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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults.
- 2026-04
- RCT · n = 11
- The American journal of clinical nutrition 123(4)
- - Freyja Ad Haigh
  - Alistair J Monteyne
  - Doaa R Abdelrahman
  - Andrew J Murton
  - Tim Ja Finnigan
  - Hannah E Theobald
  - Francis B Stephens
  - Benjamin T Wall
- PubMed: 41643855
- DOI: 10.1016/j.ajcnut.2026.101231
2 Insights on
- Improved Whole Body Net Protein Balance
- Increased Myofibrillar Protein Synthesis
- High evidence
Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions.
- 2026-04
- Review
- Journal of advanced research 82
- - Qiong Wu
  - Guangqi Gao
  - Lai-Yu Kwok
  - Huimin Lv
  - Zhihong Sun
- PubMed: 40651630
- DOI: 10.1016/j.jare.2025.07.005
2 Insights on
- Improved Sleep Quality
- Improved Insomnia
- Low evidence
Multi-Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.
- 2026-04
- RCT · n = 80
- Food science & nutrition 14(4)
- - Sijia Zhu
  - Yan Qiao
  - Wenjing He
  - Yaojie Xiao
  - Guiqin Song
  - Kang Liu
  - Shuguang Fang
- PubMed: 41971606
- DOI: 10.1002/fsn3.71735
11 Insights on
- High evidence
Prebiotics of Lactobacillus plantarum mitigate inflammation but compromise immunity.
- 2026-04
- Microbial pathogenesis 213
- - Shanshan Yang
  - Qiuxia Cao
  - Kexin Yan
  - Zhenkong Cheng
  - Jianhao Zheng
  - Baochao Fan
  - Xu Song
  - Xianyu Bian
  - Gege Zhang
  - Xuesong Yuan
  - Rongli Guo
  - Yuanyuan Wang
  - Hailin Huan
  - Chuping Luo
  - Junshu Yan
  - Bin Li
- PubMed: 41651082
- DOI: 10.1016/j.micpath.2026.108363
2 Insights on
- Reduced Inflammation
- Reduced Immune Cell Activity
- Low evidence
- Animal Study
Exploring the Hypoglycemic Activity and Mechanism of Polyphenols From Highland Barley Through Lactobacillus acidophilus Fermentation.
- 2026-04
- Journal of food science 91(4)
- - Mengyao Zhu
  - Xu Guo
  - Yingying Chen
  - Shutao Sun
  - Qidong Ren
  - Muxuan Wang
  - Mengqi Zhang
  - Chao Liu
  - Ningyang Li
- PubMed: 41972482
- DOI: 10.1111/1750-3841.71061
4 Insights on
- Low evidence
- Rigorous Journal
The role of Lactobacillus in dibutyl phthalate-induced gut and liver injury: Probiotic intervention and multi-omics evidence.
- 2026-04
- Ecotoxicology and environmental safety 314
- - Siming Huo
  - Bo Li
  - Jiayu Du
  - Zheng Cao
- PubMed: 41895142
- DOI: 10.1016/j.ecoenv.2026.120051
2 Insights on
- Improved Intestinal Barrier Function
- Reduced Liver Injury
- Low evidence
- Animal Study
Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple-Masked, Randomized, Placebo-Controlled Phase 2 Trial.
- 2026-03
- RCT · n = 20
- Molecular nutrition & food research 70(6)
- - Ryan Bradley
  - Carina A Staab
  - Paige E Jamieson
  - Blake O Langley
  - Thomas O Metz
  - Jan F Stevens
- PubMed: 41834265
- DOI: 10.1002/mnfr.70438
2 Insights on
- Reduced Body Mass Index
- Reduced Gamma-Glutamyl Transferase Levels
- High evidence
- Rigorous Journal
Decreased risk of cardiovascular disease in dermatology patients taking niacinamide: A TriNetX cohort study.
- 2026-03
- Observational · n = 3,231
- Journal of the American Academy of Dermatology 94(3)
- - Yousef Salem
  - Mahnoor Liaqat
  - Nadeen Gonna
  - Dina Zamil
  - Ferris Abu-Ghosh
  - Anwar Merie
  - Dimitri Cassimatis
  - Ida Orengo
- PubMed: 41177359
- DOI: 10.1016/j.jaad.2025.10.115
3 Insights on
- High evidence
Effect of Flaxseed Supplementation on Headache Characteristics and Quality of Life in Patients with Migraine: A Randomized Controlled Trial.
- 2026-03
- RCT · n = 68
- The Journal of nutrition 156(3)
- - Amirhosein Jafarpour
  - Vahid Reza Ostovan
  - Masoumeh Akhlaghi
- PubMed: 41478596
- DOI: 10.1016/j.tjnut.2025.101312
10 Insights on
- High evidence
The unsaturated fatty acid of the cell membrane and the accumulation of intracellular glutamic acid as key determinants of freeze-drying tolerance in Bifidobacterium bifidum.
- 2026-03
- Food research international (Ottawa, Ont.) 228
- - Shuyu Guo
  - Wenrui Zhou
  - Bingyong Mao
  - Xin Tang
  - Qiuxiang Zhang
  - Jianxin Zhao
  - Wei Chen
  - Shumao Cui
- PubMed: 41703885
- DOI: 10.1016/j.foodres.2026.118444
1 Insight on
- Improved Survival
- Low evidence
Effect of Perioperative Glutamine-Enhanced Parenteral Nutrition on Short-Term Outcomes in Colorectal Cancer Patients Undergoing Radical Resection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-03
- Meta-Analysis · n = 950
- Technology in cancer research & treatment 25
- - Yong Huang
  - Xiuzhi Yang
  - Songhan Qin
  - Tao Zhang
  - Ming Xie
  - Jiwei Wang
- PubMed: 41891764
- DOI: 10.1177/15330338261438204
3 Insights on
- High evidence
Serum magnesium is linked with sperm concentration, motile sperm count and serum anti-Müllerian hormone in infertile men.
- 2026-03
- RCT · n = 299
- Reproductive biomedicine online 52(3)
- - Sam Kafai Yahyavi
  - Benedicte Probst-Drejer
  - Nadia Nicholine Poulsen
  - Mads Joon Jorsal
  - Anders Juul
  - Niels Jørgensen
  - Martin Blomberg Jensen
- PubMed: 41653852
- DOI: 10.1016/j.rbmo.2025.105232
1 Insight on
- Increased Sperm Concentration
- High evidence
- Large Human Trial
N-Acetylcysteine is associated with changes in functional connectivity in patients with Parkinson's disease.
- 2026-03
- RCT
- Parkinsonism & related disorders 144
- - Daniel A Monti
  - George Zabrecky
  - Daniel Kremens
  - Tsao-Wei Liang
  - Nancy A Wintering
  - Faezeh Vedaei
  - Emily Navarreto
  - Monisha Gupta
  - Alicia Steinmetz
  - Anthony J Bazzan
  - Feroze Mohammed
  - Andrew B Newberg
- PubMed: 41619526
- DOI: 10.1016/j.parkreldis.2026.108216
2 Insights on
- Improved Parkinson's Disease Motor Symptoms
- Changed Functional Connectivity
- High evidence
Probiotic-derived extracellular vesicles attenuate cholestatic liver damage via gut-liver axis.
- 2026-03
- Pharmacological research 225
- - Xianjiao Liu
  - Yanyan Wang
  - Andrea Abreo Medina
  - Dandan Liu
  - Jinyan Liu
  - Wenxuan Tang
  - Mengmeng Wang
  - Xingxiang Chen
  - Kehe Huang
  - Min Liu
  - Chunfeng Wang
  - Yunhuan Liu
- PubMed: 41747917
- DOI: 10.1016/j.phrs.2026.108152
3 Insights on
- Low evidence
- Animal Study
Regulation effect of Lactobacillus johnsonii on chickens infected with Ascaridia galli.
- 2026-03
- RCT
- Poultry science 105(3)
- - Zhi-Hui Xu
  - Kai-Zhi Mo
  - Peng-Xi Cai
  - Jing-Yun Xu
  - Qian Han
- PubMed: 41539233
- DOI: 10.1016/j.psj.2026.106399
8 Insights on
- Low evidence
- Animal Study
Whole genome sequence analysis of Bifidobacterium animalis subsp. lactis KL101 and comparative genomics with BB12.
- 2026-03
- Journal of animal science and technology 68(2)
- - Kiyeop Kim
  - Junghee Lee
  - Seung-Ji Kang
  - Sejong Oh
- PubMed: 41983001
- DOI: 10.5187/jast.2024.e76
3 Insights on
- Low evidence
Effects of Asparagus officinalis for burning mouth syndrome: A systematic review of randomized controlled trials.
- 2026-03
- Review · n = 336
- Integrative medicine research 15(1)
- - Chen Shen
  - Xue-Feng Wang
  - Xiao-Ti Wu
  - Xin-Xin Liu
  - Nicola Robinson
  - Jian-Ping Liu
- PubMed: 40950801
- DOI: 10.1016/j.imr.2025.101223
9 Insights on
- High evidence
Niacin Modulates Immune Responses in a Phase I Dose-Escalation Clinical Trial of Newly Diagnosed Glioblastoma.
- 2026-03
- Clinical Trial
- Neurology(R) neuroimmunology & neuroinflammation 13(2)
- - Candice C Poon
  - Kathleen M Hagen
  - Susobhan Sarkar
  - Reza Mirzaei
  - Claudia Silva
  - Aito Ueno
  - Paula de Robles
  - Gloria Roldan-Urgoiti
  - V Wee Yong
- PubMed: 41632924
- DOI: 10.1212/nxi.0000000000200530
6 Insights on
- Moderate evidence
The Effect of L-Tryptophan Intake on Dynamic Strength in Paralympic Powerlifting.
- 2026-03
- RCT
- International journal of tryptophan research : IJTR 19
- - Márcio Getirana-Mota
  - Felipe J Aidar
  - Raphael Fabricio de Souza
  - Ciro José Brito
  - Taísa Pereira Santos
  - Jonason Espínola Lacerda
  - Lúcio Marques Vieira-Souza
  - Georgian Badicu
- PubMed: 41799862
- DOI: 10.1177/11786469261420614
3 Insights on
- High evidence
N-acetylcysteine reduces incidence and duration of linezolid-associated thrombocytopenia in critically ill patients: A randomized controlled trial.
- 2026-03
- RCT
- Environmental toxicology and pharmacology 122
- - Mohamed Abdeltawab
  - Abdel-Hameed Ebid
  - Osama Ahmed
  - Mohamed A Mobarez
  - Mahmoud Ibrahim
- PubMed: 41577060
- DOI: 10.1016/j.etap.2026.104944
4 Insights on
- High evidence
Acute Effects of a High-Fat Meal Enriched with Pomegranate Seed Oil on Postprandial Lipemia and Endothelial Function in Postmenopausal Women: a Randomized Controlled Crossover Trial.
- 2026-03
- RCT
- The Journal of nutrition 156(3)
- - Manal M Almoraie
  - Jeremy Pe Spencer
  - Carol Wagstaff
  - Kim G Jackson
- PubMed: 41580088
- DOI: 10.1016/j.tjnut.2026.101374
6 Insights on
- High evidence
Comparative genomics reveals population structure and ecological adaptation in Lactobacillus helveticus.
- 2026-03
- Observational
- Food research international (Ottawa, Ont.) 227
- - Haimin Hu
  - Jiao Wu
  - Jiaqi Sun
  - Simeng Wang
  - Jinhui Liu
  - Tong Dan
- PubMed: 41652681
- DOI: 10.1016/j.foodres.2025.118266
1 Insight on
- Reduced Angiotensin I-Converting Enzyme Activity
- Low evidence
Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.
- 2026-03
- Journal of ethnopharmacology 359
- - Lumeng Yao
  - Qiuying Xu
  - Yongbin Xu
  - Yue Chen
  - Zhun Xiao
  - Zhenjie Gao
  - Lingyan Zhu
  - Jianjun Wu
  - Luping Qin
  - Siqi Gao
- PubMed: 41443484
- DOI: 10.1016/j.jep.2025.121066
3 Insights on
- Low evidence
Profile of neural tube defects in pediatric patients in Nigeria: A systematic review.
- 2026-03
- Systematic Review · n = 390
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 145
- - Nicholas Kendall
  - Joshua Woo
  - Brady K Browning
  - Oluwafemi Owagbemi
  - Temitayo O Ayantayo
  - Sean C Holden-Kapshuck
  - Haley G Kieny
  - Zoey Petitt
  - Megan E H Still
  - Elizabeth Blackwood
  - Bamidele O Adebayo
  - Olawale A R Sulaiman
  - Muhammad R Mahmud
  - Amos O Adeleye
  - Matthew T Shokunbi
  - Michael M Haglund
  - Alvan-Emeka K Ukachukwu
- PubMed: 41500170
- DOI: 10.1016/j.jocn.2026.111853
2 Insights on
- Reduced Neural Tube Defect Mortality
- Improved Folate Level
- High evidence
Screening for Biotinidase deficiency in children with spinal cord demyelination.
- 2026-03
- Observational
- Multiple sclerosis and related disorders 107
- - Maha Mohammed
  - Iman El Agouza
  - Raghda Zaitoun
  - Khaled Ahmad
  - Shaimaa Mohammad
  - Ola Sallam
  - Hoda Tomoum
- PubMed: 41483680
- DOI: 10.1016/j.msard.2025.106946
1 Insight on
- Improved Neurobehavioral Function
- Low evidence
Vaginal-Derived Potential Probiotics and Their Postbiotics Alleviate Aerobic Vaginitis via Suppressing TLR4/MyD88/NF-κB Signalling Pathway and Potentially Enhancing Vaginal Barrier.
- 2026-03
- Microbial biotechnology 19(3)
- - Meiyun Tian
  - Xinyi Zhang
  - Xuan Xu
  - Xia He
  - Xiaoyun Wu
  - Jing Wei
  - Buzhen Tan
  - Tingtao Chen
- PubMed: 41807990
- DOI: 10.1111/1751-7915.70327
4 Insights on
- Low evidence
- Animal Study
Red panda intestinal organoids for the functional analysis of Lactobacillus salivarius.
- 2026-03
- iScience 29(3)
- - Qiang Guo
  - Junjin Xie
  - Qian Zhou
  - Rong Hou
  - Xia Yan
  - Xu Li
  - Lin Li
  - Shuran Yu
  - Yubao Duan
  - Jielong Zhou
  - Wenping Zhang
  - Xiaoyan Su
- PubMed: 41852748
- DOI: 10.1016/j.isci.2026.114844
3 Insights on
- Low evidence
Alginate-Based Microencapsulation of Saccharomyces Boulardii for Enhanced In Vitro Stability in Poultry Sector: A Novel Strategy for Probiotic Delivery.
- 2026-03
- Veterinary medicine and science 12(2)
- - Elahe Khademi
  - Fahimeh Nemati
  - Tohid Piri-Gharaghie
- PubMed: 41840959
- DOI: 10.1002/vms3.70841
1 Insight on
- Increased Antibacterial Activity Against Pathogens
- Low evidence
- Animal Study
Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial.
- 2026-03
- RCT · n = 276
- BMJ paediatrics open 10(1)
- - Jitender Nagpal
  - Manu Mathur
  - Swapnil Rawat
  - Atul Singhal
  - Rajendra Pant
  - Anita Shah
  - Laura Nixon
  - Vijay Kumar Mishra
  - Deepti Nagrath
  - Michelle Heys
  - Mario Cortina-Borja
  - Colin Michie
  - Jageshwor Gautam
  - Shailendra Bir Karmacharya
  - Snighda Rai
  - Monica Lakhanpaul
- PubMed: 41850742
- DOI: 10.1136/bmjpo-2025-004112
1 Insight on
- Improved Mental Developmental Quotient
- High evidence
- Large Human Trial
The impact of vitamin D supplementation on sudden sensorineural hearing loss in vitamin D deficient patients: A double-blind, placebo-controlled trial: A pilot study.
- 2026-03
- RCT
- American journal of otolaryngology 47(2)
- - Bahareh Tavakoli
  - Sohrab Rabiei
- PubMed: 41570758
- DOI: 10.1016/j.amjoto.2026.104793
6 Insights on
- High evidence