Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Complete Genome Sequence of Bifidobacterium animalis subsp. lactis BB-12, a Widely Consumed Probiotic Strain
- 2010-05
- Journal of Bacteriology 192(9)
- - C. Garrigues
  - E. Johansen
  - M. Pedersen
- PubMed: 20190051
- DOI: 10.1128/JB.00109-10
2 Insights on
- Improved Gut Microbiota
- Improved General Health
- Low evidence
- Highly Cited
Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species.
- 2010-05
- Review
- Future Microbiology 5(5)
- - B. Neville
  - P. O’Toole
- PubMed: 20441548
- DOI: 10.2217/fmb.10.35
2 Insights on
- Alleviated Intestinal Disease
- Enhanced Host Well-being
- Moderate evidence
- Highly Cited
Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome.
- 2010-04
- RCT · n = 88
- Annals of Allergy, Asthma & Immunology 104(4)
- - S. Woo
  - Ji-Yon Kim
  - Yong-Ju Lee
  - Nam-Shik Kim
  - Y. Hahn
- PubMed: 20408346
- DOI: 10.1016/j.anai.2010.01.020
2 Insights on
- Improved Atopic Dermatitis Symptoms
- Reduced Serum Chemokine Levels
- High evidence
- Highly Cited
Safety evaluation of probiotic bifidobacteria by analysis of mucin degradation activity and translocation ability.
- 2010-04
- Anaerobe 16(2)
- - F. Abe
  - Masamichi Muto
  - T. Yaeshima
  - K. Iwatsuki
  - Hiroaki Aihara
  - Y. Ohashi
  - T. Fujisawa
- PubMed: 19638311
- DOI: 10.1016/j.anaerobe.2009.07.006
1 Insight on
- No Adverse Translocation
- Low evidence
- Highly Cited
Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial.
- 2010-04
- RCT · n = 68
- Nutrition 26(4)
- - Fumiko Higashikawa
  - M. Noda
  - Tomokazu Awaya
  - K. Nomura
  - H. Oku
  - M. Sugiyama
- PubMed: 19628371
- DOI: 10.1016/j.nut.2009.05.008
2 Insights on
- Improved Bowel Movement Frequency
- Improved Liver Function
- High evidence
- Highly Cited
Dietary supplementation with lactobacilli and bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy.
- 2010-03
- RCT · n = 462
- The Journal of Nutrition 140(3)
- - Stephen J Allen
  - S. Jordan
  - M. Storey
  - C. Thornton
  - M. Gravenor
  - I. Garaiová
  - S. Plummer
  - Duolao Wang
  - G. Morgan
- PubMed: 20089774
- DOI: 10.3945/jn.109.117093
3 Insights on
- High evidence
- Large Human Trial
- Highly Cited
Distinct Bifidobacterium strains drive different immune responses in vitro.
- 2010-03
- International Journal of Food Microbiology 138(1-2)
- - P. López
  - M. Gueimonde
  - A. Margolles
  - A. Suárez
- PubMed: 20071048
- DOI: 10.1016/j.ijfoodmicro.2009.12.023
1 Insight on
- Increased Th17 Polarization
- Low evidence
- Highly Cited
Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice.
- 2010-03
- RCT · n = 3
- Nutrition 26(3)
- - J. Jeun
  - Suk-Whan Kim
  - Sung‐yun Cho
  - H. Jun
  - Hyun-Jin Park
  - Jae-gu Seo
  - M. Chung
  - Sung-Joon Lee
- PubMed: 19695834
- DOI: 10.1016/j.nut.2009.04.011
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effect of dietary probiotic, Bacillus coagulans, on growth performance, chemical composition, and meat quality of Guangxi Yellow chicken.
- 2010-03
- RCT
- Poultry Science 89(3)
- - Xuxia Zhou
  - Yan-bo Wang
  - Q. Gu
  - Weifen Li
- PubMed: 20181878
- DOI: 10.3382/ps.2009-00319
12 Insights on
- High evidence
- Highly Cited
- Rigorous Journal
Intake of Lactobacillus plantarum Reduces Certain Gastrointestinal Symptoms During Treatment With Antibiotics
- 2010-02
- RCT
- Journal of Clinical Gastroenterology 44(2)
- - Elisabet Lönnermark
  - V. Friman
  - G. Lappas
  - T. Sandberg
  - A. Berggren
  - I. Adlerberth
- PubMed: 19727002
- DOI: 10.1097/MCG.0b013e3181b2683f
16 Insights on
- High evidence
- Highly Cited
Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals.
- 2010-02
- RCT · n = 116
- Journal of alternative and complementary medicine (New York, N.Y.) 16(2)
- - Mark A Moyad
  - Larry E Robinson
  - Edward T Zawada
  - Julie Kittelsrud
  - Ding-Geng Chen
  - Stuart G Reeves
  - Susan Weaver
- PubMed: 20180695
- DOI: 10.1089/acm.2009.0310
2 Insights on
- Improved Safety Profile
- Unchanged Symptom Severity
- High evidence
- Large Human Trial
Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomised double-blind placebo controlled trial.
- 2010-02
- RCT
- Journal of ethnopharmacology 127(2)
- - Konstantinos J Dabos
  - Ekaterini Sfika
  - Lisa J Vlatta
  - Despoina Frantzi
  - Georgios I Amygdalos
  - Georgios Giannikopoulos
- PubMed: 19961914
- DOI: 10.1016/j.jep.2009.11.021
6 Insights on
- High evidence
Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial.
- 2010-01
- RCT · n = 16
- Atherosclerosis 208(1)
- - Caroline L J Karlsson
  - S. Ahrné
  - G. Molin
  - A. Berggren
  - I. Palmquist
  - G. N. Fredrikson
  - B. Jeppsson
- PubMed: 19608185
- DOI: 10.1016/j.atherosclerosis.2009.06.019
3 Insights on
- High evidence
- Highly Cited
Effect of Lactobacillus gasseri BNR17 on blood glucose levels and body weight in a mouse model of type 2 diabetes.
- 2009-11
- Journal of applied microbiology 107(5)
- - S I Yun
  - H O Park
  - J H Kang
- PubMed: 19457033
- DOI: 10.1111/j.1365-2672.2009.04350.x
3 Insights on
- Low evidence
- Highly Cited
Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice.
- 2009-11
- Clinical Trial
- International Immunopharmacology 9(12)
- - Y. Nishitani
  - T. Tanoue
  - Katsushige Yamada
  - T. Ishida
  - Masaru Yoshida
  - T. Azuma
  - M. Mizuno
- PubMed: 19733697
- DOI: 10.1016/j.intimp.2009.08.018
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis.
- 2009-11
- American Journal of Physiology-Gastrointestinal and Liver Physiology 297(5)
- - L. Khailová
  - K. Dvorak
  - Kelly M. Arganbright
  - M. Halpern
  - T. Kinouchi
  - M. Yajima
  - B. Dvořák
- PubMed: 20501441
- DOI: 10.1152/AJPGI.00141.2009
3 Insights on
- Low evidence
- Highly Cited
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial.
- 2009-11
- RCT · n = 89
- Menopause (New York, N.Y.) 16(6)
- - Stacie E Geller
  - Lee P Shulman
  - Richard B van Breemen
  - Suzanne Banuvar
  - Ying Zhou
  - Geena Epstein
  - Samad Hedayat
  - Dejan Nikolic
  - Elizabeth C Krause
  - Colleen E Piersen
  - Judy L Bolton
  - Guido F Pauli
  - Norman R Farnsworth
- PubMed: 19609225
- DOI: 10.1097/gme.0b013e3181ace49b
4 Insights on
- High evidence
- Highly Cited
Safety assessment of Lactobacillus brevis KB290 as a probiotic strain.
- 2009-10
- Clinical Trial
- Food and Chemical Toxicology 47(10)
- - T. Yakabe
  - E. Moore
  - S. Yokota
  - H. Sui
  - Y. Nobuta
  - M. Fukao
  - H. Palmer
  - N. Yajima
- PubMed: 19583990
- DOI: 10.1016/j.fct.2009.07.001
7 Insights on
- Low evidence
- Animal Study
Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice.
- 2009-09
- Clinical Trial
- Gastroenterology 137(3)
- - Xinhua Chen
  - J. Fruehauf
  - J. Goldsmith
  - Hua Xu
  - K. Katchar
  - H. Koon
  - Dezheng Zhao
  - E. Kokkotou
  - C. Pothoulakis
  - C. Kelly
- PubMed: 19482027
- DOI: 10.1053/j.gastro.2009.05.050
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Should Lactobacillus sporogenes and Bacillus coagulans Have a future?
- 2009-08
- Review
- Journal of Chemotherapy 21(4)
- - L. Drago
  - E. De Vecchi
- PubMed: 19622453
- DOI: 10.1179/joc.2009.21.4.371
1 Insight on
- Improved Gut Health
- Low evidence
Safety studies of LP20 powder produced from heat-killed Lactobacillus plantarum L-137.
- 2009-08
- Clinical Trial
- Regulatory Toxicology and Pharmacology 54(3)
- - Y. Hirose
  - S. Murosaki
  - Y. Yamamoto
  - K. Muroyama
  - Y. Miwa
  - A. Fujishima
  - B. Lynch
- PubMed: 19328216
- DOI: 10.1016/j.yrtph.2009.03.007
2 Insights on
- Absence of Acute Toxicity
- Absence of Genotoxicity
- Low evidence
- Animal Study
Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice.
- 2009-08
- Clinical Trial
- International Immunopharmacology 9(9)
- - N. Maeda
  - R. Nakamura
  - Y. Hirose
  - S. Murosaki
  - Yoshihiro Yamamoto
  - T. Kase
  - Y. Yoshikai
- PubMed: 19410659
- DOI: 10.1016/j.intimp.2009.04.015
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
In vivo study on the effectiveness of pediocin PA-1 and Pediococcus acidilactici UL5 at inhibiting Listeria monocytogenes.
- 2009-08
- Clinical Trial
- International Journal of Food Microbiology 133(3)
- - N. Dabour
  - Annina Zihler
  - E. Kheadr
  - C. Lacroix
  - I. Fliss
- PubMed: 19541383
- DOI: 10.1016/j.ijfoodmicro.2009.05.005
2 Insights on
- Reduced Risk of Listeria Monocytogenes Infection
- No Change in Mouse Intestinal Flora Composition
- Low evidence
- Highly Cited
- Animal Study
Characterization of salivaricin CRL 1328, a two-peptide bacteriocin produced by Lactobacillus salivarius CRL 1328 isolated from the human vagina.
- 2009-07
- Research in Microbiology 160(6)
- - E. Vera Pingitore
  - E. Hebert
  - M. Nader-Macías
  - F. Sesma
- PubMed: 19591924
- DOI: 10.1016/j.resmic.2009.06.009
2 Insights on
- Reduced Urogenital Pathogen Growth
- Membrane Disruption
- Low evidence
Bifidobacterium animalis causes extensive duodenitis and mild colonic inflammation in monoassociated interleukin‐10‐deficient mice
- 2009-07
- Clinical Trial
- Inflammatory Bowel Diseases 15(7)
- - J. P. Moran
  - J. Walter
  - G. Tannock
  - S. Tonkonogy
  - B. Sartor
- PubMed: 19235917
- DOI: 10.1002/ibd.20900
1 Insight on
- Increased Duodenal Inflammation
- Low evidence
- Animal Study
Cancer and yerba mate consumption: a review of possible associations.
- 2009-06
- Review
- Revista panamericana de salud publica = Pan American journal of public health 25(6)
- - Dora Loria
  - Enrique Barrios
  - Roberto Zanetti
- PubMed: 19695149
- DOI: 10.1590/s1020-49892009000600010
3 Insights on
- Low evidence
Dietary supplement with fermented soybeans, natto, improved the neurobehavioral deficits after sciatic nerve injury in rats
- 2009-06
- Clinical Trial
- Neurological Research 31(5)
- - Hung-Chuan Pan
  - F. Cheng
  - Chun-Jung Chen
  - Shu-zhen Lai
  - Mu-Jung Liu
  - Ming-Hong Chang
  - Yeou-Chih Wang
  - Dar‐Yu Yang
  - S. Ho
- PubMed: 19309538
- DOI: 10.1179/174313209X403878
2 Insights on
- Improved Neurobehavioral Function
- Reduced Injury-Induced Fibrin Deposition
- Low evidence
- Animal Study
Safety assessment of a proprietary preparation of a novel Probiotic, Bacillus coagulans, as a food ingredient
- 2009-06
- Clinical Trial
- Food and Chemical Toxicology 47(6)
- - J. Endres
  - A. Clewell
  - K. A. Jade
  - T. Farber
  - J. Hauswirth
  - A. Schauss
- PubMed: 19248815
- DOI: 10.1016/j.fct.2009.02.018
9 Insights on
- Low evidence
- Highly Cited
- Animal Study
Fermentation characteristics and transit tolerance of probiotic Lactobacillus casei Zhang in soymilk and bovine milk during storage.
- 2009-06
- Journal of Dairy Science 92(6)
- - Jicheng Wang
  - Zhuang Guo
  - Qing Zhang
  - Liya Yan
  - Wei Chen
  - Xinjin Liu
  - H. P. Zhang
- PubMed: 19447978
- DOI: 10.3168/jds.2008-1849
4 Insights on
- Low evidence
- Highly Cited
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo.
- 2009-06
- Clinical Trial
- Journal of Dairy Science 92(6)
- - E. Miyauchi
  - H. Morita
  - S. Tanabe
- PubMed: 19447972
- DOI: 10.3168/jds.2008-1698
8 Insights on
- Low evidence
- Highly Cited
- Animal Study