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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Leveraging microbiome-based interventions to improve the management of neurodegenerative diseases: evidence for effects along the microbiota-gut-brain axis.
- 2025-12-11
- Review
- Frontiers in nutrition 12
- - Noémie Auclair-Ouellet
  - Ola Kassem
  - Stéphane Bronner
  - Marie-Laure Oula
  - Sylvie Binda
- PubMed: 41459056
- DOI: 10.3389/fnut.2025.1699884
4 Insights on
- Low evidence
EFFICACY OF PROBIOTICS IN PREVENTING CHEMOTHERAPY-INDUCED DIARRHEA IN GASTROINTESTINAL CANCER PATIENTS.
- 2025-12-11
- RCT · n = 28
- Arquivos de gastroenterologia 62
- - Gabriel Caio DE Souza
  - Humberto Bezerra de Araujo Filho
  - Cleyton Zanardo DE Oliveira
  - Ana Paula Ribeiro Paiotti
  - Nora Manoukian Forones
- PubMed: 41379184
- DOI: 10.1590/s0004-2803.24612025-020
2 Insights on
- Reduced Chemotherapy-Induced Diarrhea
- Probiotic-Related Infection
- High evidence
Effect of oral silymarin in patients with acute hepatotoxic mushroom poisoning: an analysis of poison center data.
- 2025-12-11
- Observational · n = 255
- Clinical toxicology (Philadelphia, Pa.) 64(2)
- - Theerapon Tangsuwanaruk
  - Phantakan Tansuwannarat
  - Achara Tongpoo
  - Kanyapak Mirin
  - Satariya Trakulsrichai
- PubMed: 41378447
- DOI: 10.1080/15563650.2025.2586098
4 Insights on
- High evidence
Effectiveness and safety of dietary supplements in the adjunctive treatment of psoriasis: a systematic review and network meta-analysis.
- 2025-12-11
- Systematic Review · n = 463
- Frontiers in nutrition 12
- - Danping Chen
  - Jie Yang
  - Wenwen Yang
  - Xinying Liu
  - Zhihong Li
- PubMed: 41459063
- DOI: 10.3389/fnut.2025.1718828
3 Insights on
- High evidence
Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain.
- 2025-12-11
- RCT
- Nutrients 17(24)
- - Lena-Christin Ingwersen
  - Alina Kistenmacher
  - Uwe H Melchert
  - Kerstin M Oltmanns
- PubMed: 41470820
- DOI: 10.3390/nu17243875
1 Insight on
- Improved Insulin Sensitivity
- High evidence
- Rigorous Journal
Optimization of solid-state fermentation conditions for high β-galactosidase-producing lactic acid bacteria and its application in low-lactose dairy products.
- 2025-12-11
- Frontiers in bioengineering and biotechnology 13
- - Zhanjia Zhang
- PubMed: 41459252
- DOI: 10.3389/fbioe.2025.1708601
1 Insight on
- Reduced Lactose Content in Milk
- Low evidence
Zinc deficiency and zinc/copper ratio imbalance in autism spectrum disorder: a reanalysis of six multinational studies.
- 2025-12-10
- Meta-Analysis
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 39(1)
- - Geir Bjørklund
- PubMed: 41372683
- DOI: 10.1007/s10534-025-00761-y
1 Insight on
- Improved Motor Function
- High evidence
Elucidating the Probiotic Potential of Lactobacillus and Bifidobacterium Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review.
- 2025-12-10
- Systematic Review
- Nutrition reviews 84(5)
- - Sidra A Uzair
  - Angela Ajeesh
  - Salma H Ahmed
  - Shaikha Alabduljabbar
  - Fatima Ahmad
  - Arun P Lakshmanan
  - Annalisa Terranegra
- PubMed: 41370015
- DOI: 10.1093/nutrit/nuaf238
3 Insights on
- High evidence
Thermal Versus Ultrasound Inactivation of Bifidobacterium animalis subsp. lactis BB-12: Functional Implications for Postbiotics.
- 2025-12-10
- Probiotics and antimicrobial proteins 18(1)
- - Nimet Marsak
  - Ecem Akan
  - Adem Yavaş
  - Zafer Erbay
- PubMed: 41369876
- DOI: 10.1007/s12602-025-10876-w
5 Insights on
- Low evidence
- Rigorous Journal
Comparative Genomics Analysis Combined with Homologous Overexpression Reveals the Mechanism of Species-Specific Acid Stress Resistance in Bifidobacterium animalis.
- 2025-12-10
- Foods (Basel, Switzerland) 14(24)
- - Li Lin
  - Yanyu Zhang
  - Fazheng Ren
  - Shaoyang Ge
  - Yanling Hao
  - Zhengyuan Zhai
  - Ming Zhang
  - Shusen Li
  - Liang Zhao
  - Erna Sun
- PubMed: 41464950
- DOI: 10.3390/foods14244243
1 Insight on
- Improved Acid Stress Resistance
- Low evidence
Clinical Assessment of the Efficacy of Natural Nutraceuticals in Gingival Massage Therapy: A Randomized Clinical Study.
- 2025-12-10
- RCT
- International journal of dental hygiene 24(2)
- - Fizza Khalid
  - Shahbaz Ahmed
  - Waqas Ahmed Farooqui
  - Haseeb Pervaiz
  - Sania Riaz
  - Sumaiya Shabbir
  - Mehwish Ghazal
  - Ziaur Rahman Khan
- PubMed: 41373073
- DOI: 10.1111/idh.70014
3 Insights on
- High evidence
From Ancient Fermentations to Modern Biotechnology: Historical Evolution, Microbial Mechanisms, and the Role of Natural and Commercial Starter Cultures in Shaping Organic and Sustainable Food Systems.
- 2025-12-10
- Review
- Foods (Basel, Switzerland) 14(24)
- - Yasmin Muhammed Refaie Muhammed
  - Fabio Minervini
  - Ivana Cavoski
- PubMed: 41464947
- DOI: 10.3390/foods14244240
5 Insights on
- Low evidence
In Vitro and In Vivo Safety Evaluation of Streptococcus salivarius eK12, a Genetically Modified Dietary Probiotic Derived from the Oral Probiotic S. salivarius K12.
- 2025-12-09
- Journal of microbiology and biotechnology 35
- - Francesco Di Pierro
  - Gayathri Veeraraghavan
  - Kuppusamy Kalaiselvan
  - Bahrudeen Ashif
  - Logeshwari Jeyakumar
  - Gopikrishnan Gopalakrishnan
  - Massimiliano Cazzaniga
  - Alexander Bertuccioli
  - Maria Laura Tanda
  - Nicola Zerbinati
  - Ikram Ujjan
  - Ali Akbar Bugti
  - Aasiya Bano
  - Yasmeen Gull
  - Nasrin Mumtaz
  - Amjad Khan
- PubMed: 41391486
- DOI: 10.4014/jmb.2509.09016
4 Insights on
- Low evidence
- Animal Study
Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes.
- 2025-12-09
- Systematic Review · n = 590
- Annals of agricultural and environmental medicine : AAEM 33(1)
- - Joanna Łuszczak
  - Janusz Kocki
- PubMed: 41906501
- DOI: 10.26444/aaem/213417
8 Insights on
- High evidence
Clinical Effectiveness of Ocimum basilicum Mouthwash as an Adjunct to Toothbrushing in Managing Patients With Plaque-Induced Gingivitis: A Randomised Controlled Trial.
- 2025-12-09
- RCT · n = 35
- International journal of dental hygiene 24(2)
- - Atrey J Pai Khot
  - Anu Sara Varghese
  - Anil V Ankola
  - Roopali M Sankeshwari
  - Vinuta Hampiholi
  - Kishori P Sutar
  - Prajakta J Chavan
  - Ram Surath Kumar
- PubMed: 41366506
- DOI: 10.1111/idh.70017
2 Insights on
- Reduced Gingival Index
- Reduced Plaque Index
- High evidence
Experimental and Clinical Approaches to Preventing Aminoglycoside-Induced Ototoxicity: A Scoping Review.
- 2025-12-07
- Review
- Antioxidants (Basel, Switzerland) 14(12)
- - Marek Zadrożniak
  - Maciej Biskupski
  - Marcin Szymański
  - Jarogniew J Łuszczki
- PubMed: 41462666
- DOI: 10.3390/antiox14121467
1 Insight on
- Reduced Hearing Loss
- Low evidence
Apple cider vinegar for prevention of urinary lithiasis (APUL): a randomized crossover trial.
- 2025-12-06
- RCT
- International urology and nephrology 58(6)
- - Benjamin Baker
  - Christine Herforth
  - Josiah Low
  - Ryan Craig
  - Matthew Christman
- PubMed: 41351751
- DOI: 10.1007/s11255-025-04944-x
3 Insights on
- High evidence
Compiling an early life human gut microbiome atlas and identification of key microbial drivers.
- 2025-12-05
- Observational
- NPJ biofilms and microbiomes 12(1)
- - Chiara Tarracchini
  - Giulia Longhi
  - Emma Gennaioli
  - Aryanna Muscò
  - Sonia Mirjam Rizzo
  - Alice Viappiani
  - Salvatore Giovanni Vitale
  - Leonardo Mancabelli
  - Gabriele Andrea Lugli
  - Stefano Angioni
  - Francesca Turroni
  - Douwe van Sinderen
  - Christian Milani
  - Marco Ventura
- PubMed: 41350579
- DOI: 10.1038/s41522-025-00868-7
1 Insight on
- Improved Microbial Identification
- Low evidence
Harnessing postbiotics for liver health: Emerging perspectives.
- 2025-12-05
- Review
- World journal of gastrointestinal pharmacology and therapeutics 16(4)
- - Naveen Jeyaraman
  - Madhan Jeyaraman
  - Tejaswin Mariappan
  - Arulkumar Nallakumarasamy
  - Preethi Subramanian
  - Priyadarshini T
  - Vinnisa Nithiakala Vetrivel
- PubMed: 41378079
- DOI: 10.4292/wjgpt.v16.i4.109177
1 Insight on
- Improved Liver Function
- Low evidence
Gut microbiota-driven dysbiosis of the SCFA-immune axis in pediatric allergic rhinitis-constipation comorbidity: mechanisms and synbiotic remodeling.
- 2025-12-03
- Observational
- Frontiers in immunology 16
- - WeiKeng Yang
  - Xiaojiao Zhang
  - Bin Wu
  - Binyu Ni
  - Hongbin Lin
  - Congfu Huang
- PubMed: 41415290
- DOI: 10.3389/fimmu.2025.1639359
2 Insights on
- Improved Constipation
- Increased Abundance of Bifidobacterium
- Low evidence
Bioconversion of Geniposide from Gardenia jasminoides via Levilactobacillus Enhancing Anti-Inflammatory Activity.
- 2025-12-03
- n = 191
- Foods (Basel, Switzerland) 14(23)
- - Chun-Zhi Jin
  - Long Jin
  - Ye Zhuo
  - Ting Li
  - Huimin Liu
  - Kee-Sun Shin
  - Le Kang
- PubMed: 41376093
- DOI: 10.3390/foods14234156
1 Insight on
- Reduced Inflammation
- Moderate evidence
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.
- 2025-12-03
- Meta-Analysis · n = 9,430
- The Cochrane database of systematic reviews 2026(1)
- - Catherine A Cluver
  - Christa Rohwer
  - Anke C Rohwer
- PubMed: 41330480
- DOI: 10.1002/14651858.cd001059.pub6
8 Insights on
- High evidence
An update on probiotics in paediatrics.
- 2025-12-03
- Review
- Current opinion in clinical nutrition and metabolic care 29(3)
- - Maria Zemła
  - Maja Kotowska-Bąbol
  - Hania Szajewska
- PubMed: 41334956
- DOI: 10.1097/mco.0000000000001192
1 Insight on
- Reduced Risk of Necrotizing Enterocolitis
- Low evidence
The effect of probiotic supplementation on sexual function in premenopausal and menopausal women: a randomized controlled clinical trial.
- 2025-12-02
- RCT
- Scientific reports 16(1)
- - Roghayyeh Valizadeh
  - Fatemeh Borhani
  - Fatemeh Shabani
  - Mojgan Mirghafourvand
- PubMed: 41326645
- DOI: 10.1038/s41598-025-30879-5
2 Insights on
- Improved Sexual Function
- Improved Menopause Quality of Life
- High evidence
- Rigorous Journal
The Effect of Fermented Lingonberry Spray on Oral Health-A Pilot Study.
- 2025-12-02
- Clinical Trial
- Dentistry journal 13(12)
- - Hanna Lähteenmäki
  - Leo Pärnänen
  - Ismo T Räisänen
  - Marjut Sakko
  - Pirjo Pärnänen
  - Timo Sorsa
- PubMed: 41440328
- DOI: 10.3390/dj13120568
2 Insights on
- Reduced Bleeding on Probing (BOP)
- Reduced Plaque Index
- Moderate evidence
The role of probiotics in preventing dental caries: a systematic review of clinical evidence.
- 2025-12-02
- Systematic Review
- Frontiers in oral health 6
- - Alessio Danilo Inchingolo
  - Angelo Michele Inchingolo
  - Irene Palumbo
  - Mariafrancesca Guglielmo
  - Lilla Riccaldo
  - Roberta Morolla
  - Francesco Inchingolo
  - Andrea Palermo
  - Gianna Dipalma
- PubMed: 41409473
- DOI: 10.3389/froh.2025.1720036
5 Insights on
- High evidence
From periodontal infection to oral-systemic dysbiosis: re-framing the oral microbiome's role in systemic health and the prophylactic potential of Streptococcus salivarius probiotics.
- 2025-12-02
- Review
- Frontiers in microbiology 16
- - Francesco Di Pierro
  - Carlo Fornaini
  - Chiara Maria Palazzi
  - Alexander Bertuccioli
  - John Tagg
  - Nicola Zerbinati
- PubMed: 41409978
- DOI: 10.3389/fmicb.2025.1685071
3 Insights on
- Low evidence
Biosynthesized TiO₂ Nanoparticles to Enhance the Mechanical and Antibacterial Properties of Type-II Glass Ionomer Cement for Dental Restorative Applications.
- 2025-12-02
- Cureus 17(12)
- - Shubha P
  - Harini Ks
  - Ganesh S
  - Anubhav Jannu
  - Preethi Kusugal
  - Zarir Ruttonji
- PubMed: 41487806
- DOI: 10.7759/cureus.98281
1 Insight on
- Reduced Bacterial Viability in Dental Plaque
- Low evidence
Effects of chamomile and -theanine beverage on menstrual pain, menstrual symptoms, mood, and sleep quality in young women experiencing primary dysmenorrhea: A randomized, double-blind, placebo-controlled study.
- 2025-12-01
- RCT · n = 15
- Journal of food and drug analysis 33(4)
- - Ziqing Soh
  - Soo Cing Tan
  - Tak Hiong Wong
  - Seok Tyug Tan
  - Seok Shin Tan
  - Chin Xuan Tan
- PubMed: 41525193
- DOI: 10.38212/2224-6614.3565
3 Insights on
- High evidence
The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.
- 2025-12-01
- Meta-Analysis · n = 315
- Clinical and experimental dental research 11(6)
- - Sara A Abdulla
  - Bushra A Abdalla
  - Aisha Ali Muhammed
  - Hayam A Elawamy
  - Salima M Hawda
  - Najah Mohamed
  - Enass H Abduallah
  - Mustafa Y G Younis
  - Hajir Omar Alsanfaz
  - Hiba Abdelmunim Suliman
- PubMed: 41158097
- DOI: 10.1002/cre2.70215
4 Insights on
- High evidence