December 2014 Supplement Research Papers

• December 1

  • The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial.

    • 2014-12-01
    • RCT · n = 40
    • Journal of Gastrointestinal and Liver Diseases 23(4)
    • • V. Ojetti
      • G. Ianiro
      • A. Tortora
      • G. D'angelo
      • T. D. Di Rienzo
      • S. Bibbò
      • A. Migneco
      • A. Gasbarrini

    • PubMed: 25531996
    • DOI: 10.15403/jgld.2014.1121.234.elr

    4 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Increased Bowel Movement Frequency
    • Unchanged Stool Consistency

    • High evidence
    • Highly Cited

  • Effects of probiotic Lactobacillus brevis KB290 on incidence of influenza infection among schoolchildren: an open-label pilot study

    • 2014-12-01
    • RCT · n = 1,783
    • Letters in Applied Microbiology 59(6)
    • • Naoko Waki
      • Mai Matsumoto
      • Y. Fukui
      • H. Suganuma

    • PubMed: 25294223
    • DOI: 10.1111/lam.12340

    1 Insight on

    • Reduced Incidence of Influenza

    • High evidence
    • Large Human Trial
    • Highly Cited

  • No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses

    • 2014-12-01
    • Clinical Trial · n = 15
    • PLoS ONE 9(12)
    • • P. Hibberd
      • L. Kleimola
      • Anne‐Maria Fiorino
      • Christine Botelho
      • Miriam Haverkamp
      • Irina Andreyeva
      • D. Poutsiaka
      • C. Fraser
      • G. Solano-Aguilar
      • D. Snydman

    • PubMed: 25438151
    • DOI: 10.1371/journal.pone.0113456

    10 Insights on

    • Reduced Gastrointestinal Symptoms
    • Absence of Adverse Effects
    • Increased Interleukin 8 Levels
    • Elevated Interleukin-8 Levels
    • Reduced Interleukin-8 Levels
    • Reduced Pro-inflammatory Cytokine Interleukin-8 Levels
    • Absence of Serious Adverse Events
    • Regulated Interleukin 8 Levels
    • Mild Gastrointestinal Symptoms
    • Reduced Gastrointestinal Disorders

    • High evidence
    • Rigorous Journal

  • Effect of tablets containing probiotic bacteria (Lactobacillus reuteri) on early caries lesions in adolescents: a pilot study.

    • 2014-12-01
    • RCT · n = 36
    • Beneficial Microbes 5(4)
    • • M. Keller
      • I. N. Larsen
      • I. Karlsson
      • S. Twetman

    • PubMed: 24889893
    • DOI: 10.3920/BM2013.0089

    1 Insight on

    • Reduced Enamel Demineralization

    • High evidence
• December 3

  • Bifidobacterium longum bacteremia in preterm infants receiving probiotics.

    • 2014-12-03
    • Case Report · n = 2
    • Clinical Infectious Diseases 60(6)
    • • C. Bertelli
      • T. Pillonel
      • Anaïs Torregrossa
      • G. Prod'Hom
      • C. Fischer
      • Gilbert GREUB
      • E. Giannoni

    • PubMed: 25472946
    • DOI: 10.1093/cid/ciu946

    6 Insights on

    • Reduced All-Cause Mortality
    • Prevention of Necrotising Enterocolitis
    • Reduced Bacteremia in Preterm Infants
    • Bifidobacterium longum infantis Bacteremia
    • Reduced Bacteremia Incidence
    • Sepsis Management Improvement

    • Low evidence
    • Highly Cited
• December 15

  • Lactobacillus acidophilus ATCC 4356 Prevents Atherosclerosis via Inhibition of Intestinal Cholesterol Absorption in Apolipoprotein E-Knockout Mice

    • 2014-12-15
    • Clinical Trial
    • Applied and Environmental Microbiology 80(24)
    • • Ying Huang
      • Jinfeng Wang
      • Guihua Quan
      • Xiaojun Wang
      • Longfei Yang
      • Lili Zhong

    • PubMed: 25261526
    • DOI: 10.1128/AEM.02926-14

    3 Insights on

    • Reduced Plasma Cholesterol Levels
    • Reduced Intestinal Cholesterol Absorption
    • Enhanced Reverse Cholesterol Transport

    • Low evidence
    • Highly Cited
    • Animal Study
• December 23

  • Effect of Bacillus amyloliquefaciens-based Direct-fed Microbial on Performance, Nutrient Utilization, Intestinal Morphology and Cecal Microflora in Broiler Chickens

    • 2014-12-23
    • RCT
    • Asian-Australasian Journal of Animal Sciences 28(2)
    • • X. Lei
      • X. Piao
      • Y. Ru
      • Hongyu Zhang
      • A. Péron
      • Huifang Zhang

    • PubMed: 25557820
    • DOI: 10.5713/ajas.14.0330

    5 Insights on

    • Increased Body Weight
    • Improved Intestinal Morphology
    • Increased Lactobacillus Population
    • Enhanced Nutrient Utilization
    • Reduced Escherichia coli Population

    • High evidence
    • Highly Cited
    • Rigorous Journal
• Undated – 5 supplement studies

  • Effect of Bacillus subtilis C-3102 spores as a probiotic feed supplement on growth performance, noxious gas emission, and intestinal microflora in broilers.

    • 2014-12
    • RCT · n = 816
    • Poultry Science 93(12)
    • • J. Jeong
      • I. H. Kim

    • PubMed: 25260523
    • DOI: 10.3382/ps.2014-04086

    12 Insights on

    • Reduced Flatulence
    • Reduced Levels of C. perfringens
    • Improved Growth Performance
    • Improved Nutrient Digestibility
    • Reduced Escherichia coli Counts
    • Reduced Salmonella Population
    • Improved Microflora Composition
    • Improved Lactobacillus Counts
    • Enhanced Average Daily Gain
    • Improved Intestinal Microflora
    • Improved Digestive Function
    • Neutral Blood Profile Impact

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Dietary supplementation of probiotics affects growth, immune response and disease resistance of Cyprinus carpio fry.

    • 2014-12
    • Fish & Shellfish Immunology 41(2)
    • • Akhil Gupta
      • Paromita Gupta
      • A. Dhawan

    • PubMed: 25160796
    • DOI: 10.1016/j.fsi.2014.08.023

    3 Insights on

    • Improved Immune Response
    • Improved Growth Performance
    • Enhanced Disease Resistance

    • Low evidence
    • Highly Cited

  • Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086.

    • 2014-12
    • RCT
    • Anaerobe 30
    • • Edna P Nyangale
      • S. Farmer
      • D. Keller
      • D. Chernoff
      • G. Gibson

    • PubMed: 25219857
    • DOI: 10.1016/j.anaerobe.2014.09.002

    4 Insights on

    • Increased Bifidobacterial Population
    • Increased Beneficial Organic Acid Levels
    • Improved Response to Prebiotics
    • Increased Beneficial Bacteria Populations

    • High evidence

  • Influence of l-carnosine on pro-antioxidant status in elite kayakers and canoeists.

    • 2014-12
    • RCT
    • Acta physiologica Hungarica 101(4)
    • • Malgorzata Slowinska-Lisowska
      • A Zembron-Lacny
      • M Rynkiewicz
      • T Rynkiewicz
      • W Kopec

    • PubMed: 25201708
    • DOI: 10.1556/aphysiol.101.2014.008

    8 Insights on

    • Increased Antioxidant Enzyme Levels
    • Reduced Nitric Oxide Level
    • Reduced Oxidized Glutathione Level
    • Reduced 8-Isoprostane Level
    • Reduced 3-Nitrotyrosine Level
    • Elevated Redox Status
    • Reduced Hydrogen Peroxide Concentration
    • Reduced Glutathione Loss

    • High evidence

  • An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects.

    • 2014-12
    • Clinical Trial
    • BMC complementary and alternative medicine 14(1)
    • • Malkanthi Evans
      • Elaine Paterson
      • David M Barnes

    • PubMed: 25490898
    • DOI: 10.1186/1472-6882-14-475

    6 Insights on

    • Reduced Gamma-Glutamyl Transferase Levels
    • Reduced Glucuronide Metabolite Level
    • Reduced Acetaminophen AUC
    • Increased Sulfate Metabolite Level
    • Increased Mercapturate Metabolite Level
    • Reduced Estradiol Level

    • Low evidence