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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Lactobacillus plantarum and Its Probiotic and Food Potentialities
- 2017-03-07
- Review
- Probiotics and Antimicrobial Proteins 9(2)
- - H. Seddik
  - F. Bendali
  - F. Gancel
  - I. Fliss
  - G. Spano
  - D. Drider
- PubMed: 28271469
- DOI: 10.1007/s12602-017-9264-z
3 Insights on
- Moderate evidence
- Highly Cited
Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors
- 2017-03-07
- Frontiers in Microbiology 8
- - Krisztián Bene
  - D. Kavanaugh
  - C. Leclaire
  - A. P. Gunning
  - D. Mackenzie
  - Alexandra Wittmann
  - Ian D Young
  - N. Kawasaki
  - E. Rajnavolgyi
  - N. Juge
- PubMed: 28326063
- DOI: 10.3389/fmicb.2017.00321
2 Insights on
- Increased Pro-inflammatory Cytokine Release
- Th1 Polarized Immune Response Through Activation of moDCs
- Low evidence
Lactobacillus paracasei modulates the immune system of Galleria mellonella and protects against Candida albicans infection
- 2017-03-07
- Clinical Trial
- PLOS ONE 12(3)
- - R. D. Rossoni
  - B. Fuchs
  - P. P. de Barros
  - Marisol dos Santos Velloso
  - A. O. Jorge
  - J. C. Junqueira
  - E. Mylonakis
- PubMed: 28267809
- DOI: 10.1371/journal.pone.0173332
9 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat
- 2017-03-07
- RCT
- Scientific Reports 7(1)
- - E. Patterson
  - E. Patterson
  - R. Wall
  - R. Wall
  - Sara Lisai
  - R. Ross
  - T. Dinan
  - J. Cryan
  - G. Fitzgerald
  - S. Banni
  - E. Quigley
  - F. Shanahan
  - C. Stanton
  - C. Stanton
- PubMed: 28265110
- DOI: 10.1038/srep43300
7 Insights on
- High evidence
Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense
- 2017-03-06
- Clinical Trial
- Scientific Reports 7(1)
- - Xiaolong He
  - Qing Zeng
  - Santhosh Puthiyakunnon
  - Zhijie Zeng
  - Weijun Yang
  - Jiawen Qiu
  - Lei Du
  - S. Boddu
  - Tongwei Wu
  - Danxian Cai
  - Sheng-He Huang
  - Hong-yong Cao
- PubMed: 28262688
- DOI: 10.1038/srep43305
3 Insights on
- Low evidence
- Animal Study
Anti-nociceptive effects of Paecilomyces hepiali via multiple pathways in mouse models.
- 2017-03-03
- Clinical Trial
- Genetics and Molecular Research 15(3)
- - C. Wang
  - Juan Wang
  - D. Jia
  - Leilei Li
  - B. Jia
  - S. Fan
  - Junfeng Song
  - X. Hu
  - Yan Wang
  - Di Wang
- PubMed: 27706666
- DOI: 10.4238/gmr.15038996
3 Insights on
- Low evidence
- Animal Study
Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease
- 2017-02-28
- International Journal of Molecular Sciences 18(3)
- - Yunqi Weng
  - Jian Yao
  - S. Sparks
  - K. Wang
- PubMed: 28264497
- DOI: 10.3390/ijms18030523
1 Insight on
- Improved Antithrombotic Prevention
- Low evidence
- Highly Cited
Influence of Oral Probiotic Streptococcus salivarius K12 on Ear and Oral Cavity Health in Humans: Systematic Review
- 2017-02-24
- Systematic Review
- Probiotics and Antimicrobial Proteins 9(2)
- - Katarina-Kaja Župančić
  - V. Krikšić
  - Irena Kovačević
  - D. Kovačević
- PubMed: 28236205
- DOI: 10.1007/s12602-017-9261-2
2 Insights on
- Reduced Halitosis
- Reduced Occurrence of Secretory Otitis Media
- High evidence
The Effect of Bifidobacterium animalis ssp. lactis HN019 on Cellular Immune Function in Healthy Elderly Subjects: Systematic Review and Meta-Analysis
- 2017-02-24
- Meta-Analysis
- Nutrients 9(3)
- - L. Miller
  - L. Lehtoranta
  - M. Lehtinen
- PubMed: 28245559
- DOI: 10.3390/nu9030191
5 Insights on
- High evidence
Milk kefir: nutritional, microbiological and health benefits
- 2017-02-22
- Review
- Nutrition Research Reviews 30(1)
- - D. Rosa
  - M. Dias
  - Ł. Grześkowiak
  - S. A. Reis
  - L. L. Conceição
  - M. Pelúzio
- PubMed: 28222814
- DOI: 10.1017/S0954422416000275
10 Insights on
- Moderate evidence
- Highly Cited
Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice
- 2017-02-20
- Clinical Trial
- International Journal of Molecular Sciences 18(2)
- - Linlin Wang
  - Lujun Hu
  - Qi Xu
  - B. Yin
  - Dongsheng Fang
  - Gang Wang
  - Jianxin Zhao
  - H. Zhang
  - Wei Chen
- PubMed: 28230723
- DOI: 10.3390/ijms18020318
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled trial.
- 2017-02-07
- RCT · n = 46
- Diabetes, obesity & metabolism 19(4)
- - Reza Mobini
  - Valentina Tremaroli
  - Marcus Ståhlman
  - Fredrik Karlsson
  - Max Levin
  - Maria Ljungberg
  - Maja Sohlin
  - Heléne Bertéus Forslund
  - Rosie Perkins
  - Fredrik Bäckhed
  - Per-Anders Jansson
- PubMed: 28009106
- DOI: 10.1111/dom.12861
5 Insights on
- High evidence
- Highly Cited
Antimicrobial activity of Lactobacillus salivarius and Lactobacillus fermentum against Staphylococcus aureus
- 2017-02-02
- Pathogens and Disease 75(2)
- - Mi-Sun Kang
  - Hae-Soon Lim
  - Jong-Suk Oh
  - Y. Lim
  - K. Wuertz-Kozak
  - Janette M. Harro
  - M. Shirtliff
  - Y. Achermann
- PubMed: 28158586
- DOI: 10.1093/femspd/ftx009
5 Insights on
- Low evidence
- Highly Cited
Reduction of Aflatoxin B1 Toxicity by Lactobacillus plantarum C88: A Potential Probiotic Strain Isolated from Chinese Traditional Fermented Food “Tofu”
- 2017-01-27
- Clinical Trial
- PLOS ONE 12(1)
- - Li Huang
  - Cui-cui Duan
  - Yujuan Zhao
  - Lei Gao
  - Chunhua Niu
  - Jingbo Xu
  - Shengyu Li
- PubMed: 28129335
- DOI: 10.1371/journal.pone.0170109
4 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Promotility Action of the Probiotic Bifidobacterium lactis HN019 Extract Compared with Prucalopride in Isolated Rat Large Intestine
- 2017-01-26
- Clinical Trial · n = 20
- Frontiers in Neuroscience 11
- - J. Dalziel
  - R. Anderson
  - J. Peters
  - A. Lynch
  - N. Spencer
  - J. Dekker
  - N. Roy
- PubMed: 28184185
- DOI: 10.3389/fnins.2017.00020
1 Insight on
- Reduced Constipation
- Low evidence
- Animal Study
Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii.
- 2017-01-19
- Journal of the Science of Food and Agriculture 97(9)
- - S. Datta
  - D. Timson
  - U. Annapure
- PubMed: 27868205
- DOI: 10.1002/jsfa.8147
2 Insights on
- Improved Antioxidant Capacity
- Improved Stress Tolerance
- Low evidence
- Rigorous Journal
Lactobacillus rhamnosus GR-1 Attenuates Induction of Hypertrophy in Cardiomyocytes but Not through Secreted Protein MSP-1 (p75)
- 2017-01-13
- PLOS ONE 12(1)
- - G. Ettinger
  - J. Burton
  - G. Gloor
  - G. Reid
- PubMed: 28085895
- DOI: 10.1371/journal.pone.0168622
1 Insight on
- Reduced Cardiac Hypertrophy
- Low evidence
- Rigorous Journal
Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity.
- 2017-01-10
- Frontiers in behavioral neuroscience 10
- - Robert S Thompson
  - Rachel Roller
  - Agnieszka Mika
  - Benjamin N Greenwood
  - Rob Knight
  - Maciej Chichlowski
  - Brian M Berg
  - Monika Fleshner
- PubMed: 28119579
- DOI: 10.3389/fnbeh.2016.00240
5 Insights on
- Low evidence
The Association of Hot Red Chili Pepper Consumption and Mortality: A Large Population-Based Cohort Study
- 2017-01-09
- Observational · n = 16,179
- PLOS ONE 12(1)
- - Mustafa Chopan
  - B. Littenberg
- PubMed: 28068423
- DOI: 10.1371/journal.pone.0169876
2 Insights on
- Reduced Cardiovascular Disease Mortality
- Reduced Overall Mortality Rate
- High evidence
- Highly Cited
- Rigorous Journal
Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats
- 2017-01-05
- RCT · n = 3
- BMC Pediatrics 17(1)
- - Wenshen Wu
  - Yanli Wang
  - Jingjing Zou
  - Fang Long
  - Huiheng Yan
  - L. Zeng
  - Yunbin Chen
- PubMed: 28056921
- DOI: 10.1186/s12887-016-0759-7
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
- 2017-01-03
- RCT · n = 10
- Scientific Reports 7(1)
- - Z. Mujagic
  - P. de Vos
  - M. Boekschoten
  - C. Govers
  - Harm-Jan H. M. Pieters
  - N. D. de Wit
  - P. Bron
  - A. Masclee
  - F. Troost
- PubMed: 28045137
- DOI: 10.1038/srep40128
2 Insights on
- No Significant Effect on Small Intestinal Permeability
- Enhanced Intestinal Repair Processes
- High evidence
- Highly Cited
Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
- 2017-01-01
- RCT
- Medicina oral, patologia oral y cirugia bucal 22(1)
- - L-P Dantas
  - A de Oliveira-Ribeiro
  - L-M de Almeida-Souza
  - F-C Groppo
- PubMed: 27918731
- DOI: 10.4317/medoral.21140
5 Insights on
- High evidence
Probiotic Lactobacillus reuteri has antifungal effects on oral Candida species in vitro
- 2017-01-01
- Journal of Oral Microbiology 9(1)
- - M. Jørgensen
  - C. Kragelund
  - P. Ø. Jensen
  - M. Keller
  - S. Twetman
- PubMed: 28326154
- DOI: 10.1080/20002297.2016.1274582
2 Insights on
- Reduced Candida albicans Growth
- Reduced Candida albicans Aggregation
- Moderate evidence
- Highly Cited
- Rigorous Journal
Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children
- 2017-01-01
- RCT
- Microbial Ecology in Health and Disease 28(1)
- - R. Hemalatha
  - A. Ouwehand
  - M. Saarinen
  - U. Prasad
  - K. Swetha
  - V. Bhaskar
- PubMed: 28572751
- DOI: 10.1080/16512235.2017.1298340
2 Insights on
- Increased Total Bacterial Count
- Reduced Risk of Diarrhea
- High evidence
- Rigorous Journal
Effects of protein-carbohydrate supplementation on immunity and resistance training outcomes: a double-blind, randomized, controlled clinical trial.
- 2016-12-27
- RCT · n = 9
- European journal of applied physiology 117(2)
- - Fernando Naclerio
  - Eneko Larumbe-Zabala
  - Nadia Ashrafi
  - Marco Seijo
  - Birthe Nielsen
  - Judith Allgrove
  - Conrad P Earnest
- PubMed: 28028619
- DOI: 10.1007/s00421-016-3520-x
6 Insights on
- High evidence
The Surface-Associated Exopolysaccharide of Bifidobacterium longum 35624 Plays an Essential Role in Dampening Host Proinflammatory Responses and Repressing Local TH17 Responses
- 2016-12-15
- Clinical Trial
- Applied and Environmental Microbiology 82(24)
- - E. Schiavi
  - Marita Gleinser
  - Evelyn M. Molloy
  - D. Groeger
  - R. Frei
  - Ruth Ferstl
  - Noelia Rodriguez-Perez
  - M. Ziegler
  - R. Grant
  - T. F. Moriarty
  - S. Plattner
  - S. Healy
  - M. O'Connell Motherway
  - C. Akdis
  - J. Roper
  - F. Altmann
  - D. van Sinderen
  - L. O’Mahony
- PubMed: 27736791
- DOI: 10.1128/AEM.02238-16
6 Insights on
- Low evidence
- Highly Cited
- Rigorous Journal
- Animal Study
Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers
- 2016-12-14
- RCT
- Gut Microbes 8(1)
- - T. Kabbani
  - K. Pallav
  - S. Dowd
  - J. Villafuerte-Gálvez
  - R. Vanga
  - N. Castillo
  - J. Hansen
  - M. Dennis
  - D. Leffler
  - C. Kelly
- PubMed: 27973989
- DOI: 10.1080/19490976.2016.1267890
2 Insights on
- Reduced Antibiotic-Associated Diarrhea
- Mitigated Microbiota Changes
- High evidence
- Highly Cited
- Rigorous Journal
In vitro assessment of the antimicrobial potentials of Lactobacillus helveticus strains isolated from traditional cheese in Sinkiang China against food-borne pathogens.
- 2016-12-13
- Food & Function 7(2)
- - Xin Bian
  - S. Evivie
  - Zafarullah Muhammad
  - Guangwen Luo
  - Hong-zhang Liang
  - Nana Wang
  - G. Huo
- PubMed: 26648272
- DOI: 10.1039/c5fo01041a
1 Insight on
- Reduced Foodborne Pathogens
- Low evidence
Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats
- 2016-12-13
- Clinical Trial
- Journal of Diabetes Research 2016
- - Juan Wang
  - Lirong Teng
  - Yange Liu
  - Wenji Hu
  - Wenqi Chen
  - Xiaowen Hu
  - Yingwu Wang
  - Di Wang
- PubMed: 27034961
- DOI: 10.1155/2016/4368380
6 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Manuka honey sinus irrigation for the treatment of chronic rhinosinusitis: a randomized controlled trial.
- 2016-12-09
- RCT · n = 22
- International forum of allergy & rhinology 7(4)
- - Victoria S Lee
  - Ian M Humphreys
  - Patricia L Purcell
  - Greg E Davis
- PubMed: 27935259
- DOI: 10.1002/alr.21898
3 Insights on
- High evidence