Should Lactobacillus sporogenes and Bacillus coagulans Have a future?2009-08ReviewJournal of Chemotherapy 21(4)L. DragoE. De VecchiPubMed: 19622453DOI: 10.1179/joc.2009.21.4.3711 Insight on Improved Gut HealthLow evidence
Safety studies of LP20 powder produced from heat-killed Lactobacillus plantarum L-137.2009-08Clinical TrialRegulatory Toxicology and Pharmacology 54(3)Y. HiroseS. MurosakiY. YamamotoK. MuroyamaY. MiwaA. FujishimaB. LynchPubMed: 19328216DOI: 10.1016/j.yrtph.2009.03.0072 Insights on Absence of Acute ToxicityAbsence of GenotoxicityLow evidenceAnimal Study
In vivo study on the effectiveness of pediocin PA-1 and Pediococcus acidilactici UL5 at inhibiting Listeria monocytogenes.2009-08Clinical TrialInternational Journal of Food Microbiology 133(3)N. DabourAnnina ZihlerE. KheadrC. LacroixI. FlissPubMed: 19541383DOI: 10.1016/j.ijfoodmicro.2009.05.0052 Insights on Reduced Risk of Listeria Monocytogenes InfectionNo Change in Mouse Intestinal Flora CompositionLow evidenceHighly CitedAnimal Study
Characterization of salivaricin CRL 1328, a two-peptide bacteriocin produced by Lactobacillus salivarius CRL 1328 isolated from the human vagina.2009-07Research in Microbiology 160(6)E. Vera PingitoreE. HebertM. Nader-MacíasF. SesmaPubMed: 19591924DOI: 10.1016/j.resmic.2009.06.0092 Insights on Reduced Urogenital Pathogen GrowthMembrane DisruptionLow evidence
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin‐10‐deficient mice2009-07Clinical TrialInflammatory Bowel Diseases 15(7)J. P. MoranJ. WalterG. TannockS. TonkonogyB. SartorPubMed: 19235917DOI: 10.1002/ibd.209001 Insight on Increased Duodenal InflammationLow evidenceAnimal Study
Dietary supplement with fermented soybeans, natto, improved the neurobehavioral deficits after sciatic nerve injury in rats2009-06Clinical TrialNeurological Research 31(5)Hung-Chuan PanF. ChengChun-Jung ChenShu-zhen LaiMu-Jung LiuMing-Hong ChangYeou-Chih WangDar‐Yu YangS. HoPubMed: 19309538DOI: 10.1179/174313209X4038782 Insights on Improved Neurobehavioral FunctionReduced Injury-Induced Fibrin DepositionLow evidenceAnimal Study
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo.2009-06Clinical TrialJournal of Dairy Science 92(6)E. MiyauchiH. MoritaS. TanabePubMed: 19447972DOI: 10.3168/jds.2008-16988 Insights on Improved Intestinal Barrier FunctionReduced Body WeightReduced Colonic InflammationMaintained WeightReduced Mucosal PermeabilityReduced Epithelial PermeabilityRecovered Colon LengthRestored Barrier FunctionLow evidenceHighly CitedAnimal Study
Fermentation characteristics and transit tolerance of probiotic Lactobacillus casei Zhang in soymilk and bovine milk during storage.2009-06Journal of Dairy Science 92(6)Jicheng WangZhuang GuoQing ZhangLiya YanWei ChenXinjin LiuH. P. ZhangPubMed: 19447978DOI: 10.3168/jds.2008-18494 Insights on Reduced Total Cholesterol LevelsImproved Immune FunctionImproved ImmunomodulationEnhanced ImmunomodulationLow evidenceHighly Cited
Safety assessment of a proprietary preparation of a novel Probiotic, Bacillus coagulans, as a food ingredient2009-06Clinical TrialFood and Chemical Toxicology 47(6)J. EndresA. ClewellK. A. JadeT. FarberJ. HauswirthA. SchaussPubMed: 19248815DOI: 10.1016/j.fct.2009.02.0189 Insights on Ensured Safety for Human ConsumptionAbsence of Genetic DamageNo Adverse EffectsNo Mutagenic EffectsSafe for Chronic ConsumptionNo Observed Adverse EffectsAbsence of Clastogenic EffectsAbsence of Genotoxic EffectsNo Observed Adverse Effect LevelLow evidenceHighly CitedAnimal Study
Dietary administration of the probiotic, Lactobacillus plantarum, enhanced the growth, innate immune responses, and disease resistance of the grouper Epinephelus coioides.2009-05Fish & Shellfish Immunology 26(5)V. M. SonChin-Chyuan ChangMingjuan WuY. GuuC. ChiuW. ChengPubMed: 19264134DOI: 10.1016/j.fsi.2009.02.0186 Insights on Increased PMN Cell Phagocytic CapacityIncreased Serum Lysozyme ActivityIncreased Body WeightIncreased Glutathione Peroxidase ActivityImproved Survival Rate After Bacterial ChallengeEnhanced Alternative Complement ActivityLow evidenceHighly Cited
Synbiotic promotion of epithelial proliferation by orally ingested encapsulated Bifidobacterium breve and raffinose in the small intestine of rats.2009-05RCTMolecular Nutrition & Food Research 53(S1)S. IshizukaAmi IwamaA. DinotoA. SuksomcheepK. MaetaT. KasaiH. HaraA. YokotaPubMed: 18837471DOI: 10.1002/mnfr.2008000411 Insight on Increased Epithelial Proliferation in the Small IntestineHigh evidence
Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor.2009-05American Journal of Obstetrics and Gynecology 200(5)M. YeganegiC. WatsonA. MartinsS. O. KimG. ReidJ. ChallisA. BockingPubMed: 19285652DOI: 10.1016/j.ajog.2008.12.0324 Insights on Increased Interleukin-10 LevelsReduced TNF-α LevelsIncreased PGDH Expression in Female PlacentaePartially Reduced PTGS2 Levels in Male PlacentasLow evidenceHighly Cited
Effect of a single oral administration of Lactobacillus plantarum DSMZ 8862/8866 before and at the time point of weaning on intestinal microbial communities in piglets.2009-04RCT · n = 176International Journal of Food Microbiology 130(3)Robert PieperP. JanczykV. UrubschurovU. KornB. PieperW. SouffrantPubMed: 19237219DOI: 10.1016/j.ijfoodmicro.2009.01.0268 Insights on Increased Presence of Bifidobacterium lactisImproved Gastrointestinal HealthIncreased Microbial DiversityIncreased Beneficial Bacteria LevelsImproved Microbial DiversityImproved Overall Gastrointestinal HealthModification of Gastrointestinal MicrobiomeAltered Gastrointestinal Microbial CommunitiesLow evidenceAnimal Study
Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.2009-04FEMS Immunology & Medical Microbiology 55(3)N. IwabuchiN. TakahashiJ. XiaoS. YonezawaT. YaeshimaK. IwatsukiS. HachimuraPubMed: 19291170DOI: 10.1111/j.1574-695X.2008.00510.x1 Insight on Reduced Ocular Symptoms of Japanese Cedar PollinosisLow evidence
Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins2009-04Human Vaccines 5(4)L. Bermúdez-HumaránPubMed: 19202351DOI: 10.4161/hv.5.4.75531 Insight on Improved Crohn's Disease SymptomsLow evidenceHighly Cited
Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli.2009-04American Journal of Physiology-Gastrointestinal and Liver Physiology 296(4)Xuelian MaY. MaoB. WangJ. HuizingaJ. BienenstockW. KunzePubMed: 19179624DOI: 10.1152/ajpgi.90511.20081 Insight on Reduced Hyperexcitability of Colonic DRG NeuronsLow evidenceHighly Cited
Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice.2009-04Nutrition Research 29(4)Hai-ying YangSongling LiuS. IbrahimLiang ZhaoJingjun JiangWencheng SunF. RenPubMed: 19410981DOI: 10.1016/j.nutres.2009.03.0104 Insights on Improved Immune FunctionImproved Natural Killer Cell ActivityEnhanced Delayed-Type Hypersensitivity ResponseIncreased Splenic Lymphocyte ProliferationLow evidence
Influence of vitamins and osmolites on growth and bacteriocin production by Lactobacillus salivarius CRL 1328 in a chemically defined medium.2009-03Canadian Journal of Microbiology 55(3)E. Vera PingitoreE. HebertF. SesmaM. Nader-MacíasPubMed: 19370073DOI: 10.1139/w08-0921 Insight on Improved GrowthLow evidence
A patented strain of Bacillus coagulans increased immune response to viral challenge.2009-03Clinical Trial · n = 10Postgraduate Medicine 121(2)Mira BaronPubMed: 19332969DOI: 10.3810/pgm.2009.03.19712 Insights on Improved Immune Response to AdenovirusImproved Immune Response to Influenza AModerate evidence
Early treatment with Lactobacillus delbrueckii strain induces an increase in intestinal T-cells and granulocytes and modulates immune-related genes of larval Dicentrarchus labrax (L.).2009-03Clinical TrialFish & Shellfish Immunology 26(3)S. PicchiettiA. FaustoE. RandelliO. CarnevaliA. TaddeiF. BuonocoreG. ScapigliatiL. AbelliPubMed: 18996487DOI: 10.1016/j.fsi.2008.10.0085 Insights on Improved Immune FunctionReduced Inflammation LevelsEnhanced Immune FunctionIncreased Intestinal T-Cell CountReduced Pro-inflammatory Gene TranscriptionLow evidenceHighly CitedAnimal Study
Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.2009-03RCT · n = 44Postgraduate Medicine 121(2)Larysa HunPubMed: 19332970DOI: 10.3810/pgm.2009.03.19843 Insights on Reduced BloatingReduced Abdominal PainImproved Treatment SafetyHigh evidenceHighly Cited
Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study.2009-02RCT · n = 1,062Vaccine 27(7)Jun-Song LinY. ChiuNien-Tsung LinChia-Hsiang ChuKuo-Chin HuangK. LiaoK. PengPubMed: 19114073DOI: 10.1016/j.vaccine.2008.11.1141 Insight on Reduced Incidence of Bacterial InfectionsHigh evidenceLarge Human TrialHighly Cited
Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial.2009-02RCT · n = 64Canadian Journal of Microbiology 55(2)R. C. MartinezS. FranceschiniM. C. PattaS. QuintanaB. C. GomesE. D. De MartinisG. ReidPubMed: 19295645DOI: 10.1139/w08-1022 Insights on Increased Cure Rate of Bacterial VaginosisNormalized Vaginal MicrobiotaHigh evidenceHighly Cited
Fermented milk containing Bifidobacterium lactis DN‐173 010 improved self‐reported digestive comfort amongst a general population of adults. A randomized, open‐label, controlled, pilot study2009-02RCTJournal of Digestive Diseases 10(1)D. GuyonnetA. WoodcockBlandine StefaniC. TrevisanC. HallPubMed: 19236549DOI: 10.1111/j.1751-2980.2008.00366.x3 Insights on Reduced Digestive SymptomsImproved Gastrointestinal SymptomsImproved Digestive ComfortHigh evidence
Enhancement of immunity and disease resistance in the white shrimp, Litopenaeus vannamei, by the probiotic, Bacillus subtilis E20.2009-02Clinical TrialFish & Shellfish Immunology 26(2)D. TsengP. HoSung-Yan HuangSheng-Chi ChengYa‐Li ShiuChiu-Shia ChiuChun‐Hung LiuPubMed: 19111620DOI: 10.1016/j.fsi.2008.12.0036 Insights on Increased PMN Cell Phagocytic CapacityImproved Immune ResponseImproved Cell Survival RatesEnhanced Phenoloxidase ActivityImproved Clearance EfficiencyIncreased Survival RateLow evidenceHighly CitedAnimal Study
In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.2009-01Antimicrobial agents and chemotherapy 53(1)Kaori TanakaHiroshige MikamoKenichi NakaoTaku IchiishiTakatsugu GotoYuka YamagishiKunitomo WatanabePubMed: 18955522DOI: 10.1128/aac.00595-081 Insight on Reduced Pathogenic Bacterial ActivityLow evidence
Lactobacillus fermentum ME-3 – an antimicrobial and antioxidative probiotic2009-01Microbial Ecology in Health and Disease 21(1)M. MikelsaarM. ZilmerPubMed: 19381356DOI: 10.1080/089106009028155617 Insights on Increased Antioxidant ActivityReduced Oxidative StressIncreased Antioxidant LevelsImproved Low-Density Lipoprotein CompositionReduced AtherosclerosisReduced Salmonella InfectionImproved Blood Lipid ProfileLow evidenceHighly Cited
Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice.2008-12Clinical TrialInternational Journal of Food Microbiology 128(2)S. SegawaYoshihisa WakitaH. HirataJ. WatariPubMed: 18976829DOI: 10.1016/j.ijfoodmicro.2008.09.02322 Insights on Improved Intestinal Barrier FunctionReduced Aminotransferase LevelsReduced Inflammatory MarkersReduced Liver Fat ContentReduced Inflammation LevelsReduced Hepatic Fat AccumulationReduced TNF-α LevelsReduced Liver Enzyme LevelsReduced Liver Triglyceride ContentReduced Liver TriglyceridesReduced AST LevelsReduced Liver FatReduced Elevated Liver EnzymesReduced Liver Cholesterol ContentReduced Hepatic InflammationReduced Liver CholesterolReduced Liver Injury IndicatorsIncreased Expression of Heat Shock Protein 25Reduced Alcohol-Induced Liver InjuryImproved Alcohol-induced Liver InjuryImprovement in Alcoholic Liver DiseaseIncreased Intestinal Barrier CytoprotectionLow evidenceHighly CitedAnimal Study
Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101.2008-12Clinical TrialInternational Journal of Food Microbiology 128(2)Yueh-Ting TsaiPo-Ching ChengC. FanT. PanPubMed: 18809220DOI: 10.1016/j.ijfoodmicro.2008.08.0099 Insights on Improved Gut MicrobiotaImproved Immune ResponseIncreased Beneficial Gut MicrobiotaReduced Harmful Gut BacteriaEnhanced Antibody ProductionChronic Immune ActivationImproved Intestinal MicrofloraImproved Antigen-Presenting Ability of Dendritic CellsIncreased Lymphocyte ProliferationLow evidenceHighly CitedAnimal Study
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.2008-12Clinical TrialJournal of Psychiatric Research 43(2)L. DesbonnetL. GarrettG. ClarkeJ. BienenstockT. DinanPubMed: 18456279DOI: 10.1016/j.jpsychires.2008.03.0098 Insights on Reduced Pro-Inflammatory CytokinesReduced Pro-inflammatory Cytokine ReleaseReduced Pro-inflammatory Cytokine LevelsIncreased Plasma Tryptophan ConcentrationIncreased Plasma Kynurenic Acid LevelsReduced DOPAC Levels in Amygdaloid CortexReduced Pro-inflammatory Immune ResponsesElevated Serum Tryptophan LevelsLow evidenceHighly CitedAnimal Study