September 2012 Supplement Research Papers

• September 1

  • Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis

    • 2012-09-01
    • Clinical Trial
    • European Journal of Nutrition 52(2)
    • • Borja Ocón
      • Andrea Anzola
      • Mercedes Ortega-González
      • A. Zarzuelo
      • M. D. Suárez
      • F. Sánchez de Medina
      • O. Martínez-Augustin

    • PubMed: 22941198
    • DOI: 10.1007/s00394-012-0347-z

    1 Insight on

    • Reduced Intestinal Inflammation

    • Low evidence
    • Animal Study
• September 5

  • Immunoprotective effects of oral intake of heat-killed Lactobacillus pentosus strain b240 in elderly adults: a randomised, double-blind, placebo-controlled trial

    • 2012-09-05
    • RCT · n = 300
    • British Journal of Nutrition 109(10)
    • • S. Shinkai
      • Masamichi Toba
      • Takao Saito
      • I. Sato
      • M. Tsubouchi
      • K. Taira
      • K. Kakumoto
      • T. Inamatsu
      • H. Yoshida
      • Y. Fujiwara
      • T. Fukaya
      • Tetsuya Matsumoto
      • K. Tateda
      • K. Yamaguchi
      • N. Kohda
      • S. Kohno

    • PubMed: 22947249
    • DOI: 10.1017/S0007114512003753

    2 Insights on

    • Improved General Health
    • Reduced Risk of Common Cold

    • High evidence
    • Large Human Trial
    • Highly Cited
• September 6

  • Safety and Tolerability of Lactobacillus reuteri DSM 17938 and Effects on Biomarkers in Healthy Adults: Results from a Randomized Masked Trial

    • 2012-09-06
    • RCT · n = 40
    • PLoS ONE 7(9)
    • • Nisha Mangalat
      • Yuying Liu
      • Nicole Y. Fatheree
      • M. Ferris
      • M. Arsdall
      • Zhongxue Chen
      • M. Rahbar
      • M. Rahbar
      • W. Gleason
      • J. Norori
      • D. Tran
      • J. M. Rhoads

    • PubMed: 22970150
    • DOI: 10.1371/journal.pone.0043910

    1 Insight on

    • Increased Fecal Calprotectin Levels

    • High evidence
• September 12

  • Black cohosh (Cimicifuga spp.) for menopausal symptoms.

    • 2012-09-12
    • Meta-Analysis · n = 2,027
    • The Cochrane database of systematic reviews 2012(10)
    • • Matthew J Leach
      • Vivienne Moore

    • PubMed: 22972105
    • DOI: 10.1002/14651858.cd007244.pub2

    4 Insights on

    • Reduced Hot Flush Frequency
    • Reduced Menopausal Symptom Score
    • Reduced Vulvovaginal Atrophy Symptom
    • Reduced Night Sweats

    • High evidence
• September 13

  • A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts.

    • 2012-09-13
    • Review
    • Phytotherapy research : PTR 27(8)
    • • Sidney J Stohs
      • Sidhartha D Ray

    • PubMed: 22976133
    • DOI: 10.1002/ptr.4846

    4 Insights on

    • Reduced Body Weight
    • Improved Bone Fracture Healing
    • Reduced Osteoporosis
    • Improved Body Building Activity

    • Low evidence
• September 17

  • Probiotic metabolites from Bacillus coagulans GanedenBC30™ support maturation of antigen-presenting cells in vitro.

    • 2012-09-17
    • World Journal of Gastroenterology 18(16)
    • • K. Benson
      • Kimberlee A Redman
      • Steve G. Carter
      • D. Keller
      • S. Farmer
      • J. Endres
      • G. Jensen

    • PubMed: 22563167
    • DOI: 10.3748/wjg.v18.i16.1875

    4 Insights on

    • Matured Antigen-Presenting Cells
    • Reduced Pro-Inflammatory Cells
    • Improved Antigen Presentation
    • Increased Generation of T Regulatory Cells

    • Low evidence
    • Rigorous Journal
• September 18

  • Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C)

    • 2012-09-18
    • Clinical Trial
    • BMC Immunology 13(1)
    • • J. Villena
      • Eriko Chiba
      • Yohsuke Tomosada
      • S. Salva
      • Gabriela Marranzino
      • H. Kitazawa
      • S. Alvarez

    • PubMed: 22989047
    • DOI: 10.1186/1471-2172-13-53

    2 Insights on

    • Reduced Lung Injury
    • Increased CD3+CD4+IFN-γ+ T Cell Count

    • Low evidence
    • Highly Cited
    • Animal Study

  • Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: a randomized, double-blind study.

    • 2012-09-18
    • RCT · n = 50
    • World Journal of Gastroenterology 18(17)
    • • M. Dapoigny
      • T. Piche
      • P. Ducrotte
      • B. Lunaud
      • J. Cardot
      • A. Bernalier-Donadille

    • PubMed: 22563194
    • DOI: 10.3748/wjg.v18.i17.2067

    4 Insights on

    • Reduced IBS Symptom Severity (Diarrhea-Predominant)
    • Reduced Abdominal Pain Severity in Diarrhea-Predominant IBS
    • No Significant Change in IBS Symptom Severity
    • No Clinically Relevant Changes in Gastrointestinal Quality of Life

    • High evidence
    • Highly Cited
    • Rigorous Journal

  • Behavioral Predictors of Colonization with Lactobacillus crispatus or Lactobacillus jensenii after Treatment for Bacterial Vaginosis: A Cohort Study

    • 2012-09-18
    • Observational · n = 44
    • Infectious Diseases in Obstetrics and Gynecology 2012
    • • C. Mitchell
      • L. Manhart
      • Kathy Thomas
      • T. Fiedler
      • D. Fredricks
      • J. Marrazzo

    • PubMed: 22693410
    • DOI: 10.1155/2012/706540

    3 Insights on

    • Increased Cure Rate of Bacterial Vaginosis
    • Colonization with Lactobacillus jensenii Post-Treatment
    • Improved Vaginal Health

    • Moderate evidence
• September 19

  • Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

    • 2012-09-19
    • RCT · n = 127
    • European Journal of Clinical Nutrition 66(11)
    • • M. L. Jones
      • C. Martoni
      • S. Prakash

    • PubMed: 22990854
    • DOI: 10.1038/ejcn.2012.126

    26 Insights on

    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Fibrinogen Levels
    • Reduced Inflammatory Markers
    • Reduced Triglyceride Levels
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Reduced C-Reactive Protein Levels
    • Reduced Non-HDL Cholesterol
    • Reduced Apolipoprotein B-100
    • Improved LDL-C to HDL-C Ratio
    • Improved ApoB-100/ApoA-1 Ratio
    • Increased Plasma Deconjugated Bile Acids
    • Reduced Plasma Non-Cholesterol Sterols
    • Reduced Campesterol Absorption
    • Reduced Sitosterol Absorption
    • Reduced Stigmasterol Absorption
    • Reduced Plant Sterols
    • Reduced Apolipoprotein B Levels
    • Improved Blood Lipid Profile
    • Increased High-Density Lipoprotein Cholesterol
    • Reduced High-Sensitivity C-Reactive Protein Level
    • Reduced Apolipoprotein B-100 to Apolipoprotein A-1 Ratio
    • Increased Deconjugated Bile Acid Level
    • Reduced Sitosterol Level
    • Reduced Stigmasterol Level

    • High evidence
    • Highly Cited
    • Rigorous Journal
• September 20

  • Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters

    • 2012-09-20
    • Gut Microbes 3(5)
    • • S. Fukuda
      • Hidehiro Toh
      • T. Taylor
      • H. Ohno
      • M. Hattori

    • PubMed: 22825494
    • DOI: 10.4161/gmic.21214

    2 Insights on

    • Reduced Enteropathogenic Infection Risk
    • Enhanced Epithelial Cell Defense Functions

    • Low evidence
    • Highly Cited

  • Bifidobacterium breve UCC2003 surface exopolysaccharide production is a beneficial trait mediating commensal-host interaction through immune modulation and pathogen protection

    • 2012-09-20
    • Gut Microbes 3(5)
    • • S. Fanning
      • L. Hall
      • D. van Sinderen

    • PubMed: 22713271
    • DOI: 10.4161/gmic.20630

    5 Insights on

    • Modulated Immune Response
    • Reduced Pathogenic Colonies
    • Enhanced Immune Evasion
    • Reduced Pathogen Colonization
    • Improved Gut Resilience

    • Low evidence
• September 25

  • The use of galactogogues in the breastfeeding mother.

    • 2012-09-25
    • Review
    • The Annals of pharmacotherapy 46(10)
    • • Alicia B Forinash
      • Abigail M Yancey
      • Kylie N Barnes
      • Thomas D Myles

    • PubMed: 23012383
    • DOI: 10.1345/aph.1r167

    1 Insight on

    • Improved Breast Milk Production

    • Low evidence
• September 30

  • Immunomodulatory effects of heat-killed Enterococcus faecalis TH10 on murine macrophage cells

    • 2012-09-30
    • MicrobiologyOpen 1(4)
    • • T. Itoh
      • Y. Miyake
      • A. Onda
      • Junko Kubo
      • M. Ando
      • Y. Tsukamasa
      • Muneaki Takahata

    • PubMed: 23233442
    • DOI: 10.1002/mbo3.41

    2 Insights on

    • Improved Immune Response
    • Enhanced Nitric Oxide Production

    • Low evidence
• Undated – 4 supplement studies

  • Effects of probiotic, Clostridium butyricum, on growth performance, immune function, and cecal microflora in broiler chickens.

    • 2012-09
    • RCT · n = 450
    • Poultry Science 91(9)
    • • C. M. Yang
      • G. Cao
      • P. Ferket
      • Tao Liu
      • L. Zhou
      • L. Zhang
      • Y. Xiao
      • A. Chen

    • PubMed: 22912445
    • DOI: 10.3382/ps.2011-02131

    3 Insights on

    • Improved Immune Function
    • Improved Growth Performance
    • Balanced Intestinal Microflora

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and immunity of host animals.

    • 2012-09
    • RCT · n = 100
    • Journal of Dairy Science 95(9)
    • • S. Wang
      • H. Zhu
      • C. Lu
      • Z. Kang
      • Y. Luo
      • L. Feng
      • X. Lu

    • PubMed: 22916885
    • DOI: 10.3168/jds.2012-5426

    3 Insights on

    • Improved Humoral Immunity
    • Reduced Fecal Enterobacilli
    • Improved Cell-mediated Immunity

    • High evidence
    • Highly Cited

  • Polypodium leucotomos extract in atopic dermatitis: a randomized, double-blind, placebo-controlled, multicenter trial.

    • 2012-09
    • RCT · n = 105
    • Actas dermo-sifiliograficas 103(7)
    • • A Ramírez-Bosca
      • P Zapater
      • I Betlloch
      • F Albero
      • A Martínez
      • J Díaz-Alperi
      • J F Horga

    • PubMed: 22560125
    • DOI: 10.1016/j.ad.2012.01.008

    2 Insights on

    • Reduced Topical Corticosteroid Use
    • Reduced Oral Antihistamine Use

    • High evidence
    • Large Human Trial

  • In vitro evaluation of Lactobacillus crispatus K313 and K243: high-adhesion activity and anti-inflammatory effect on Salmonella braenderup infected intestinal epithelial cell.

    • 2012-09
    • Veterinary Microbiology 159(1-2)
    • • Zhilan Sun
      • Lihua Huang
      • J. Kong
      • Shumin Hu
      • Xiao-Wan Zhang
      • W. Kong

    • PubMed: 22542524
    • DOI: 10.1016/j.vetmic.2012.03.043

    1 Insight on

    • Reduced Inflammatory Response

    • Low evidence