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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Synbiotic promotion of epithelial proliferation by orally ingested encapsulated Bifidobacterium breve and raffinose in the small intestine of rats.
- 2009-05
- RCT
- Molecular Nutrition & Food Research 53(S1)
- - S. Ishizuka
  - Ami Iwama
  - A. Dinoto
  - A. Suksomcheep
  - K. Maeta
  - T. Kasai
  - H. Hara
  - A. Yokota
- PubMed: 18837471
- DOI: 10.1002/mnfr.200800041
1 Insight on
- Increased Epithelial Proliferation in the Small Intestine
- High evidence
Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor.
- 2009-05
- American Journal of Obstetrics and Gynecology 200(5)
- - M. Yeganegi
  - C. Watson
  - A. Martins
  - S. O. Kim
  - G. Reid
  - J. Challis
  - A. Bocking
- PubMed: 19285652
- DOI: 10.1016/j.ajog.2008.12.032
4 Insights on
- Low evidence
- Highly Cited
A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.
- 2009-05
- RCT
- Phytomedicine : international journal of phytotherapy and phytopharmacology 16(5)
- - Samer S El-Kamary
  - Michelle D Shardell
  - Mohamed Abdel-Hamid
  - Soheir Ismail
  - Mohamed El-Ateek
  - Mohamed Metwally
  - Nabiel Mikhail
  - Mohamed Hashem
  - Amr Mousa
  - Amr Aboul-Fotouh
  - Mohamed El-Kassas
  - Gamal Esmat
  - G Thomas Strickland
- PubMed: 19303273
- DOI: 10.1016/j.phymed.2009.02.002
7 Insights on
- High evidence
Dietary administration of the probiotic, Lactobacillus plantarum, enhanced the growth, innate immune responses, and disease resistance of the grouper Epinephelus coioides.
- 2009-05
- Fish & Shellfish Immunology 26(5)
- - V. M. Son
  - Chin-Chyuan Chang
  - Mingjuan Wu
  - Y. Guu
  - C. Chiu
  - W. Cheng
- PubMed: 19264134
- DOI: 10.1016/j.fsi.2009.02.018
6 Insights on
- Low evidence
- Highly Cited
Yacon syrup: beneficial effects on obesity and insulin resistance in humans.
- 2009-04
- RCT
- Clinical nutrition (Edinburgh, Scotland) 28(2)
- - Susana Genta
  - Wilfredo Cabrera
  - Natalia Habib
  - Juan Pons
  - Iván Manrique Carillo
  - Alfredo Grau
  - Sara Sánchez
- PubMed: 19254816
- DOI: 10.1016/j.clnu.2009.01.013
10 Insights on
- High evidence
- Highly Cited
Lactococcus lactis as a live vector for mucosal delivery of therapeutic proteins
- 2009-04
- Human Vaccines 5(4)
- - L. Bermúdez-Humarán
- PubMed: 19202351
- DOI: 10.4161/hv.5.4.7553
1 Insight on
- Improved Crohn's Disease Symptoms
- Low evidence
- Highly Cited
Lactobacillus reuteri ingestion prevents hyperexcitability of colonic DRG neurons induced by noxious stimuli.
- 2009-04
- American Journal of Physiology-Gastrointestinal and Liver Physiology 296(4)
- - Xuelian Ma
  - Y. Mao
  - B. Wang
  - J. Huizinga
  - J. Bienenstock
  - W. Kunze
- PubMed: 19179624
- DOI: 10.1152/ajpgi.90511.2008
1 Insight on
- Reduced Hyperexcitability of Colonic DRG Neurons
- Low evidence
- Highly Cited
Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions.
- 2009-04
- FEMS Immunology & Medical Microbiology 55(3)
- - N. Iwabuchi
  - N. Takahashi
  - J. Xiao
  - S. Yonezawa
  - T. Yaeshima
  - K. Iwatsuki
  - S. Hachimura
- PubMed: 19291170
- DOI: 10.1111/j.1574-695X.2008.00510.x
1 Insight on
- Reduced Ocular Symptoms of Japanese Cedar Pollinosis
- Low evidence
Effect of a single oral administration of Lactobacillus plantarum DSMZ 8862/8866 before and at the time point of weaning on intestinal microbial communities in piglets.
- 2009-04
- RCT · n = 176
- International Journal of Food Microbiology 130(3)
- - Robert Pieper
  - P. Janczyk
  - V. Urubschurov
  - U. Korn
  - B. Pieper
  - W. Souffrant
- PubMed: 19237219
- DOI: 10.1016/j.ijfoodmicro.2009.01.026
7 Insights on
- Low evidence
- Animal Study
Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice.
- 2009-04
- Nutrition Research 29(4)
- - Hai-ying Yang
  - Songling Liu
  - S. Ibrahim
  - Liang Zhao
  - Jingjun Jiang
  - Wencheng Sun
  - F. Ren
- PubMed: 19410981
- DOI: 10.1016/j.nutres.2009.03.010
4 Insights on
- Low evidence
Pharmacological effects of saw palmetto extract in the lower urinary tract.
- 2009-03
- Review
- Acta pharmacologica Sinica 30(3)
- - Mayumi Suzuki
  - Yoshihiko Ito
  - Tomomi Fujino
  - Masayuki Abe
  - Keizo Umegaki
  - Satomi Onoue
  - Hiroshi Noguchi
  - Shizuo Yamada
- PubMed: 19262550
- DOI: 10.1038/aps.2009.1
2 Insights on
- Improved Voiding Symptom
- Reduced Urinary Dysfunction
- Low evidence
Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.
- 2009-03
- RCT · n = 44
- Postgraduate Medicine 121(2)
- - Larysa Hun
- PubMed: 19332970
- DOI: 10.3810/pgm.2009.03.1984
4 Insights on
- High evidence
- Highly Cited
A patented strain of Bacillus coagulans increased immune response to viral challenge.
- 2009-03
- Clinical Trial · n = 10
- Postgraduate Medicine 121(2)
- - Mira Baron
- PubMed: 19332969
- DOI: 10.3810/pgm.2009.03.1971
2 Insights on
- Improved Immune Response to Adenovirus
- Improved Immune Response to Influenza A
- Moderate evidence
Influence of vitamins and osmolites on growth and bacteriocin production by Lactobacillus salivarius CRL 1328 in a chemically defined medium.
- 2009-03
- Canadian Journal of Microbiology 55(3)
- - E. Vera Pingitore
  - E. Hebert
  - F. Sesma
  - M. Nader-Macías
- PubMed: 19370073
- DOI: 10.1139/w08-092
1 Insight on
- Improved Growth
- Low evidence
Early treatment with Lactobacillus delbrueckii strain induces an increase in intestinal T-cells and granulocytes and modulates immune-related genes of larval Dicentrarchus labrax (L.).
- 2009-03
- Clinical Trial
- Fish & Shellfish Immunology 26(3)
- - S. Picchietti
  - A. Fausto
  - E. Randelli
  - O. Carnevali
  - A. Taddei
  - F. Buonocore
  - G. Scapigliati
  - L. Abelli
- PubMed: 18996487
- DOI: 10.1016/j.fsi.2008.10.008
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Fermented milk containing Bifidobacterium lactis DN‐173 010 improved self‐reported digestive comfort amongst a general population of adults. A randomized, open‐label, controlled, pilot study
- 2009-02
- RCT
- Journal of Digestive Diseases 10(1)
- - D. Guyonnet
  - A. Woodcock
  - Blandine Stefani
  - C. Trevisan
  - C. Hall
- PubMed: 19236549
- DOI: 10.1111/j.1751-2980.2008.00366.x
3 Insights on
- High evidence
Enhancement of immunity and disease resistance in the white shrimp, Litopenaeus vannamei, by the probiotic, Bacillus subtilis E20.
- 2009-02
- Clinical Trial
- Fish & Shellfish Immunology 26(2)
- - D. Tseng
  - P. Ho
  - Sung-Yan Huang
  - Sheng-Chi Cheng
  - Ya‐Li Shiu
  - Chiu-Shia Chiu
  - Chun‐Hung Liu
- PubMed: 19111620
- DOI: 10.1016/j.fsi.2008.12.003
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Beneficial effects of oolong tea consumption on diet-induced overweight and obese subjects.
- 2009-02
- Clinical Trial · n = 70
- Chinese journal of integrative medicine 15(1)
- - Rong-Rong He
  - Ling Chen
  - Bing-Hui Lin
  - Yokichi Matsui
  - Xin-Sheng Yao
  - Hiroshi Kurihara
- PubMed: 19271168
- DOI: 10.1007/s11655-009-0034-8
5 Insights on
- High evidence
Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial.
- 2009-02
- RCT · n = 77
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 140(2)
- - Shraddha S Mukerji
  - Melissa A Pynnonen
  - Hyungjin Myra Kim
  - Andrew Singer
  - Mark Tabor
  - Jeffrey E Terrell
- PubMed: 19201289
- DOI: 10.1016/j.otohns.2008.11.020
3 Insights on
- High evidence
Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial.
- 2009-02
- RCT · n = 64
- Canadian Journal of Microbiology 55(2)
- - R. C. Martinez
  - S. Franceschini
  - M. C. Patta
  - S. Quintana
  - B. C. Gomes
  - E. D. De Martinis
  - G. Reid
- PubMed: 19295645
- DOI: 10.1139/w08-102
2 Insights on
- Increased Cure Rate of Bacterial Vaginosis
- Normalized Vaginal Microbiota
- High evidence
- Highly Cited
Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study.
- 2009-02
- RCT · n = 1,062
- Vaccine 27(7)
- - Jun-Song Lin
  - Y. Chiu
  - Nien-Tsung Lin
  - Chia-Hsiang Chu
  - Kuo-Chin Huang
  - K. Liao
  - K. Peng
- PubMed: 19114073
- DOI: 10.1016/j.vaccine.2008.11.114
1 Insight on
- Reduced Incidence of Bacterial Infections
- High evidence
- Large Human Trial
- Highly Cited
Lactobacillus fermentum ME-3 – an antimicrobial and antioxidative probiotic
- 2009-01
- Microbial Ecology in Health and Disease 21(1)
- - M. Mikelsaar
  - M. Zilmer
- PubMed: 19381356
- DOI: 10.1080/08910600902815561
7 Insights on
- Low evidence
- Highly Cited
In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.
- 2009-01
- Antimicrobial agents and chemotherapy 53(1)
- - Kaori Tanaka
  - Hiroshige Mikamo
  - Kenichi Nakao
  - Taku Ichiishi
  - Takatsugu Goto
  - Yuka Yamagishi
  - Kunitomo Watanabe
- PubMed: 18955522
- DOI: 10.1128/aac.00595-08
1 Insight on
- Reduced Pathogenic Bacterial Activity
- Low evidence
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
- 2008-12
- Clinical Trial
- Journal of Psychiatric Research 43(2)
- - L. Desbonnet
  - L. Garrett
  - G. Clarke
  - J. Bienenstock
  - T. Dinan
- PubMed: 18456279
- DOI: 10.1016/j.jpsychires.2008.03.009
8 Insights on
- Low evidence
- Highly Cited
- Animal Study
Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice.
- 2008-12
- Clinical Trial
- International Journal of Food Microbiology 128(2)
- - S. Segawa
  - Yoshihisa Wakita
  - H. Hirata
  - J. Watari
- PubMed: 18976829
- DOI: 10.1016/j.ijfoodmicro.2008.09.023
22 Insights on
- Low evidence
- Highly Cited
- Animal Study
Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101.
- 2008-12
- Clinical Trial
- International Journal of Food Microbiology 128(2)
- - Yueh-Ting Tsai
  - Po-Ching Cheng
  - C. Fan
  - T. Pan
- PubMed: 18809220
- DOI: 10.1016/j.ijfoodmicro.2008.08.009
9 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effects of Bifidobacterium lactis Bb12 Supplementation on Body Weight, Fecal pH, Acetate, Lactate, Calprotectin, and IgA in Preterm Infants
- 2008-10
- RCT · n = 69
- Pediatric Research 64(4)
- - R. Mohan
  - C. Koebnick
  - J. Schildt
  - M. Mueller
  - M. Radke
  - M. Blaut
- PubMed: 18552710
- DOI: 10.1203/PDR.0b013e318181b7fa
13 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Effect of fructo-oligosaccharides and different doses of Bifidobacterium animalis in a weaning diet on bacterial translocation and Toll-like receptor gene expression in pigs.
- 2008-10
- RCT
- Nutrition 24(10)
- - P. Trevisi
  - S. De Filippi
  - L. Minieri
  - M. Mazzoni
  - M. Modesto
  - B. Biavati
  - P. Bosi
- PubMed: 18562167
- DOI: 10.1016/j.nut.2008.04.008
1 Insight on
- Increased Bifidobacterium spp. DNA in Lymph Nodes
- High evidence
Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8+ T cells against Listeria monocytogenes in the murine infection model
- 2008-09
- Clinical Trial
- Vaccine 26(41)
- - M. Bahey-El-Din
  - P. G. Casey
  - B. Griffin
  - C. Gahan
- PubMed: 18691625
- DOI: 10.1016/j.vaccine.2008.07.047
2 Insights on
- Improved Immune Response Against Listeria monocytogenes
- Induction of Specific CD8+ T Cells
- Low evidence
- Animal Study
New functional probiotic Lactobacillus sakei probio 65 alleviates atopic symptoms in the mouse.
- 2008-09
- Clinical Trial
- Journal of Medicinal Food 11(3)
- - C. Park
  - M. Youn
  - Young-mi Jung
  - Hong-Joong Kim
  - Y. Jeong
  - Han-Ki Lee
  - H. Kim
  - I. Lee
  - Soo Won Lee
  - K. Kang
  - Yong-Ha Park
- PubMed: 18800885
- DOI: 10.1089/jmf.2007.0144
2 Insights on
- Reduced Symptoms of Allergic Dermatitis
- Reduced Allergen-Induced Skin Inflammation
- Low evidence
- Animal Study