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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of antioxidants on oxidative stress in adult patients with coronary artery disease: A systematic review.
- 2025-10
- Systematic Review
- Clinical nutrition ESPEN 69
- - Islam M Alhusban
  - Misook L Chung
  - Martha Biddle
- PubMed: 40914496
- DOI: 10.1016/j.clnesp.2025.08.037
1 Insight on
- Reduced Oxidative Stress
- High evidence
Comparative effectiveness of oral nutritional supplements in preventing respiratory tract infections among adults: a systematic review and network meta-analysis.
- 2025-10
- Meta-Analysis · n = 751
- EClinicalMedicine 88
- - Zhixin Zhu
  - Xiaoxia Zhu
  - Yanru Chu
  - Bing Zhang
  - Yi Chen
- PubMed: 40969681
- DOI: 10.1016/j.eclinm.2025.103479
3 Insights on
- High evidence
The effects of purslane consumption on blood pressure in adults: A grading of recommendations, assessment, development, and evaluation-assessed systematic review and meta-analysis of randomized controlled trials.
- 2025-10
- Review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 30(1)
- - Mahdi Vajdi
  - Negin Tahvilian
  - Shirin Hassanizadeh
  - Malihe Jafari
  - Gholamreza Askari
- PubMed: 41306619
- DOI: 10.4103/jrms.jrms_48_24
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- Low evidence
Artichoke and cardiometabolic health: A systematic and meta-analytic synthesis of current evidence.
- 2025-10
- Meta-Analysis
- Diabetes & metabolic syndrome 19(10)
- - Ali Jafari
  - Mohammad Amin Karimi
  - Mahsa Mahmoudinezhad
  - Fatemeh Razavi
  - Helia Mardani
  - Vali Musazadeh
- PubMed: 41270328
- DOI: 10.1016/j.dsx.2025.103328
11 Insights on
- High evidence
Is avocado beneficial for lipid profiles? An umbrella review of systematic reviews and meta-analyses.
- 2025-10
- Systematic Review
- Clinical nutrition ESPEN 69
- - Bruno M Candeloro
  - Sandra M Barbalho
  - Lucas Fornari Laurindo
  - Rodrigo D Raimundo
  - Beatriz L Stevanato
  - Maria C B Assumpção
  - Estela M D Casangel
  - Edson H Ito
  - Matheus C Barros
  - Andrey A Porto
  - David M Garner
  - Vitor E Valenti
- PubMed: 40876535
- DOI: 10.1016/j.clnesp.2025.08.019
9 Insights on
- High evidence
Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis.
- 2025-10
- Meta-Analysis · n = 683
- Endocrinologia, diabetes y nutricion 72(8)
- - Mohammed Hamsho
  - Yazan Ranneh
  - Abdulmannan Fadel
- PubMed: 41067797
- DOI: 10.1016/j.endien.2025.501578
13 Insights on
- High evidence
The potential bactericidal effect of oral probiotics on extrinsic black stain-associated bacteria in children: An in-vitro and in-vivo study.
- 2025-10
- Journal of dental sciences 20(4)
- - Nour Wahba
  - Dina Sharaf
  - Mohamed Wagdy
  - Ahmed El-Motayam
  - Basma Nagi
- PubMed: 41040574
- DOI: 10.1016/j.jds.2025.04.032
1 Insight on
- Reduced Bacterial Load
- Low evidence
Long-Term Effect of Cocoa Extract Supplementation on Incident Hypertension.
- 2025-10
- RCT · n = 442
- Hypertension (Dallas, Tex. : 1979) 82(10)
- - Rikuta Hamaya
  - Sidong Li
  - Jessica Lau
  - Matthew Allison
  - Bernhard Haring
  - Aladdin H Shadyab
  - Nudy Matthew
  - Lisa Warsinger Martin
  - Pamela M Rist
  - JoAnn E Manson
  - Howard D Sesso
- PubMed: 40832703
- DOI: 10.1161/hypertensionaha.125.25209
1 Insight on
- Reduced Incident Hypertension
- High evidence
- Large Human Trial
Probiotics Enhance Bone Density and Reduce Inflammation Postalveolar Surgery.
- 2025-10
- RCT · n = 80
- International dental journal 75(5)
- - Dongjie Fu
  - Xiaoxiang He
  - Jian Lu
  - Ting Du
- PubMed: 40614466
- DOI: 10.1016/j.identj.2025.100881
3 Insights on
- High evidence
Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.
- 2025-10
- Meta-Analysis · n = 415
- Clinical nutrition ESPEN 69
- - Ping Luo
  - Jingfeng Chen
  - Kang Liu
  - Jia Zhang
- PubMed: 40789388
- DOI: 10.1016/j.clnesp.2025.07.1130
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence
Microbiota basis of antidepressant effects of Zhi-zi-chi Decoction: Lactobacillus rhamnosus and gut microbiota metabolism.
- 2025-10
- Chinese herbal medicines 17(4)
- - Jing He
  - Zixin Zhao
  - Ying Ye
  - Yujia Zhai
  - Dexun Yu
  - Fangyuan Gao
  - Jianlin Wu
  - Jun Wen
  - Tingting Zhou
- PubMed: 41399797
- DOI: 10.1016/j.chmed.2025.05.001
3 Insights on
- Low evidence
The role of whey protein supplementation after one-anastomosis gastric bypass: Results of a double-blind randomized controlled trial.
- 2025-10
- RCT
- Clinical nutrition ESPEN 69
- - Keivan Sabooni
  - Farnaz Farsi
  - Shiva Safari
  - Mohammad Mahjoubi
  - Amir Hossein Davarpanah Jazi
  - Delaram Moosavi
  - Zahra Gholi
  - Mohammad Kermansaravi
  - Shahab Shahabi
- PubMed: 40744414
- DOI: 10.1016/j.clnesp.2025.07.1122
2 Insights on
- Reduced Lean Body Mass Loss
- Preserved Muscle Mass
- High evidence
Bilateral keratomalacia years after biliopancreatic diversion with duodenal switch surgery: A case of severe vitamin A deficiency and literature review.
- 2025-10
- Review
- The Journal of international medical research 53(10)
- - Jaron C Sanchez
  - Omar Nusair
  - Dipen Kumar
  - Mohammad Soleimani
- PubMed: 41130926
- DOI: 10.1177/03000605251387932
2 Insights on
- Improved Vision
- Resolved Keratomalacia
- Low evidence
The Role of Vitamin D in Postoperative Tendon Healing: A Scoping Review.
- 2025-10
- Review · n = 10
- Orthopaedic journal of sports medicine 13(10)
- - Marc Daniel Bouchard
  - Danielle Dagher
  - Carl Keogh
  - Muath Alqahtani
  - Moin Khan
- PubMed: 41116768
- DOI: 10.1177/23259671251371300
3 Insights on
- Low evidence
Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 administration to Long-Evans rats has interactive effects with sex and diet on anxiety-related feeding behaviors and specific endocrine outcomes.
- 2025-10
- Physiology & behavior 300
- - Elizabeth M Myles
  - M Elizabeth O'Leary
  - Isaac D Romkey
  - Sara I Hamm
  - Laura Dauphinee
  - Amanda Piano
  - Stéphane Bronner
  - Tara S Perrot
- PubMed: 40664306
- DOI: 10.1016/j.physbeh.2025.115030
2 Insights on
- Reduced Anxiety-Related Feeding Behavior
- Increased Feeding Bouts in the Center of the Open Field
- Low evidence
- Animal Study
Effect of selenium supplementation on inflammatory markers and joint symptoms in patients with rheumatoid arthritis: A meta-analysis and systematic review.
- 2025-10
- Meta-Analysis · n = 367
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 91
- - Manyu Long
  - Shaohong Xu
  - Songyuan Tie
  - Shuming Dong
  - Hui Liang
  - Jing Wang
  - Shuya Wang
- PubMed: 40695138
- DOI: 10.1016/j.jtemb.2025.127695
2 Insights on
- Reduced Pain
- Reduced Joint Tenderness
- High evidence
Caffeine and taurine: a systematic review and network meta-analysis of their individual and combined effects on physical capacity, cognitive function, and physiological markers.
- 2025-10
- Systematic Review
- Journal of the International Society of Sports Nutrition 22(1)
- - Hengzhi Deng
  - Li Wang
  - Ping Liu
  - Mohamed Nashrudin Bin Naharudin
  - Xiaohan Fan
- PubMed: 41032459
- DOI: 10.1080/15502783.2025.2566371
5 Insights on
- High evidence
The effect of lavender essential oil aromatherapy on anxiety and fatigue in patients with implantable cardioverter defibrillator: randomized controlled trial.
- 2025-09
- RCT · n = 43
- Explore (New York, N.Y.) 21(5)
- - Sebiha Aktaş Us
  - Sultan Taşcı
  - Abdullah Orhan Demirtaş
- PubMed: 40795547
- DOI: 10.1016/j.explore.2025.103233
4 Insights on
- High evidence
Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial.
- 2025-09
- RCT · n = 18
- General hospital psychiatry 96
- - Margaret L Ross
  - Ravi Iyer
  - Martin L Williams
  - Mark Boughey
  - Clare O'Callaghan
  - Richard Hiscock
  - Justin Dwyer
- PubMed: 40858059
- DOI: 10.1016/j.genhosppsych.2025.08.001
2 Insights on
- Reduced Depression Symptoms
- Reduced Anxiety
- High evidence
Effects of the Probiotics Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 on Anxiety-Related and Emotional Behaviors in Male Wistar Rats Under an Altered Light-Dark Cycle.
- 2025-09
- Brain and behavior 15(9)
- - Farnaz Ghayour Babaei
  - Ali Moghimi
  - Ehsan Saburi
  - Ali Makhdoumi
  - Morteza Behnam Rasouli
- PubMed: 40931813
- DOI: 10.1002/brb3.70814
2 Insights on
- Increased Exploratory Behavior
- Reduced Anxiety-like Behavior
- Low evidence
- Animal Study
Age-dependent efficacy of Bifidobacterium strains on cognitive impairment and dementia: A systematic review and meta-analysis.
- 2025-09
- Meta-Analysis · n = 1,195
- Ageing research reviews 111
- - Wenliang Yu
  - Yao Li
  - Zeyang Liu
  - Siqi Hua
  - Ziyi Tan
  - Wei Tang
  - Mengyue Gao
  - Xiaoran Zhou
  - Zichun Hua
- PubMed: 40752774
- DOI: 10.1016/j.arr.2025.102850
7 Insights on
- High evidence
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis.
- 2025-09
- RCT · n = 27
- Med (New York, N.Y.) 6(9)
- - Lasha Gogokhia
  - Nancy Tran
  - Alex Grier
  - Manabu Nagayama
  - Grace Xiang
  - Gabriela Funez-dePagnier
  - Alexa Lavergne
  - Caroline Ericsson
  - Sarah Ben Maamar
  - Mengrui Zhang
  - Robert Battat
  - Ellen Scherl
  - Dana J Lukin
  - Randy S Longman
- PubMed: 40460824
- DOI: 10.1016/j.medj.2025.100707
3 Insights on
- High evidence
Association of maternal exposure to trace elements and toxic metals with repeated measurements of foetal and early-childhood growth: a systematic review.
- 2025-09
- Systematic Review
- Occupational and environmental medicine 82(9)
- - Yingying Zuo
  - Yanyan Jiang
  - Xinyun Li
  - Juan Tong
  - Fang-Biao Tao
- PubMed: 41167610
- DOI: 10.1136/oemed-2025-110158
2 Insights on
- Reduced Physical Growth
- Improved Child Growth and Development
- High evidence
The characteristics of Lactobacillus curvatus R5 protease at different pH and temperature levels: structural change, molecular dynamics simulation, hydrolysis ability were extracted from Harbin dry sausage.
- 2025-09
- International journal of biological macromolecules 321
- - Ziyuan Zhang
  - Renjie Gan
  - Yixin Zhang
  - Jiayu Xu
  - Sitong Liu
  - Qian Liu
  - Xiufang Xia
  - Hui Wang
  - Baohua Kong
  - Fangda Sun
- PubMed: 40701460
- DOI: 10.1016/j.ijbiomac.2025.146189
1 Insight on
- Improved Protein Hydrolysis Capacity
- Low evidence
Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial.
- 2025-09
- RCT · n = 863
- Critical care explorations 7(9)
- - Mattia M Müller
  - Ruxandra Pinto
  - François Lamontagne
  - Neill K J Adhikari
  - Lorenzo Del Sorbo
- PubMed: 40927646
- DOI: 10.1097/cce.0000000000001310
2 Insights on
- Reduced Mortality Risk
- Reduced Platelet Count
- High evidence
- Large Human Trial
Effect of gluten and wheat on symptoms and behaviours in adults with irritable bowel syndrome: a single-centre, randomised, double-blind, sham-controlled crossover trial.
- 2025-09
- RCT · n = 42
- The lancet. Gastroenterology & hepatology 10(9)
- - Caroline Larissa Seiler
  - Gaston Horacio Rueda
  - Pedro Miguel Miranda
  - Andrea Nardelli
  - Rajka Borojevic
  - Amber Hann
  - Sara Rahmani
  - Russell De Souza
  - Alberto Caminero
  - Valentina Curella
  - Manjusha Neerukonda
  - Stephen Vanner
  - Detlef Schuppan
  - Paul Moayyedi
  - Stephen Michael Collins
  - Elena Francisca Verdu
  - Maria Ines Pinto-Sanchez
  - Premysl Bercik
- PubMed: 40706614
- DOI: 10.1016/s2468-1253(25)00090-1
1 Insight on
- Worsened IBS Symptoms
- High evidence
L-ornithine supplementation in periodontitis treatment yields greater benefits than L-arginine after one year: Part II of a randomized controlled pilot study.
- 2025-09
- RCT · n = 75
- Complementary therapies in medicine 92
- - Viktoriya I Shynkevych
  - Svitlana V Kolomiiets
  - Kristina O Udaltsova
  - Igor P Kaidashev
- PubMed: 40614877
- DOI: 10.1016/j.ctim.2025.103202
5 Insights on
- High evidence
Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials.
- 2025-09
- Meta-Analysis · n = 5,026
- Pharmacological research 219
- - Ali Jafari
  - Helia Mardani
  - Amir Hossein Faghfouri
  - Zahra Mirzaei Fashtali
  - Mohtaram Hashemi
  - Matin Abdollahi Yousefabady
  - Reihane Javid
  - Sahar Golabi
  - Bahareh Arghavan
  - Vali Musazadeh
  - Mahshid Naghashpour
- PubMed: 40714301
- DOI: 10.1016/j.phrs.2025.107882
35 Insights on
- High evidence
Dynamic alterations of the intestinal microbiome and metabolome during transmissible gastroenteritis virus infection in weaned pigs.
- 2025-09
- RCT
- Microbial pathogenesis 206
- - Ya-Mei Chen
  - Chia-An Yeh
  - Wei-Hao Lin
  - Chao-Nan Lin
  - Ming-Tang Chiou
- PubMed: 40383241
- DOI: 10.1016/j.micpath.2025.107705
1 Insight on
- Improved Intestinal Health Biomarkers During Infection
- Low evidence
- Animal Study
Supplementation of heat-killed probiotics mixture improves intestinal morphology, antioxidant capacity, and meat quality in broilers.
- 2025-09
- RCT · n = 300
- Veterinary and animal science 29
- - Bishnu Prasad Bhattarai
  - Fu-Yuan Cheng
  - Yu-Cheng Xu
  - Chi Yu
  - Ting-Yu Lee
  - Hsiao-Tung Chang
  - Hsiao-Ching Lin
  - Hsiu-Ming Weng
  - Hsin-Hsuan Huang
  - Jin-Seng Lin
  - Chao-Wei Huang
- PubMed: 40487027
- DOI: 10.1016/j.vas.2025.100462
2 Insights on
- Improved Intestinal Morphology
- Improved Antioxidant Capacity
- High evidence