June 2016 Supplement Research Papers

• June 1

  • Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial.

    • 2016-06-01
    • RCT · n = 581
    • Beneficial microbes 7(3)
    • • T Culpepper
      • M C Christman
      • C Nieves
      • G J Specht
      • C C Rowe
      • S J Spaiser
      • A L Ford
      • W J Dahl
      • S A Girard
      • B Langkamp-Henken

    • PubMed: 26839075
    • DOI: 10.3920/bm2015.0156

    2 Insights on

    • Reduced Diarrhea Rate
    • Reduced Stress Level

    • High evidence
    • Large Human Trial
    • Rigorous Journal

  • Effects of heat-killed Lactobacillus kunkeei YB38 on human intestinal environment and bowel movement: a pilot study.

    • 2016-06-01
    • RCT · n = 29
    • Beneficial Microbes 7(3)
    • • T. Asama
      • Y. Kimura
      • T. Kono
      • T. Tatefuji
      • K. Hashimoto
      • Y. Benno

    • PubMed: 26839076
    • DOI: 10.3920/BM2015.0132

    4 Insights on

    • Reduced Faecal pH
    • Increased Bowel Movement Frequency
    • Increased Acetic Acid Levels in Feces
    • Reduced Bacteroides Fragilis Group Numbers

    • High evidence
• June 2

  • The diagnostic value of component-resolved diagnostics in peanut allergy in children attending a Regional Paediatric Allergology Clinic.

    • 2016-06-02
    • Clinical Trial · n = 72
    • BMC pediatrics 16(1)
    • • Leonieke N van Veen
      • Michiel Heron
      • Manou Batstra
      • Paul M M van Haard
      • Hans de Groot

    • PubMed: 27255511
    • DOI: 10.1186/s12887-016-0609-7

    2 Insights on

    • Improved Immune Response
    • Reduced Reaction Severity

    • High evidence
• June 8

  • Anti-viral Effect of Bifidobacterium adolescentis against Noroviruses

    • 2016-06-08
    • Frontiers in Microbiology 7
    • • Dan Li
      • A. Breiman
      • J. Le Pendu
      • M. Uyttendaele

    • PubMed: 27375585
    • DOI: 10.3389/fmicb.2016.00864

    2 Insights on

    • Reduced Norovirus Multiplication
    • Reduced Viral Binding

    • Low evidence
• June 9

  • Probiotics (Bifidobacterium longum) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy

    • 2016-06-09
    • RCT · n = 3
    • BioMed Research International 2015
    • • Kolsoom Parvaneh
      • M. Ebrahimi
      • M. Sabran
      • G. Karimi
      • Angela Ng Min Hwei
      • Saif Abdul-Majeed
      • Z. Ahmad
      • Z. Ibrahim
      • R. Jamaluddin

    • PubMed: 26366421
    • DOI: 10.1155/2015/897639

    4 Insights on

    • Reduced Alveolar Bone Resorption
    • Improved Bone Mass Density
    • Improved Bone Microstructure
    • Improved Bone Formation

    • Low evidence
    • Highly Cited
    • Rigorous Journal
    • Animal Study

  • Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model

    • 2016-06-09
    • RCT
    • Frontiers in Microbiology 7
    • • C. Hidalgo-Cantabrana
      • F. Algieri
      • A. Rodríguez‐Nogales
      • T. Vezza
      • P. Martínez-Camblor
      • A. Margolles
      • P. Ruas-Madiedo
      • J. Gálvez

    • PubMed: 27375589
    • DOI: 10.3389/fmicb.2016.00868

    9 Insights on

    • Improved Disease Activity Index Score
    • Increased Regulatory T Cell Count
    • Enhanced Regulatory T-Cells in Mesenteric Lymphoid Nodes
    • Reduced Disease Activity Index (DAI) Levels
    • Improved Gastrointestinal Survival
    • Reduced Disease Activity in Colitis
    • Increased Regulatory T-Cells in Mesenteric Lymphoid Nodes
    • Reduced Disease Activity Index in Colitis Model
    • Improved Clinical Outcomes in Colitis

    • High evidence

  • Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial.

    • 2016-06-09
    • RCT · n = 17
    • Phytotherapy research : PTR 30(10)
    • • Jee Hyun An
      • Dong-Lim Kim
      • Tae-Bum Lee
      • Kyeong Jin Kim
      • Sun Hwa Kim
      • Nam Hoon Kim
      • Hee Young Kim
      • Dong Seop Choi
      • Sin Gon Kim

    • PubMed: 27279471
    • DOI: 10.1002/ptr.5664

    4 Insights on

    • Reduced Postprandial Glucose
    • Reduced Oxidized Low-Density Lipoprotein Level
    • Reduced Monocyte Chemoattractant Protein-1 Level
    • Improved HOMA-B

    • High evidence
• June 13

  • Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial

    • 2016-06-13
    • RCT · n = 243
    • European Journal of Applied Physiology 116(8)
    • • M. Gleeson
      • N. Bishop
      • Lauren Struszczak

    • PubMed: 27294502
    • DOI: 10.1007/s00421-016-3415-x

    2 Insights on

    • Reduced Plasma CMV Antibody Titres
    • Reduced Plasma EBV Antibody Titres

    • High evidence
    • Rigorous Journal

  • In vitro and in vivo probiotic assessment of Leuconostoc mesenteroides P45 isolated from pulque, a Mexican traditional alcoholic beverage.

    • 2016-06-13
    • SpringerPlus 5(1)
    • • Martha Giles-Gómez
      • Jorge Giovanni Sandoval García
      • Violeta Matus
      • Itzia Campos Quintana
      • Francisco Bolívar
      • Adelfo Escalante

    • PubMed: 27375977
    • DOI: 10.1186/s40064-016-2370-7

    2 Insights on

    • Reduced Pathogen Growth
    • Reduced Salmonella Infection

    • Low evidence
• June 15

  • Bifidobacteria and Their Role as Members of the Human Gut Microbiota

    • 2016-06-15
    • Frontiers in Microbiology 7
    • • A. O’Callaghan
      • D. van Sinderen

    • PubMed: 27379055
    • DOI: 10.3389/fmicb.2016.00925

    1 Insight on

    • Positive Health Benefits

    • Low evidence
    • Highly Cited

  • Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress

    • 2016-06-15
    • RCT · n = 47
    • Applied and Environmental Microbiology 82(12)
    • • Akito Kato-Kataoka
      • K. Nishida
      • M. Takada
      • M. Kawai
      • H. Kikuchi-Hayakawa
      • K. Suda
      • H. Ishikawa
      • Y. Gondo
      • K. Shimizu
      • T. Matsuki
      • A. Kushiro
      • Ryoutaro Hoshi
      • O. Watanabe
      • Tomoki Igarashi
      • K. Miyazaki
      • Y. Kuwano
      • K. Rokutan

    • PubMed: 27208120
    • DOI: 10.1128/AEM.04134-15

    15 Insights on

    • Improved Gut Microbiota Diversity
    • Reduced Gastrointestinal Symptoms
    • Reduced Abdominal Pain
    • Reduced Salivary Cortisol Levels Under Stress
    • Reduced Perceived Stress
    • Reduced Abdominal Dysfunction
    • Preserved Gut Microbiota Diversity
    • Maintained Gut Microbiota Diversity
    • Maintained Lower Salivary Cortisol Levels
    • Relieved Abdominal Dysfunction
    • Reduced Stress Markers
    • Reduced Percentage of Bacteroidaceae in Gut Microbiota
    • Reduced Stress Levels
    • Reduced Stress-Related Abdominal Dysfunction
    • Reduced Stress-Induced Gastrointestinal Symptoms

    • High evidence
    • Highly Cited
    • Rigorous Journal
• June 22

  • Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies.

    • 2016-06-22
    • Review
    • Journal of evidence-based complementary & alternative medicine 22(1)
    • • Haider Abdul-Lateef Mousa

    • PubMed: 27055821
    • DOI: 10.1177/2156587216641831

    2 Insights on

    • Reduced Cold Duration
    • Reduced Cold Severity

    • Low evidence
• June 24

  • Antiviral activity of Lactobacillus reuteri Protectis against Coxsackievirus A and Enterovirus 71 infection in human skeletal muscle and colon cell lines.

    • 2016-06-24
    • Virology journal 13(1)
    • • Lei Yin Emily Ang
      • Horng Khit Issac Too
      • Eng Lee Tan
      • Tak-Kwong Vincent Chow
      • Lynette Pei-Chi Shek
      • Elizabeth Huiwen Tham
      • Sylvie Alonso

    • PubMed: 27341804
    • DOI: 10.1186/s12985-016-0567-6

    1 Insight on

    • Reduced Enterovirus Infectivity

    • Low evidence
• June 28

  • Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

    • 2016-06-28
    • Frontiers in Microbiology 7
    • • A. Rivière
      • Marija Selak
      • D. Lantin
      • F. Leroy
      • L. De Vuyst

    • PubMed: 27446020
    • DOI: 10.3389/fmicb.2016.00979

    8 Insights on

    • Enhanced Immune Function
    • Enhanced Pathogen Protection
    • Increased Serum Antioxidant Levels
    • Increased Butyrate Production
    • Degraded Non-Digestible Carbohydrates
    • Increased Vitamin B Production
    • Increased Conjugated Linoleic Acid Production
    • Increased Bifidobacteria in Colon

    • Low evidence
    • Highly Cited
• June 29

  • Lactobacillus crispatus inhibits the infectivity of Chlamydia trachomatis elementary bodies, in vitro study

    • 2016-06-29
    • Scientific Reports 6(1)
    • • P. Nardini
      • Rogers A. Ñahui Palomino
      • C. Parolin
      • L. Laghi
      • C. Foschi
      • R. Cevenini
      • B. Vitali
      • A. Marangoni

    • PubMed: 27354249
    • DOI: 10.1038/srep29024

    1 Insight on

    • Reduced Chlamydia trachomatis Infectivity

    • Low evidence
    • Highly Cited
• Undated – 4 supplement studies

  • Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.

    • 2016-06
    • RCT · n = 51
    • Nutrition 32(6)
    • • L. J. Bernini
      • A. Simão
      • D. Alfieri
      • M. A. Lozovoy
      • Naiara Lourenço Mari
      • C. H. B. de Souza
      • I. Dichi
      • G. N. Costa

    • PubMed: 27126957
    • DOI: 10.1016/j.nut.2015.11.001

    11 Insights on

    • Reduced Body Mass Index
    • Reduced Total Cholesterol Levels
    • Reduced Low-Density Lipoprotein Level
    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Interleukin-6 Levels
    • Reduced Pro-Inflammatory Cytokines
    • Reduced LDL Cholesterol
    • Reduced Blood Cholesterol
    • Reduced Low-Density Lipoprotein Cholesterol
    • Reduced Tumor Necrosis Factor-α (TNF-α)
    • Reduced Tumor Necrosis Factor-α Levels

    • High evidence
    • Highly Cited

  • Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins

    • 2016-06
    • Antimicrobial Agents and Chemotherapy 60(6)
    • • Gabrielle Ripert
      • S. Racedo
      • A. Elie
      • C. Jacquot
      • P. Bressollier
      • M. Urdaci

    • PubMed: 27001810
    • DOI: 10.1128/AAC.02815-15

    3 Insights on

    • Reduced Cytotoxic Effects
    • Normalized Expression of rhoB Gene
    • Reduced Toxin-induced Cytotoxicity

    • Low evidence
    • Highly Cited

  • Does Short-Term High Dose Probiotic Supplementation Containing Lactobacillus casei Attenuate Exertional-Heat Stress Induced Endotoxaemia and Cytokinaemia?

    • 2016-06
    • RCT · n = 8
    • International Journal of Sport Nutrition and Exercise Metabolism 26(3)
    • • S. Gill
      • D. Allerton
      • Paula Ansley-Robson
      • K. Hemmings
      • Martin Cox
      • R. Costa

    • PubMed: 26568577
    • DOI: 10.1123/ijsnem.2015-0186

    2 Insights on

    • Reduced Exertional Heat Stress-Induced Endotoxemia
    • Reduced Cytokine Response to Exertional Heat Stress

    • High evidence

  • Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers - Randomized, double blind, placebo-controlled study.

    • 2016-06
    • RCT · n = 210
    • Clinical Nutrition 35(3)
    • • I. Hojsak
      • Ana Močić Pavić
      • T. Kos
      • J. Dumančić
      • S. Kolaček

    • PubMed: 26031908
    • DOI: 10.1016/j.clnu.2015.05.004

    7 Insights on

    • Reduced Gastrointestinal Infections
    • Reduced Total Infections
    • Reduced Respiratory Infections
    • Reduced Day Care Absenteeism Due to Infections
    • Reduced Antibiotic Use Due to Infections
    • Reduced Mean Number of Infections per Child
    • Duration of Symptoms

    • High evidence