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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials.
- 2024-12
- Meta-Analysis · n = 835
- Prostaglandins & other lipid mediators 175
- - Hawal Lateef Fateh
  - Dyari H Ahmed
  - Maryam Sharifi Najafabadi
  - Jalal Moludi
- PubMed: 39299649
- DOI: 10.1016/j.prostaglandins.2024.106907
4 Insights on
- High evidence
Extensive genomic characterization, pre-clinical probiotic evaluation, and safety analysis of Bifidobacterium longum subsp. longum BL21 isolated from infant feces.
- 2024-12
- Microbial pathogenesis 197
- - Yao Dong
  - Yinan Zhang
  - Fei Xu
  - Kang Zou
- PubMed: 39505088
- DOI: 10.1016/j.micpath.2024.107100
2 Insights on
- Reduced Toxicity
- Enhanced Gastrointestinal Stress Resistance
- Low evidence
Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.
- 2024-12
- RCT · n = 303
- Annals of vascular surgery 109
- - Suh Min Kim
  - Jin Hyun Joh
  - In Mok Jung
  - Mi Jin Kim
  - Sang Su Lee
  - Hong Pil Hwang
  - Jin Mo Kang
  - Hyuk Jae Jung
  - Shin-Seok Yang
  - Seung-Kee Min
  - Young Sun Yoo
  - Jun Gyo Gwon
  - Hyung Sub Park
  - Taeseung Lee
- PubMed: 39009117
- DOI: 10.1016/j.avsg.2024.06.011
4 Insights on
- High evidence
- Large Human Trial
"Protective effects of artichoke extract and Bifidobacterium longum on male infertility in diabetic rats".
- 2024-12
- RCT
- Biochemistry and biophysics reports 40
- - Zahra Ansari
  - Mohammad Hasan Maleki
  - Fatemeh Roohy
  - Zahra Ebrahimi
  - Mesbah Shams
  - Pooneh Mokaram
  - Zahra Zamanzadeh
  - Zahra Hosseinzadeh
  - Farhad Koohpeyma
  - Sanaz Dastghaib
- PubMed: 39386078
- DOI: 10.1016/j.bbrep.2024.101834
1 Insight on
- Improved Fertility
- High evidence
Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial.
- 2024-12
- RCT · n = 402
- The journal of prevention of Alzheimer's disease 11(6)
- - W Liu
  - D Zheng
  - X Li
  - T Wang
  - L Wang
  - L Hao
  - M Ju
  - W Feng
  - Z Guo
  - X Sun
  - H Yu
  - Z Qin
  - R Xiao
- PubMed: 39559875
- DOI: 10.14283/jpad.2024.165
1 Insight on
- Improved Overall Cognitive Function
- High evidence
- Large Human Trial
The Use of Ginger Bioactive Compounds in Pregnancy: An Evidence Scan and Umbrella Review of Existing Meta-Analyses.
- 2024-11
- Review
- Advances in nutrition (Bethesda, Md.) 15(11)
- - Kendra A Tiani
  - Cristina M Arenaz
  - Maureen K Spill
  - Margaret J Foster
  - Julie S Davis
  - Regan L Bailey
  - Martha S Field
  - Patrick J Stover
  - Amanda J MacFarlane
- PubMed: 39343171
- DOI: 10.1016/j.advnut.2024.100308
1 Insight on
- Reduced Vomiting Frequency
- Low evidence
The effects of aromatherapy massage in menopausal women with knee osteoarthritis: A randomized controlled study.
- 2024-11
- RCT · n = 20
- Explore (New York, N.Y.) 20(6)
- - Şerife İrem Döner
  - Hasan Gerçek
  - Özlem Akkoyun Sert
  - Ayça Aytar
  - Aydan Aytar
- PubMed: 38845299
- DOI: 10.1016/j.explore.2024.05.012
4 Insights on
- High evidence
Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota.
- 2024-11
- Clinical Trial
- Food science of animal resources 44(6)
- - Gwang Il Kim
  - Hwa Yeong Jeong
  - In Sung Kim
  - Seung Ho Lee
  - Sung Hak Kim
  - Yang Soo Moon
  - Kwang Keun Cho
- PubMed: 39554831
- DOI: 10.5851/kosfa.2024.e100
3 Insights on
- Moderate evidence
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
- 2024-11
- RCT · n = 45
- Journal of the Academy of Nutrition and Dietetics 124(11)
- - Nursyafiqah Aqilah Suhaimi
  - Su Peng Loh
  - Norhafizah Ab Manan
  - Nurzalinda Zalbahar
  - Muhammad Najib Mohamad Alwi
  - Salma Faeza Ahmad Fuzi
- PubMed: 38408566
- DOI: 10.1016/j.jand.2024.02.013
3 Insights on
- High evidence
Anti-colorectal cancer activity of mannatide from spent brewer's yeast by regulating immune cells and immune function in the tumor microenvironment.
- 2024-11
- International journal of biological macromolecules 280
- - Fei Li
  - Xiaopeng Sun
  - Xiang Gao
  - Shuang Zhao
  - Samad Tavakoli
  - Zubo Du
  - Yuxi Wei
- PubMed: 39270895
- DOI: 10.1016/j.ijbiomac.2024.135531
4 Insights on
- Low evidence
Comparison of Coconut and Sunflower Seed Oils in Improving the Skin Integrity and Weight Gain of Infants in the Neonatal ICU.
- 2024-11
- RCT
- Advances in skin & wound care 37(11&12)
- - Öznur Tiryaki
  - Hamide Zengin
  - Nursan Çınar
  - Meltem Karabay
  - İbrahim Caner
  - Ertuğrul Güçlü
- PubMed: 39792519
- DOI: 10.1097/asw.0000000000000241
2 Insights on
- Increased Weight
- Improved Skin Condition Score
- High evidence
Efficacy and safety of Plantago major seeds in patients with diabetic nephropathy: A randomized open-labeled controlled clinical trial.
- 2024-11
- RCT
- Explore (New York, N.Y.) 20(6)
- - Romella Haider
  - Majid Asghari
  - Fatemeh Aliasl
  - Mohammad Aghaali
  - Razieh Borujerdi
  - Hossein Saghafi
  - Hossein Moradi
- PubMed: 38797623
- DOI: 10.1016/j.explore.2024.05.003
2 Insights on
- Improved Quality of Life
- Reduced Proteinuria
- High evidence
Evaluation of the Efficacy of Medicinal Plants in Treating Bacterial Vaginosis: A Comprehensive Systematic Review of Interventional Studies.
- 2024-11
- Review · n = 2,685
- Iranian journal of nursing and midwifery research 29(6)
- - Mohadese Kamali
  - Zarrin Sarhadynejad
  - Haleh Tajadini
  - Mojtaba Keikha
  - Zohreh Salari
  - Tania Dehesh
  - Mahdiyeh Lashkarizadeh
  - Mitra Esmaili
- PubMed: 39759925
- DOI: 10.4103/ijnmr.ijnmr_311_23
1 Insight on
- Improved Bacterial Vaginosis Treatment
- High evidence
Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment.
- 2024-10
- Microbial biotechnology 17(10)
- - Zhe Yin
  - Yilin Wang
  - Xiaojuan Feng
  - Changqing Liu
  - Xiaoyang Guan
  - Shuyan Liu
  - Zhanyi Long
  - Zhonghua Miao
  - Fang He
  - Ruyue Cheng
  - Yanting Han
  - Ka Li
- PubMed: 39422648
- DOI: 10.1111/1751-7915.70031
4 Insights on
- Low evidence
- Animal Study
Effects of breast-fed infants-derived Limosilactobacillus reuteri and Bifidobacterium breve ameliorate DSS-induced colitis in mice.
- 2024-10
- iScience 27(10)
- - Zhipeng Huang
  - Bingdong Liu
  - Lanlin Xiao
  - Miaomiao Liao
  - Liujing Huang
  - Xiaogan Zhao
  - Kai Ma
  - Runxin Wang
  - Feng Ji
  - Wei Li
  - Liping Huang
  - Liwei Xie
- PubMed: 39351200
- DOI: 10.1016/j.isci.2024.110902
1 Insight on
- Improved Colitis Symptoms
- Low evidence
The effect of vitamin D2 on lipid profile, anthropometric indices, blood pressure, and inflammatory and glycemic biomarkers in humans: A systematic review and meta-analysis of randomized controlled trials.
- 2024-10
- Meta-Analysis
- Prostaglandins & other lipid mediators 174
- - Zhihong Zhou
  - Jiyuan Liu
  - Hui Zhang
  - Kousalya Prabahar
  - Benjamin Hernández-Wolters
  - Yuanhong Yuan
- PubMed: 39154789
- DOI: 10.1016/j.prostaglandins.2024.106883
12 Insights on
- High evidence
The Role of Microbiome and Probiotics in Chemo-Radiotherapy-Induced Diarrhea: A Narrative Review of the Current Evidence.
- 2024-10
- Review
- Cancer reports (Hoboken, N.J.) 7(10)
- - Sanaz Khorashadizadeh
  - Sara Abbasifar
  - Mohammad Yousefi
  - Farzad Fayedeh
  - AmirAli Moodi Ghalibaf
- PubMed: 39410854
- DOI: 10.1002/cnr2.70029
4 Insights on
- Low evidence
Relationship between vitamin B12 levels and motor development: A systematic review.
- 2024-10
- Systematic Review · n = 684
- Clinical nutrition ESPEN 63
- - Maria Eduarda Rodrigues Alves Dos Santos
  - Karollainy Gomes da Silva
  - Ana Patrícia da Silva Souza
  - Ana Beatriz Januário da Silva
  - Robson Feliciano da Silva
  - Erica Helena Alves da Silva
  - Sandra Lopes de Souza
  - Waleska Maria Almeida Barros
- PubMed: 38944829
- DOI: 10.1016/j.clnesp.2024.06.026
1 Insight on
- Improved Motor Development
- High evidence
The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials.
- 2024-10
- Meta-Analysis · n = 30
- Prostaglandins & other lipid mediators 174
- - Shabnam Shirvani
  - Maryam Falahatzadeh
  - Elham Oveili
  - Mehrdad Jamali
  - Pedram Pam
  - Maryam Parang
  - Mehrnaz Shakarami
- PubMed: 39181437
- DOI: 10.1016/j.prostaglandins.2024.106885
4 Insights on
- High evidence
Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice.
- 2024-10
- Molecular metabolism 88
- - Jorge Lopez-Tello
  - Raymond Kiu
  - Zoe Schofield
  - Cindy X W Zhang
  - Douwe van Sinderen
  - Gwénaëlle Le Gall
  - Lindsay J Hall
  - Amanda N Sferruzzi-Perri
- PubMed: 39127167
- DOI: 10.1016/j.molmet.2024.102004
1 Insight on
- Modified Fetal Brain Metabolism
- Low evidence
- Animal Study
Lactobacillus gasseri BNR17 and Limosilactobacillus fermentum ABF21069 Ameliorate High Sucrose-Induced Obesity and Fatty Liver via Exopolysaccharide Production and β-oxidation.
- 2024-10
- Journal of microbiology (Seoul, Korea) 62(10)
- - Yu Mi Jo
  - Yoon Ji Son
  - Seul-Ah Kim
  - Gyu Min Lee
  - Chang Won Ahn
  - Han-Oh Park
  - Ji-Hyun Yun
- PubMed: 39417925
- DOI: 10.1007/s12275-024-00173-6
3 Insights on
- Low evidence
- Animal Study
Overview of the therapeutic efficacy of marine fish oil in managing obesity and associated metabolic disorders.
- 2024-10
- Review
- Physiological reports 12(19)
- - Riya Kar
  - Titli Panchali
  - Pipika Das
  - Ananya Dutta
  - Manisha Phoujdar
  - Shrabani Pradhan
- PubMed: 39358834
- DOI: 10.14814/phy2.70019
5 Insights on
- Low evidence
Effects of soy protein-rich meals on muscle health of older adults in long-term care: A randomized clinical trial.
- 2024-10
- RCT · n = 84
- Nutrition (Burbank, Los Angeles County, Calif.) 126
- - Wuke Yuan
  - Min Chen
  - Yanqiu Chen
  - Danfeng Xu
  - Zhen Li
  - Huijing Bai
  - Qi Xu
  - Yuanrong Jiang
  - Jie Gu
  - Shengqi Li
  - Chenxi Su
  - Lili Gu
  - Jiaxin Fang
  - Xinyao Zhu
  - Jianqin Sun
  - Jie Chen
- PubMed: 39003895
- DOI: 10.1016/j.nut.2024.112507
5 Insights on
- High evidence
Evaluating the impact of short-term nitrate-rich dietary supplementation on endothelial function in COPD: A randomized crossover study.
- 2024-10
- RCT
- Respiratory medicine 232
- - Fernanda Beatriz Costa Delacoste
  - Cassia da Luz Goulart
  - Augusto Baumhardt Guidoti
  - Patrick Türck
  - Bruna Eibel
  - Maria Claudia Irigoyen
  - Cintia Laura Pereira de Araujo
  - Pedro Dal Lago
- PubMed: 39053520
- DOI: 10.1016/j.rmed.2024.107745
3 Insights on
- High evidence
Vitamin D3 and cancer risk in healthy subjects: An umbrella review of systematic review and meta-analysis.
- 2024-10
- Systematic Review · n = 71
- Clinical nutrition ESPEN 63
- - Fausto Petrelli
  - Rita Deda
  - Karen Borgonovo
  - Giuseppina Dognini
  - Mara Ghilardi
  - Maria Chiara Parati
  - Daniela Petrò
  - Veronica Lonati
  - Lorenzo Dottorini
  - Antonio Ghidini
- PubMed: 39178988
- DOI: 10.1016/j.clnesp.2024.08.014
7 Insights on
- High evidence
Synergistic effects of oral inoculation with a recombinant Lactobacillus plantarum NC8 strain co-expressing interleukin-2 and interleukin-17B on the efficacy of the infectious bronchitis vaccine in chickens.
- 2024-09
- Poultry science 103(9)
- - Shaohua Guo
  - Junjie Peng
  - Yongle Xiao
  - Jianlin Chen
  - Rong Gao
- PubMed: 38981363
- DOI: 10.1016/j.psj.2024.103908
3 Insights on
- Low evidence
- Animal Study
The effect of Panax ginseng supplementation on markers of resistance exercise-induced muscle damage: a systematic review.
- 2024-09
- Systematic Review
- The Journal of sports medicine and physical fitness 64(10)
- - Ryland Morgans
  - Jule S Scholten
  - Dave Rhodes
  - Halil I Ceylan
  - Ben Ryan
  - Rafael Oliveira
  - Tom Clifford
- PubMed: 38888561
- DOI: 10.23736/s0022-4707.24.15832-x
3 Insights on
- High evidence
β-Alanine supplementation improves fractional anisotropy scores in the hippocampus and amygdala in 60-80-year-old men and women.
- 2024-09
- RCT
- Experimental gerontology 194
- - Ishay Ostfeld
  - Amit Zamir
  - Tavor Ben-Zeev
  - Chagai Levi
  - Yftach Gepner
  - David Peled
  - Daniel Barazany
  - Shmuel Springer
  - Jay R Hoffman
- PubMed: 38971131
- DOI: 10.1016/j.exger.2024.112513
6 Insights on
- High evidence
Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials.
- 2024-09
- Meta-Analysis · n = 339
- Complementary therapies in medicine 84
- - Piyameth Dilokthornsakul
  - Natnicha Rattanachaisit
  - Phiyanuch Thimkorn
  - Supawan Pongpattanawut
  - Witoo Dilokthornsakul
  - Teerapon Dhippayom
- PubMed: 38878905
- DOI: 10.1016/j.ctim.2024.103063
3 Insights on
- High evidence
Effect of peanut butter supplementation on physical and cognitive functions in community-dwelling older adults: study protocol for a 6-month randomised controlled trial.
- 2024-09
- RCT · n = 120
- BMJ open 14(9)
- - Jeew Hettiarachchi
  - Ilili Feyesa
  - Robin M Daly
  - Elena S George
  - Ekavi N Georgousopoulou
  - David Scott
  - Brenton J Baguley
  - Sze-Yen Tan
- PubMed: 39242158
- DOI: 10.1136/bmjopen-2024-086232
11 Insights on
- High evidence
- Large Human Trial