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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis
- 2008-09
- Infection and Immunity 76(9)
- - C. Cosseau
  - D. Devine
  - Edie M. Dullaghan
  - J. Gardy
  - Avinash Chikatamarla
  - S. Gellatly
  - Lorraine L. Yu
  - J. Pistolic
  - R. Falsafi
  - J. Tagg
  - R. Hancock
- PubMed: 18625732
- DOI: 10.1128/IAI.00188-08
9 Insights on
- Low evidence
- Highly Cited
Lactobacillus rhamnosus LC705 Together with Propionibacterium freudenreichii ssp shermanii JS Administered in Capsules Is Ineffective in Lowering Serum Lipids
- 2008-08
- RCT · n = 38
- Journal of the American College of Nutrition 27(4)
- - K. Hatakka
  - M. Mutanen
  - R. Holma
  - M. Saxelin
  - R. Korpela
- PubMed: 18978162
- DOI: 10.1080/07315724.2008.10719723
2 Insights on
- Improved Serum Lipids
- No Change in Serum Lipid Levels
- High evidence
- Highly Cited
Evaluation of Reuterin Production in Urogenital Probiotic Lactobacillus reuteri RC-14
- 2008-08
- Applied and Environmental Microbiology 74(15)
- - P. Cadieux
  - A. Wind
  - P. Sommer
  - Laura Schaefer
  - K. Crowley
  - R. Britton
  - G. Reid
- PubMed: 18539802
- DOI: 10.1128/AEM.00139-08
1 Insight on
- Restored Normal Microbiota
- Low evidence
Effects of short-term oral administration of dietary marine oils in patients with inflammatory bowel disease and joint pain: a pilot study comparing seal oil and cod liver oil.
- 2008-08
- RCT · n = 20
- Clinical nutrition (Edinburgh, Scotland) 27(4)
- - Linn A Brunborg
  - Tor M Madland
  - Ragna A Lind
  - Gülen Arslan
  - Arnold Berstad
  - Livar Frøyland
- PubMed: 18374458
- DOI: 10.1016/j.clnu.2008.01.017
3 Insights on
- High evidence
Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c‐Jun
- 2008-08
- Inflammatory Bowel Diseases 14(8)
- - Yea Ping Lin
  - Carolyn Thibodeaux
  - J. Peña
  - G. Ferry
  - J. Versalovic
- PubMed: 18425802
- DOI: 10.1002/ibd.20448
2 Insights on
- Reduced TNF Production
- Reduced MCP-1/CCL2 Levels
- Low evidence
- Highly Cited
Oral Administration of Lactobacillus Strains Isolated from Breast Milk as an Alternative for the Treatment of Infectious Mastitis during Lactation
- 2008-08
- RCT · n = 20
- Applied and Environmental Microbiology 74(15)
- - E. Jiménez
  - L. Fernández
  - Antonio Maldonado
  - Rosario Martín
  - M. Olivares
  - J. Xaus
  - J. Rodriguez
- PubMed: 18539795
- DOI: 10.1128/AEM.02599-07
4 Insights on
- High evidence
- Highly Cited
Probiotic Lactobacillus reuteri promotes TNF‐induced apoptosis in human myeloid leukemia‐derived cells by modulation of NF‐κB and MAPK signalling
- 2008-07
- Cellular Microbiology 10(7)
- - C. Iyer
  - A. Kosters
  - G. Sethi
  - A. Kunnumakkara
  - B. Aggarwal
  - J. Versalovic
- PubMed: 18331465
- DOI: 10.1111/j.1462-5822.2008.01137.x
1 Insight on
- Enhanced Pro-Apoptotic MAPK Signaling
- Low evidence
- Highly Cited
Effects of probiotic Lactobacillus casei DN-114 001 in prevention of radiation-induced diarrhea: results from multicenter, randomized, placebo-controlled nutritional trial.
- 2008-07
- RCT · n = 85
- International Journal of Radiation Oncology*Biology*Physics 71(4)
- - J. Giralt
  - J. P. Regadera
  - R. Vergés
  - Jesús Romero
  - I. de la Fuente
  - A. Biete
  - J. Villoria
  - J. Cobo
  - F. Guarner
- PubMed: 18243569
- DOI: 10.1016/j.ijrobp.2007.11.009
3 Insights on
- High evidence
- Highly Cited
Studies on Bacillus subtilis and Lactobacillus acidophilus, as potential probiotics, on the immune response and resistance of Tilapia nilotica (Oreochromis niloticus) to challenge infections.
- 2008-07
- Fish & Shellfish Immunology 25(1-2)
- - S. Aly
  - Yousef Abdel-Galil Ahmed
  - Ahlam Abdel-Aziz Ghareeb
  - Moahmed Fathi Mohamed
- PubMed: 18450477
- DOI: 10.1016/j.fsi.2008.03.013
7 Insights on
- Low evidence
- Highly Cited
A detailed safety assessment of a saw palmetto extract.
- 2008-06
- RCT · n = 225
- Complementary therapies in medicine 16(3)
- - Andrew L Avins
  - Stephen Bent
  - Suzanne Staccone
  - Evelyn Badua
  - Amy Padula
  - Harley Goldberg
  - John Neuhaus
  - Esther Hudes
  - Katusto Shinohara
  - Christopher Kane
- PubMed: 18534327
- DOI: 10.1016/j.ctim.2007.10.005
5 Insights on
- High evidence
- Large Human Trial
Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial.
- 2008-06
- RCT
- FEMS immunology and medical microbiology 53(1)
- - Damien Paineau
  - Didier Carcano
  - Greg Leyer
  - Sylviane Darquy
  - Marie-Alexandra Alyanakian
  - Guy Simoneau
  - Jean-François Bergmann
  - Dominique Brassart
  - Francis Bornet
  - Arthur C Ouwehand
- PubMed: 18422632
- DOI: 10.1111/j.1574-695x.2008.00413.x
3 Insights on
- High evidence
- Highly Cited
Lactobacillus acidophilus strain L-92 induces apoptosis of antigen-stimulated T cells by modulating dendritic cell function.
- 2008-06
- Immunobiology 213(5)
- - H. Kanzato
  - S. Fujiwara
  - W. Ise
  - S. Kaminogawa
  - R. Sato
  - S. Hachimura
- PubMed: 18472048
- DOI: 10.1016/j.imbio.2007.10.001
7 Insights on
- Low evidence
Characterization of homofermentative lactobacilli isolated from kefir grains: potential use as probiotic
- 2008-05
- Journal of Dairy Research 75(2)
- - M. Golowczyc
  - M. J. Gugliada
  - A. Hollmann
  - L. Delfederico
  - G. L. Garrote
  - A. Abraham
  - L. Semorile
  - G. D. De Antoni
- PubMed: 18474139
- DOI: 10.1017/S0022029908003117
4 Insights on
- Low evidence
Predominance of a bacteriocin-producing Lactobacillus salivarius component of a five-strain probiotic in the porcine ileum and effects on host immune phenotype.
- 2008-05
- Clinical Trial
- FEMS Microbiology Ecology 64(2)
- - M. Walsh
  - G. Gardiner
  - O. Hart
  - P. Lawlor
  - M. Daly
  - B. Lynch
  - B. Richert
  - S. Radcliffe
  - L. Giblin
  - C. Hill
  - G. Fitzgerald
  - C. Stanton
  - P. Ross
- PubMed: 18373687
- DOI: 10.1111/j.1574-6941.2008.00454.x
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women.
- 2008-05
- RCT · n = 71
- Menopause (New York, N.Y.) 15(3)
- - Jittima Manonai
  - Apichart Chittacharoen
  - Umaporn Udomsubpayakul
  - Hathai Theppisai
  - Urusa Theppisai
- PubMed: 18202589
- DOI: 10.1097/gme.0b013e31815c5fd8
4 Insights on
- High evidence
The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B.
- 2008-04
- Clinical Trial
- Journal of alternative and complementary medicine (New York, N.Y.) 14(3)
- - Chung-Hua Hsu
  - Kung-Chang Hwang
  - Yi-Hsiung Chiang
  - Pesus Chou
- PubMed: 18370584
- DOI: 10.1089/acm.2006.6344
2 Insights on
- Reduced Alanine Aminotransferase Level
- Reduced Aspartate Aminotransferase Level
- Moderate evidence
In vitro studies of Lactobacillus delbrueckii subsp. lactis in Atlantic salmon (Salmo salar L.) foregut: tissue responses and evidence of protection against Aeromonas salmonicida subsp. salmonicida epithelial damage.
- 2008-04
- Veterinary Microbiology 128(1-2)
- - I. Salinas
  - R. Myklebust
  - M. Esteban
  - R. Olsen
  - J. Meseguer
  - E. Ringø
- PubMed: 18054448
- DOI: 10.1016/J.VETMIC.2007.10.011
4 Insights on
- Low evidence
- Highly Cited
Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
- 2008-03
- RCT
- International journal of oral and maxillofacial surgery 37(3)
- - T H Al-Khateeb
  - Y Nusair
- PubMed: 18272344
- DOI: 10.1016/j.ijom.2007.11.011
3 Insights on
- High evidence
Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment.
- 2008-03
- RCT
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(3)
- - Katerina Valentová
  - David Stejskal
  - Josef Bartek
  - Svatava Dvorácková
  - Vladimír Kren
  - Jitka Ulrichová
  - Vilím Simánek
- PubMed: 18054420
- DOI: 10.1016/j.fct.2007.10.031
3 Insights on
- High evidence
Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study.
- 2008-03
- RCT · n = 59
- The American Journal of Clinical Nutrition 87(3)
- - F. Dépeint
  - G. Tzortzis
  - J. Vulevic
  - K. I’Anson
  - G. Gibson
- PubMed: 18326619
- DOI: 10.1093/AJCN/87.3.785
2 Insights on
- Increased Bifidobacterial Population
- Improved Prebiotic Index
- High evidence
- Highly Cited
Yogurt Containing Probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 Helps Resolve Moderate Diarrhea and Increases CD4 Count in HIV/AIDS Patients
- 2008-03
- Clinical Trial · n = 24
- Journal of Clinical Gastroenterology 42(3)
- - K. Anukam
  - Emanual O Osazuwa
  - H. Osadolor
  - A. Bruce
  - G. Reid
- PubMed: 18223503
- DOI: 10.1097/MCG.0b013e31802c7465
2 Insights on
- Increased CD4 Counts
- Resolved Moderate Diarrhea
- High evidence
- Highly Cited
Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events.
- 2008-03
- American Journal of Physiology-Gastrointestinal and Liver Physiology 294(3)
- - K. Mumy
  - Xinhua Chen
  - C. Kelly
  - B. McCormick
- PubMed: 18032477
- DOI: 10.1152/AJPGI.00391.2007
3 Insights on
- Low evidence
- Highly Cited
Enhanced innate immune parameters in Labeo rohita (Ham.) following oral administration of Bacillus subtilis.
- 2008-02
- RCT
- Fish & Shellfish Immunology 24(2)
- - Rajesh Kumar
  - Subhradip Mukherjee
  - R. Ranjan
  - S. Nayak
- PubMed: 18060807
- DOI: 10.1016/J.FSI.2007.10.008
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effect of oral administration of heat-killed Lactobacillus brevis SBC8803 on total and ovalbumin-specific immunoglobulin E production through the improvement of Th1/Th2 balance.
- 2008-01
- Clinical Trial
- International Journal of Food Microbiology 121(1)
- - S. Segawa
  - Y. Nakakita
  - Y. Takata
  - Yoshihisa Wakita
  - T. Kaneko
  - H. Kaneda
  - J. Watari
  - H. Yasui
- PubMed: 18055049
- DOI: 10.1016/J.IJFOODMICRO.2007.10.004
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors.
- 2008-01
- Clinical Trial
- American Journal of Physiology-Gastrointestinal and Liver Physiology 294(1)
- - Xiujuan Wu
  - Bruce A. Vallance
  - L. Boyer
  - K. Bergstrom
  - John Walker
  - Karen Madsen
  - J. O'kusky
  - Alison M. J. Buchan
  - Kevan Jacobson
- PubMed: 18032474
- DOI: 10.1152/AJPGI.00173.2007
7 Insights on
- Low evidence
- Highly Cited
- Animal Study
Short-term effect of ice-cream containing Bifidobacterium lactis Bb-12 on the number of salivary mutans streptococci and lactobacilli
- 2008-01
- RCT · n = 24
- Acta Odontologica Scandinavica 66(3)
- - E. Çaglar
  - Ozgur Onder Kuscu
  - Senem Selvi Kuvvetli
  - Sule Kavaloglu Cildir
  - N. Sandalli
  - S. Twetman
- PubMed: 18568474
- DOI: 10.1080/00016350802089467
1 Insight on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
- Highly Cited
Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine models.
- 2008-01
- International Journal of Food Microbiology 121(1)
- - G. Zoumpopoulou
  - B. Foligné
  - K. Christodoulou
  - C. Grangette
  - B. Pot
  - E. Tsakalidou
- PubMed: 18077037
- DOI: 10.1016/J.IJFOODMICRO.2007.10.013
3 Insights on
- Low evidence
- Highly Cited
Molecular analysis of yogurt containing Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus in human intestinal microbiota.
- 2008-01
- RCT · n = 79
- The American Journal of Clinical Nutrition 87(1)
- - Raimundo García-Albiach
  - María José Pozuelo de Felipe
  - Santiago Angulo
  - M. Morosini
  - D. Bravo
  - F. Baquero
  - R. del Campo
- PubMed: 18175741
- DOI: 10.1093/AJCN/87.1.91
1 Insight on
- Increased Clostridium perfringens Density
- High evidence
- Highly Cited
Herbal medicines for the treatment of allergic rhinitis: a systematic review.
- 2007-12
- Systematic Review
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 99(6)
- - Ruoling Guo
  - Max H Pittler
  - Edzard Ernst
- PubMed: 18219828
- DOI: 10.1016/s1081-1206(10)60375-4
1 Insight on
- Reduced Severity of Allergic Rhinitis Symptoms
- High evidence
Effect of growth conditions of Lactobacillus gasseri OLL2809 on the immunostimulatory activity for production of interleukin-12 (p70) by murine splenocytes.
- 2007-12
- International Journal of Food Microbiology 120(3)
- - T. Sashihara
  - Natsuko Sueki
  - K. Furuichi
  - S. Ikegami
- PubMed: 17936392
- DOI: 10.1016/J.IJFOODMICRO.2007.09.003
2 Insights on
- Increased Interleukin-12 Production
- Improved Immunostimulatory Activity
- Low evidence