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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Effects of Yacon Consumption on Body Weight and C-reactive Protein: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- 2026-06
- Review · n = 246
- Current therapeutic research, clinical and experimental 104
- - Fariborz Porbafrani
  - Mohammad Samadi
  - Karim Parastouei
- PubMed: 41685137
- DOI: 10.1016/j.curtheres.2025.100817
4 Insights on
- High evidence
Short-term isolated leucine supplementation was not associated with improvements in muscle mass or function in patients with head and neck cancer: A randomized, double-blind, proof-of-concept trial with an elderly non-cancer comparator cohort.
- 2026-06
- RCT · n = 41
- Clinical nutrition ESPEN 73
- - Márcia Fábia Andrade
  - Gabriela Salim de Castro
  - Silvio Pires Gomes
  - Marcelo de Carvalho
  - Joyce Cristina Ferreira de Resende
  - Ivanir Pires
  - Jaline Zandonato Faiad
  - Ana Paula Noronha Barrère
  - Ana Laura Camilo Venturini
  - Rafael Souza
  - Rafael De Cicco
  - José Francisco de Gois Filho
  - Bruna Franchi
  - Everson Luiz Almeida Artifon
  - José Pinhata Otoch
  - Daniela Caetano Gonçalves
  - Marília Seelaender
- PubMed: 41786247
- DOI: 10.1016/j.clnesp.2026.103100
7 Insights on
- High evidence
Lactobacillus salivarius D5 improves growth performance and immune function in broilers by reducing Escherichia coli abundance and regulating the gut microbiota.
- 2026-06
- Clinical Trial
- Poultry science 105(6)
- - Yingting You
  - Yonglong Zhu
  - Deshi Shi
  - Xiang Li
  - Muhammad Akhtar
  - Lizhen Ren
  - Guilin Fu
  - Yingying Chen
  - Qiujing Chen
  - Naiji Zhou
  - Zutao Zhou
  - Yuncai Xiao
- PubMed: 41905065
- DOI: 10.1016/j.psj.2026.106768
5 Insights on
- Moderate evidence
A comprehensive review on structural, chemical, and functional perspectives of dietary polysaccharide-driven gut microbiota modulation: Mechanisms and challenges.
- 2026-06
- Review
- Biochemistry and biophysics reports 46
- - Athira Jayasree Subhash
  - Mohamed Abdin
  - Gafar Babatunde Bamigbade
  - Maduni Paththuwe Arachchi
  - Naeem Ullah
  - Mutamed Ayyash
- PubMed: 42004542
- DOI: 10.1016/j.bbrep.2026.102575
1 Insight on
- Modulated Gut Microbiota
- Low evidence
Effects of one avocado a day for six months on cognitive performance in overweight adults: A randomized controlled trial.
- 2026-06
- RCT · n = 251
- The journal of nutrition, health & aging 30(6)
- - Grace J Lee
  - Holly E R Morrell
  - Michelle Adams
  - Joan Sabaté
  - David M Reboussin
  - Penny M Kris-Etherton
  - Kristina S Petersen
  - Alice H Lichtenstein
  - Nirupa R Matthan
  - Zhaoping Li
  - Sujatha Rajaram
- PubMed: 41999682
- DOI: 10.1016/j.jnha.2026.100847
5 Insights on
- High evidence
New combination therapy of praziquantel and Lactobacillus plantarum for enhancing the treatment of clonorchiasis in mice.
- 2026-06
- Food and waterborne parasitology 43
- - Yeting Ma
  - Xiaocen Wang
  - Xu Zhang
  - Yanhui Yu
  - Zhenzhen Liu
  - Penglin Bao
  - Meng Liu
  - Yuru Wang
  - Xiaodan Yuan
  - Hongyu Wang
  - Pengtao Gong
  - Nan Zhang
  - Xin Li
  - Jianhua Li
- PubMed: 41969850
- DOI: 10.1016/j.fawpar.2026.e00333
6 Insights on
- Low evidence
Influence of synbiotic supplementation on performance, fecal consistency, cecal microbiome, and egg quality of hens during late laying phase.
- 2026-06
- RCT · n = 240
- Poultry science 105(6)
- - Koonphol Pongmanee
  - Konkawat Rassmidatta
  - Ting-Yu Lee
  - Jin-Seng Lin
  - Chanporn Chaosap
  - Kazeem D Adeyemi
  - Yuwares Ruangpanit
- PubMed: 41916054
- DOI: 10.1016/j.psj.2026.106851
3 Insights on
- High evidence
The Role of Electrolytes in Muscle Pain Syndromes: A Systematic Review and Meta-Analysis With Implications for Temporomandibular Disorder.
- 2026-06
- Meta-Analysis
- International dental journal 76(3)
- - Shankargouda Patil
  - Andrea Falkowski
  - Venkata Suresh Venkataiah
  - Shilpa Bhandi
  - Frank W Licari
  - Amey G Patil
- PubMed: 41812583
- DOI: 10.1016/j.identj.2026.109488
2 Insights on
- Reduced Cramp Frequency
- Reduced Cramp Susceptibility
- High evidence
White kidney bean extract reduces body weight and adiposity with acceptable safety in adults with overweight and obese: a systematic review and meta-analysis.
- 2026-06
- Review · n = 543
- Nutrition research (New York, N.Y.) 150
- - Nan Shi
  - Ruye Wang
  - Xinyi Cao
  - Zanche Huang
  - Fangxuan Lin
  - Ruoyi Xu
  - Qin Zhang
- PubMed: 42066439
- DOI: 10.1016/j.nutres.2026.04.001
5 Insights on
- High evidence
Efficacy of herbaceous Apiaceae plants in primary dysmenorrhea: A systematic review and meta-analysis of RCTs.
- 2026-06
- Review
- Annales pharmaceutiques francaises 84(4)
- - Athul Thaliyil Poduval
  - Vijaya Lekshmi Ramalekshmi
  - Nithya Vijayan Sarangi
  - Susdev Karippattil Murali
  - Akash Dey
  - Bidhan Mahajon
  - Meenakshi Pandey
  - Ruknuddin Galib
  - Sanjay M Jachak
  - Tanuja Manoj Nesari
  - Meena Shamrao Deogade
- PubMed: 41653970
- DOI: 10.1016/j.pharma.2026.01.005
1 Insight on
- Reduced Pain Intensity
- Low evidence
Improved Iron Status, but Not Protein Source, Is Related to Appetite, Satiety, and Mood in Women of Reproductive Age With Iron Deficiency: A Randomized Controlled Trial.
- 2026-06
- RCT
- The Journal of nutrition 156(6)
- - Stephen R Hennigar
  - Katelyn M Miller
  - Robert D Murphy
  - Amy Braymer
  - Christy L Mayet
  - Frank L Greenway
  - Susan N Cheung
  - Camila Weschenfelder
  - Claire E Berryman
- PubMed: 42061720
- DOI: 10.1016/j.tjnut.2026.101559
10 Insights on
- High evidence
Foods rich in anti-inflammatory components and anti-inflammatory supplements for the prevention and treatment of Sarcopenia in older adults: A systematic review and network meta-analysis.
- 2026-06
- Meta-Analysis
- Complementary therapies in medicine 98
- - Shan Li
  - Jiaxue Li
  - Keke Ren
  - Xilin Yang
  - Xinyu Yu
  - Qinghua Zhao
  - Huanhuan Huang
- PubMed: 41796642
- DOI: 10.1016/j.ctim.2026.103343
3 Insights on
- High evidence
The relationship between vitamin B9 (folate) supplementation and suicidality: a scoping review.
- 2026-06
- Review · n = 475
- The mental health clinician 16(3)
- - Chris Noel
  - Nick Lombardi
  - Michelle Price
  - Erik Herbert
  - Jill E Lavigne
- PubMed: 42239831
- DOI: 10.9740/mhc.2026.06.150
2 Insights on
- Reduced Suicide-Related Emergency or Hospital Visit
- Reduced Suicide-Related Endpoints
- High evidence
Bifidobacterium longum subsp. infantis B8762 modulates the infant gut-lung axis via microbial and metabolic reprogramming.
- 2026-06
- RCT · n = 115
- Microbial pathogenesis 215
- - Rui Ma
  - Bo Jia
  - Xiangyang Zhang
  - Zhixin Zhao
  - Feiyan Zhao
  - Min-Tze Liong
  - Adli Ali
  - Intan Juliana Abd Hamid
  - Taufiq Hidayat Hasan
  - Fahisham Taib
  - Zhihong Sun
- PubMed: 41802657
- DOI: 10.1016/j.micpath.2026.108431
3 Insights on
- High evidence
The effect of red pepper/capsaicin on cardiovascular risk factors: a systematic review, meta-analysis, and GRADE assessment.
- 2026-06
- Meta-Analysis · n = 821
- Nutrition, metabolism, and cardiovascular diseases : NMCD 36(6)
- - Seyed Mojtaba Ghoreishy
  - Maryam Zeydi
  - Vahid Hadi
  - Nastaran Jafarbeglou
  - Yasamin Atabaki
  - Mohammad Keshavarz Mohammadian
  - Hossein Imani
  - Amirhossein Hemmati
  - Saeid Hadi
- PubMed: 41856833
- DOI: 10.1016/j.numecd.2026.104616
1 Insight on
- Reduced Blood Cholesterol
- High evidence
A 90-day oral toxicity study of heat-treated Bifidobacterium longum CECT 7347 (ES1 HT) Postbiotic in rats.
- 2026-06
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 212
- - Jay S Petrick
  - Roger Mariné-Casadó
  - Richard Day
  - Patricia Martorell
  - Carolina C Venditti
  - Empar Chenoll
- PubMed: 41724422
- DOI: 10.1016/j.fct.2026.116025
2 Insights on
- No Adverse Effects
- Maintained Safety with Repeated Oral Exposure
- Low evidence
- Animal Study
Engineering SCFAs with dietary fibre combinations: insights from a kinetic-microbiome single-subject longitudinal study.
- 2026-06
- Case Report
- Food research international (Ottawa, Ont.) 233
- - Christo Opperman
  - Charmaine Lloyd
  - Vishal Ratanpaul
  - Thi Thu Hao Van
  - Charles Brennan
  - Rajaraman Eri
- PubMed: 41942178
- DOI: 10.1016/j.foodres.2026.118846
1 Insight on
- Increased Butyrate Production
- Low evidence
Effects of a combination of olive leaf extract and potassium on blood pressure in participants with mild to moderate hypertension: A double blind, randomized, placebo-controlled trial.
- 2026-06
- RCT · n = 70
- Phytomedicine : international journal of phytotherapy and phytopharmacology 155
- - Johannes-Paul Fladerer-Grollitsch
  - Franz Bucar
  - Thomas Klein
  - Albert Kompek
  - Daniel Menzel
  - Christiane Schön
- PubMed: 41935461
- DOI: 10.1016/j.phymed.2026.158138
17 Insights on
- High evidence
In vitro and in vivo toxicological safety assessment of indigenous probiotic Lacticaseibacillus rhamnosus NCDC 610.
- 2026-06
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 212
- - Angela Joseph
  - S V Salini
  - Battula Narsimlu
  - Sachin Kumar
  - Manorama Kumari
  - Pradip V Behare
- PubMed: 41819674
- DOI: 10.1016/j.fct.2026.116060
2 Insights on
- Safety And Tolerability
- Reduced Virulence-Associated Activity
- Low evidence
The association between micronutrient status and clinical outcomes in children with cancer undergoing treatment: A systematic review and meta-analysis.
- 2026-06
- Meta-Analysis
- Clinical nutrition (Edinburgh, Scotland) 61
- - Hala AbuSalameh
  - Ruijie Li
  - Nubia Maria de Oliveira
  - Judy Schoeman
  - Minke Huibers
  - Mirjam van den Brink
  - Amy L Lovell
  - Paul C Rogers
  - Raquel Revuelta Iniesta
- PubMed: 41967219
- DOI: 10.1016/j.clnu.2026.106653
6 Insights on
- High evidence
Pea protein preload improves postprandial glucose response in healthy adults: a randomized, double-blind, controlled pilot study.
- 2026-06
- RCT
- European journal of nutrition 65(4)
- - Arig Elbira
  - Priscilla Grace Gnanasekaran Punithalayal
  - Alan Javier Hernández-Álvarez
  - Christine Boesch
- PubMed: 42274793
- DOI: 10.1007/s00394-026-03971-3
5 Insights on
- High evidence
- Rigorous Journal
Lactobacillus gasseri suppresses the Helicobacter pylori-induced expression of the proliferation-associated factors HBEGF and TGF-α in gastric host cells.
- 2026-06
- International journal of medical microbiology : IJMM 322
- - Tanvi Somiah
  - Priyodip Paul
  - Sarah Pilheden
  - James Trumbo
  - Ann-Beth Jonsson
- PubMed: 41401561
- DOI: 10.1016/j.ijmm.2025.151694
2 Insights on
- Reduced Gastric Inflammation
- Reduced Gastric Epithelial Proliferation Signaling
- Low evidence
A detoxifying multi-strain probiotic formula attenuates toxicity induced by heavy metals and phthalates.
- 2026-06
- Food research international (Ottawa, Ont.) 233
- - Rui Xiao
  - Yaqi Yu
  - Deshan Ning
  - Zehua Chen
  - Chuguang Ning
  - Leilei Yu
  - Shumao Cui
  - Jianxin Zhao
  - Gang Wang
  - Yong Zhou
  - Xing Jin
- PubMed: 41956665
- DOI: 10.1016/j.foodres.2026.119002
4 Insights on
- Low evidence
- Animal Study
Effect of extra virgin olive oil on mild cognitive impairment and dementia in older adults: a systematic review and meta-analysis of clinical trials.
- 2026-06
- Meta-Analysis · n = 747
- Clinical nutrition ESPEN 73
- - Victor Cordeiro Simão
  - Tiago Paiva Prudente
  - Arthur De Prado Lopes Oliveira
  - Cesar De Oliveira
  - Erika Aparecida Silveira
- PubMed: 41740793
- DOI: 10.1016/j.clnesp.2026.102977
4 Insights on
- High evidence
Host-directed therapy for tuberculosis: Repurposed drugs toward global tuberculosis elimination.
- 2026-06
- Review
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 167
- - Yi Hao Wong
  - Hai Tarng Chong
  - Ting Huey Hu
  - Catherine Wei Min Ong
- PubMed: 41856464
- DOI: 10.1016/j.ijid.2026.108545
1 Insight on
- Reduced Bacterial Load
- Low evidence
Impact of lactic acid bacteria and Bifidobacterium intervention on pathogenic bacteria and short-chain fatty acid production in diarrheic calves: an in vitro fermentation study.
- 2026-06
- Veterinary and animal science 32
- - Yannan He
  - Jiaxing Tian
  - Junguo Liu
  - Han Lu
  - Xinfeng Hou
  - Jinping Zhang
  - Jie Gao
  - Ling Yang
  - Shijie Wang
- PubMed: 41783829
- DOI: 10.1016/j.vas.2026.100603
2 Insights on
- Increased Short-Chain Fatty Acid Production
- Reduced Pathogenic Bacteria in Gut
- Low evidence
Lactobacillus casei serves as a primary functional strain in fecal microbiota-mediated neuroprotection against cerebral ischemia/reperfusion injury.
- 2026-06
- Pathology, research and practice 282
- - Li Niu
  - Yumin Tan
  - Wenlu Cao
  - Ermin Wang
  - Feng Qi
- PubMed: 41946028
- DOI: 10.1016/j.prp.2026.156441
4 Insights on
- Low evidence
Structure-activity relationship of Laminaria japonica polysaccharide in promoting acetic acid synthesis by Lactobacillus rhamnosus GG.
- 2026-05
- Food research international (Ottawa, Ont.) 231
- - Jiabin Wu
  - Yaqing Lin
  - Hangyu Huang
  - Lin Wang
  - Yi Zhang
  - Jin Wang
  - Lei Pan
- PubMed: 41819923
- DOI: 10.1016/j.foodres.2026.118756
4 Insights on
- Low evidence
Probiotic combinations affect characteristics of chickpea yogurt: an investigation on physicochemical, rheological, and organoleptic properties and SCFAs fermentation.
- 2026-05
- Food chemistry 510
- - Haiyang Shi
  - Jing Luo
  - Zhexin Fan
  - Baokun Li
  - Xiaoqian Chen
  - Bingyuan Lei
  - Yingying Qiu
  - Jiancheng Wang
  - Tong Pan
  - Wenwei Lu
  - Zhifeng Fang
- PubMed: 41795525
- DOI: 10.1016/j.foodchem.2026.148756
2 Insights on
- Increased Short-Chain Fatty Acid Production
- Improved Short-Chain Fatty Acid Production
- Low evidence
Effects of marine-derived Enterococcus durans YQ-6 on growth performance, intestinal health and microbial community of Leizhou black ducks.
- 2026-05
- RCT · n = 180
- Poultry science 105(5)
- - Yufeng Gou
  - Jiang Wu
  - Qiucheng Yao
  - Namula Zhao
  - Haiyan Wu
  - Zhibao Chen
- PubMed: 41691807
- DOI: 10.1016/j.psj.2026.106568
2 Insights on
- Improved Growth Performance
- Improved Intestinal Health
- High evidence