Bone-Up

4.8 (4K reviews)

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Supplement Ingredients
Ingredients	Amount Per Serving
Vitamin C (as Calcium Ascorbate) Vitamin C	66.7 mg
Vitamin D (as D3 Cholecalciferol) Vitamin D	8.3 mcg
Calcium (Elemental) (from Microcrystalline Hydroxyapatite) Calcium	333.3 mg
Magnesium (as Magnesium Oxide) Magnesium	166.7 mg
Zinc (as Zinc L-Methionine Sulfate) Zinc	3.3 mg
Copper (as Copper Gluconate) Copper	333 mcg
Manganese (as Manganese Citrate) Manganese	333 mcg
Potassium (as Potassium citrate) Potassium	33 mg
Vitamin K2 (as naturally Derived MK-7 [menaquinone-7])	15 mcg
Boron (as Boron Citrate) Boron	1 mg

Ingredient Research

Vitamin C
- ModerateReduced Pain8 studies
- ModerateReduced Interleukin-6 Levels7 studies
- ModerateReduced Systolic Blood Pressure4 studies
Vitamin D
- HighIncreased 25-hydroxyvitamin D Level16 studies
- HighReduced Inflammation6 studies
- ModerateReduced C-Reactive Protein Levels9 studies
Calcium
- LowIncreased Total Hip Bone Mineral Density4 studies
- LowImproved Bone Mineral Density3 studies
- LowReduced Stillbirth3 studies
Magnesium
- ModerateReduced Depression Symptoms3 studies
- LowReduced C-Reactive Protein Levels3 studies
Zinc
- LowReduced Zinc Level4 studies
- LowIncreased Hemoglobin Levels3 studies

How this product's ingredient doses compare to doses studied in research.

Vitamin C66.7 mg
Studies used 12–1,200 mg/day (median 500) across 19 studies
Low end of studied doses
Calcium333.3 mg
Studies used 500–1,000 mg/day (median 750) across 4 studies
Below studied range
Form mismatch: this product uses Hydroxyapatite. Most research support uses Calcium Carbonate (1 study).
Magnesium166.7 mg
Studies used 80–637 mg/day (median 250) across 8 studies
In typical studied range
Zinc3.3 mg
Studies used 10–100 mg/day (median 55) across 2 studies
Below studied range

Ingredient pairs in this product that have synthesised research evidence together.

Very low evidenceVitamin D + Vitamin Cfor Improved Cognitive Function· 3 studies
Of the 3 studies examining the combination of vitamin D and vitamin C for cognitive function, 1 reported a beneficial effect while 2 found neutral effects. The single beneficial finding came from a systematic review that did not isolate the combination, and the other two reviews/meta-analyses found no significant effect. Compared to vitamin D alone (which showed neutral effects across 3 solo studies), the combination evidence is similarly inconclusive. No consistent dose, form, or duration data were reported across studies.

Supports bone health with 333.3 mg of Elemental Calcium from Microcrystalline Hydroxyapatite, which is closer to the form found in the human body.
Enhances calcium absorption with 8.3 mcg of Vitamin D3 (Cholecalciferol).
Boosts collagen formation for stronger bones and joints with 66.7 mg of Vitamin C (Calcium Ascorbate).
Provides essential bone metabolism support with 15 mcg of Vitamin K2 (menaquinone-7), aiding in proper calcium utilization.
Includes Magnesium Oxide to support bone mineral density and overall bone health.
Contains Zinc (Zinc L-Methionine Sulfate) for bone tissue formation and immune support.
Aids in collagen synthesis and bone matrix development with 0.333 mg of Manganese.
Offers 0.333 mg of Copper for enzyme functions necessary for bone strength.
Provides Boron (1 mg Boron Citrate) for optimal bone growth and maintenance.
Supports electrolyte balance with 33 mg of Potassium (Potassium Citrate).
The formula is Wheat Free and Gluten Free, ensuring suitability for people with specific dietary restrictions.