August 2010 Supplement Research Papers

• August 9

  • Tolerance and safety of the potentially probiotic strain Lactobacillus rhamnosus PRSF-L477: a randomised, double-blind placebo-controlled trial in healthy volunteers

    • 2010-08-09
    • RCT · n = 34
    • British Journal of Nutrition 104(12)
    • • R. D. Wind
      • Hermien Tolboom
      • I. Klare
      • G. Huys
      • J. Knol

    • PubMed: 20691131
    • DOI: 10.1017/S0007114510002746

    19 Insights on

    • Improved Blood Parameters
    • Improved Gastric Tolerance
    • No Significant Change in Gastrointestinal Symptoms
    • Increased Lactobacillus rhamnosus Presence in Stool
    • Stable Antibiotic Susceptibility Profiles
    • Stable Blood Parameters
    • Increased Antibiotic Susceptibility
    • Improved Tolerance to Lactobacillus rhamnosus PRSF-L477
    • Safety of Probiotic Strain Lactobacillus rhamnosus PRSF-L477
    • Normal Blood Parameters
    • Presence of Lactobacillus rhamnosus in Feces
    • Maintained Antibiotic Susceptibility
    • Unchanged Blood Parameters
    • Increased Probiotic Levels
    • Improved Antibiotic Susceptibility
    • Improved Gut Tolerance
    • Altered Blood Parameters
    • Tolerance to Lactobacillus rhamnosus PRSF-L477
    • No Significant Change in Gastrointestinal Tolerance

    • High evidence
• August 20

  • Systematic review and meta-analysis of Saccharomyces boulardii in adult patients.

    • 2010-08-20
    • Meta-Analysis
    • World Journal of Gastroenterology 16(18)
    • • L. Mcfarland

    • PubMed: 20458757
    • DOI: 10.3748/WJG.V16.I18.2202

    7 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Diarrhea Rate
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Helicobacter Pylori Treatment-Related Symptoms
    • Reduced C. difficile Disease Recurrences
    • Effective Treatment of Crohn's Disease
    • Treatment Efficacy for Giardiasis

    • High evidence
    • Highly Cited

  • Adhesion and immunomodulatory effects of Bifidobacterium lactis HN019 on intestinal epithelial cells INT-407.

    • 2010-08-20
    • World Journal of Gastroenterology 16(18)
    • • Chang Liu
      • Zhuo-Yang Zhang
      • K. Dong
      • Xiao-kui Guo

    • PubMed: 20458767
    • DOI: 10.3748/WJG.V16.I18.2283

    2 Insights on

    • Reduced Interleukin-8 Secretion
    • Reduced Pathogen Adhesion

    • Low evidence
• August 23

  • Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

    • 2010-08-23
    • Clinical Trial
    • Bioscience, Biotechnology, and Biochemistry 74(8)
    • • S. Kondo
      • J. Xiao
      • T. Satoh
      • T. Odamaki
      • Sachiko Takahashi
      • H. Sugahara
      • T. Yaeshima
      • K. Iwatsuki
      • A. Kamei
      • K. Abe

    • PubMed: 20699581
    • DOI: 10.1271/bbb.100267

    9 Insights on

    • Improved Insulin Sensitivity
    • Improved Insulin Levels
    • Reduced Weight Gain
    • Improved Cholesterol Levels
    • Increased Bifidobacterial Population
    • Reduced Body Weight Accumulation
    • Improved Total Cholesterol Levels
    • Improved Fasting Glucose Levels
    • Reduced Epididymal Adipose Tissue

    • Low evidence
    • Highly Cited
    • Animal Study
• August 26

  • Oral intake of Lactobacillus pentosus strain b240 accelerates salivary immunoglobulin A secretion in the elderly: A randomized, placebo-controlled, double-blind trial

    • 2010-08-26
    • RCT · n = 80
    • Immunity & Ageing 7(1)
    • • Yoshifumi Kotani
      • S. Shinkai
      • H. Okamatsu
      • Masamichi Toba
      • K. Ogawa
      • H. Yoshida
      • T. Fukaya
      • Y. Fujiwara
      • P. Chaves
      • K. Kakumoto
      • N. Kohda

    • PubMed: 20796295
    • DOI: 10.1186/1742-4933-7-11

    1 Insight on

    • Increased Salivary Immunoglobulin A Secretion

    • High evidence
    • Highly Cited
• August 27

  • Orally supplemented Lactobacillus acidophilus strain L‐92 inhibits passive and active cutaneous anaphylaxis as well as 2,4‐dinitroflurobenzene and mite fecal antigen induced atopic dermatitis‐like skin lesions in mice

    • 2010-08-27
    • Clinical Trial
    • Microbiology and Immunology 54(9)
    • • M. Shah
      • Y. Miyamoto
      • Yoshihito Yamada
      • H. Yamashita
      • Hiroyuki Tanaka
      • T. Ezaki
      • H. Nagai
      • N. Inagaki

    • PubMed: 20840151
    • DOI: 10.1111/j.1348-0421.2010.00251.x

    3 Insights on

    • Improved Atopic Dermatitis Symptoms
    • Reduced Vascular Permeability
    • Reduced Ovalbumin-Specific IgE Level

    • Low evidence
    • Animal Study
• August 28

  • Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections

    • 2010-08-28
    • RCT · n = 272
    • European Journal of Nutrition 50(3)
    • • A. Berggren
      • I. Lazou Ahrén
      • N. Larsson
      • G. Önning

    • PubMed: 20803023
    • DOI: 10.1007/s00394-010-0127-6

    6 Insights on

    • Reduced Risk of Common Cold Infections
    • Reduced Duration of Common Cold Symptoms
    • Reduced Total Symptom Score
    • Reduced Pharyngeal Symptoms
    • Reduced B Lymphocyte Proliferation
    • Reduced Risk of Common Cold

    • High evidence
    • Highly Cited
    • Rigorous Journal
• Undated – 2 supplement studies

  • Interaction of dietary Bacillus subtilis and fructooligosaccharide on the growth performance, non-specific immunity of sea cucumber, Apostichopus japonicus.

    • 2010-08
    • Fish & Shellfish Immunology 29(2)
    • • Qin Zhang
      • Hongming Ma
      • K. Mai
      • Wenbing Zhang
      • Zhiguo Liufu
      • W. Xu

    • PubMed: 20371291
    • DOI: 10.1016/j.fsi.2010.03.009

    8 Insights on

    • Improved Growth Performance
    • Enhanced Disease Resistance
    • Improved Immunity
    • Reduced Vibrio Counts in Intestine
    • Enhanced Phagocytic Activity
    • Increased Total Coelomocyte Count
    • Increased Viable Bacteria Count
    • Reduced Vibrio Counts

    • Low evidence
    • Highly Cited

  • Effect of Bifidobacterium animalis subsp lactis Supplementation in Preterm Infants: A Systematic Review of Randomized Controlled Trials

    • 2010-08
    • Systematic Review
    • Journal of Pediatric Gastroenterology and Nutrition 51(2)
    • • H. Szajewska
      • S. Guandalini
      • L. Morelli
      • J. V. van Goudoever
      • A. Walker

    • PubMed: 20543719
    • DOI: 10.1097/MPG.0b013e3181dc0d93

    30 Insights on

    • Reduced Body Mass Index
    • Reduced Faecal pH
    • Reduced Intestinal Permeability
    • Reduced Enterobacteriaceae Counts
    • Reduced Clostridium Counts
    • Reduced Faecal Calprotectin
    • Increased Fecal Bifidobacteria Levels
    • Increased Short Chain Fatty Acids
    • Increased Fecal Bifidobacteria
    • Increased Fecal Immunoglobulin A Concentrations
    • No Change in Risk of Necrotizing Enterocolitis
    • No Change in Sepsis Risk
    • No Change in Antibiotic Usage
    • No Adverse Events Observed
    • Increased Fecal Immunoglobulin A Levels
    • Absence of Adverse Events
    • Reduced Enterobacterial Counts
    • No Change in Risk of Stage 2 or Higher Necrotizing Enterocolitis
    • Increased Antibiotic Use
    • Reduced Clostridium Species Counts
    • Increased Short-Chain Fatty Acids Concentrations
    • Reduced Stool pH
    • No Adverse Events Associated with B Lactis Supplementation
    • Increased Risk of Necrotizing Enterocolitis Stage 2 or Higher
    • Increased Risk of Sepsis
    • Unchanged Use of Antibiotics
    • Adverse Events Due to Supplementation
    • No Reduced Risk of Necrotizing Enterocolitis
    • Unchanged Risk of Sepsis
    • No Reduction in Antibiotic Use

    • High evidence