July 2018 Supplement Research Papers

• July 2

  • Fermented camel milk by Lactococcus lactis subsp. cremoris attenuates erythrocytes oxidative stress-induced hematological and immunological damage in CCl4-intoxicated mice

    • 2018-07-02
    • RCT · n = 28
    • Environmental Science and Pollution Research 25(26)
    • • H. Hamed
      • Fatma Châari
      • Zied Ghannoudi
      • Kaouther Dhouib
      • S. Châabouni
      • A. Feki
      • A. Gargouri

    • PubMed: 29968212
    • DOI: 10.1007/s11356-018-2623-9

    4 Insights on

    • Reduced Inflammatory Markers
    • Improved Hematological Parameters
    • Reduced Oxidative Stress in Red Blood Cells
    • Improved Immunoglobulin Levels

    • Low evidence
    • Animal Study
• July 3

  • A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock.

    • 2018-07-03
    • RCT
    • Chronobiology international 35(10)
    • • Takafumi Fukuda
      • Atsushi Haraguchi
      • Masaki Takahashi
      • Takashi Nakaoka
      • Mayuko Fukazawa
      • Jin Okubo
      • Mamiho Ozaki
      • Ayana Kanatome
      • Rena Ohya
      • Yutaka Miura
      • Kuniaki Obara
      • Shigenobu Shibata

    • PubMed: 29969301
    • DOI: 10.1080/07420528.2018.1490315

    1 Insight on

    • Delayed Dim Light Melatonin Onset

    • High evidence
• July 4

  • Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study

    • 2018-07-04
    • RCT · n = 40
    • Food & Nutrition Research 62(0)
    • • M. Majeed
      • K. Nagabhushanam
      • S. Arumugam
      • Shaheen Majeed
      • Furqan Ali

    • PubMed: 29997457
    • DOI: 10.29219/fnr.v62.1218

    9 Insights on

    • Improved Quality of Life
    • Reduced Inflammatory Markers
    • Reduced Depression Symptoms
    • Reduced Inflammation Levels
    • Improved Irritable Bowel Syndrome Symptoms
    • Reduced Myeloperoxidase Levels
    • Reduced Abdominal Discomfort
    • Improved Quality of Life for IBS-D Patients
    • Improved Gastrointestinal Discomfort

    • High evidence
    • Highly Cited
    • Rigorous Journal
• July 6

  • Antihypertensive peptides from whey proteins fermented by lactic acid bacteria.

    • 2018-07-06
    • Food science and biotechnology 27(6)
    • • Eric Banan-Mwine Daliri
      • Byong H Lee
      • Byun-Jae Park
      • Se-Hun Kim
      • Deog-Hwan Oh

    • PubMed: 30483443
    • DOI: 10.1007/s10068-018-0423-0

    3 Insights on

    • Reduced Blood Pressure
    • Reduced Angiotensin I-Converting Enzyme Activity
    • Reduced ACE Activity

    • Low evidence
• July 10

  • The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.

    • 2018-07-10
    • Review
    • Frontiers in microbiology 9
    • • Iman Salem
      • Amy Ramser
      • Nancy Isham
      • Mahmoud A Ghannoum

    • PubMed: 30042740
    • DOI: 10.3389/fmicb.2018.01459

    2 Insights on

    • Improved Skin Hydration
    • Improved Skin Barrier Function

    • Moderate evidence
    • Highly Cited

  • Lactobacillus rhamnosus Probiotic Food as a Tool for Empowerment Across the Value Chain in Africa

    • 2018-07-10
    • Frontiers in Microbiology 9
    • • Nieke Westerik
      • R. Kort
      • W. Sybesma
      • G. Reid

    • PubMed: 30042747
    • DOI: 10.3389/fmicb.2018.01501

    1 Insight on

    • Improved Nutritional Status

    • Low evidence
• July 22

  • Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial

    • 2018-07-22
    • RCT
    • Journal of Internal Medicine 284(3)
    • • Anna G. Nilsson
      • Anna G. Nilsson
      • D. Sundh
      • Fredrik Bäckhed
      • Fredrik Bäckhed
      • M. Lorentzon
      • M. Lorentzon

    • PubMed: 29926979
    • DOI: 10.1111/joim.12805

    1 Insight on

    • Reduced Bone Loss

    • High evidence
    • Highly Cited
• July 24

  • The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans.

    • 2018-07-24
    • RCT
    • Nutrients 10(8)
    • • Emma L Wightman
      • Philippa A Jackson
      • Julie Khan
      • Joanne Forster
      • Felix Heiner
      • Bjoern Feistel
      • Cynthia G Suarez
      • Ivo Pischel
      • David O Kennedy

    • PubMed: 30042362
    • DOI: 10.3390/nu10080955

    8 Insights on

    • Increased Hemoglobin Levels
    • Decreased Oxygen Saturation
    • Increased Deoxygenated Hemoglobin Level
    • Reduced Prefrontal Cortex Oxygen Saturation
    • Decreased Oxygenated Hemoglobin Level
    • Increased Prefrontal Cortex Deoxygenated Hemoglobin Level
    • Reduced Prefrontal Cortex Oxygenated Hemoglobin
    • Reduced Prefrontal Cortex Total Hemoglobin Level

    • High evidence
    • Rigorous Journal

  • Characterization of Mucus-Related Properties of Streptococcus thermophilus: From Adhesion to Induction

    • 2018-07-24
    • Frontiers in Physiology 9
    • • N. Fernandez
      • Laura Wrzosek
      • J. M. Radziwill-Bienkowska
      • B. Ringot-Destrez
      • M. Duviau
      • Marie‐Louise Noordine
      • V. Laroute
      • V. Robert
      • C. Cherbuy
      • M. Daveran-Mingot
      • M. Cocaign-Bousquet
      • R. Léonard
      • C. Robbe-Masselot
      • F. Rul
      • E. Ogier-Denis
      • Muriel Thomas
      • M. Mercier-Bonin

    • PubMed: 30087622
    • DOI: 10.3389/fphys.2018.00980

    6 Insights on

    • Improved Lactose Digestion
    • Increased Ileal Goblet Cell Count
    • Increased Mucin Production
    • Increased KLF4 Protein Levels
    • Increased Lactate Production
    • Increased Goblet Cell Count

    • Low evidence
• July 26

  • Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players

    • 2018-07-26
    • RCT · n = 25
    • Sports 6(3)
    • • Jeremy R. Townsend
      • David Bender
      • William C. Vantrease
      • Philip A. Sapp
      • Ann M. Toy
      • Clint A Woods
      • Kent D. Johnson

    • PubMed: 30049931
    • DOI: 10.3390/sports6030070

    1 Insight on

    • Reduced TNF-α Concentration

    • High evidence
• July 30

  • Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

    • 2018-07-30
    • Clinical Trial · n = 33
    • British Journal of Nutrition 120(6)
    • • L. J. Bernini
      • A. Simão
      • C. H. B. de Souza
      • D. Alfieri
      • L. Segura
      • G. N. Costa
      • I. Dichi

    • PubMed: 30058513
    • DOI: 10.1017/S0007114518001861

    6 Insights on

    • Increased Adiponectin Levels
    • Reduced IL-6 Levels
    • Reduced Serum Homocysteine Levels
    • Reduced Hydroperoxide Levels
    • Increased Nitric Oxide Metabolite Levels in Metabolic Syndrome Patients
    • Increased Total Radical-Trapping Antioxidant Parameter Levels

    • High evidence
• Undated – 5 supplement studies

  • Benefaction of probiotics for human health: A review.

    • 2018-07
    • Review
    • Journal of food and drug analysis 26(3)
    • • Rout George Kerry
      • Jayanta Kumar Patra
      • Sushanto Gouda
      • Yooheon Park
      • Han-Seung Shin
      • Gitishree Das

    • PubMed: 29976412
    • DOI: 10.1016/j.jfda.2018.01.002

    1 Insight on

    • Improved Gastrointestinal Symptoms

    • Moderate evidence
    • Highly Cited

  • Synbiotics Bifidobacterium infantis and milk oligosaccharides are effective in reversing cancer-prone nonalcoholic steatohepatitis using western diet-fed FXR knockout mouse models.

    • 2018-07
    • Clinical Trial
    • The Journal of Nutritional Biochemistry 57
    • • P. Jena
      • Lili Sheng
      • Nidhi Nagar
      • Chao Wu
      • D. Barile
      • D. Mills
      • Y. J. Wan

    • PubMed: 29800811
    • DOI: 10.1016/j.jnutbio.2018.04.007

    7 Insights on

    • Improved Insulin Sensitivity
    • Reduced Liver Triglycerides
    • Reduced Hepatic Inflammation
    • Reduced Hepatic Cholesterol
    • Reduced Bile Acid Synthesis
    • Enhanced Detoxification
    • Enhanced TGR5 Signaling

    • Low evidence
    • Animal Study

  • High‐throughput sequencing reveals the effect of Bacillus subtilis CGMCC 1.921 on the cecal microbiota and gene expression in ileum mucosa of laying hens

    • 2018-07
    • Poultry Science 97(7)
    • • J. R. Guo
      • X. Dong
      • S. Liu
      • J. Tong

    • PubMed: 29897524
    • DOI: 10.3382/ps/pey112

    2 Insights on

    • Improved Microbiota Diversity
    • Improved Nutrient Absorption

    • Low evidence
    • Rigorous Journal

  • Effect of Oral Probiotic Streptococcus salivarius K12 on Group A Streptococcus Pharyngitis: A Pragmatic Trial in Schools

    • 2018-07
    • RCT · n = 1,314
    • Pediatric Infectious Disease Journal 37(7)
    • • H. Doyle
      • N. Pierse
      • Ramona Tiatia
      • D. Williamson
      • M. Baker
      • J. Crane

    • PubMed: 29189607
    • DOI: 10.1097/INF.0000000000001847

    1 Insight on

    • Reduced Group A Streptococcus Pharyngitis

    • High evidence
    • Large Human Trial

  • Effects of the probiotics Lactococcus lacttis (MTCC-440) on Salmonella enteric serovar Typhi in co-culture study.

    • 2018-07
    • Microbial Pathogenesis 120
    • • Anand Kumar
      • S. Kundu
      • M. Debnath

    • PubMed: 29704985
    • DOI: 10.1016/j.micpath.2018.04.045

    2 Insights on

    • Reduced Pathogen Growth
    • Reduced S. Typhi Growth

    • Low evidence