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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota
- 2019-11-06
- RCT
- BMC Microbiology 19(1)
- - Chunsaier Wang
  - Wen-bin Li
  - Hongying Wang
  - Yiming Ma
  - Xinhua Zhao
  - Xudong Zhang
  - Hong Yang
  - J. Qian
  - Jingnan Li
- PubMed: 31694526
- DOI: 10.1186/s12866-019-1610-8
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Heat-killed Lactobacillus reuteri and cell-free culture supernatant have similar effects to viable probiotics during interaction with Porphyromonas gingivalis.
- 2019-11-06
- Journal of Periodontal Research 55(2)
- - B. Geraldo
  - Marianna N Batalha
  - N. V. Milhan
  - R. D. Rossoni
  - L. Scorzoni
  - A. Anbinder
- PubMed: 31691977
- DOI: 10.1111/jre.12704
2 Insights on
- Reduced Porphyromonas gingivalis Colony-Forming Units
- Increased Hemocyte Density
- Low evidence
Evaluation of different inclusion levels of dry live yeast impacts on various rumen parameters and in situ digestibilities of dry matter and neutral detergent fiber in growing and finishing beef cattle.
- 2019-11-04
- RCT
- Journal of Animal Science 97(12)
- - Caitlyn M Cagle
  - L. F. Batista
  - Robin C. Anderson
  - M. Fonseca
  - M. Cravey
  - C. Julien
  - L. Tedeschi
- PubMed: 31679025
- DOI: 10.1093/jas/skz342
4 Insights on
- High evidence
- Rigorous Journal
Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
- 2019-11-03
- Meta-Analysis
- Complementary therapies in medicine 48
- - Jason A Hawrelak
  - Hans Wohlmuth
  - Martina Pattinson
  - Stephen P Myers
  - Joshua Z Goldenberg
  - Joanna Harnett
  - Kieran Cooley
  - Claudine Van De Venter
  - Rebecca Reid
  - Dawn L Whitten
- PubMed: 31987249
- DOI: 10.1016/j.ctim.2019.102233
1 Insight on
- Reduced Irritable Bowel Syndrome Symptoms
- High evidence
A Multi-strain Potential Probiotic Formulation of GABA-Producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with Antidepressant Effects
- 2019-11-01
- Clinical Trial
- Probiotics and Antimicrobial Proteins 12(3)
- - R. Yunes
  - E. Poluektova
  - E. Vasileva
  - M. Odorskaya
  - M. Marsova
  - G. Kovalev
  - V. Danilenko
- PubMed: 31677091
- DOI: 10.1007/s12602-019-09601-1
1 Insight on
- Reduced Depressive Behavior
- Low evidence
- Highly Cited
- Animal Study
Complementary and Integrative Therapies for Childhood Atopic Dermatitis.
- 2019-10-30
- Review
- Children (Basel, Switzerland) 6(11)
- - Adrienne L Adler-Neal
  - Abigail Cline
  - Travis Frantz
  - Lindsay Strowd
  - Steven R Feldman
  - Sarah Taylor
- PubMed: 31671707
- DOI: 10.3390/children6110121
1 Insight on
- Improved Clinical Severity Score
- Low evidence
Anti-obesity effect of Lactobacillus rhamnosus LS-8 and Lactobacillus crustorum MN047 on high-fat and high-fructose diet mice base on inflammatory response alleviation and gut microbiota regulation
- 2019-10-28
- Clinical Trial
- European Journal of Nutrition 59(6)
- - Tao Wang
  - Hong Yan
  - Yingying Lu
  - Xin Li
  - Xin Wang
  - Y. Shan
  - Yanglei Yi
  - Bianfang Liu
  - Yuan Zhou
  - Xin Lü
- PubMed: 31659451
- DOI: 10.1007/s00394-019-02117-y
5 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Fortification of rice with vitamins and minerals for addressing micronutrient malnutrition.
- 2019-10-25
- Meta-Analysis · n = 8,245
- The Cochrane database of systematic reviews 2019(10)
- - Juan Pablo Peña-Rosas
  - Prasanna Mithra
  - Bhaskaran Unnikrishnan
  - Nithin Kumar
  - Luz Maria De-Regil
  - N Sreekumaran Nair
  - Maria N Garcia-Casal
  - Juan Antonio Solon
- PubMed: 31684687
- DOI: 10.1002/14651858.cd009902.pub2
8 Insights on
- High evidence
The Step of Incorporation of Bacillus coagulans GBI-30 6086 Into “requeijão cremoso” Processed Cheese Does Not Affect Metabolic Homeostasis of Rats
- 2019-10-22
- RCT · n = 20
- Frontiers in Microbiology 10
- - Mariana B. Soares
  - V. A. Santos-Junior
  - E. T. Tavares Filho
  - P. Lollo
  - P. Morato
  - J. Amaya-Farfan
  - Eliene Pereira
  - C. Balthazar
  - A. G. Cruz
  - R. C. Martinez
  - A. Sant’Ana
- PubMed: 31695686
- DOI: 10.3389/fmicb.2019.02332
1 Insight on
- Maintained Metabolic Homeostasis
- Low evidence
- Animal Study
Evaluation of the safety, tolerance and efficacy of 1-year consumption of infant formula supplemented with Lactobacillus fermentum CECT5716 Lc40 or Bifidobacterium breve CECT7263: a randomized controlled trial
- 2019-10-21
- RCT · n = 236
- BMC Pediatrics 19(1)
- - José Maldonado
  - Mercedes Gil-Campos
  - J. Maldonado-Lobón
  - M. R. Benavides
  - K. Flores-Rojas
  - R. Jaldo
  - I. J. D. Barco
  - V. Bolívar
  - A. Valero
  - E. Prados
  - I. Peñalver
  - M. Olivares
- PubMed: 31630683
- DOI: 10.1186/s12887-019-1753-7
8 Insights on
- High evidence
- Rigorous Journal
A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study.
- 2019-10-17
- RCT
- Nutrients 11(10)
- - Liane Bolke
  - Gerrit Schlippe
  - Joachim Gerß
  - Werner Voss
- PubMed: 31627309
- DOI: 10.3390/nu11102494
4 Insights on
- High evidence
- Rigorous Journal
Clinical efficacy of Lactobacillus reuteri-containing lozenges in the supportive therapy of generalized periodontitis stage III and IV, grade C: 1-year results of a double-blind randomized placebo-controlled pilot study
- 2019-10-16
- RCT · n = 20
- Clinical Oral Investigations 24(6)
- - M. G. Grusovin
  - S. Bossini
  - S. Calza
  - V. Cappa
  - G. Garzetti
  - E. Scotti
  - E. Gherlone
  - M. Mensi
- PubMed: 31620939
- DOI: 10.1007/s00784-019-03065-x
5 Insights on
- High evidence
Daily intake of heat-killed Lactobacillus plantarum L-137 improves inflammation and lipid metabolism in overweight healthy adults: a randomized-controlled trial
- 2019-10-16
- RCT · n = 100
- European Journal of Nutrition 59(6)
- - Yusuke Tanaka
  - Y. Hirose
  - Yoshihiro Yamamoto
  - Y. Yoshikai
  - S. Murosaki
- PubMed: 31620886
- DOI: 10.1007/s00394-019-02112-3
12 Insights on
- High evidence
- Rigorous Journal
Modulation of T Regulatory and Dendritic Cell Phenotypes Following Ingestion of Bifidobacterium longum, AHCC® and Azithromycin in Healthy Individuals
- 2019-10-15
- RCT · n = 40
- Nutrients 11(10)
- - A. Chowdhury
  - M. Cámara
  - C. Verma
  - O. Eremin
  - A. Kulkarni
  - D. Lobo
- PubMed: 31618905
- DOI: 10.3390/nu11102470
1 Insight on
- Increased IFN-γ to IL-4 Ratio
- High evidence
Recovery of Lactobacillus casei strain Shirota (LcS) from faeces of healthy Singapore adults after intake of fermented milk.
- 2019-10-14
- Beneficial Microbes 10(7)
- - W. W. T. Khine
  - X. Ang
  - Y. S. Chan
  - W. Q. Lee
  - S. Quek
  - S. H. Tan
  - H. T. A. Teo
  - J. Teo
  - Q. Lau
  - Y.K. Lee
- PubMed: 31965844
- DOI: 10.3920/BM2018.0173
7 Insights on
- Low evidence
Effect of Yeast Fermentate Supplementation on Intestinal Health and Plasma Biochemistry in Heat-Stressed Pekin Ducks.
- 2019-10-12
- RCT
- Animals : an open access journal from MDPI 9(10)
- - Jill R Nelson
  - Gregory S Archer
- PubMed: 31614703
- DOI: 10.3390/ani9100790
5 Insights on
- High evidence
Oral L-Tyrosine Supplementation Improves Core Temperature Maintenance in Older Adults.
- 2019-10-11
- RCT
- Medicine and science in sports and exercise 52(4)
- - James A Lang
  - Alex C Krajek
  - Kelsey S Schwartz
  - Joel E Rand
- PubMed: 31609301
- DOI: 10.1249/mss.0000000000002188
2 Insights on
- Improved Core Temperature Regulation
- Improved Cutaneous Vasoconstriction
- High evidence
Carica papaya extract in dengue: a systematic review and meta-analysis.
- 2019-10-11
- Meta-Analysis · n = 580
- BMC complementary and alternative medicine 19(1)
- - Senaka Rajapakse
  - Nipun Lakshitha de Silva
  - Praveen Weeratunga
  - Chaturaka Rodrigo
  - Chathurani Sigera
  - Sumadhya Deepika Fernando
- PubMed: 31601215
- DOI: 10.1186/s12906-019-2678-2
5 Insights on
- High evidence
The Effect of Clostridium butyricum on Gut Microbiota, Immune Response and Intestinal Barrier Function During the Development of Necrotic Enteritis in Chickens
- 2019-10-11
- Frontiers in Microbiology 10
- - Ting Huang
  - Xinyu Peng
  - B. Gao
  - Qingying Wei
  - Rong Xiang
  - Minggui Yuan
  - Zhihong Xu
- PubMed: 31681193
- DOI: 10.3389/fmicb.2019.02309
1 Insight on
- Altered Gastrointestinal Health Post-Infection
- Low evidence
Propionibacterium freudenreichii CIRM-BIA 129 Osmoadaptation Coupled to Acid-Adaptation Increases Its Viability During Freeze-Drying
- 2019-10-09
- Frontiers in Microbiology 10
- - Floriane Gaucher
  - Koffigan Kponouglo
  - Houem Rabah
  - S. Bonnassie
  - Jordane Ossemond
  - Sandrine Pottier
  - J. Jardin
  - V. Briard-Bion
  - P. Marchand
  - P. Blanc
  - R. Jeantet
  - G. Jan
- PubMed: 31681198
- DOI: 10.3389/fmicb.2019.02324
1 Insight on
- Improved Immunomodulation
- Low evidence
Hypnotic Effects of Lactobacillus fermentum PS150TM on Pentobarbital-Induced Sleep in Mice.
- 2019-10-09
- Nutrients 11(10)
- - Alexander Lin
  - Ching-Ting Shih
  - Chin-Lin Huang
  - Chien-Chen Wu
  - Ching-Ting Lin
  - Ying-Chieh Tsai
- PubMed: 31600934
- DOI: 10.3390/nu11102409
2 Insights on
- Improved Sleep Quality
- Reduced Circadian Sleep Disturbance
- Low evidence
- Rigorous Journal
- Animal Study
Systematic Review of l-glutamine for Prevention of Vaso-occlusive Pain Crisis in Patients with Sickle Cell Disease.
- 2019-10-09
- Systematic Review
- Pharmacotherapy 39(11)
- - Nicole E Cieri-Hutcherson
  - Timothy C Hutcherson
  - Erin E Conway-Habes
  - Brianna N Burns
  - Nathan A White
- PubMed: 31505045
- DOI: 10.1002/phar.2329
2 Insights on
- Reduced Vaso-occlusive Crisis
- Reduced Hospitalization Related to VOC
- High evidence
Lactobacillus gasseri Suppresses the Production of Proinflammatory Cytokines in Helicobacter pylori-Infected Macrophages by Inhibiting the Expression of ADAM17
- 2019-10-04
- Frontiers in Immunology 10
- - Hanna G. Gebremariam
  - K. R. Qazi
  - Tanvi Somiah
  - S. Pathak
  - Hong Sjölinder
  - E. Sverremark Ekström
  - A. Jonsson
- PubMed: 31636639
- DOI: 10.3389/fimmu.2019.02326
4 Insights on
- Low evidence
Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.
- 2019-10-03
- RCT · n = 30
- Nutrients 11(10)
- - Shinsuke Hidese
  - Shintaro Ogawa
  - Miho Ota
  - Ikki Ishida
  - Zenta Yasukawa
  - Makoto Ozeki
  - Hiroshi Kunugi
- PubMed: 31623400
- DOI: 10.3390/nu11102362
8 Insights on
- High evidence
- Rigorous Journal
Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis.
- 2019-10-03
- Meta-Analysis
- The Journal of international medical research 47(11)
- - Qiong-Li Fan
  - Xiu-Mei Yu
  - Quan-Xing Liu
  - Wang Yang
  - Qin Chang
  - Yu-Ping Zhang
  - Yu-Ping Zhang
- PubMed: 31578896
- DOI: 10.1177/0300060519876753
3 Insights on
- High evidence
Development of a Mucoadhesive In Situ Gelling Formulation for the Delivery of Lactobacillus gasseri into Vaginal Cavity
- 2019-10-03
- Pharmaceutics 11(10)
- - B. Vigani
  - Angela Faccendini
  - S. Rossi
  - G. Sandri
  - M. C. Bonferoni
  - P. Grisoli
  - F. Ferrari
- PubMed: 31623341
- DOI: 10.3390/pharmaceutics11100511
1 Insight on
- Reduced Recurrences of Candidosis
- Low evidence
Tea Compounds and the Gut Microbiome: Findings from Trials and Mechanistic Studies.
- 2019-10-03
- Systematic Review
- Nutrients 11(10)
- - Timothy Bond
  - Emma Derbyshire
- PubMed: 31623411
- DOI: 10.3390/nu11102364
3 Insights on
- High evidence
- Rigorous Journal
Nutraceutical treatment and prevention of benign prostatic hyperplasia and prostate cancer.
- 2019-10-02
- Review
- Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 91(3)
- - Arrigo F G Cicero
  - Olta Allkanjari
  - Gian Maria Busetto
  - Tommaso Cai
  - Gaetano Larganà
  - Vittorio Magri
  - Gianpaolo Perletti
  - Francesco Saverio Robustelli Della Cuna
  - Giorgio Ivan Russo
  - Kostantinos Stamatiou
  - Alberto Trinchieri
  - Annabella Vitalone
- PubMed: 31577095
- DOI: 10.4081/aiua.2019.3.139
11 Insights on
- Low evidence
Efficacy of L-leucine Supplementation Coupled With Resistance Training in Untrained Midlife Women.
- 2019-10-02
- RCT
- Journal of the American College of Nutrition 39(4)
- - LesLee K Funderburk
  - Kaitlan N Beretich
  - Marcus D Chen
  - Darryn S Willoughby
- PubMed: 31577520
- DOI: 10.1080/07315724.2019.1650675
7 Insights on
- High evidence
- Rigorous Journal
Bifidobacterial Dialogue With Its Human Host and Consequent Modulation of the Immune System
- 2019-10-01
- Frontiers in Immunology 10
- - Giulia Alessandri
  - M. C. Ossiprandi
  - John Macsharry
  - D. van Sinderen
  - M. Ventura
- PubMed: 31632412
- DOI: 10.3389/fimmu.2019.02348
3 Insights on
- Low evidence