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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

β-alanine supplementation in adults with overweight and obesity: a randomized controlled feasibility trial.
- 2025-01-12
- RCT · n = 27
- Obesity (Silver Spring, Md.) 33(2)
- - Joseph J Matthews
  - Jade V Creighton
  - James Donaldson
  - Paul A Swinton
  - Ioannis Kyrou
  - Srikanth Bellary
  - Iskandar Idris
  - Lívia Santos
  - Mark D Turner
  - Craig L Doig
  - Kirsty J Elliott-Sale
  - Craig Sale
- PubMed: 39800667
- DOI: 10.1002/oby.24204
4 Insights on
- High evidence
Exploring the Intricate Connection Between Vitamin B12 Deficiency and Hearing Loss: A Systematic Literature Review.
- 2025-01-11
- Systematic Review · n = 612
- Ear, nose, & throat journal 105(2)
- - Joyline Rodrigues
  - Shubhangi Anand
  - Dhanshree R Gunjawate
  - Kaushlendra Kumar
  - Rohit Ravi
- PubMed: 39797597
- DOI: 10.1177/01455613241298070
3 Insights on
- High evidence
Correction: Exploring the gut microbiome: probiotics, prebiotics, synbiotics, and postbiotics as key players in human health and disease improvement.
- 2025-01-09
- Food science and biotechnology 34(14)
- - You-Tae Kim
  - David A Mills
- PubMed: 40918478
- DOI: 10.1007/s10068-024-01809-4
1 Insight on
- Improved Gastrointestinal Health
- Low evidence
Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists.
- 2025-01-09
- RCT
- Nutrients 17(2)
- - Jennifer A Kurtz
  - Rafaela G Feresin
  - Jacob Grazer
  - Jeff Otis
  - Kathryn E Wilson
  - J Andrew Doyle
  - Kevin A Zwetsloot
- PubMed: 39861353
- DOI: 10.3390/nu17020224
4 Insights on
- High evidence
- Rigorous Journal
Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies.
- 2025-01-08
- Observational
- Microorganisms 13(1)
- - Longbao Lv
  - Feiyan Zhang
  - Haimei Zhou
  - Wenxian Xiao
  - Yingzhou Hu
  - Wenchao Wang
  - Zhu Zhu
  - Fangming Zhu
  - Dongdong Qin
  - Xintian Hu
- PubMed: 39858885
- DOI: 10.3390/microorganisms13010117
1 Insight on
- Increased Beneficial Gut Microbiota Abundance
- Low evidence
Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies.
- 2025-01-08
- Review
- Foods (Basel, Switzerland) 14(2)
- - Aleksandra Hyży
  - Hanna Rozenek
  - Ewa Gondek
  - Mariusz Jaworski
- PubMed: 39856843
- DOI: 10.3390/foods14020176
2 Insights on
- Improved Cognitive Function
- Improved Gut Health
- Low evidence
Oral Lipids/Fatty Acids Supplements and Eczema: What Is Known?
- 2025-01-08
- Review
- Dermatitis : contact, atopic, occupational, drug 37(1)
- - Andrea Cespedes Zablah
  - Peter Lio
- PubMed: 39772730
- DOI: 10.1089/derm.2024.0317
1 Insight on
- Reduced Atopic Dermatitis Severity
- Low evidence
The efficacy of lavender oil on fatigue and sleep quality in patients with hematological malignancy receiving chemotherapy: a single-blind randomized controlled trial.
- 2025-01-08
- RCT · n = 120
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 33(2)
- - Dilek Yildirim
  - Merve Harman Ozdogan
  - Seckin Erdal
  - Sevinc Selcuk
  - Azize Guneri
  - Elif Begum Simsek
  - Taha Berkay Can
  - Hazal Gunduz
  - Aysem Kuni
- PubMed: 39775962
- DOI: 10.1007/s00520-024-09143-5
5 Insights on
- High evidence
- Large Human Trial
Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis.
- 2025-01-07
- Meta-Analysis
- Inflammopharmacology 33(3)
- - Shooka Mohammadi
  - Damoon Ashtary-Larky
  - Milad Mehrbod
  - Narges Kouhi Sough
  - Hossein Salehi Omran
  - Sina Dolatshahi
  - Niusha Amirani
  - Omid Asbaghi
- PubMed: 39775243
- DOI: 10.1007/s10787-024-01615-8
5 Insights on
- High evidence
Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis.
- 2025-01-07
- Systematic Review · n = 310
- Frontiers in medicine 11
- - Fenfang Wu
  - Chunhua Xu
  - Xinlei Si
  - Fei He
  - Kang Xu
  - Yu Zhang
  - Shan Lin
- PubMed: 39839641
- DOI: 10.3389/fmed.2024.1477569
3 Insights on
- High evidence
Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats.
- 2025-01-07
- n = 28
- World journal of gastroenterology 31(1)
- - Ping Zhang
  - Ying Zhu
  - Pu Chen
  - Tong Zhou
  - Zhe-Yi Han
  - Jun Xiao
  - Jian-Feng Ma
  - Wen Ma
  - Peng Zang
  - Ying Chen
- PubMed: 39777246
- DOI: 10.3748/wjg.v31.i1.96199
3 Insights on
- Low evidence
- Animal Study
Limited Changes in Red Blood Cell Parameters After Probiotic Supplementation in Depressive Individuals: Insights from a Secondary Analysis of the PRO-DEMET Randomized Controlled Trial.
- 2025-01-05
- RCT · n = 116
- Journal of clinical medicine 14(1)
- - Agata Gajewska
  - Adam Wysokiński
  - Dominik Strzelecki
  - Oliwia Gawlik-Kotelnicka
- PubMed: 39797347
- DOI: 10.3390/jcm14010265
2 Insights on
- Stable Blood Parameters
- No Significant Changes in Blood Parameters
- High evidence
Therapeutic Potential of Saffron Extract in Mild Depression: A Study of Its Role on Anhedonia in Rats and Humans.
- 2025-01-04
- RCT
- Phytotherapy research : PTR 39(3)
- - Eleonora Corridori
  - Sara Salviati
  - Maria Graziella Demontis
  - Pamela Vignolini
  - Chiara Vita
  - Andrea Fagiolini
  - Alessandro Cuomo
  - Pietro Carmellini
  - Carla Gambarana
  - Simona Scheggi
- PubMed: 39754520
- DOI: 10.1002/ptr.8424
2 Insights on
- Reduced Depression Symptoms
- Reduced Anhedonia
- High evidence
Effect of Amaranth-Containing Dietary Intervention in Improving Hemoglobin Concentration: A Systematic Review and Meta-Analysis.
- 2025-01-03
- Systematic Review · n = 1
- Public health reviews 45
- - Mekdes Tigistu Yilma
  - Aberash Eifa
  - Mehretu Belayneh
  - Alemselam Zebdewos Orsango
- PubMed: 39829607
- DOI: 10.3389/phrs.2024.1607597
1 Insight on
- Increased Hemoglobin Levels
- High evidence
Advantages of different dietary supplements for elite combat sports athletes: a systematic review and Bayesian network meta-analysis.
- 2025-01-02
- Systematic Review
- Scientific reports 15(1)
- - Hua Luo
  - Tengku Fadilah Tengku Kamalden
  - Xiaolin Zhu
  - Changqing Xiang
  - Nurul Amelina Nasharuddin
- PubMed: 39747536
- DOI: 10.1038/s41598-024-84359-3
1 Insight on
- Increased Blood Lactate Level
- High evidence
- Rigorous Journal
Analysis of the Effects of Short-Term Pterostilbene Intake on Healthy Participants: A Pilot Study.
- 2025-01-01
- RCT
- Journal of nutritional science and vitaminology 71(1)
- - Kurataka Otsuka
  - Daisuke Kuriki
  - Keiko Kamachi
  - Akira Tanaka
  - Ryosuke Matsuoka
- PubMed: 40024751
- DOI: 10.3177/jnsv.71.70
2 Insights on
- Improved Blood Biochemistry
- Regulated Blood miRNA Expression
- High evidence
Phytoestrogens in osteoporosis.
- 2025-01-01
- Review
- Wiadomosci lekarskie (Warsaw, Poland : 1960) 78(3)
- - Mateusz Kaczmarski
  - Mateusz Trubalski
  - Paweł Kamiński
  - Marta Żerebiec
  - Aleksandra Bełżek
  - Natalia Saj
  - Zuzanna Rupeć
  - Joanna Niezbecka-Zając
  - Nataliia Fedorenko
  - Wojciech Kłapeć
- PubMed: 40219889
- DOI: 10.36740/wlek/202326
4 Insights on
- Low evidence
New targets for the treatment of ulcerative colitis: Gut microbiota and its metabolites.
- 2025-01-01
- Review
- Computational and structural biotechnology journal 27
- - Huanyu Li
  - Meng Pan
  - Yifan Li
  - Manli Cui
  - Mingxin Zhang
- PubMed: 40470314
- DOI: 10.1016/j.csbj.2025.05.006
2 Insights on
- Reduced Ulcerative Colitis Symptoms
- Improved Gut Microbiota-Related Disease Support in Ulcerative Colitis
- Low evidence
Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis.
- 2025-01-01
- Meta-Analysis
- Biochemistry and cell biology = Biochimie et biologie cellulaire 103
- - Valerie S Mayorga
  - Rafaella Navarro
  - Victor D Torres Roldan
  - Meritxell Urtecho
  - Silvia Tipe
  - Bea Calvert
  - Laura A Wright
  - Theresa J Ochoa
- PubMed: 39841980
- DOI: 10.1139/bcb-2024-0181
1 Insight on
- Reduced Diarrhea
- High evidence
A Combination of Punica granatum Fruit Rind and Theobroma cacao Seed Extracts Enhances Sexual Function in Aging Males in a Randomized, Double-blind, Placebo-controlled Study.
- 2025-01-01
- RCT · n = 60
- International journal of medical sciences 22(2)
- - Manoj Kumar Srivastava
  - Gaurav Singh
  - Raveendra Ramamurthy Kodur
  - Amulya Yalamanchi
- PubMed: 39781534
- DOI: 10.7150/ijms.99958
3 Insights on
- High evidence
Carnosine-enriched functional food enhances micro- and macrovascular endothelium-independent vasodilation in competitive athletes-a randomized study.
- 2025-01-01
- RCT
- Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 50
- - Leon Perić
  - Ines Drenjančević
  - Ivana Jukić
  - Alina Boris
  - Petar Šušnjara
  - Nikolina Kolobarić
  - Zrinka Mihaljević
  - Zlata Kralik
  - Gordana Kralik
  - Manuela Košević
  - Olivera Galović
  - Ana Stupin
- PubMed: 39983097
- DOI: 10.1139/apnm-2024-0458
4 Insights on
- High evidence
The potential effects of cinnamon, cumin, and Rosuvastatin on lipid profile among Iraqi patients with dyslipidemia.
- 2025-01-01
- RCT · n = 30
- Wiadomosci lekarskie (Warsaw, Poland : 1960) 78(10)
- - Qayssar Joudah Fadheel
- PubMed: 41401318
- DOI: 10.36740/wlek/210069
4 Insights on
- High evidence
The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial.
- 2025-01-01
- RCT
- Iranian journal of medical sciences 50(1)
- - Mehran Kouchek
  - Niloufar Taherpour
  - Mahya Farasat
  - Mirmohammad Miri
  - Sara Salarian
  - Seyedpouzhia Shojaei
  - Rezvan Hassanpour
  - Hossein Amini
  - Mohammad Sistanizad
- PubMed: 39957812
- DOI: 10.30476/ijms.2024.99691.3182
3 Insights on
- High evidence
Lactobacillus rhamnosus Helps to Reduce the Duration of Bleeding in Breastfed Infants with Allergic Proctocolitis.
- 2025-01-01
- RCT · n = 48
- Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine 20(1)
- - Armen Malekiantaghi
  - Faezeh Ghanaati
  - Hosein Shabani-Mirzaee
  - Mamak Shariat
  - Sayed-Yousef Mojtahedi
  - Kambiz Eftekhari
- PubMed: 39417285
- DOI: 10.1089/bfm.2024.0185
2 Insights on
- Reduced Faecal pH
- Reduced Occult Blood Positivity
- High evidence
Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A Randomized Clinical Trial.
- 2025-01-01
- RCT · n = 36
- International journal of community based nursing and midwifery 13(1)
- - Roya Partovi Golshan
  - Maryam Moradi
  - Hasan Rakhshandeh
  - Vahid Ghavami
  - Seyed Mostafa Moshirian Farahi
- PubMed: 39906250
- DOI: 10.30476/ijcbnm.2024.102930.2543
1 Insight on
- Reduced Premenstrual Syndrome Symptom
- High evidence
A comparison of the effects of dairy products with their plant-based alternatives on metabolic responses in healthy young Canadian adults: a randomized crossover study.
- 2025-01-01
- RCT
- Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 50
- - Nicole Da Silva
  - G Harvey Anderson
  - Amira M Amr
  - Shirley Vien
  - Hrvoje Fabek
- PubMed: 39146559
- DOI: 10.1139/apnm-2024-0158
2 Insights on
- Increased Intestinal GLP-1 Levels
- Increased Insulin Level
- High evidence
Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate.
- 2024-12-31
- ACS synthetic biology 14(1)
- - Mengdi Yang
  - Noah Hutchinson
  - Ningyuan Ye
  - Hania Timek
  - Maria Jennings
  - Jianing Yin
  - Ming Guan
  - Zongqi Wang
  - Peiru Chen
  - Shaobo Yang
  - Justin D Crane
  - Ke Zhang
  - Xuesong He
  - Jiahe Li
- PubMed: 39739838
- DOI: 10.1021/acssynbio.4c00399
1 Insight on
- Reduced Lactate Levels
- Low evidence
- Animal Study
Exploring Gut Microbiota Imbalance in Irritable Bowel Syndrome: Potential Therapeutic Effects of Probiotics and Their Metabolites.
- 2024-12-31
- Review
- Nutrients 17(1)
- - María José García Mansilla
  - María Jesús Rodríguez Sojo
  - Andrea Roxana Lista
  - Ciskey Vanessa Ayala Mosqueda
  - Antonio Jesús Ruiz Malagón
  - Julio Gálvez
  - Alba Rodríguez Nogales
  - María José Rodríguez Sánchez
- PubMed: 39796588
- DOI: 10.3390/nu17010155
2 Insights on
- Improved Irritable Bowel Syndrome Symptoms
- Reduced Irritable Bowel Syndrome Symptoms
- Moderate evidence
- Rigorous Journal
Dietary interventions to reduce heavy metal exposure in antepartum and postpartum women: a systematic review.
- 2024-12-31
- Systematic Review
- Women's health nursing (Seoul, Korea) 30(4)
- - Su Ji Heo
  - Nalae Moon
  - Ju Hee Kim
- PubMed: 39756471
- DOI: 10.4069/whn.2024.12.16
1 Insight on
- Reduced Heavy Metal Level in Blood
- High evidence
Dileucine ingestion, but not leucine, increases lower body strength and performance following resistance training: A double-blind, randomized, placebo-controlled trial.
- 2024-12-31
- RCT
- PloS one 19(12)
- - Anthony M Hagele
  - Joesi M Krieger
  - Connor J Gaige
  - Kevin F Holley
  - Kristen N Gross
  - Joshua M Iannotti
  - Leah E Allen
  - Paige J Sutton
  - Logan S Orr
  - Petey W Mumford
  - Martin Purpura
  - Ralf Jager
  - Chad M Kerksick
- PubMed: 39739679
- DOI: 10.1371/journal.pone.0312997
9 Insights on
- High evidence