Vitamin D

Name: Supplements for Vitamin D
Creator: Pillser
License: https://creativecommons.org/licenses/by/4.0/

What does the research say about Vitamin D?

3 health outcomes synthesised

Vitamin D is one of the most extensively studied vitamins on Pillser, with research syntheses covering three health outcomes. The strongest evidence, rated as high strength, comes from 5 studies showing that vitamin D supplementation consistently increases 25-hydroxyvitamin D levels, with a moderate effect size and doses ranging from 1,000 to 7,000 IU per day. Key populations studied include older adults, healthy children, and clinical groups such as those with Parkinson's disease or multiple sclerosis.

Strongest evidence: The highest-rated evidence (high strength) is for increased 25-hydroxyvitamin D levels, supported by all 5 studies reporting statistically significant beneficial effects. The effect size is moderate to large, observed typically within 8–12 weeks, with doses of 1,000–7,000 IU/day (or up to 100,000 IU weekly). One study noted that calcifediol may be more efficacious than cholecalciferol.

Moderate evidence: Two outcomes have moderate evidence strength. For improved insulin sensitivity, all 4 studies reported beneficial effects (mostly moderate size), with 3 reaching statistical significance. The evidence is strongest in women with PCOS, diabetes, and prediabetes, particularly when baseline vitamin D is low. A typical dose (4,000 IU/day) was used in one study. For reduced C-reactive protein (CRP) levels, 3 of 4 studies found moderate beneficial effects in obese/overweight adults and those with diabetes/prediabetes, though 1 study found no effect. Many studies used co-supplementation with other nutrients, complicating attribution.

Effective dose patterns: Across outcomes, doses around 1,000–4,000 IU/day are common, with one study using up to 7,000 IU/day for raising blood levels. No consistent effective dose emerged for insulin sensitivity or CRP due to incomplete reporting.

Population insights: Benefits are most consistent in populations with low baseline vitamin D levels (deficiency), such as older adults, obese individuals, and clinical groups (PCOS, diabetes, multiple sclerosis). Effects on inflammation and insulin sensitivity were less clear in replete individuals.

Notable caveats: Publication bias is a concern across all outcomes — null results may be underrepresented. The evidence base is small (4–5 studies per outcome), so conclusions are preliminary. Co-supplementation in CRP studies and wide dosing variability across all outcomes limit specificity.

Frequently asked

What is Vitamin D good for according to research?
Based on research syntheses, vitamin D supplementation is most strongly associated with increasing blood levels of 25-hydroxyvitamin D (5 out of 5 studies). Moderate evidence suggests benefits for improving insulin sensitivity (4 out of 4 studies) and reducing C-reactive protein levels (3 out of 4 studies), particularly in deficient or clinical populations.
What dose of Vitamin D is typically used in studies?
For raising vitamin D levels, studies used doses of 1,000–7,000 IU per day, with one study using weekly dosing up to 100,000 IU. For insulin sensitivity, 4,000 IU/day was used in one study. Doses for C-reactive protein reduction were not consistently reported across studies.
Who benefits most from Vitamin D?
Research shows the strongest benefits in people with low baseline vitamin D levels (deficiency). Clinical populations such as older adults, women with PCOS, patients with diabetes or prediabetes, and obese individuals tend to show the most consistent effects. For healthy individuals with adequate vitamin D levels, benefits are less certain.
Are there caveats or limitations in the research on Vitamin D?
Yes. Across all outcomes, publication bias is a concern — studies with null results are less likely to be published. The evidence base is small (only 4–5 studies per outcome), making conclusions preliminary. For C-reactive protein, most beneficial studies used co-supplementation with other nutrients, making it hard to attribute effects to vitamin D alone.
Does Vitamin D help with insulin sensitivity?
Moderate evidence from 4 studies indicates vitamin D supplementation may improve insulin sensitivity, with 3 of 4 studies showing statistically significant effects. Benefits appear most pronounced in women with PCOS and people with diabetes or prediabetes, especially when baseline vitamin D levels are low. The effect size is generally moderate.
Does Vitamin D reduce inflammation (C-reactive protein)?
Evidence is moderate: 3 of 4 studies reported that vitamin D supplementation reduced C-reactive protein levels with a moderate effect size, while 1 study found no effect. Results are strongest in obese or overweight adults and those with diabetes. However, many studies combined vitamin D with other nutrients, so the independent effect is unclear.

High evidenceIncreased 25-hydroxyvitamin D Level
Moderate evidenceReduced C-Reactive Protein Levels
Moderate evidenceImproved Insulin Sensitivity
MixedReduced Systolic Blood Pressure
Reduced Tumor Necrosis Factor Alpha
Reduced Diastolic Blood Pressure
Reduced Total Cholesterol
Reduced LDL Cholesterol
Reduced Triglyceride Levels
Increased Total Hip Bone Mineral Density

Most-studied combinations with Vitamin D

most supplement research is combination research

Also studied with:Calcium (3), Magnesium (2)

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Men's Multivitamin Gummies

By Nature's Craft

4.9 (32 reviews)

In Stock

Pricing Information
Ingredient	Vitamin D
Amount per Pill	5 mcg
Total Amount	900 mcg
Price per mg	USD 20

Supplement Ingredients
Ingredients	Amount Per Serving
Calories	-
Total Carbohydrate	4 g
Total Sugars	4 g
Includes added sugars	-
Vitamin A Vitamin A	1.2 mg
Retinyl Acetate Vitamin A	-
Vitamin C Vitamin C	60 mg
Ascorbic Acid Vitamin C	-
Vitamin D Vitamin D	10 mcg
cholecalciferol Vitamin D	-
Vitamin E Vitamin E	18 mg
dl-Alpha Tocopheryl Acetate Vitamin E	-
Vitamin B-6 Vitamin B6	2 mg
Pyridoxine HCL Vitamin B6	-
folate Vitamin B9	670 mcg
vitamin B-12 Vitamin B12	8 mcg
cyanocobalamin Vitamin B12	-
biotin Vitamin B7	150 mcg
Pantothenic Acid Vitamin B5	10 mg
Calcium D-Pantothenate Vitamin B5	-
Iodine Iodine	80 mcg
Potassium Iodide Iodine	-
Zinc Zinc	5 mg
Zinc Citrate Zinc	-
sodium Sodium	15 mg

Gluten Free

GMP Certified

Product Description

Supports Immune Health: Contains Vitamin C and Zinc to help fortify your immune system.
Promotes Skin and Hair Health: Biotin and Vitamin E to maintain healthy skin and hair.
Boosts Energy Levels: B-Vitamins including B-6 and B-12 help convert food into energy, keeping you active and alert.
Enhances Bone Health: Vitamin D and Iodine work together to support bone strength and overall skeletal health.
Maintains Vision and Eye Health: Vitamin A to support good vision and eye health.
Easy Consumption: Gummy format for a tasty and convenient way to get your daily vitamins.
Gluten-Free: Perfect for those with gluten sensitivities or dietary restrictions.
GMP Certified: Manufactured following Good Manufacturing Practices for quality assurance.

Crafted with your daily wellness in mind, Nature's Craft Men’s Multivitamin Gummies offer a comprehensive blend of essential vitamins and minerals for overall health, packed into a delicious and easy-to-eat gummy form. Make your health routine enjoyable and effective with these specifically formulated gummies designed to keep you feeling your best every day.

Other ingredients

glucose syrup
sugar
glucose
pectin
citric acid
sodium citrate
natural flavors
vegetable oil (contains carnauba wax)
purple carrot juice concentrate (for color)
beta-carotene (for color)

Free of

Serving Size: 2

Servings per Container: 45

Pill Type: Gummy

Flavor: -

UPC: 850019770711

Best Price Guarantee

Women's One Daily MultiVitamin

By MegaFood

4.8 (100 reviews)

In Stock

Pricing Information
Ingredient	Vitamin D
Amount per Pill	10 mcg
Total Amount	900 mcg
Price per mg	USD 50

Supplement Ingredients
Ingredients	Amount Per Serving
Vitamin A Vitamin A	370 mcg RAE
beta carotene Vitamin A	-
Vitamin C Vitamin C	60 mg
ascorbic acid Vitamin C	-
Vitamin D3 Vitamin D	10 mcg
fermented cholecalciferol Vitamin D3	-
Vitamin E Vitamin E	10 mg
d-alpha tocopherol Vitamin E	-
sunflower seed oil Sunflower Oil	-
Vitamin K Vitamin K	75 mcg
phytonadione Vitamin K1	-
thiamin Vitamin B1	1.5 mg
thiamine hydrochloride Vitamin B1	-
riboflavin Vitamin B2	1.7 mg
riboflavin Vitamin B2	-
niacin Vitamin B3	20 mg
niacinamide Vitamin B3	-
Vitamin B6 Vitamin B6	4 mg
pyridoxine hydrochloride Vitamin B6	-
folate Vitamin B9	400 mcg DFE
folic acid Vitamin B9	-
Vitamin B12 Vitamin B12	10 mg
cyanocobalamin Vitamin B12	-
Biotin Vitamin B7	30 mcg
biotin Vitamin B7	-
Pantothenic Acid Vitamin B5	10 mg
d-calcium pantothenate Vitamin B5	-
iron Iron	9 mg
fermented iron bisglycinate Iron	-
Iodine Iodine	100 mcg
fermented iodine glycinate Iodine	-
zinc Zinc	9 mg
fermented zinc bisglycinate Zinc	-
selenium Selenium	18 mcg
fermented selenium glycinate Selenium	-
cooper Copper	40 mcg
fermented copper bisglycinate Copper	-
manganese Manganese	2 mg
fermented manganese bisglycinate	-
GTF chromium Chromium	40 mcg
fermented chromium glycinate Chromium	-
nicotinate	-
glutamate L-Glutamic Acid	-
Molybdenum Molybdenum	37 mcg
fermented molybdenum bisglycinate Molybdenum	-
Boron Boron	500 mcg
fermented boron glycinate Boron	-
Food & Herb Blend	259 mg
organic brown rice	-
organic orange	-
carrot	-
organic chaste tree fruit Chaste Tree	-
organic astragalus root Astragalus	-
organic eleuthero root Eleuthero	-
organic cranberry	-
organic ashwagandha root Ashwagandha	-
organic ginger root	-
organic nettle leaf Stinging Nettle	-
organic schisandra fruit Schisandra	-
organic broccoli head	-
organic blueberry	-
cabbage head	-
organic dandelion leaf Dandelion	-
organic dandelion root Dandelion	-
organic red raspberry leaf	-
organic springtail leaf	-
organic shiitake mushroom	-