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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Characterization of a Bacteriocin-Like Substance Produced by a Vaginal Lactobacillus salivariusStrain
- 1999-12
- Applied and Environmental Microbiology 65(12)
- - V. Ocaña
  - A. A. Pesce de Ruiz Holgado
  - M. Nader-Macías
- PubMed: 10584033
- DOI: 10.1128/AEM.65.12.5631-5635.1999
1 Insight on
- Reduced Urogenital Infections
- Low evidence
- Highly Cited
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children.
- 1999-11
- RCT · n = 222
- The Journal of Pediatrics 135(5)
- - J. Vanderhoof
  - David B. Whitney
  - D. Antonson
  - T. Hanner
  - J. V. Lupo
  - R. Young
- PubMed: 10547243
- DOI: 10.1016/S0022-3476(99)70053-3
2 Insights on
- Improved Stool Consistency
- Reduced Antibiotic-Associated Diarrhea
- High evidence
- Highly Cited
Increase of intestinal Bifidobacterium and suppression of coliform bacteria with short-term yogurt ingestion.
- 1999-11
- Clinical Trial · n = 34
- Journal of Dairy Science 82(11)
- - R. M. Chen
  - J. Wu
  - S. C. Lee
  - A. Huang
  - H. Wu
- PubMed: 10575598
- DOI: 10.3168/JDS.S0022-0302(99)75479-2
3 Insights on
- High evidence
Lactobacillus salivarius CTC2197 Prevents Salmonella enteritidis Colonization in Chickens
- 1999-11
- Clinical Trial
- Applied and Environmental Microbiology 65(11)
- - Mònica Pascual
  - M. Hugas
  - J. I. Badiola
  - Josep Maria Monfort
  - M. Garriga
- PubMed: 10543812
- DOI: 10.1128/AEM.65.11.4981-4986.1999
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model.
- 1999-09
- Gastroenterology 117(3)
- - M. Caplan
  - R. Miller-Catchpole
  - S. Kaup
  - Tanya Russell
  - Matthew J Lickerman
  - M. Amer
  - Yu Xiao
  - R. Thomson
- PubMed: 10464133
- DOI: 10.1016/S0016-5085(99)70450-6
4 Insights on
- Low evidence
- Highly Cited
Effects of a Saccharomyces cerevisiae culture on in vitro mixed ruminal microorganism fermentation.
- 1999-09
- Journal of Dairy Science 82(9)
- - H. M. Sullivan
  - S. A. Martin
- PubMed: 10509261
- DOI: 10.3168/JDS.S0022-0302(99)75438-X
4 Insights on
- Low evidence
- Highly Cited
Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo.
- 1999-07
- Journal of Investigative Dermatology 113(1)
- - Luisa Di Marzio
  - B. Cinque
  - Claudio De Simone
  - M. Cifone
- PubMed: 10417626
- DOI: 10.1046/J.1523-1747.1999.00633.X
2 Insights on
- Elevated Ceramide Levels in Skin
- Improved Lipid Barrier Function
- Low evidence
- Highly Cited
Modulation of nonspecific mechanisms of defense by lactic acid bacteria: effective dose.
- 1999-05
- RCT · n = 30
- Journal of Dairy Science 82(5)
- - A. Donnet-Hughes
  - F. Rochat
  - P. Serrant
  - J. Aeschlimann
  - E. Schiffrin
- PubMed: 10342225
- DOI: 10.3168/JDS.S0022-0302(99)75304-X
2 Insights on
- Increased Respiratory Burst Activity
- Improved Phagocytic Activity
- High evidence
- Highly Cited
Effect of bacteriocin-producing lactobacilli on the survival of Escherichia coli and Listeria in a dynamic model of the stomach and the small intestine.
- 1999-04
- International Journal of Food Microbiology 48(1)
- - M. Gänzle
  - C. Hertel
  - J. D. Vossen
  - W. Hammes
- PubMed: 10375132
- DOI: 10.1016/S0168-1605(99)00025-2
2 Insights on
- Reduced Survival of Listeria innocua
- Increased Lethality of Escherichia coli in Acidic Conditions
- Low evidence
- Highly Cited
Effect of fermented milk (yogurt) containing Lactobacillus acidophilus L1 on serum cholesterol in hypercholesterolemic humans.
- 1999-02
- RCT
- Journal of the American College of Nutrition 18(1)
- - James W. Anderson
  - Stanley E. Gilliland
- PubMed: 10067658
- DOI: 10.1080/07315724.1999.10718826
2 Insights on
- Reduced Serum Cholesterol Levels
- Reduced Risk of Coronary Heart Disease
- High evidence
- Highly Cited
Saccharomyces boulardii Protease Inhibits the Effects of Clostridium difficile Toxins A and B in Human Colonic Mucosa
- 1999-01
- Infection and Immunity 67(1)
- - I. Castagliuolo
  - Martin F. Riegler
  - L. Valenick
  - J. Lamont
  - C. Pothoulakis
- PubMed: 9864230
- DOI: 10.1128/IAI.67.1.302-307.1999
3 Insights on
- Low evidence
- Highly Cited
A randomized trial of Lactobacillus acidophilus BG2FO4 to treat lactose intolerance.
- 1999-01
- RCT · n = 42
- The American Journal of Clinical Nutrition 69(1)
- - J. Saltzman
  - R. Russell
  - B. Golner
  - S. Barakat
  - G. Dallal
  - B. Goldin
- PubMed: 9925136
- DOI: 10.1093/AJCN/69.1.140
1 Insight on
- No Improvement in Lactose Malabsorption Symptoms
- High evidence
- Highly Cited
Safety and tolerance of Lactobacillus reuteri supplementation to a population infected with the human immunodeficiency virus.
- 1998-12
- RCT · n = 39
- Food and Chemical Toxicology 36(12)
- - B. W. Wolf
  - K. Wheeler
  - D. G. Ataya
  - K. Garleb
- PubMed: 9862651
- DOI: 10.1016/S0278-6915(98)00090-8
8 Insights on
- High evidence
- Highly Cited
Effect of a Saccharomyces cerevisiae culture on nutrient digestion in lactating dairy cows.
- 1998-12
- Journal of Dairy Science 81(12)
- - M. Doreau
  - J. Jouany
- PubMed: 9891266
- DOI: 10.3168/JDS.S0022-0302(98)75885-0
2 Insights on
- Improved Degradability of Acid Detergent Fiber
- Increased Nitrogen Degradation Postprandially
- Low evidence
- Highly Cited
Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model
- 1998-11
- American Journal of Gastroenterology 93(11)
- - Y. Aiba
  - Nobuyuki Suzuki
  - A. M. Kabir
  - A. Takagi
  - Y. Koga
- PubMed: 9820379
- DOI: 10.1111/j.1572-0241.1998.00600.x
2 Insights on
- Reduced Inflammatory Response
- Reduced Helicobacter pylori Colonization
- Low evidence
- Highly Cited
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice.
- 1998-07
- Clinical Trial
- Journal of Allergy and Clinical Immunology 102(1)
- - S. Murosaki
  - Yoshihiro Yamamoto
  - Kazue Ito
  - Takeaki Inokuchi
  - Hiroaki Kusaka
  - Hitoshi Ikeda
  - Y. Yoshikai
- PubMed: 9679848
- DOI: 10.1016/S0091-6749(98)70055-7
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Stimulation of cytokine production in clonal macrophage and T-cell models by Streptococcus thermophilus: comparison with Bifidobacterium sp. and Lactobacillus bulgaricus.
- 1998-07
- Journal of Food Protection 61(7)
- - M. Marín
  - M. Tejada-Simon
  - J. H. Lee
  - J. Murtha
  - Z. Ustunol
  - J. Pestka
- PubMed: 9678170
- DOI: 10.4315/0362-028X-61.7.859
5 Insights on
- Low evidence
- Highly Cited
Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats.
- 1998-06
- RCT
- International Journal of Food Microbiology 42(1-2)
- - M. Johansson
  - S. Nobaek
  - A. Berggren
  - M. Nyman
  - I. Björck
  - S. Ahrné
  - Bengt Jeppsson
  - G. Molin
- PubMed: 9706795
- DOI: 10.1016/S0168-1605(98)00055-5
19 Insights on
- High evidence
- Highly Cited
Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects.
- 1998-05
- Clinical Trial · n = 10
- Journal of Dairy Science 81(5)
- - M. Romond
  - Assia Ais
  - F. Guillemot
  - Rachid Bounouader
  - A. Cortot
  - C. Romond
- PubMed: 9621224
- DOI: 10.3168/JDS.S0022-0302(98)75683-8
13 Insights on
- Moderate evidence
Adherence of Human Vaginal Lactobacilli to Vaginal Epithelial Cells and Interaction with Uropathogens
- 1998-05
- Infection and Immunity 66(5)
- - S. Boris
  - J. Suárez
  - F. Vázquez
  - C. Barbés
- PubMed: 9573080
- DOI: 10.1128/IAI.66.5.1985-1989.1998
2 Insights on
- Reduced Pathogen Growth
- Improved Vaginal Colonization with Probiotics
- Low evidence
- Highly Cited
Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia.
- 1998-03
- RCT · n = 286
- The American journal of clinical nutrition 67(3)
- - M H Davidson
  - K C Maki
  - J C Kong
  - L D Dugan
  - S A Torri
  - H A Hall
  - K B Drennan
  - S M Anderson
  - V L Fulgoni
  - L G Saldanha
  - B H Olson
- PubMed: 9497178
- DOI: 10.1093/ajcn/67.3.367
3 Insights on
- High evidence
- Large Human Trial
Characterisation and selection of probiotic lactobacilli for a preliminary minipig feeding trial and their effect on serum cholesterol levels, faeces pH and faeces moisture content.
- 1998-03
- International Journal of Food Microbiology 40(1-2)
- - M. Toit
  - C. Franz
  - L. Dicks
  - U. Schillinger
  - P. Haberer
  - B. Warlies
  - F. Ahrens
  - W. Holzapfel
- PubMed: 9600615
- DOI: 10.1016/S0168-1605(98)00024-5
3 Insights on
- Low evidence
- Highly Cited
Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis.
- 1997-12
- RCT · n = 66
- The Pediatric Infectious Disease Journal 16(12)
- - Aino-Vieno Shornikova
  - I. Casas
  - H. Mykkänen
  - E. Salo
  - T. Vesikari
- PubMed: 9427453
- DOI: 10.1097/00006454-199712000-00002
4 Insights on
- High evidence
- Highly Cited
Effects of a live yeast culture and enzymes on in vitro ruminal fermentation and milk production of dairy cows.
- 1997-09
- Journal of Dairy Science 80(9)
- - L. Kung
  - E. Kreck
  - R. Tung
  - A. Hession
  - A. Sheperd
  - M. Cohen
  - H. E. Swain
  - J. Leedle
- PubMed: 9313146
- DOI: 10.3168/JDS.S0022-0302(97)76149-6
2 Insights on
- Increased Milk Production
- Unchanged Milk Composition
- Low evidence
- Highly Cited
Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection.
- 1997-08
- RCT
- The American journal of clinical nutrition 66(2)
- - E J Schiffrin
  - D Brassart
  - A L Servin
  - F Rochat
  - A Donnet-Hughes
- PubMed: 9250141
- DOI: 10.1093/ajcn/66.2.515s
2 Insights on
- Increased PMN Cell Phagocytic Capacity
- Altered Lymphocyte Subset
- High evidence
- Highly Cited
In vitro lactose fermentation by human colonic bacteria is modified by Lactobacillus acidophilus supplementation.
- 1997-08
- The Journal of Nutrition 127(8)
- - T. Jiang
  - D. Savaiano
- PubMed: 9237942
- DOI: 10.1093/JN/127.8.1489
2 Insights on
- Improved Lactose Digestion
- Increased Short-Chain Fatty Acid Production
- Low evidence
- Highly Cited
Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk: influence of bile sensitivity, lactose transport, and acid tolerance of Lactobacillus acidophilus.
- 1997-08
- RCT · n = 11
- Journal of Dairy Science 80(8)
- - A. Mustapha
  - T. Jiang
  - D. Savaiano
- PubMed: 9276791
- DOI: 10.3168/JDS.S0022-0302(97)76083-1
2 Insights on
- Improved Lactose Digestion
- Improved Lactose Tolerance
- High evidence
- Highly Cited
Characterization of a neurotoxigenic Clostridium butyricum strain isolated from the food implicated in an outbreak of food-borne type E botulism
- 1997-08
- Journal of Clinical Microbiology 35(8)
- - X. Meng
  - T. Karasawa
  - K. Zou
  - X. Kuang
  - X. Wang
  - C. Lu
  - C. Wang
  - K. Yamakawa
  - S. Nakamura
- PubMed: 9230405
- DOI: 10.1128/jcm.35.8.2160-2162.1997
1 Insight on
- Reduction in Food-borne Botulism
- Low evidence
- Highly Cited
The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo
- 1997-07
- Applied and Environmental Microbiology 63(7)
- - M. Bernet-Camard
  - V. Liévin
  - D. Brassart
  - J. Neeser
  - A. Servin
  - S. Hudault
- PubMed: 9212421
- DOI: 10.1128/aem.63.7.2747-2753.1997
3 Insights on
- Low evidence
- Highly Cited
Prevention of onset in an insulin‐dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus casei
- 1997-07
- APMIS 105(7-12)
- - T. Matsuzaki
  - Y. Nagata
  - S. Kado
  - K. Uchida
  - I. Kato
  - S. Hashimoto
  - T. Yokokura
- PubMed: 9298104
- DOI: 10.1111/j.1699-0463.1997.tb05066.x
5 Insights on
- Low evidence
- Highly Cited