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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Probiotic and aroma-producing Bacillus sp. isolates from teles, a traditional fermented fish from Assam, India: functional characterisation and potential application in fermented foods.
- 2025-09-24
- BMC microbiology 25(1)
- - Debashree Borthakur
  - Bipin Kumar Sharma
  - Vijay Jagdish Upadhye
- PubMed: 40993571
- DOI: 10.1186/s12866-025-04312-w
1 Insight on
- Improved Gastrointestinal Resilience
- Low evidence
- Animal Study
Bifidobacterium treatment for chronic low back pain in patients with Modic changes: study protocol for a multicenter, randomized, placebo-controlled trial.
- 2025-09-24
- RCT
- Trials 26(1)
- - Sunqi Nian
  - Chengjin Li
  - Na Li
  - Fei Chen
  - Caiwang Zhao
  - Guangyao Zhang
  - Sheng Lu
  - Jiayu Chen
- PubMed: 40993700
- DOI: 10.1186/s13063-025-09084-2
5 Insights on
- High evidence
Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.
- 2025-09-24
- Meta-Analysis · n = 985
- Systematic reviews 14(1)
- - Peishan Cai
  - Zhou Shu
  - Taotao Zhou
  - Jie Li
  - Wei Chen
  - Xianpeng Zeng
  - Fang Zeng
- PubMed: 40993781
- DOI: 10.1186/s13643-025-02828-w
13 Insights on
- High evidence
A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease.
- 2025-09-24
- NPJ biofilms and microbiomes 11(1)
- - Aline Ovalle
  - Estefanía López
  - Jimena Sierralta
  - Nuria Paricio
  - Daniel Garrido
- PubMed: 40993130
- DOI: 10.1038/s41522-025-00797-5
3 Insights on
- Low evidence
- Animal Study
Synbiotics in Alzheimer's disease: mechanisms, clinical evidence, and therapeutic prospects.
- 2025-09-24
- Review
- Journal of translational medicine 23(1)
- - Yuhua Lin
  - Rongping Weng
  - Huayang Pan
  - Yangbo Hou
  - Yipeng Sun
  - Junkai Wen
- PubMed: 40993787
- DOI: 10.1186/s12967-025-07064-3
5 Insights on
- Low evidence
Probiotics in Pet Food: A Decade of Research, Patents, and Market Trends.
- 2025-09-24
- Review
- Foods (Basel, Switzerland) 14(19)
- - Phatthranit Klinmalai
  - Pitiya Kamonpatana
  - Janenutch Sodsai
  - Atcharawan Srisa
  - Khwanchat Promhuad
  - Yeyen Laorenza
  - Attawit Kovitvadhi
  - Sathita Areerat
  - Anusorn Seubsai
  - Massalin Nakphaichit
  - Nathdanai Harnkarnsujarit
- PubMed: 41097477
- DOI: 10.3390/foods14193307
4 Insights on
- Low evidence
Flaxseed in Diabetes Management: Nutritional and Therapeutic Insights.
- 2025-09-24
- Review
- Current nutrition reports 14(1)
- - Preedhi Kapoor
  - Zubair Ahmad Parrey
  - Bilal Ahmad Mir
  - Ab Waheed Wani
  - Ritu Kumari
  - Gurseen Rakhra
  - Ridhi Joshi
  - Gurmeen Rakhra
  - Wajid Aslam Khan
  - Kasim Sakran Abass
  - Bodour S Rajab
  - Arshad Farid
  - Saad Alghamdi
- PubMed: 40991096
- DOI: 10.1007/s13668-025-00696-3
4 Insights on
- Low evidence
Effect of Probiotics Containing Lactobacillus plantarum on Blood Lipids: Systematic Review, Meta-Analysis, and Network Pharmacological Analysis.
- 2025-09-23
- Review · n = 2,104
- Foods (Basel, Switzerland) 14(19)
- - Jinshi Zuo
  - Dan Huang
  - Jie Liu
  - Zidan Wang
  - Yuerong Ren
  - Yang Su
  - Yuxia Ma
- PubMed: 41097469
- DOI: 10.3390/foods14193300
6 Insights on
- High evidence
Probiotics as Adjuvants to Standard Helicobacter pylori Treatment: Evidence for the Use of Lacidofil®, an Established Blend of Thoroughly Characterized Strains.
- 2025-09-23
- Review
- Microorganisms 13(10)
- - Noémie Auclair-Ouellet
  - Annie Tremblay
  - Ola Kassem
  - Sara E Caballero-Calero
  - Stéphane Bronner
  - Sylvie Binda
- PubMed: 41156685
- DOI: 10.3390/microorganisms13102223
3 Insights on
- Low evidence
Performance-enhancing effects of caffeine and L-Theanine among Iranian elite wrestlers: a focus on cognitive and specific physical performance.
- 2025-09-22
- RCT
- Journal of the International Society of Sports Nutrition 22(1)
- - Rouzbeh Razazan
  - Mohammad Hemmatinafar
  - Babak Imanian
  - Nima Jahaniboushehri
  - Rasoul Rezaei
  - Gholamhossein Nazemzadegan
- PubMed: 40977612
- DOI: 10.1080/15502783.2025.2564238
9 Insights on
- High evidence
Effect of vitamin D-fortified foods on bone health and osteoporosis: a scoping review and future policies focusing on the United Arab Emirates.
- 2025-09-22
- Systematic Review · n = 14
- Archives of osteoporosis 20(1)
- - Sehar Iqbal
  - Maya Abuajlan
  - Amira Alktheri
  - Zoha Imtiaz Malik
  - Abdul Momin Rizwan Ahmad
  - Taima Qudah
  - Suhad Abumweis
- PubMed: 40982112
- DOI: 10.1007/s11657-025-01611-7
3 Insights on
- High evidence
Curcumin Versus Corticosteroids for Symptomatic Oral Lichen Planus: A Systematic Review and Meta-Analysis.
- 2025-09-22
- Meta-Analysis
- Clinical and experimental dental research 11(5)
- - Sadeq A Al-Maweri
  - Gamilah Al-Qadhi
  - Ahmed Yaseen Alqutaibi
  - Nadhem M Sallam
  - Mounzer Assad
  - Mahfoudh A Abdulghani
  - Marwan Mansoor Ali Mohammed
- PubMed: 40977174
- DOI: 10.1002/cre2.70227
2 Insights on
- Reduced Pain
- Improved Clinical Lesion Score
- High evidence
Systematic Review of the Effects of Plant-Based Foods on Metabolic Outcomes in Adults with MASLD and Comorbidities Such as Obesity, Metabolic Syndrome, and Type 2 Diabetes.
- 2025-09-22
- Systematic Review
- Nutrients 17(18)
- - Joanna Michalina Jurek
  - Katarzyna Zablocka-Slowinska
  - Joanna Pieczynska
  - Helena Clavero Mestres
  - Teresa Auguet
- PubMed: 41010543
- DOI: 10.3390/nu17183020
8 Insights on
- High evidence
- Rigorous Journal
Efficacy of dietary supplements on sports performance outcomes: a systematic review of evidence in elite athletes.
- 2025-09-22
- Systematic Review · n = 928
- Frontiers in nutrition 12
- - Tongwu Yu
  - Chuanwei Ding
- PubMed: 41058995
- DOI: 10.3389/fnut.2025.1675654
1 Insight on
- Improved Athletic Performance
- High evidence
Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.
- 2025-09-20
- RCT
- Molecular nutrition & food research 69(23)
- - Nicola Mangieri
  - Viola Termine
  - Giorgio Gargari
  - Nicolò Fornasari
  - Michele Isotti
  - Susana Salva
  - Julio Villena
  - María Pía Taranto
  - Valentina Taverniti
  - Susana Álvarez
  - Graciela Font
  - Ylenia Zanchetta
  - Stefania Arioli
  - Diego Mora
- PubMed: 40974119
- DOI: 10.1002/mnfr.70272
3 Insights on
- High evidence
- Rigorous Journal
Acid whey valorization: novel approaches for probiotic and functional products development.
- 2025-09-19
- Review
- Frontiers in nutrition 12
- - B Mutaliyeva
  - E Turkeyeva
  - G Madybekova
  - L Živković
  - Vssl Prasad Talluri
  - A Issayeva
  - M Vinceković
- PubMed: 41049378
- DOI: 10.3389/fnut.2025.1630925
3 Insights on
- Low evidence
The efficacy and safety of Epimedium in the treatment of primary osteoporosis: a systematic review and meta-analysis.
- 2025-09-19
- Systematic Review · n = 10
- Frontiers in medicine 12
- - Xian-Quan Zhang
  - Zhen-Hui Hua
  - Chu-Jia Huang
  - Hai-Yun Chen
  - Zong-Ren Hu
  - Mei-Ren Zhang
  - Jun Liu
- PubMed: 41048931
- DOI: 10.3389/fmed.2025.1675160
9 Insights on
- High evidence
Calcium supplementation commenced before pregnancy for preventing hypertensive disorders and related problems.
- 2025-09-18
- Meta-Analysis · n = 1,355
- The Cochrane database of systematic reviews 2025(9)
- - Catherine A Cluver
  - Christa Rohwer
  - Anke Rohwer
  - Maria Eduarda Dos Santos Santos Puga
  - Maria Regina Torloni
  - G Justus Hofmeyr
- PubMed: 40965861
- DOI: 10.1002/14651858.cd011192.pub4
7 Insights on
- High evidence
Efficacy of collagen peptide supplementation on bone and muscle health: a meta-analysis.
- 2025-09-18
- Review
- Frontiers in nutrition 12
- - Chongxiao Sun
  - Ao Yang
  - Fei Teng
  - Yayi Xia
- PubMed: 41049371
- DOI: 10.3389/fnut.2025.1646090
1 Insight on
- Increased Total Hip Bone Mineral Density
- Low evidence
Effectiveness of Vitamin D Supplementation on Biochemical, Clinical, and Inflammatory Parameters in Patients with Different Types of Diabetes: A Systematic Review and Meta-Analysis.
- 2025-09-18
- Meta-Analysis
- Nutrients 17(18)
- - Alejandro Bruna-Mejías
  - Rocío Valdivia-Arroyo
  - Emelyn Sofia Becerra-Rodríguez
  - Ignacio Clasing-Cárdenas
  - Yesica Tatiana Castaño-Gallego
  - Guinevere Granite
  - Mathias Orellana-Donoso
  - Gustavo Oyanedel-Amaro
  - Pablo Nova-Baeza
  - Gloria Cifuentes-Suazo
  - Alejandra Suazo-Santibañez
  - Juan Sanchis-Gimeno
  - Héctor Gutiérrez Espinoza
  - Juan José Valenzuela-Fuenzalida
- PubMed: 41010515
- DOI: 10.3390/nu17182991
13 Insights on
- High evidence
- Rigorous Journal
Probing the adhesion potential of Bifidobacterium animalis subsp. lactis MCM-B-2007 via in vitro and in silico analyses.
- 2025-09-18
- Archives of microbiology 207(11)
- - Vaidehi Pisu
  - Neelam Kapse
  - Deepa Shetty
  - Shilpa Wagh
  - Sumit Singh Dagar
  - Prashant K Dhakephalkar
- PubMed: 40965632
- DOI: 10.1007/s00203-025-04469-y
3 Insights on
- Low evidence
Probiotics in IBD: Evidence and Perspectives on Patient Health and Disease Management.
- 2025-09-17
- Review
- International journal of molecular sciences 26(18)
- - Emília Hijová
- PubMed: 41009629
- DOI: 10.3390/ijms26189065
8 Insights on
- Moderate evidence
- Rigorous Journal
Cardiovascular toxicity associated with supplement use.
- 2025-09-17
- Review
- Clinical toxicology (Philadelphia, Pa.) 63(11)
- - Justin Corcoran
- PubMed: 40960841
- DOI: 10.1080/15563650.2025.2550983
5 Insights on
- Low evidence
Use of the Probiotic Limosilactobacillus reuteri as an Adjunct to Subgingival Instrumentation in the Treatment of Periodontitis Patients With Diabetes: A Randomised Clinical Trial.
- 2025-09-17
- RCT · n = 40
- Journal of clinical periodontology 53(1)
- - Rocío Bujaldón
  - Eduardo Montero
  - Juan Daniel Gamonal
  - Alejandro Abuelo
  - María José Marín
  - Margarita Iniesta
  - Mariano Sanz
  - David Herrera
- PubMed: 40958659
- DOI: 10.1111/jcpe.70035
3 Insights on
- High evidence
Effects of Rice Bran Supplementation on Metabolic Syndrome-Related Parameters: A Systematic Review and Meta-Analysis.
- 2025-09-17
- Meta-Analysis · n = 1,255
- International journal of molecular sciences 26(18)
- - Sirapatsorn Tantayakhom
  - Ratchanon Inpan
  - Kantirat Yaja
  - Nut Koonrungsesomboon
  - Supanimit Teekachunhatean
  - Mingkwan Na Takuathung
- PubMed: 41009614
- DOI: 10.3390/ijms26189051
3 Insights on
- High evidence
- Rigorous Journal
Imaging and Microorganism Analyses of the Effects of Oral Bifidobacterium breve Intake on Facial Skin in Females: A Randomized, Double-Blind, Placebo-Controlled Study.
- 2025-09-17
- RCT · n = 120
- Nutrients 17(18)
- - Yuriko Nishikawa
  - Chendong Xu
  - Shin Yoshimoto
  - Noriko Katsumata
  - Noriyuki Iwabuchi
  - Naotake Yanagisawa
  - Shigeo Koido
  - Miyuki Tanaka
  - Jin-Zhong Xiao
  - Daisuke Asaoka
  - Toshifumi Ohkusa
  - Nobuhiro Sato
- PubMed: 41010502
- DOI: 10.3390/nu17182976
4 Insights on
- High evidence
- Large Human Trial
- Rigorous Journal
Oropharyngeal microbiome alterations in sarcopenia: a nested case-control study in older adults.
- 2025-09-17
- Observational · n = 120
- The journals of gerontology. Series A, Biological sciences and medical sciences 80(12)
- - Runjie Li
  - Wenhua Jiang
  - Huiyu Tang
  - Shuyue Luo
  - Xiaoyan Chen
  - Qian Chen
  - Ming Yang
- PubMed: 40973066
- DOI: 10.1093/gerona/glaf201
1 Insight on
- Association with Sarcopenia
- High evidence
Review of quinoa fermentation: product diversity, process optimization, and nutritional enhancement.
- 2025-09-16
- Review
- Frontiers in nutrition 12
- - Chen Li
  - Tong Liu
  - Xiaohong Li
  - Wenli Gao
  - Jiayin Lv
  - Gaojian Hu
  - Chunjiang Li
  - Fangfang Liu
  - Xianjun Liu
  - Xianglong Meng
- PubMed: 41036200
- DOI: 10.3389/fnut.2025.1605558
2 Insights on
- Increased Antioxidant Activity
- Improved Gut Health
- Low evidence
The Effect of Different Types of Olive Oil on Glucose Control and Insulin Sensitivity: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of 51 Randomized Controlled Trials.
- 2025-09-15
- Meta-Analysis · n = 4,334
- Nutrition reviews 84(2)
- - Alireza Takhttavous
  - Kimia Rostampour
  - Shirin Gerami
  - Mohsen Mohammadi-Sartang
- PubMed: 40971936
- DOI: 10.1093/nutrit/nuaf099
4 Insights on
- High evidence
Akkermansia muciniphila and osteoporosis: emerging role of gut microbiota in skeletal homeostasis.
- 2025-09-15
- Review
- Frontiers in microbiology 16
- - Yanlong Gong
  - Xin Ma
  - Jiumei Huang
  - Pengwei Zhang
  - Yunxiang Hai
  - Yongjia Song
  - Min Song
  - Yuanzhen Li
  - Haonan Wen
  - Wantao Dong
- PubMed: 41030554
- DOI: 10.3389/fmicb.2025.1665101
1 Insight on
- Improved Bone Health
- Low evidence