December 2015 Supplement Research Papers

• December 1

  • Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota

    • 2015-12-01
    • Clinical Trial
    • Journal of Immunology Research 2015
    • • P. Carasi
      • P. Carasi
      • S. Racedo
      • C. Jacquot
      • D. Romanin
      • M. Serradell
      • M. Urdaci

    • PubMed: 25811034
    • DOI: 10.1155/2015/361604

    8 Insights on

    • Increased Interleukin-10 Levels
    • Reduced Inflammatory Response
    • Increased Serum Immunoglobulin A (IgA) Levels
    • Reduced Proinflammatory Mediators
    • Reduced LPS-Induced Inflammation
    • Increased IL-10 Levels
    • Elevated Fecal IgA Levels
    • Reduced Expression of Proinflammatory Mediators

    • Low evidence
    • Highly Cited
    • Animal Study

  • The serotonin receptor mediates changes in autonomic neurotransmission and gastrointestinal transit induced by heat-killed Lactobacillus brevis SBC8803.

    • 2015-12-01
    • Clinical Trial
    • Beneficial Microbes 6(6)
    • • Y. Horii
      • Y. Nakakita
      • Y. Misonou
      • T. Nakamura
      • Katsuya Nagai

    • PubMed: 26259890
    • DOI: 10.3920/BM2015.0031

    2 Insights on

    • Improved Bowel Movement Frequency
    • Improved Gastrointestinal Transit

    • Low evidence
    • Animal Study
• December 4

  • The Effect of Lactobacillus plantarum 299v on the Incidence of Clostridium difficile Infection in High Risk Patients Treated with Antibiotics

    • 2015-12-04
    • Observational · n = 3,533
    • Nutrients 7(12)
    • • A. Kujawa-Szewieczek
      • M. Adamczak
      • Katarzyna Kwiecień
      • S. Dudzicz
      • M. Gazda
      • A. Więcek

    • PubMed: 26690209
    • DOI: 10.3390/nu7125526

    1 Insight on

    • Reduced Incidence of Clostridium Difficile Infection

    • High evidence
• December 18

  • Effects of Lactobacillus plantarum NCU116 on Intestine Mucosal Immunity in Immunosuppressed Mice.

    • 2015-12-18
    • Journal of Agricultural and Food Chemistry 63(51)
    • • Junhua Xie
      • Qiang Yu
      • Shaoping Nie
      • S. Fan
      • T. Xiong
      • M. Xie

    • PubMed: 26651209
    • DOI: 10.1021/acs.jafc.5b04757

    3 Insights on

    • Improved Intestinal Mucosal Immunity
    • Increased Immune Factor Levels
    • Reduced Interleukin-4 Levels

    • Low evidence
• December 27

  • The effects of non-viable Lactobacillus on immune function in the elderly: a randomised, double-blind, placebo-controlled study

    • 2015-12-27
    • RCT · n = 42
    • International Journal of Food Sciences and Nutrition 67(1)
    • • M. Maruyama
      • Ryoji Abe
      • T. Shimono
      • N. Iwabuchi
      • F. Abe
      • J. Xiao

    • PubMed: 26708938
    • DOI: 10.3109/09637486.2015.1126564

    1 Insight on

    • Improved Immune Response to Influenza Vaccination

    • High evidence
• December 28

  • Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.

    • 2015-12-28
    • RCT · n = 110
    • Journal of Microbiology and Biotechnology 25(12)
    • • Dong Eun Lee
      • C. Huh
      • J.‐H. Ra
      • Il-dong Choi
      • Ji-Woong Jeong
      • Sung-Hwan Kim
      • J. Ryu
      • Y. Seo
      • J. Koh
      • Junghee Lee
      • J. Sim
      • Y. Ahn

    • PubMed: 26428734
    • DOI: 10.4014/jmb.1509.09021

    5 Insights on

    • Improved Skin Hydration
    • Reduced Transepidermal Water Loss
    • Reduced Wrinkle Depth
    • Enhanced Skin Gloss
    • Improved Skin Elasticity

    • High evidence
    • Highly Cited
• December 29

  • Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

    • 2015-12-29
    • Clinical Trial
    • Aging Cell 15(2)
    • • H. Nakagawa
      • T. Shiozaki
      • Eiji Kobatake
      • T. Hosoya
      • Tomohiro Moriya
      • F. Sakai
      • Hidenori Taru
      • T. Miyazaki

    • PubMed: 26710940
    • DOI: 10.1111/acel.12431

    3 Insights on

    • Increased Lifespan
    • Improved Antioxidant Defense
    • Increased Mitochondrial Levels

    • Low evidence
    • Highly Cited
    • Animal Study

  • The Effect of Lactobacillus casei 32G on the Mouse Cecum Microbiota and Innate Immune Response Is Dose and Time Dependent

    • 2015-12-29
    • Clinical Trial
    • PLOS ONE 10(12)
    • • B. Aktas
      • T. D. De Wolfe
      • K. Tandee
      • N. Safdar
      • B. Darien
      • J. Steele

    • PubMed: 26714177
    • DOI: 10.1371/journal.pone.0145784

    1 Insight on

    • Increased Commensal Lactobacilli Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• December 30

  • Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.

    • 2015-12-30
    • Clinical Trial
    • Molecular Medicine Reports 13(2)
    • • Juan Wang
      • Lanzhou Li
      • Yan Liu
      • Li-rong Teng
      • J. Lu
      • Jing Xie
      • Wenji Hu
      • Yan Liu
      • Yang Liu
      • Di Wang
      • L. Teng

    • PubMed: 26717979
    • DOI: 10.3892/mmr.2015.4734

    3 Insights on

    • Reduced Neurotoxicity
    • Increased Antioxidant Activity
    • Reduced Hypoxia

    • Low evidence
    • Rigorous Journal
    • Animal Study
• December 31

  • Identification of Antihypertensive Peptides Derived from Low Molecular Weight Casein Hydrolysates Generated during Fermentation by Bifidobacterium longum KACC 91563.

    • 2015-12-31
    • Korean journal for food science of animal resources 35(6)
    • • Go Eun Ha
      • Oun Ki Chang
      • Su-Mi Jo
      • Gi-Sung Han
      • Beom-Young Park
      • Jun-Sang Ham
      • Seok-Geun Jeong

    • PubMed: 26877633
    • DOI: 10.5851/kosfa.2015.35.6.738

    1 Insight on

    • Reduced Blood Pressure

    • Low evidence
• Undated – 8 supplement studies

  • Probiotic strain Bacillus subtilis CU1 stimulates immune system of elderly during common infectious disease period: a randomized, double-blind placebo-controlled study

    • 2015-12
    • RCT · n = 100
    • Immunity & Ageing 12(1)
    • • Marie Lefevre
      • S. Racedo
      • Gabrielle Ripert
      • B. Housez
      • M. Cazaubiel
      • C. Maudet
      • Peter Jüsten
      • P. Marteau
      • M. Urdaci

    • PubMed: 26640504
    • DOI: 10.1186/s12979-015-0051-y

    6 Insights on

    • Increased Secretory IgA Level
    • Reduced Frequency of Upper Respiratory Tract Infections
    • Increased Secretory Immunoglobulin A
    • Increased Salivary IgA Levels
    • Increased Salivary Secretory Immunoglobulin A Levels
    • No Significant Reduction in CID Symptoms

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study

    • 2015-12
    • RCT · n = 36
    • Nutrition Journal 15(1)
    • • M. Majeed
      • K. Nagabhushanam
      • Sankaran Natarajan
      • A. Sivakumar
      • Furqan Ali
      • A. Pande
      • Shaheen Majeed
      • S. K. Karri

    • PubMed: 26922379
    • DOI: 10.1186/s12937-016-0140-6

    11 Insights on

    • Reduced Stool Frequency
    • Improved Quality of Life
    • Reduced Abdominal Pain
    • No Significant Safety Parameter Changes
    • Reduced Disease Severity
    • Reduced IBS Symptoms
    • Reduced Diarrhea
    • Reduced IBS Symptom Severity (Diarrhea-Predominant)
    • Improved Quality of Life for IBS-D Patients
    • Reduced Vomiting
    • Improved IBS Severity

    • High evidence
    • Highly Cited

  • A novel consortium of Lactobacillus rhamnosus and Streptococcus thermophilus for increased access to functional fermented foods

    • 2015-12
    • Microbial Cell Factories 14(1)
    • • R. Kort
      • Nieke Westerik
      • L. M. Serrano
      • François P Douillard
      • W. Gottstein
      • I. M. Mukisa
      • C. Tuijn
      • L. Basten
      • B. Hafkamp
      • W. Meijer
      • B. Teusink
      • W. Vos
      • W. Vos
      • G. Reid
      • G. Reid
      • W. Sybesma

    • PubMed: 26643044
    • DOI: 10.1186/s12934-015-0370-x

    1 Insight on

    • Alleviated Diarrhea

    • Low evidence
    • Highly Cited

  • Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro.

    • 2015-12
    • International Journal of Medical Microbiology 305(8)
    • • A. Rizzo
      • M. Fiorentino
      • E. Buommino
      • G. Donnarumma
      • A. Losacco
      • N. Bevilacqua

    • PubMed: 26372530
    • DOI: 10.1016/j.ijmm.2015.07.005

    7 Insights on

    • Increased Anti-Inflammatory Cytokine Levels
    • Reduced Pro-Inflammatory Cytokines
    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Proinflammatory Cytokine Production
    • Increased Production of Anti-inflammatory Cytokine IL-10
    • Increased IL-10 Production
    • Increased Anti-Inflammatory Cytokine IL-10

    • Low evidence

  • The effects of the DDS-1 strain of lactobacillus on symptomatic relief for lactose intolerance - a randomized, double-blind, placebo-controlled, crossover clinical trial

    • 2015-12
    • RCT
    • Nutrition Journal 15(1)
    • • M. Pakdaman
      • J. Udani
      • J. Molina
      • M. Shahani

    • PubMed: 27207411
    • DOI: 10.1186/s12937-016-0172-y

    11 Insights on

    • Reduced Diarrhea Incidence
    • Reduced Diarrhea Rate
    • Reduced Vomiting Incidence
    • Reduced Diarrhea Symptoms
    • Reduced Abdominal Cramping
    • Improved Overall Symptom Score
    • Reduced Vomiting Symptoms
    • Reduced Symptom Severity
    • Reduced Overall Symptoms
    • Improved Symptom Relief for Lactose Intolerance
    • Reduced Vomiting

    • High evidence

  • Probiotics and gut health in infants: A preliminary case-control observational study about early treatment with Lactobacillus reuteri DSM 17938.

    • 2015-12
    • Observational · n = 60
    • Clinica Chimica Acta 451
    • • F. Savino
      • Stefania Fornasero
      • Simone Ceratto
      • A. De Marco
      • N. Mandras
      • J. Roana
      • V. Tullio
      • G. Amisano

    • PubMed: 25704298
    • DOI: 10.1016/j.cca.2015.02.027

    4 Insights on

    • Reduced Pathogen Colonization
    • Reduced Anaerobic Gram-Negative Bacterial Counts
    • Increased Total Anaerobic Gram-Positive Bacteria Counts
    • Reduced Colonization by Diarrheagenic E. coli (EPEC)

    • Moderate evidence

  • Dietary Bacillus subtilis FPTB13 and chitin, single or combined, modulate systemic and cutaneous mucosal immunity and resistance of catla, Catla catla (Hamilton) against edwardsiellosis.

    • 2015-12
    • Clinical Trial
    • Comparative Immunology, Microbiology and Infectious Diseases 43
    • • T. Sangma
      • D. Kamilya

    • PubMed: 26616655
    • DOI: 10.1016/j.cimid.2015.09.003

    6 Insights on

    • Improved Survival Rate
    • Improved Intestinal Mucosal Immunity
    • Enhanced Disease Resistance
    • Enhanced Resistance to Edwardsiella tarda
    • Improved Health Condition
    • Improved Systemic Immunity

    • Low evidence
    • Animal Study

  • Effects of Lactobacillus gasseri OLL2716 on Helicobacter pylori-Associated Dyspepsia: A Multicenter Randomized Double-Blind Controlled Trial

    • 2016
    • RCT · n = 131
    • Gastroenterology Research and Practice 2016
    • • A. Takagi
      • Hidetaka Yanagi
      • H. Ozawa
      • N. Uemura
      • S. Nakajima
      • Kazuhiko Inoue
      • T. Kawai
      • Toshihiro Ohtsu
      • Y. Koga

    • PubMed: 27478434
    • DOI: 10.1155/2016/7490452

    3 Insights on

    • Reduced Bloating
    • Reduced Postprandial Fullness
    • Reduced Dyspepsia Symptoms

    • High evidence
    • Rigorous Journal