September 2015 Supplement Research Papers

• September 1

  • Th17 Cells as Potential Probiotic Therapeutic Targets in Inflammatory Bowel Diseases.

    • 2015-09-01
    • Review
    • International journal of molecular sciences 16(9)
    • • Eddy Owaga
      • Rong-Hong Hsieh
      • Beatrice Mugendi
      • Sakhile Masuku
      • Chun-Kuang Shih
      • Jung-Su Chang

    • PubMed: 26340622
    • DOI: 10.3390/ijms160920841

    2 Insights on

    • Reduced Intestinal Inflammation
    • Modulated Inflammatory Response

    • Moderate evidence
    • Rigorous Journal
• September 2

  • Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.

    • 2015-09-02
    • RCT · n = 60
    • Molecular Nutrition & Food Research 59(11)
    • • M. Gómez-Guzmán
      • M. Toral
      • M. Romero
      • R. Jiménez
      • P. Galindo
      • M. Sánchez
      • M. J. Zarzuelo
      • M. Olivares
      • J. Gálvez
      • J. Duarte

    • PubMed: 26255877
    • DOI: 10.1002/mnfr.201500290

    4 Insights on

    • Reduced Systolic Blood Pressure
    • Improved Vascular Endothelial Function
    • Reduced Aortic Superoxide Levels
    • Increased Endothelial Nitric Oxide Synthase Activity

    • Low evidence
    • Highly Cited
    • Animal Study
• September 11

  • Biopolymers from lactic acid bacteria. Novel applications in foods and beverages.

    • 2015-09-11
    • Review
    • Frontiers in microbiology 6
    • • María I Torino
      • Graciela Font de Valdez
      • Fernanda Mozzi

    • PubMed: 26441845
    • DOI: 10.3389/fmicb.2015.00834

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• September 14

  • Bifidobacterium infantis attenuates colitis by regulating T cell subset responses.

    • 2015-09-14
    • Clinical Trial
    • World Journal of Gastroenterology 20(48)
    • • L. Zuo
      • Kai-Tao Yuan
      • Li Yu
      • Qing-Hong Meng
      • P. C. Chung
      • Ding-hua Yang

    • PubMed: 25561798
    • DOI: 10.3748/wjg.v20.i48.18316

    4 Insights on

    • Reduced Pro-Inflammatory Cytokines
    • Increased Regulatory T-Cells
    • Reduced Immune Cell Infiltration
    • Reduced Severity of Acute Colitis

    • Low evidence
    • Rigorous Journal
    • Animal Study
• September 15

  • Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood

    • 2015-09-15
    • RCT · n = 109
    • Pediatric Research 79(1)
    • • T. Taipale
      • K. Pienihäkkinen
      • E. Isolauri
      • J. Jokela
      • E. Söderling

    • PubMed: 26372517
    • DOI: 10.1038/pr.2015.174

    7 Insights on

    • Reduced Fever
    • Reduced Respiratory Tract Infections
    • No Significant Change in Gastrointestinal Symptoms
    • Unchanged Gastrointestinal Symptoms
    • Reduced Respiratory Tract Infection
    • Reduced Gastrointestinal Symptom
    • Reduced Otitis Media Infection

    • High evidence

  • The vaginal isolate Lactobacillus paracasei LPC-S01 (DSM 26760) is suitable for oral administration

    • 2015-09-15
    • Clinical Trial
    • Frontiers in Microbiology 6
    • • S. Balzaretti
      • Valentina Taverniti
      • Greta Rondini
      • Giorgio Marcolegio
      • M. Minuzzo
      • M. C. Remagni
      • W. Fiore
      • S. Arioli
      • S. Guglielmetti

    • PubMed: 26441886
    • DOI: 10.3389/fmicb.2015.00952

    4 Insights on

    • Reduced Inflammatory Response
    • Improved Gastric Tolerance
    • Increased Antibiotic Susceptibility
    • Increased Fecal Cell Persistence

    • Moderate evidence
• September 18

  • Gut microbiota and liver diseases.

    • 2015-09-18
    • Review
    • World journal of gastroenterology 21(6)
    • • Masami Minemura
      • Yukihiro Shimizu

    • PubMed: 25684933
    • DOI: 10.3748/wjg.v21.i6.1691

    1 Insight on

    • Reduced Liver Disease Symptoms

    • Moderate evidence
    • Highly Cited

  • Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial

    • 2015-09-18
    • RCT · n = 1,248
    • British Journal of Nutrition 114(10)
    • • D. Eskesen
      • L. Jespersen
      • B. Michelsen
      • P. Whorwell
      • S. Müller-lissner
      • Cathrine M Morberg

    • PubMed: 26382580
    • DOI: 10.1017/S0007114515003347

    9 Insights on

    • Improved Bowel Movement Frequency
    • Improved Gastrointestinal Health
    • Reduced Abdominal Pain
    • Improved Intestinal Function
    • Reduced Abdominal Discomfort
    • Improved Gastrointestinal Well-Being
    • Increased Defecation Frequency
    • Increased Stool Frequency
    • Improved Stool Frequency

    • High evidence
    • Large Human Trial

  • Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial.

    • 2015-09-18
    • RCT · n = 1,248
    • The British journal of nutrition 114(10)
    • • Dorte Eskesen
      • Lillian Jespersen
      • Birgit Michelsen
      • Peter J Whorwell
      • Stefan Müller-Lissner
      • Cathrine M Morberg

    • PubMed: 26382580
    • DOI: 10.1017/s0007114515003347

    5 Insights on

    • Improved Bowel Movement Frequency
    • Improved Gastrointestinal Well-Being
    • Increased Defecation Frequency
    • Improved Defecation Condition
    • No Significant Improvement in Global Gastrointestinal Well-being

    • High evidence
    • Large Human Trial
• September 28

  • Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis.

    • 2015-09-28
    • FEMS Microbiology Letters 362(21)
    • • D. Ríos-Covian
      • M. Gueimonde
      • S. Duncan
      • H. Flint
      • C. G. de los Reyes-Gavilán

    • PubMed: 26420851
    • DOI: 10.1093/femsle/fnv176

    1 Insight on

    • Increased Butyrate Production

    • Low evidence
    • Highly Cited
• September 29

  • Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers

    • 2015-09-29
    • RCT · n = 96
    • European Journal of Nutrition 56(1)
    • • K. Shida
      • Tadashi Sato
      • R. Iizuka
      • R. Hoshi
      • O. Watanabe
      • Tomoki Igarashi
      • K. Miyazaki
      • M. Nanno
      • F. Ishikawa

    • PubMed: 26419583
    • DOI: 10.1007/s00394-015-1056-1

    7 Insights on

    • Maintained Natural Killer Cell Activity
    • Reduced Salivary Cortisol Levels Under Stress
    • Reduced Incidence of Upper Respiratory Tract Infections
    • Increased URTI-Free Rate
    • Increased NK Cell Activity
    • Reduced Duration of Upper Respiratory Tract Infection
    • Reduced Upper Respiratory Tract Infection Symptoms

    • High evidence
    • Highly Cited
    • Rigorous Journal
• Undated – 4 supplement studies

  • Patients Receiving Prebiotics and Probiotics Before Liver Transplantation Develop Fewer Infections Than Controls: A Systematic Review and Meta-Analysis.

    • 2015-09
    • Meta-Analysis
    • Clinical Gastroenterology and Hepatology 13(9)
    • • Tarek Sawas
      • Shadi Al Halabi
      • Ruben Hernaez
      • W. Carey
      • W. Cho

    • PubMed: 26044318
    • DOI: 10.1016/j.cgh.2015.05.027

    5 Insights on

    • Reduced Hospitalization Duration
    • Reduced Pediatric Intensive Care Unit Stay
    • Reduced Urinary Tract Infection Incidence
    • Reduced Intra-Abdominal Infections
    • Reduced Duration of Antibiotic Usage

    • High evidence
    • Highly Cited

  • In vitro probiotic characteristics of Lactobacillus plantarum ZDY 2013 and its modulatory effect on gut microbiota of mice.

    • 2015-09
    • Journal of Dairy Science 98(9)
    • • Renhui Huang
      • X. Tao
      • C. Wan
      • S. Li
      • Hengyi Xu
      • Feng Xu
      • N. Shah
      • Hua Wei

    • PubMed: 26142853
    • DOI: 10.3168/jds.2014-9153

    4 Insights on

    • Improved Gut Microbiota Composition
    • Enhanced Resistance to Infections
    • Increased Antibacterial Activity
    • Enhanced Gastrointestinal Stress Resistance

    • Low evidence
    • Rigorous Journal

  • Streptococcus salivarius K12 Limits Group B Streptococcus Vaginal Colonization

    • 2015-09
    • Clinical Trial
    • Infection and Immunity 83(9)
    • • K. Patras
      • P. Wescombe
      • B. Rösler
      • J. Hale
      • J. Tagg
      • K. Doran

    • PubMed: 26077762
    • DOI: 10.1128/IAI.00409-15

    2 Insights on

    • Reduced Group B Streptococcus Colonization
    • Reduced Vaginal Group B Streptococcus Colonization

    • Low evidence
    • Animal Study

  • Lactobacillus sakei K040706 evokes immunostimulatory effects on macrophages through TLR 2-mediated activation.

    • 2015-09
    • Clinical Trial
    • International Immunopharmacology 28(1)
    • • J. Jung
      • Ji-Sun Shin
      • Suel-Gie Lee
      • Y. Rhee
      • Chang-Won Cho
      • Hee‐Do Hong
      • Kyung-Tae Lee

    • PubMed: 26049027
    • DOI: 10.1016/j.intimp.2015.05.037

    4 Insights on

    • Improved Immune Function
    • Improved Phagocytic Activity of Macrophages
    • Enhanced Immune Signaling Molecule Production
    • Restored Immunological Function in Immunosuppressed Mice

    • Low evidence
    • Rigorous Journal
    • Animal Study