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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis
- 2020-01-15
- Clinical Trial
- Nutrients 12(1)
- - K. Toda
  - Yuki Yamauchi
  - A. Tanaka
  - T. Kuhara
  - T. Odamaki
  - Shin Yoshimoto
  - J. Xiao
- PubMed: 31952193
- DOI: 10.3390/nu12010219
5 Insights on
- Low evidence
- Animal Study
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity
- 2020-01-15
- RCT · n = 20
- Nutrients 12(1)
- - I. Sergeev
  - Thamer Aljutaily
  - G. Walton
  - E. Huarte
- PubMed: 31952249
- DOI: 10.3390/nu12010222
1 Insight on
- Reduced Blood Glucose Levels
- High evidence
- Highly Cited
Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial
- 2020-01-15
- RCT · n = 60
- Nutrients 12(1)
- - M. Kubota
  - Kazuya Ito
  - K. Tomimoto
  - Mitsuharu Kanazaki
  - K. Tsukiyama
  - A. Kubota
  - H. Kuroki
  - M. Fujita
  - Y. Vandenplas
- PubMed: 31952280
- DOI: 10.3390/nu12010225
4 Insights on
- High evidence
Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet.
- 2020-01-15
- Food & Function 10(8)
- - Shuangqiu Li
  - Ce Qi
  - Hualing Zhu
  - R. Yu
  - C. Xie
  - Yuande Peng
  - S. Yin
  - Jianhui Fan
  - Suqing Zhao
  - Jin Sun
- PubMed: 31304501
- DOI: 10.1039/c9fo00417c
17 Insights on
- Low evidence
Dose-Response Recovery of Probiotic Strains in Simulated Gastro-Intestinal Passage.
- 2020-01-13
- Microorganisms 8(1)
- - Sofia Forssten
  - Arthur C Ouwehand
- PubMed: 31941108
- DOI: 10.3390/microorganisms8010112
3 Insights on
- Low evidence
XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products.
- 2020-01-06
- Review
- Marine drugs 18(1)
- - Rui Pedrosa
  - Susana P Gaudêncio
  - Vitor Vasconcelos
- PubMed: 31935809
- DOI: 10.3390/md18010040
1 Insight on
- Improved Gastrointestinal Health
- Low evidence
Effect of dietary supplementation with brewer's yeast hydrolysate on growth performance, faecal microbial counts, diarrhoea score, blood profile, rectal temperature in weanling pigs challenged with lipopolysaccharide.
- 2020-01-03
- RCT · n = 40
- Journal of Animal Physiology and Animal Nutrition 104(2)
- - Jing Hu
  - J. W. Park
  - I. Kim
- PubMed: 31899588
- DOI: 10.1111/jpn.13301
2 Insights on
- Reduced Diarrhea Incidence
- Improved Gain:Feed Ratio
- Low evidence
- Animal Study
Beta alanine supplementation effects on metabolic contribution and swimming performance.
- 2020-01-03
- RCT
- Journal of the International Society of Sports Nutrition 17(1)
- - Matheus Silva Norberto
  - Ricardo Augusto Barbieri
  - Danilo Rodrigues Bertucci
  - Ronaldo Bucken Gobbi
  - Eduardo Zapaterra Campos
  - Alessandrou Moura Zagatto
  - Ellen Cristini De Freitas
  - Marcelo Papoti
- PubMed: 32711541
- DOI: 10.1186/s12970-020-00365-6
4 Insights on
- High evidence
Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.
- 2020-01-01
- Meta-Analysis · n = 535
- Journal of evidence-based integrative medicine 25
- - Noriko Shinjyo
  - Guy Waddell
  - Julia Green
- PubMed: 33086877
- DOI: 10.1177/2515690x20967323
1 Insight on
- Reduced Anxiety
- High evidence
Effects of dietary supplementation with Pediococcus acidilactici ZPA017 on reproductive performance, fecal microbial flora and serum indices in sows during late gestation and lactation.
- 2020-01-01
- RCT · n = 94
- Asian-Australasian Journal of Animal Sciences 33(1)
- - Hui Liu
  - Sixin Wang
  - Dongyan Zhang
  - Jing Wang
  - Wei Zhang
  - Yamin Wang
  - H. Ji
- PubMed: 36379222
- DOI: 10.5713/AJAS.18.0764
14 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy
- 2019-12-31
- Oncotarget 10(68)
- - F. L. R. do Carmo
  - Houem Rabah
  - B. F. Cordeiro
  - S. H. da Silva
  - R. M. Pessoa
  - S. O. Fernandes
  - V. Cardoso
  - V. Gagnaire
  - M. Deplanche
  - Bruna Savassi
  - Alessandra Figueiroa
  - E. Oliveira
  - Caio Fonseca
  - Maria Izabel Alves Queiroz
  - N. M. Rodrigues
  - S. Sandes
  - Á. Nunes
  - Luísa Lemos
  - J. Alves
  - A. C. Faria
  - Ê. Ferreira
  - Y. Le Loir
  - G. Jan
  - V. Azevedo
- PubMed: 31921383
- DOI: 10.18632/oncotarget.27319
4 Insights on
- Low evidence
Lack of effect of tart cherry concentrate dose on serum urate in people with gout.
- 2019-12-31
- RCT
- Rheumatology (Oxford, England) 59(9)
- - Lisa K Stamp
  - Peter Chapman
  - Christopher Frampton
  - Stephen B Duffull
  - Jill Drake
  - Yuqing Zhang
  - Tuhina Neogi
- PubMed: 31891407
- DOI: 10.1093/rheumatology/kez606
3 Insights on
- High evidence
Pharmacological and Nutritional Modulation of Vascular Calcification.
- 2019-12-30
- Review
- Nutrients 12(1)
- - Liv M Vossen
  - Abraham A Kroon
  - Leon J Schurgers
  - Peter W de Leeuw
- PubMed: 31905884
- DOI: 10.3390/nu12010100
1 Insight on
- Reduced Vascular Calcification
- Moderate evidence
- Rigorous Journal
Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults - A pilot study.
- 2019-12-28
- RCT · n = 10
- Experimental gerontology 131
- - R T Mankowski
  - L You
  - T W Buford
  - C Leeuwenburgh
  - T M Manini
  - S Schneider
  - P Qiu
  - S D Anton
- PubMed: 31891746
- DOI: 10.1016/j.exger.2019.110821
5 Insights on
- High evidence
Probiotic and antioxidant properties of noble Lactobacillus brevis KCCM 12203P isolated from kimchi and evaluation of immune-stimulating activities of its heat-killed cells in RAW 264.7 cells.
- 2019-12-28
- Journal of Microbiology and Biotechnology 29(12)
- - M. Song
  - H. Jang
  - Kee-Tae Kim
  - H. Paik
- PubMed: 31581386
- DOI: 10.4014/jmb.1907.07081
20 Insights on
- Low evidence
Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARγ signaling.
- 2019-12-27
- Scientific reports 9(1)
- - Sung-Soo Park
  - Yeon-Joo Lee
  - Hyuno Kang
  - Garam Yang
  - Eun Jeong Hong
  - Jin Yeong Lim
  - Sejong Oh
  - Eungseok Kim
- PubMed: 31882939
- DOI: 10.1038/s41598-019-56817-w
5 Insights on
- Low evidence
- Rigorous Journal
Are Lactobacillus salivarius G60 and inulin more efficacious to treat patients with oral halitosis and tongue coating than the probiotic alone and placebo? A randomized clinical trial.
- 2019-12-19
- RCT · n = 45
- Journal of Periodontology 91(6)
- - C. R. Mousquer
  - A. D. Bona
  - D. C. Milani
  - S. Callegari-Jacques
  - K. Ishikawa
  - M. Mayer
  - C. Rösing
  - F. Fornari
- PubMed: 31799694
- DOI: 10.1002/jper.19-0089
4 Insights on
- High evidence
Correction to: Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.
- 2019-12-19
- European journal of nutrition 59(1)
- - Irini Lazou Ahrén
  - Anna Berggren
  - Cristina Teixeira
  - Titti Martinsson Niskanen
  - Niklas Larsson
- PubMed: 31858212
- DOI: 10.1007/s00394-019-02156-5
1 Insight on
- Reduced Cold Symptoms
- Low evidence
- Rigorous Journal
Comparative Transcriptome Analysis of Thitarodes Armoricanus in Response to the Entomopathogenic Fungi Paecilomyces Hepiali and Ophiocordyceps Sinensis
- 2019-12-19
- Insects 11(1)
- - Zhongchen Rao
  - Li Cao
  - Hua Wu
  - Xue-hong Qiu
  - Guiqing Liu
  - R. Han
- PubMed: 31861642
- DOI: 10.3390/insects11010004
4 Insights on
- Low evidence
- Rigorous Journal
The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
- 2019-12-19
- Meta-Analysis
- Journal of the American College of Nutrition 39(5)
- - Jounghee Lee
  - Mei Chung
  - Zhuxuan Fu
  - Jihee Choi
  - Hae-Jeung Lee
- PubMed: 31855111
- DOI: 10.1080/07315724.2019.1691956
8 Insights on
- High evidence
- Rigorous Journal
One Week of L-Citrulline Supplementation Improves Performance in Trained Cyclists.
- 2019-12-19
- RCT
- Journal of strength and conditioning research 34(3)
- - Sean T Stanelle
  - Kelsey L McLaughlin
  - Stephen F Crouse
- PubMed: 31860534
- DOI: 10.1519/jsc.0000000000003418
8 Insights on
- High evidence
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
- 2019-12-19
- RCT · n = 41
- JCI insight 4(24)
- - Fernando Holguin
  - Hartmut Grasemann
  - Sunita Sharma
  - Daniel Winnica
  - Karen Wasil
  - Vong Smith
  - Margaret H Cruse
  - Nancy Perez
  - Erika Coleman
  - Timothy J Scialla
  - Loretta G Que
- PubMed: 31714895
- DOI: 10.1172/jci.insight.131733
4 Insights on
- High evidence
d-Amino Acids and Lactic Acid Bacteria.
- 2019-12-12
- Review
- Microorganisms 7(12)
- - Jyumpei Kobayashi
- PubMed: 31842512
- DOI: 10.3390/microorganisms7120690
2 Insights on
- Improved Gut Health
- No Human Health Outcome Reported
- Low evidence
Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis.
- 2019-12-12
- Meta-Analysis · n = 503
- Phytotherapy research : PTR 34(5)
- - Boxun Zhang
  - Rensong Yue
  - Ying Wang
  - Lizhen Wang
  - Jiawei Chin
  - Xiaoying Huang
  - Yayi Jiang
- PubMed: 31833112
- DOI: 10.1002/ptr.6592
3 Insights on
- High evidence
In vitro Study of Lactobacillus paracasei CNCM I-1518 in Healthy and Clostridioides difficile Colonized Elderly Gut Microbiota
- 2019-12-10
- Frontiers in Nutrition 6
- - Sophie Fehlbaum
  - C. Chassard
  - C. Schwab
  - Maarja Voolaid
  - Candice Fourmestraux
  - M. Derrien
  - C. Lacroix
- PubMed: 31921877
- DOI: 10.3389/fnut.2019.00184
4 Insights on
- Low evidence
Effects of the Consumption of Probiotic Yogurt Containing Bifidobacterium lactis Bb12 on the Levels of Streptococcus mutans and Lactobacilli in Saliva of Students with Initial Stages of Dental Caries: A Double-Blind Randomized Controlled Trial
- 2019-12-10
- RCT · n = 66
- Caries Research 54(1)
- - A. Zare Javid
  - Essam Amerian
  - L. Basir
  - A. Ekrami
  - M. Haghighizadeh
  - Leila Maghsoumi-Norouzabad
- PubMed: 31821997
- DOI: 10.1159/000504164
7 Insights on
- High evidence
Inclusion of the direct-fed microbial Clostridium butyricum in diets for weanling pigs increases growth performance and tends to increase villus height and crypt depth, but does not change intestinal microbial abundance.
- 2019-12-10
- RCT
- Journal of Animal Science 98(1)
- - G. Casas
  - L. Blavi
  - Tzu-Wen L. Cross
  - A. Lee
  - K. Swanson
  - H. Stein
- PubMed: 31820779
- DOI: 10.1093/jas/skz372
4 Insights on
- High evidence
- Rigorous Journal
Lactobacillus rhamnosus GG and Saccharomyces cerevisiae boulardii exert synergistic antipathogenic activity in vitro against enterotoxigenic Escherichia coli.
- 2019-12-09
- Beneficial Microbes 10(8)
- - F. Moens
  - C. Duysburgh
  - P. van den Abbeele
  - M. Morera
  - M. Marzorati
- PubMed: 31965838
- DOI: 10.3920/bm2019.0064
2 Insights on
- Reduced Enterotoxigenic Escherichia coli Abundance
- Reduced ETEC Toxin Levels
- Low evidence
The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)
- 2019-12-09
- PLOS ONE 14(12)
- - Hongqin Li
  - Ying Zhou
  - Huayun Ling
  - L. Luo
  - D. Qi
  - Lin Feng
- PubMed: 31815958
- DOI: 10.1371/journal.pone.0223428
6 Insights on
- Low evidence
- Rigorous Journal
Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review.
- 2019-12-05
- Systematic Review
- International journal of environmental research and public health 16(24)
- - Amiza Hamdan
  - Ruszymah Haji Idrus
  - Mohd Helmy Mokhtar
- PubMed: 31817324
- DOI: 10.3390/ijerph16244911
5 Insights on
- High evidence