January 2020 Supplement Research Papers

• January 1

  • Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.

    • 2020-01-01
    • Meta-Analysis · n = 535
    • Journal of evidence-based integrative medicine 25
    • • Noriko Shinjyo
      • Guy Waddell
      • Julia Green

    • PubMed: 33086877
    • DOI: 10.1177/2515690x20967323

    1 Insight on

    • Reduced Anxiety

    • High evidence

  • Effects of dietary supplementation with Pediococcus acidilactici ZPA017 on reproductive performance, fecal microbial flora and serum indices in sows during late gestation and lactation.

    • 2020-01-01
    • RCT · n = 94
    • Asian-Australasian Journal of Animal Sciences 33(1)
    • • Hui Liu
      • Sixin Wang
      • Dongyan Zhang
      • Jing Wang
      • Wei Zhang
      • Yamin Wang
      • H. Ji

    • PubMed: 36379222
    • DOI: 10.5713/AJAS.18.0764

    14 Insights on

    • Increased Fecal Lactobacilli Population
    • Reduced Aminotransferase Levels
    • Increased Weaning Weight
    • Increased Immunoglobulin G Levels
    • Increased Serum Total Protein Levels
    • Increased Weaning Piglet Count
    • Increased Survival Rate at Weaning
    • Reduced Serum Haptoglobin Concentration
    • Increased Immunoglobulin A Levels
    • Improved Survival Rate at Weaning
    • Reduced Fecal E. coli Populations
    • Reduced Fecal Staphylococcus aureus Populations
    • Elevated Serum Immunoglobulin Levels
    • Reduced Serum Alanine Aminotransferase Activity

    • Low evidence
    • Rigorous Journal
    • Animal Study
• January 3

  • Beta alanine supplementation effects on metabolic contribution and swimming performance.

    • 2020-01-03
    • RCT
    • Journal of the International Society of Sports Nutrition 17(1)
    • • Matheus Silva Norberto
      • Ricardo Augusto Barbieri
      • Danilo Rodrigues Bertucci
      • Ronaldo Bucken Gobbi
      • Eduardo Zapaterra Campos
      • Alessandrou Moura Zagatto
      • Ellen Cristini De Freitas
      • Marcelo Papoti

    • PubMed: 32711541
    • DOI: 10.1186/s12970-020-00365-6

    4 Insights on

    • Reduced Fatigue Index
    • Reduced Blood Lactate Accumulation
    • Reduced Anaerobic Lactic Energy
    • Reduced Anaerobic Participation

    • High evidence

  • Effect of dietary supplementation with brewer's yeast hydrolysate on growth performance, faecal microbial counts, diarrhoea score, blood profile, rectal temperature in weanling pigs challenged with lipopolysaccharide.

    • 2020-01-03
    • RCT · n = 40
    • Journal of Animal Physiology and Animal Nutrition 104(2)
    • • Jing Hu
      • J. W. Park
      • I. Kim

    • PubMed: 31899588
    • DOI: 10.1111/jpn.13301

    2 Insights on

    • Reduced Diarrhea Incidence
    • Improved Gain:Feed Ratio

    • Low evidence
    • Animal Study
• January 6

  • XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products.

    • 2020-01-06
    • Review
    • Marine drugs 18(1)
    • • Rui Pedrosa
      • Susana P Gaudêncio
      • Vitor Vasconcelos

    • PubMed: 31935809
    • DOI: 10.3390/md18010040

    1 Insight on

    • Improved Gastrointestinal Health

    • Low evidence
• January 13

  • Dose-Response Recovery of Probiotic Strains in Simulated Gastro-Intestinal Passage.

    • 2020-01-13
    • Microorganisms 8(1)
    • • Sofia Forssten
      • Arthur C Ouwehand

    • PubMed: 31941108
    • DOI: 10.3390/microorganisms8010112

    3 Insights on

    • Increased Short-Chain Fatty Acid Production
    • Viable Probiotic Strain Recovery
    • Improved Gastrointestinal Recovery

    • Low evidence
• January 15

  • Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity

    • 2020-01-15
    • RCT · n = 20
    • Nutrients 12(1)
    • • I. Sergeev
      • Thamer Aljutaily
      • G. Walton
      • E. Huarte

    • PubMed: 31952249
    • DOI: 10.3390/nu12010222

    1 Insight on

    • Reduced Blood Glucose Levels

    • High evidence
    • Highly Cited

  • Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial

    • 2020-01-15
    • RCT · n = 60
    • Nutrients 12(1)
    • • M. Kubota
      • Kazuya Ito
      • K. Tomimoto
      • Mitsuharu Kanazaki
      • K. Tsukiyama
      • A. Kubota
      • H. Kuroki
      • M. Fujita
      • Y. Vandenplas

    • PubMed: 31952280
    • DOI: 10.3390/nu12010225

    4 Insights on

    • Improved Bowel Movement Frequency
    • Unchanged Stool Consistency
    • Improved Defecation Condition
    • Maintained Gastrointestinal Microbiome Stability

    • High evidence

  • Lactobacillus reuteri improves gut barrier function and affects diurnal variation of the gut microbiota in mice fed a high-fat diet.

    • 2020-01-15
    • Food & Function 10(8)
    • • Shuangqiu Li
      • Ce Qi
      • Hualing Zhu
      • R. Yu
      • C. Xie
      • Yuande Peng
      • S. Yin
      • Jianhui Fan
      • Suqing Zhao
      • Jin Sun

    • PubMed: 31304501
    • DOI: 10.1039/c9fo00417c

    17 Insights on

    • Reduced Total Cholesterol Levels
    • Improved Intestinal Barrier Function
    • Reduced Triglyceride Levels
    • Improved Liver Function
    • Increased SCFA Levels
    • Increased Short-Chain Fatty Acid Production
    • Reduced Body Weight Gain
    • Reduced Weight Gain
    • Improved Cholesterol Levels
    • Reduced Testicular Fat Accumulation
    • Increased Locomotor Activity During Active Phase
    • Reduced Triglyceridemia
    • Induced Circadian Rhythm-Dependent Short-Chain Fatty Acid Production by Gut Microbiota
    • Improved Intestinal Epithelial Barrier Function
    • Modulated Diurnal Short-Chain Fatty Acid Production
    • Altered Short-Chain Fatty Acid Production by Gut Microbiota
    • Reduced Hypercholesterolemia

    • Low evidence

  • Heat-Killed Bifidobacterium breve B-3 Enhances Muscle Functions: Possible Involvement of Increases in Muscle Mass and Mitochondrial Biogenesis

    • 2020-01-15
    • Clinical Trial
    • Nutrients 12(1)
    • • K. Toda
      • Yuki Yamauchi
      • A. Tanaka
      • T. Kuhara
      • T. Odamaki
      • Shin Yoshimoto
      • J. Xiao

    • PubMed: 31952193
    • DOI: 10.3390/nu12010219

    5 Insights on

    • Increased Muscle Mass
    • Improved Muscle Strength
    • Improved Muscle Metabolism
    • Enhanced Mitochondrial Biogenesis
    • Promoted Oxidative Muscle Fiber Composition

    • Low evidence
    • Animal Study
• January 16

  • Indole-3-lactic acid, a metabolite of tryptophan, secreted by Bifidobacterium longum subspecies infantis is anti-inflammatory in the immature intestine.

    • 2020-01-16
    • Pediatric Research 88(2)
    • • Di Meng
      • E. Sommella
      • E. Salviati
      • P. Campiglia
      • K. Ganguli
      • K. Djebali
      • Weishu Zhu
      • W. Walker

    • PubMed: 31945773
    • DOI: 10.1038/s41390-019-0740-x

    3 Insights on

    • Reduced Intestinal Inflammation
    • Prevention of Necrotising Enterocolitis
    • Reduced Inflammation in Intestinal Enterocytes

    • Moderate evidence
    • Highly Cited
    • Rigorous Journal
• January 19

  • Regulation of Skeletal Muscle Function by Amino Acids.

    • 2020-01-19
    • Review
    • Nutrients 12(1)
    • • Yasutomi Kamei
      • Yukino Hatazawa
      • Ran Uchitomi
      • Ryoji Yoshimura
      • Shinji Miura

    • PubMed: 31963899
    • DOI: 10.3390/nu12010261

    2 Insights on

    • Improved Cognitive Function
    • Improved Physical Performance

    • High evidence
    • Highly Cited
    • Rigorous Journal
• January 20

  • Restitution of gut microbiota in Ugandan children administered with probiotics (Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12) during treatment for severe acute malnutrition.

    • 2020-01-20
    • RCT
    • Gut microbes 11(4)
    • • Josué L Castro-Mejía
      • Sinéad O'Ferrall
      • Łukasz Krych
      • Elaine O'Mahony
      • Hanifa Namusoke
      • Betty Lanyero
      • Witold Kot
      • Nicolette Nabukeera-Barungi
      • Kim Fleischer Michaelsen
      • Christian Mølgaard
      • Henrik Friis
      • Benedikte Grenov
      • Dennis S Nielsen

    • PubMed: 31959047
    • DOI: 10.1080/19490976.2020.1712982

    2 Insights on

    • Reduced Diarrhea Incidence
    • Improved Gut Microbiota Richness

    • High evidence
• January 21

  • Evaluation of urate-lowering therapy in hyperuricemia patients: a systematic review and Bayesian network meta-analysis of randomized controlled trials.

    • 2020-01-21
    • Systematic Review · n = 401
    • Clinical rheumatology 39(5)
    • • Yu-Jiun Lin
      • Shiyng-Yu Lin
      • Chang-Hsien Lin
      • Sen-Te Wang
      • Shy-Shin Chang

    • PubMed: 31965378
    • DOI: 10.1007/s10067-019-04893-8

    1 Insight on

    • Reduced Adherence Attrition

    • High evidence
• January 23

  • The Preliminary Development of an in vitro Poultry Cecal Culture Model to Evaluate the Effects of Original XPCTM for the Reduction of Campylobacter jejuni and Its Potential Effects on the Microbiota.

    • 2020-01-23
    • Frontiers in microbiology 10
    • • Kristina M Feye
      • Peter M Rubinelli
      • William Evan Chaney
      • Hilary O Pavlidis
      • Michael H Kogut
      • Steven C Ricke

    • PubMed: 32038534
    • DOI: 10.3389/fmicb.2019.03062

    1 Insight on

    • Reduced Campylobacter jejuni Survival

    • Low evidence
• January 24

  • Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome

    • 2020-01-24
    • PLOS ONE 15(1)
    • • A. De Cesare
      • C. Sala
      • G. Castellani
      • A. Astolfi
      • V. Indio
      • A. Giardini
      • G. Manfreda

    • PubMed: 31978143
    • DOI: 10.1371/journal.pone.0228338

    6 Insights on

    • Increased Beneficial Gut Microbiota
    • Increased Lactobacillus acidophilus in Crop at 14 Days
    • Increased Functional Genes
    • Enhanced Gut Health
    • Increased Abundance of Beneficial Microbes
    • Increased Functional Genes in Caeca

    • Low evidence
    • Rigorous Journal
• January 28

  • GABA potentiate the immunoregulatory effects of Lactobacillus brevis BGZLS10-17 via ATG5-dependent autophagy in vitro

    • 2020-01-28
    • Scientific Reports 10(1)
    • • S. S. Bajić
      • Jelena Đokić
      • M. Dinić
      • S. Tomić
      • N. Popović
      • Emilija Brdarić
      • N. Golić
      • M. Tolinački

    • PubMed: 31992761
    • DOI: 10.1038/s41598-020-58177-2

    4 Insights on

    • Enhanced Autophagy
    • Enhanced Immunoregulatory Function
    • Reduced Immune Cell Proliferation
    • Enhanced Immunoregulatory Molecule Activity

    • Low evidence
    • Rigorous Journal
• January 30

  • Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial

    • 2020-01-30
    • RCT · n = 330
    • Nutrients 12(2)
    • • C. Martoni
      • S. Srivastava
      • G. Leyer

    • PubMed: 32019158
    • DOI: 10.3390/nu12020363

    7 Insights on

    • Improved Bowel Movement Frequency
    • Improved Stool Consistency
    • Reduced Abdominal Pain Severity
    • Reduced IBS Symptoms
    • Improved Overall IBS Symptoms
    • Improved Abdominal Pain Severity
    • Reduced Irritable Bowel Syndrome Symptom Severity

    • High evidence
    • Large Human Trial

  • Effect of Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the Vaginal Microbiota, Cytokines and Chemokines in Pregnant Women

    • 2020-01-30
    • RCT · n = 86
    • Nutrients 12(2)
    • • Siwen Yang
      • G. Reid
      • J. Challis
      • G. Gloor
      • E. Asztalos
      • D. Money
      • Shannon Seney
      • A. Bocking

    • PubMed: 32019222
    • DOI: 10.3390/nu12020368

    13 Insights on

    • Increased Interleukin-10 Levels
    • No Adverse Health Effects
    • Absence of Adverse Pregnancy Complications
    • No Significant Impact on Vaginal Microbiota
    • Normal Pregnancy Outcomes
    • No Adverse Effects
    • Successful Pregnancy Outcome
    • Normalized Nugent Score
    • Maintained Vaginal Microbiota
    • No Change in Cytokines or Chemokines Levels
    • Unchanged Vaginal Microbiota Diversity
    • Stable Vaginal Microbiota
    • No Significant Improvement in Vaginal Nugent Score

    • High evidence
• January 31

  • Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial

    • 2020-01-31
    • RCT · n = 130
    • Nutrients 12(2)
    • • T. Toshimitsu
      • A. Gotou
      • T. Sashihara
      • S. Hachimura
      • Nobuhiko Shioya
      • Satoru Suzuki
      • Y. Asami

    • PubMed: 32023901
    • DOI: 10.3390/nu12020374

    3 Insights on

    • Reduced Blood HbA1c Levels
    • Increased Blood Glucose Levels
    • Reduced Aggravation of Chronic Inflammation

    • High evidence
• Undated – 5 supplement studies

  • Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota.

    • 2020-01
    • Clinical Trial
    • Cancer Letters 469
    • • Danfeng Chen
      • Duochen Jin
      • Shumin Huang
      • Jingyi Wu
      • Mengque Xu
      • Tianyu Liu
      • Wenxiao Dong
      • Xiang Liu
      • Sinan Wang
      • Weilong Zhong
      • Yi Liu
      • Ruihuan Jiang
      • Meiyu Piao
      • Bangmao Wang
      • H. Cao

    • PubMed: 31734354
    • DOI: 10.1016/j.canlet.2019.11.019

    4 Insights on

    • Reduced Intestinal Tumor Development
    • Suppressed Wnt/β-catenin Signaling
    • Reduced Fecal Secondary Bile Acid Contents
    • Activation of G-Protein Coupled Receptors

    • Low evidence
    • Highly Cited
    • Animal Study

  • Lactobacillus acidophilus LB: a useful pharmabiotic for the treatment of digestive disorders

    • 2020-01
    • Review
    • Therapeutic Advances in Gastroenterology 13
    • • José María Remes Troche
      • E. Coss Adame
      • Miguel Ángel Valdovinos Díaz
      • O. Gómez Escudero
      • María Eugenia Icaza Chávez
      • José Antonio Chávez-Barrera
      • F. Zárate Mondragón
      • José Antonio Ruíz Velarde Velasco
      • Guillermo Rafael Aceves Tavares
      • Marco Antonio Lira Pedrín
      • Eduardo Cerda Contreras
      • R. Carmona Sánchez
      • Héctor Guerra López
      • Rodolfo Solana Ortiz

    • PubMed: 33281937
    • DOI: 10.1177/1756284820971201

    3 Insights on

    • Reduced Antibiotic-Associated Diarrhea
    • Reduced Incidence of Acute Diarrhoea
    • Reduced Incidence of Chronic Diarrhea

    • Moderate evidence
    • Rigorous Journal

  • Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virus.

    • 2020-01
    • Clinical Trial
    • International Immunopharmacology 78
    • • F. Tonetti
      • M. A. Islam
      • M. G. Vizoso-Pinto
      • Hideki Takahashi
      • H. Kitazawa
      • J. Villena

    • PubMed: 31841753
    • DOI: 10.1016/j.intimp.2019.106115

    4 Insights on

    • Improved Humoral Immune Response
    • Improved Cellular Immune Response
    • Reduced Lung Inflammation
    • Improved Vaccine Response in Immunocompromised Hosts

    • Low evidence
    • Rigorous Journal
    • Animal Study

  • Effect of a bioactive product SEL001 from Lactobacillus sakei probio65 on gut microbiota and its anti-colitis effects in a TNBS-induced colitis mouse model

    • 2020-01
    • Clinical Trial
    • Saudi Journal of Biological Sciences 27(1)
    • • I. Rather
      • V. Bajpai
      • Lew L. Ching
      • R. Majumder
      • Gyeong-Jun Nam
      • N. Indugu
      • Prashant Singh
      • Sanjay Kumar
      • N. Hajrah
      • J. Sabir
      • M. Kamli
      • Yong-Ha Park

    • PubMed: 31889846
    • DOI: 10.1016/j.sjbs.2019.09.004

    3 Insights on

    • Improved Gut Microbiota Composition
    • Reduced Colonic Inflammation
    • Reduced Inflammatory Markers in Ulcerative Colitis

    • Low evidence
    • Animal Study

  • Effects of intramammary infusion of Bifidobacterium breve on mastitis pathogens and somatic cell response in quarters from dairy cows with chronic subclinical mastitis.

    • 2020-01
    • Clinical Trial · n = 77
    • Animal Science Journal 91(1)
    • • H. Nagahata
      • Takuma Mukai
      • Y. Natsume
      • Miyuki Okuda
      • T. Ando
      • K. Hisaeda
      • S. Gondaira
      • H. Higuchi

    • PubMed: 32578314
    • DOI: 10.1111/asj.13406

    4 Insights on

    • Reduced Somatic Cell Counts in Chronic Subclinical Mastitis
    • Reduced Minor Mastitis-Causing Pathogens
    • Reduced Somatic Cell Count
    • Achieved Bacteriological Cure for Coagulase-Negative Staphylococci Infections

    • Low evidence
    • Animal Study