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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Antagonistic activity of Lactobacillus casei strain shirota against gastrointestinal Listeria monocytogenes infection in rats.
- 2002-02
- Clinical Trial
- International Journal of Food Microbiology 73(1)
- - R. D. Waard
  - J. Garssen
  - G. Bokken
  - J. Vos
- PubMed: 11885574
- DOI: 10.1016/S0168-1605(01)00699-7
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
PCR-ELISA II: Analysis of Bifidobacterium populations in human faecal samples from a consumption trial with Bifidobacterium lactis Bb-12 and a galacto-oligosaccharide preparation.
- 2002-01
- Clinical Trial
- Systematic and Applied Microbiology 25(2)
- - Erja Malinen
  - J. Mättö
  - Merja Salmitie
  - M. Ålander
  - M. Saarela
  - A. Palva
- PubMed: 12353880
- DOI: 10.1078/0723-2020-00117
2 Insights on
- Reduced Bifidobacterium longum
- Transient Replacement of Native Bifidobacterium longum
- Moderate evidence
Endocarditis Caused by Lactococcus cremoris
- 2002-01
- Case Report · n = 1
- Scandinavian Journal of Infectious Diseases 34(3)
- - H. Halldorsdottir
  - V. Haraldsdóttir
  - Á. Böđvarsson
  - Gestur Þorgeirsson
  - M. Kristjansson
- PubMed: 12030395
- DOI: 10.1080/00365540110080377
1 Insight on
- Incidence of Endocarditis
- Low evidence
Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but Not L. rhamnosus GG in the Human Vagina as Demonstrated by Randomly Amplified Polymorphic DNA
- 2002-01
- Clinical Trial · n = 10
- Clinical and Vaccine Immunology 9(1)
- - G. Gardiner
  - C. Heinemann
  - A. Bruce
  - D. Beuerman
  - G. Reid
- PubMed: 11777835
- DOI: 10.1128/CDLI.9.1.92-96.2002
2 Insights on
- Increased Persistence of Probiotic Strains in Vaginal Tract
- Increased Vaginal Colonization
- High evidence
- Highly Cited
Protection against translocating Salmonella typhimurium infection in mice by feeding the immuno-enhancing probiotic Lactobacillus rhamnosus strain HN001
- 2001-12
- Medical Microbiology and Immunology 190(3)
- - H. Gill
  - Q. Shu
  - Hai Lin
  - K. Rutherfurd
  - M. L. Cross
- PubMed: 11827205
- DOI: 10.1007/s004300100095
5 Insights on
- Low evidence
- Highly Cited
Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019.
- 2001-12
- The American Journal of Clinical Nutrition 74(6)
- - H. Gill
  - K. Rutherfurd
  - M. L. Cross
  - P. Gopal
- PubMed: 11722966
- DOI: 10.1093/AJCN/74.6.833
9 Insights on
- Low evidence
- Highly Cited
Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora.
- 2001-12
- RCT · n = 42
- FEMS Immunology & Medical Microbiology 32(1)
- - G. Reid
  - G. Reid
  - D. Beuerman
  - C. Heinemann
  - A. Bruce
- PubMed: 11750220
- DOI: 10.1111/J.1574-695X.2001.TB00531.X
2 Insights on
- Restored Vaginal Flora
- Improved Asymptomatic Bacterial Vaginosis
- High evidence
- Highly Cited
Hypocholesterolemic effect of Lactobacillus gasseri SBT0270 in rats fed a cholesterol-enriched diet
- 2001-11
- Clinical Trial
- Journal of Dairy Research 68(4)
- - Usman
  - A. Hosono
- PubMed: 11928958
- DOI: 10.1017/S0022029901005179
2 Insights on
- Increased Fecal Lactobacilli
- Reduced Serum Total Cholesterol Levels
- Low evidence
- Animal Study
A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome.
- 2001-10
- RCT · n = 20
- European journal of gastroenterology & hepatology 13(10)
- - K Niedzielin
  - H Kordecki
  - B Birkenfeld
- PubMed: 11711768
- DOI: 10.1097/00042737-200110000-00004
3 Insights on
- High evidence
- Highly Cited
Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis.
- 2001-09
- RCT
- Inflammation research : official journal of the European Histamine Research Society ... [et al.] 50(9)
- - J Piscoya
  - Z Rodriguez
  - S A Bustamante
  - N N Okuhama
  - M J Miller
  - M Sandoval
- PubMed: 11603848
- DOI: 10.1007/pl00000268
5 Insights on
- High evidence
Probiotic Treatment Using Bifidobacterium lactis HN019 Reduces Weanling Diarrhea Associated With Rotavirus and Escherichia coli Infection in a Piglet Model
- 2001-08
- RCT · n = 17
- Journal of Pediatric Gastroenterology and Nutrition 33(2)
- - Q. Shu
  - Fr Qu
  - H. Gill
- PubMed: 11568519
- DOI: 10.1097/00005176-200108000-00014
2 Insights on
- Improved Immune Response
- Reduced Diarrhea Severity
- Low evidence
- Highly Cited
- Animal Study
Suppressive effects of bifidobacteria on lipid peroxidation in the colonic mucosa of iron-overloaded mice.
- 2001-07
- Clinical Trial
- Journal of Dairy Science 84(7)
- - M. Ito
  - H. Sawada
  - K. Ohishi
  - Y. Yoshida
  - W. Yokoi
  - T. Watanabe
  - T. Yokokura
- PubMed: 11467806
- DOI: 10.3168/JDS.S0022-0302(01)74591-2
1 Insight on
- Reduced Lipid Peroxidation in Colonic Mucosa
- Low evidence
- Animal Study
Systemic Immunity-Enhancing Effects in Healthy Subjects Following Dietary Consumption of the Lactic Acid Bacterium Lactobacillus rhamnosus HN001
- 2001-04
- Clinical Trial · n = 52
- Journal of the American College of Nutrition 20(2)
- - Ying-H. Sheih
  - B. Chiang
  - L. Wang
  - Chuh-K. Liao
  - H. Gill
- PubMed: 11349938
- DOI: 10.1080/07315724.2001.10719027
3 Insights on
- High evidence
- Highly Cited
Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.
- 2001-04
- Observational
- Nutrition 17(4)
- - M. Kaneki
  - S. Hedges
  - T. Hosoi
  - S. Fujiwara
  - A. Lyons
  - S. Crean
  - Nobuhiko Ishida
  - Mamoru Nakagawa
  - Masahiro Takechi
  - Y. Sano
  - Y. Mizuno
  - S. Hoshino
  - M. Miyao
  - S. Inoue
  - Kiyomi Horiki
  - M. Shiraki
  - Yasuyoshi Ouchi
  - H. Orimo
- PubMed: 11369171
- DOI: 10.1016/S0899-9007(00)00554-2
2 Insights on
- Increased Circulating Vitamin K2 Levels
- Reduced Hip Fracture Risk
- Moderate evidence
- Highly Cited
Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficileToxin A in Mice
- 2001-04
- Clinical Trial
- Infection and Immunity 69(4)
- - A. Qamar
  - Samer Aboudola
  - M. Warny
  - P. Michetti
  - C. Pothoulakis
  - J. Lamont
  - C. Kelly
- PubMed: 11254650
- DOI: 10.1128/IAI.69.4.2762-2765.2001
2 Insights on
- Increased Intestinal Immunoglobulin A Levels
- Increased Anti-toxin A Levels
- Low evidence
- Highly Cited
- Animal Study
In vitro selection criteria for probiotic bacteria of human origin: correlation with in vivo findings.
- 2001-02
- The American Journal of Clinical Nutrition 73(2)
- - C. Dunne
  - L. O’Mahony
  - L. Murphy
  - G. Thornton
  - Darrin Morrissey
  - Sile O'Halloran
  - M. Feeney
  - S. Flynn
  - G. Fitzgerald
  - C. Daly
  - B. Kiely
  - G. O'sullivan
  - F. Shanahan
  - J. Collins
- PubMed: 11157346
- DOI: 10.1093/ajcn/73.2.386s
1 Insight on
- Successful Gastrointestinal Tract Colonization
- Low evidence
- Highly Cited
Probiotics in foods not containing milk or milk constituents, with special reference to Lactobacillus plantarum 299v.
- 2001-02
- The American Journal of Clinical Nutrition 73(2)
- - G. Molin
- PubMed: 11157345
- DOI: 10.1093/ajcn/73.2.380s
4 Insights on
- Low evidence
- Highly Cited
Invited review: the scientific basis of Lactobacillus acidophilus NCFM functionality as a probiotic.
- 2001-02
- Review
- Journal of Dairy Science 84(2)
- - M. Sanders
  - T. Klaenhammer
- PubMed: 11233016
- DOI: 10.3168/JDS.S0022-0302(01)74481-5
8 Insights on
- Moderate evidence
- Highly Cited
Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis.
- 2000-12
- Systematic Review · n = 562
- The American journal of medicine 109(8)
- - A Ishani
  - R MacDonald
  - D Nelson
  - I Rutks
  - T J Wilt
- PubMed: 11099686
- DOI: 10.1016/s0002-9343(00)00604-5
5 Insights on
- High evidence
Bifidobacterium adolescentis modulates the specific immune response to another human gut bacterium, Bacteroides thetaiotaomicron, in gnotobiotic rats.
- 2000-11
- Clinical Trial
- Immunobiology 202(5)
- - L. Scharek
  - L. Hartmann
  - L. Heinevetter
  - M. Blaut
- PubMed: 11205373
- DOI: 10.1016/S0171-2985(00)80102-3
1 Insight on
- Reduced Humoral Immunity to Bacteroides thetaiotaomicron
- Low evidence
- Animal Study
Purification and characterization of a surface-binding protein from Lactobacillus fermentum RC-14 that inhibits adhesion of Enterococcus faecalis 1131.
- 2000-09
- FEMS Microbiology Letters 190(1)
- - C. Heinemann
  - J. V. H. Vlieg
  - D. Janssen
  - H. Busscher
  - H. C. Mei
  - G. Reid
  - G. Reid
- PubMed: 10981710
- DOI: 10.1111/J.1574-6968.2000.TB09282.X
1 Insight on
- Reduced Uropathogenic Bacterial Adhesion
- Low evidence
- Highly Cited
Effect of administration of Lactobacillus gasseri on serum lipids and fecal steroids in hypercholesterolemic rats.
- 2000-08
- Journal of Dairy Science 83(8)
- - Usman
  - A. Hosono
- PubMed: 10984145
- DOI: 10.3168/JDS.S0022-0302(00)75039-9
15 Insights on
- Low evidence
- Highly Cited
Saccharomyces boulardii in Maintenance Treatment of Crohn’s Disease
- 2000-07
- RCT · n = 32
- Digestive Diseases and Sciences 45(7)
- - M. Guslandi
  - G. Mezzi
  - M. Sorghi
  - P. Testoni
- PubMed: 10961730
- DOI: 10.1023/A:1005588911207
1 Insight on
- Reduced Clinical Relapse Rates
- High evidence
- Highly Cited
Safety assessment of potential probiotic lactic acid bacterial strains Lactobacillus rhamnosus HN001, Lb. acidophilus HN017, and Bifidobacterium lactis HN019 in BALB/c mice.
- 2000-05
- International Journal of Food Microbiology 56(1)
- - J. Zhou
  - Q. Shu
  - K. Rutherfurd
  - J. Prasad
  - M. Birtles
  - P. Gopal
  - H. Gill
- PubMed: 10857928
- DOI: 10.1016/S0168-1605(00)00219-1
7 Insights on
- Low evidence
- Highly Cited
Dietary Bifidobacterium lactis (HN019) Enhances Resistance to Oral Salmonella typhimurium Infection in Mice
- 2000-04
- Clinical Trial
- Microbiology and Immunology 44(4)
- - Q. Shu
  - Hai-Mei Lin
  - K. Rutherfurd
  - S. Fenwick
  - J. Prasad
  - P. Gopal
  - H. Gill
- PubMed: 10832963
- DOI: 10.1111/j.1348-0421.2000.tb02486.x
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Antagonistic Activity of Lactobacillus acidophilus LB against Intracellular Salmonella enterica Serovar Typhimurium Infecting Human Enterocyte-Like Caco-2/TC-7 Cells
- 2000-03
- Applied and Environmental Microbiology 66(3)
- - M. Coconnier
  - V. Liévin
  - M. Lorrot
  - A. Servin
- PubMed: 10698785
- DOI: 10.1128/AEM.66.3.1152-1157.2000
1 Insight on
- Reduced Salmonella-Induced Interleukin-8 Production
- Low evidence
- Highly Cited
Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019).
- 2000-02
- Clinical Trial
- British Journal of Nutrition 83(2)
- - H. Gill
  - K. Rutherfurd
  - J. Prasad
  - P. Gopal
- PubMed: 10743496
- DOI: 10.1017/S0007114500000210
8 Insights on
- Low evidence
- Highly Cited
- Animal Study
Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria.
- 2000-02
- Clinical Trial
- Food and Chemical Toxicology 38(2-3)
- - J. Zhou
  - Q. Shu
  - K. Rutherfurd
  - J. Prasad
  - P. Gopal
  - H. Gill
- PubMed: 10717355
- DOI: 10.1016/S0278-6915(99)00154-4
2 Insights on
- Reduced Bacterial Translocation
- No Adverse Health Effects
- Low evidence
- Highly Cited
- Animal Study
The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species.
- 1999-12
- Observational · n = 215
- The Journal of Infectious Diseases 180(6)
- - M. Antonio
  - S. Hawes
  - S. Hillier
- PubMed: 10558952
- DOI: 10.1086/315109
2 Insights on
- Reduced Recurrence of Bacterial Vaginosis
- Reduced Incidence of Gonorrhea
- High evidence
- Highly Cited
Bifidobacterium animalis protects intestine from damage induced by zinc deficiency in rats.
- 1999-12
- Clinical Trial
- The Journal of Nutrition 129(12)
- - E. Mengheri
  - F. Nobili
  - F. Vignolini
  - M. Pesenti
  - G. Brandi
  - B. Biavati
- PubMed: 10573559
- DOI: 10.1093/JN/129.12.2251
2 Insights on
- Increased Abundance of Bifidobacterium animalis
- Improved Intestinal Health from Zinc Deficiency Prevention
- Low evidence
- Animal Study