic.2012.03.043
1 Insight on
- Reduced Inflammatory Response
- Low evidence
Influence of Adhesion and Bacteriocin Production by Lactobacillus salivarius on the Intestinal Epithelial Cell Transcriptional Response
- 2012-08
- Applied and Environmental Microbiology 78(15)
- - J. O'callaghan
  - L. Buttó
  - John Macsharry
  - K. Nally
  - P. O’Toole
- PubMed: 22610429
- DOI: 10.1128/AEM.00507-12
4 Insights on
- Low evidence
The effect of supplementation of flax-seed oil on interaction of Lactobacillus plantarum--Biocenol™ LP96 and Escherichia coli O8:K88ab:H9 in the gut of germ-free piglets.
- 2012-08
- Research in Veterinary Science 93(1)
- - R. Nemcová
  - D. Borovská
  - J. Koščová
  - S. Gancarčíková
  - D. Mudroňová
  - V. Buleca
  - J. Pistl
- PubMed: 21864874
- DOI: 10.1016/j.rvsc.2011.07.031
3 Insights on
- Low evidence
Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals.
- 2012-08
- Meta-Analysis
- Microbial Pathogenesis 53(2)
- - M. Million
  - E. Angelakis
  - M. Paul
  - F. Armougom
  - L. Leibovici
  - D. Raoult
- PubMed: 22634320
- DOI: 10.1016/j.micpath.2012.05.007
1 Insight on
- Reduced Body Weight
- High evidence
- Highly Cited
Effect of supplementation of Bacillus subtilis LS 1-2 to broiler diets on growth performance, nutrient retention, caecal microbiology and small intestinal morphology.
- 2012-08
- RCT · n = 322
- Research in Veterinary Science 93(1)
- - Sinol Sen
  - S. Ingale
  - Y. W. Kim
  - J. S. Kim
  - K. H. Kim
  - J. Lohakare
  - E. K. Kim
  - H. Kim
  - M. Ryu
  - I. Kwon
  - B. Chae
- PubMed: 21757212
- DOI: 10.1016/j.rvsc.2011.05.021
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodour.
- 2012-08
- Archives of Oral Biology 57(8)
- - L. Masdea
  - E. Kulik
  - I. Hauser‐Gerspach
  - A. Ramseier
  - Andreas Filippi
  - T. Waltimo
- PubMed: 22405584
- DOI: 10.1016/j.archoralbio.2012.02.011
1 Insight on
- Reduced Oral Bacteria Growth
- Low evidence
- Highly Cited
Protection activity of a novel probiotic strain of Bacillus subtilis against Salmonella Enteritidis infection.
- 2012-08
- Research in Veterinary Science 93(1)
- - M. Thirabunyanon
  - N. Thongwittaya
- PubMed: 21907374
- DOI: 10.1016/j.rvsc.2011.08.008
4 Insights on
- Low evidence
- Highly Cited
Effects of a Lactobacillus salivarius probiotic intervention on infection, cold symptom duration and severity, and mucosal immunity in endurance athletes.
- 2012-08
- RCT · n = 66
- International Journal of Sport Nutrition and Exercise Metabolism 22(4)
- - M. Gleeson
  - N. Bishop
  - Marta Oliveira
  - T. McCauley
  - P. Tauler
  - C. Lawrence
- PubMed: 22645171
- DOI: 10.1123/IJSNEM.22.4.235
6 Insights on
- High evidence
- Highly Cited
Lactobacillus reuteri ATCC 55730 and L22 display probiotic potential in vitro and protect against Salmonella-induced pullorum disease in a chick model of infection.
- 2012-08
- Research in Veterinary Science 93(1)
- - Dexian Zhang
  - Rui Li
  - Jichang Li
- PubMed: 21764090
- DOI: 10.1016/j.rvsc.2011.06.020
4 Insights on
- Low evidence
Increases in GroES and GroEL from Lactobacillus acidophilus L-92 in response to a decrease in medium pH, and changes in cytokine release from splenocytes: Transcriptome and proteome analyses.
- 2012-07
- Journal of Bioscience and Bioengineering 114(1)
- - Rumiko Kuwana
  - N. Yamamoto
- PubMed: 22417456
- DOI: 10.1016/j.jbiosc.2012.02.010
7 Insights on
- Low evidence
Caenorhabditis elegans Immune Conditioning with the Probiotic Bacterium Lactobacillus acidophilus Strain NCFM Enhances Gram-Positive Immune Responses
- 2012-07
- Clinical Trial
- Infection and Immunity 80(7)
- - Younghoon Kim
  - E. Mylonakis
- PubMed: 22585961
- DOI: 10.1128/IAI.06350-11
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Evaluation of clinical safety and tolerance of a Lactobacillus reuteri NCIMB 30242 supplement capsule: a randomized control trial.
- 2012-07
- RCT · n = 131
- Regulatory Toxicology and Pharmacology 63(2)
- - M. Jones
  - C. Martoni
  - E. Di Pietro
  - R. Simon
  - S. Prakash
- PubMed: 22561556
- DOI: 10.1016/j.yrtph.2012.04.003
4 Insights on
- High evidence
Lack of an effect of Lactobacillus reuteri DSM 17938 in preventing nosocomial diarrhea in children: a randomized, double-blind, placebo-controlled trial.
- 2012-07
- RCT · n = 106
- The Journal of Pediatrics 161(1)
- - M. Wanke
  - H. Szajewska
- PubMed: 22306046
- DOI: 10.1016/j.jpeds.2011.12.049
3 Insights on
- High evidence
Clinical Saccharomyces cerevisiae isolates cannot cross the epithelial barrier in vitro.
- 2012-06
- International Journal of Food Microbiology 157(1)
- - R. Pérez-Torrado
  - S. Llopis
  - L. Jespersen
  - Teresa Fernández-Espinar
  - A. Querol
- PubMed: 22609000
- DOI: 10.1016/j.ijfoodmicro.2012.04.012
2 Insights on
- Increased Risk of Opportunistic Infection due to Compromised Epithelial Barrier
- Impaired Intestinal Barrier Function
- Low evidence
In vitro and in vivo characterization and strain safety of Lactobacillus reuteri NCIMB 30253 for probiotic applications.
- 2012-06
- Canadian Journal of Microbiology 58(6)
- - I. Sulemankhil
  - Mathieu Parent
  - M. Jones
  - Zhenqiang Feng
  - A. Labbé
  - S. Prakash
- PubMed: 22642667
- DOI: 10.1139/w2012-050
1 Insight on
- Reduced Pro-inflammatory Cytokine Interleukin-8 Levels
- Low evidence
Genome Sequence of Lactobacillus salivarius SMXD51, a Potential Probiotic Strain Isolated from Chicken Cecum, Showing Anti-Campylobacter Activity
- 2012-06
- Journal of Bacteriology 194(11)
- - Gilles Kergourlay
  - Soumaya Messaoudi
  - X. Dousset
  - H. Prévost
- PubMed: 22582370
- DOI: 10.1128/JB.00344-12
1 Insight on
- Reduced Campylobacter Infection
- Low evidence
Evaluation of safety and tolerance of microencapsulated Lactobacillus reuteri NCIMB 30242 in a yogurt formulation: a randomized, placebo-controlled, double-blind study.
- 2012-06
- RCT · n = 120
- Food and Chemical Toxicology 50(6)
- - M. Jones
  - C. Martoni
  - S. Tamber
  - Mathieu Parent
  - S. Prakash
- PubMed: 22425689
- DOI: 10.1016/j.fct.2012.03.010
2 Insights on
- Stable Fecal Deconjugated Bile Acid Levels
- Safe Use of Lactobacillus reuteri NCIMB 30242
- High evidence
Hilyses®, fermented Saccharomyces cerevisiae, enhances the growth performance and skin non-specific immune parameters in rainbow trout (Oncorhynchus mykiss).
- 2012-06
- RCT
- Fish & Shellfish Immunology 32(6)
- - N. Sheikhzadeh
  - M. Heidarieh
  - A. K. Pashaki
  - K. Nofouzi
  - Marjan Ahrab Farshbafi
  - M. Akbari
- PubMed: 22440584
- DOI: 10.1016/j.fsi.2012.03.003
3 Insights on
- High evidence
- Highly Cited