December 2008 Supplement Research Papers

• December 1

  • Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.

    • 2008-12-01
    • Cancer Research 68(23)
    • • Xingmin Wang
      • Toby D. Allen
      • R. May
      • S. Lightfoot
      • C. Houchen
      • M. Huycke

    • PubMed: 19047172
    • DOI: 10.1158/0008-5472.CAN-08-1551

    2 Insights on

    • Increased Chromosomal Instability
    • Occurrence of Aneuploidy

    • Low evidence
    • Highly Cited
• December 16

  • Prebiotics, probiotics, synbiotics in surgery—are they only trendy, truly effective or even dangerous?

    • 2008-12-16
    • Systematic Review
    • Langenbeck's Archives of Surgery 394(3)
    • • N. Rayes
      • D. Seehofer
      • P. Neuhaus

    • PubMed: 19084991
    • DOI: 10.1007/s00423-008-0445-9

    2 Insights on

    • Reduced Mortality Rate
    • Reduced Bacterial Infection Rates

    • High evidence
• Undated – 3 supplement studies

  • The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.

    • 2008-12
    • Clinical Trial
    • Journal of Psychiatric Research 43(2)
    • • L. Desbonnet
      • L. Garrett
      • G. Clarke
      • J. Bienenstock
      • T. Dinan

    • PubMed: 18456279
    • DOI: 10.1016/j.jpsychires.2008.03.009

    8 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Pro-inflammatory Cytokine Levels
    • Increased Plasma Tryptophan Concentration
    • Increased Plasma Kynurenic Acid Levels
    • Reduced DOPAC Levels in Amygdaloid Cortex
    • Reduced Pro-inflammatory Immune Responses
    • Elevated Serum Tryptophan Levels

    • Low evidence
    • Highly Cited
    • Animal Study

  • Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice.

    • 2008-12
    • Clinical Trial
    • International Journal of Food Microbiology 128(2)
    • • S. Segawa
      • Yoshihisa Wakita
      • H. Hirata
      • J. Watari

    • PubMed: 18976829
    • DOI: 10.1016/j.ijfoodmicro.2008.09.023

    22 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Aminotransferase Levels
    • Reduced Inflammatory Markers
    • Reduced Liver Fat Content
    • Reduced Inflammation Levels
    • Reduced Hepatic Fat Accumulation
    • Reduced TNF-α Levels
    • Reduced Liver Enzyme Levels
    • Reduced Liver Triglyceride Content
    • Reduced Liver Triglycerides
    • Reduced AST Levels
    • Reduced Liver Fat
    • Reduced Elevated Liver Enzymes
    • Reduced Liver Cholesterol Content
    • Reduced Hepatic Inflammation
    • Reduced Liver Cholesterol
    • Reduced Liver Injury Indicators
    • Increased Expression of Heat Shock Protein 25
    • Reduced Alcohol-Induced Liver Injury
    • Improved Alcohol-induced Liver Injury
    • Improvement in Alcoholic Liver Disease
    • Increased Intestinal Barrier Cytoprotection

    • Low evidence
    • Highly Cited
    • Animal Study

  • Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101.

    • 2008-12
    • Clinical Trial
    • International Journal of Food Microbiology 128(2)
    • • Yueh-Ting Tsai
      • Po-Ching Cheng
      • C. Fan
      • T. Pan

    • PubMed: 18809220
    • DOI: 10.1016/j.ijfoodmicro.2008.08.009

    9 Insights on

    • Improved Gut Microbiota
    • Improved Immune Response
    • Increased Beneficial Gut Microbiota
    • Reduced Harmful Gut Bacteria
    • Enhanced Antibody Production
    • Chronic Immune Activation
    • Improved Intestinal Microflora
    • Improved Antigen-Presenting Ability of Dendritic Cells
    • Increased Lymphocyte Proliferation

    • Low evidence
    • Highly Cited
    • Animal Study