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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Probiotic Lactobacillus fermentum KU200060 isolated from watery kimchi and its application in probiotic yogurt for oral health.
- 2020-10
- Microbial Pathogenesis 147
- - Sung-Min Lim
  - N. Lee
  - Kee-Tae Kim
  - H. Paik
- PubMed: 32758520
- DOI: 10.1016/j.micpath.2020.104430
6 Insights on
- Low evidence
l-Histidine Supplementation in Adults and Young Children with Atopic Dermatitis (Eczema).
- 2020-10
- Review · n = 98
- The Journal of nutrition 150
- - Neil K Gibbs
- PubMed: 33000160
- DOI: 10.1093/jn/nxaa200
3 Insights on
- Moderate evidence
The effect of Korean Red Ginseng on sarcopenia biomarkers in type 2 diabetes patients.
- 2020-09
- RCT
- Archives of gerontology and geriatrics 90
- - Kahui Park
  - Chul Woo Ahn
  - YuSik Kim
  - Ji Sun Nam
- PubMed: 32470863
- DOI: 10.1016/j.archger.2020.104108
4 Insights on
- High evidence
l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
- 2020-09
- RCT · n = 120
- The Journal of nutrition 150(9)
- - Ikuko Sasahara
  - Akiko Yamamoto
  - Masamichi Takeshita
  - Yasuyo Suga
  - Katsuya Suzuki
  - Natsumi Nishikata
  - Michihiro Takada
  - Masaki Hashimoto
  - Tomoyuki Mine
  - Yasuo Kobuna
  - Kenji Nagao
- PubMed: 32520991
- DOI: 10.1093/jn/nxaa156
5 Insights on
- High evidence
- Large Human Trial
Probiotic potentials of Pediococuss acidilactici isolated from wara; A Nigerian unripened soft cheese
- 2020-09
- Heliyon 6(9)
- - Temidayo Emmanuel Olajugbagbe
  - Oluwatosin Esther Elugbadebo
  - B. O. Omafuvbe
- PubMed: 32984599
- DOI: 10.1016/j.heliyon.2020.e04889
4 Insights on
- Low evidence
Lactobacillus gasseri JM1 with potential probiotic characteristics alleviates inflammatory response by activating the PI3K/Akt signaling pathway in vitro.
- 2020-09
- Journal of Dairy Science 103(9)
- - Linlin Sun
  - Wenli Tian
  - Xiaojie Guo
  - Yu Zhang
  - Xinyu Liu
  - Xuesong Li
  - Yazhen Tian
  - C. Man
  - Yujun Jiang
- PubMed: 32600763
- DOI: 10.3168/jds.2020-18187
2 Insights on
- Reduced Inflammatory Response
- Enhanced Anti-inflammatory Response
- Low evidence
- Rigorous Journal
Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary randomized study.
- 2020-09
- RCT · n = 190
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(5)
- - Victoria Sanborn
  - M. Azcarate-Peril
  - J. Gunstad
- PubMed: 32570015
- DOI: 10.1016/j.dsx.2020.05.034
2 Insights on
- Regulated Blood Glucose Levels
- Stabilized Hemoglobin A1c Level
- High evidence
Evaluation of the antitumor immune responses of probiotic Bifidobacterium bifidum in human papillomavirus-induced tumor model.
- 2020-08
- Clinical Trial
- Microbial Pathogenesis 145
- - Elahe Abdolalipour
  - Mehran Mahooti
  - A. Salehzadeh
  - A. Torabi
  - S. Mohebbi
  - A. Gorji
  - A. Ghaemi
- PubMed: 32325236
- DOI: 10.1016/j.micpath.2020.104207
4 Insights on
- Low evidence
- Animal Study
Titration of supplemental Bacillus subtilis subsp. subtilis American Type Culture Collection PTA-125135 to broiler chickens fed diets of 2 different metabolizable energy concentrations
- 2020-08
- Poultry Science 99(8)
- - L. Krueger
  - D. Spangler
  - M. Sims
- PubMed: 32731986
- DOI: 10.1016/j.psj.2020.04.027
1 Insight on
- Increased Mortality Rate
- Low evidence
- Rigorous Journal
Lactococcus Lactis subsp. cremoris Elicits Protection Against Metabolic Changes Induced by a Western-style Diet.
- 2020-08
- Gastroenterology 159(2)
- - C. Naudin
  - Kristal M. Maner-Smith
  - Joshua A. Owens
  - Grace M. Wynn
  - B. Robinson
  - J. Matthews
  - April R. Reedy
  - L. Luo
  - A. Wolfarth
  - T. Darby
  - E. Ortlund
  - Rheinallt M. Jones
- PubMed: 32169430
- DOI: 10.1053/j.gastro.2020.03.010
7 Insights on
- Low evidence
Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials.
- 2020-08
- Meta-Analysis
- Gastroenterology 159(2)
- - R. Morgan
  - Geoffrey A. Preidis
  - P. Kashyap
  - A. Weizman
  - B. Sadeghirad
  - Yaping Chang
  - I. Flórez
  - F. Foroutan
  - Shaneela Shahid
  - D. Zeraatkar
- PubMed: 32592699
- DOI: 10.1053/j.gastro.2020.05.096
2 Insights on
- Reduced Hospitalization Duration
- Reduced Severe Necrotizing Enterocolitis (NEC)
- High evidence
- Highly Cited
Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle.
- 2020-08
- RCT · n = 13
- Physiological reports 8(15)
- - Joaquin U Gonzales
  - Stephen M Fischer
  - Arun Maharaj
  - Heather Vellers
  - Todd Anderson
  - Adcharee Karnjanapiboonwong
  - Seenivasan Subbiah
  - J M Kellawan
  - Arturo Figueroa
- PubMed: 32776464
- DOI: 10.14814/phy2.14536
1 Insight on
- Improved Exercise-Onset Vasodilator Kinetics
- High evidence
Effect of Garcinia cambogia supplement on obesity indices: A systematic review and dose-response meta-analysis.
- 2020-08
- Meta-Analysis · n = 530
- Complementary therapies in medicine 52
- - Mahdieh Golzarand
  - Mahsa Omidian
  - Karamollah Toolabi
- PubMed: 32951714
- DOI: 10.1016/j.ctim.2020.102451
4 Insights on
- High evidence
Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study
- 2020-08
- Observational · n = 234
- Cell Reports Medicine 1(5)
- - Cristina Alcon-Giner
  - M. Dalby
  - Shabhonam Caim
  - Jennifer Ketskemety
  - A. Shaw
  - K. Sim
  - Melissa A. E. Lawson
  - R. Kiu
  - C. Leclaire
  - Lisa Chalklen
  - M. Kujawska
  - Suparna Mitra
  - Suparna Mitra
  - Fahmina Fardus-Reid
  - Gustav Belteki
  - Katherine McColl
  - J. Swann
  - J. Kroll
  - Paul Clarke
  - Paul Clarke
  - L. Hall
- PubMed: 32904427
- DOI: 10.1016/j.xcrm.2020.100077
5 Insights on
- High evidence
- Highly Cited
Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions.
- 2020-08
- Food Research International 134
- - A. T. Holkem
  - C. Fávaro-Trindade
  - M. Lacroix
- PubMed: 32517954
- DOI: 10.1016/j.foodres.2020.109274
2 Insights on
- Increased Anticancer Activity
- Increased Resistance to Simulated Gastrointestinal Conditions
- Low evidence
In vitro probiotic properties of Pediococcus pentosaceus L1 and its effects on enterotoxigenic Escherichia coli-induced inflammatory responses in porcine intestinal epithelial cells.
- 2020-07
- Microbial Pathogenesis 144
- - Huajuan Yin
  - Pengfei Ye
  - Qingzhi Lei
  - Yandong Cheng
  - Hang Yu
  - Jinjing Du
  - H. Pan
  - Zhenhui Cao
- PubMed: 32194178
- DOI: 10.1016/j.micpath.2020.104163
1 Insight on
- Reduced Inflammatory Response
- Low evidence
Bifidobacterium animalis subsp. lactis Bi‐07 contributes to increasing lactose digestion: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
- 2020-07
- EFSA Journal 18(7)
- - D. Turck
  - J. Castenmiller
  - S. de Henauw
  - K. Hirsch‐Ernst
  - J. Kearney
  - H. Knutsen
  - A. Maciuk
  - I. Mangelsdorf
  - H. Mcardle
  - A. Naska
  - C. Peláez
  - K. Pentieva
  - F. Thies
  - S. Tsabouri
  - M. Vinceti
  - Jean‐Loui s Bresson
  - A. Siani
- PubMed: 32742434
- DOI: 10.2903/j.efsa.2020.6198
3 Insights on
- Low evidence
Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis.
- 2020-07
- Meta-Analysis
- Advances in Nutrition 11(4)
- - J. Companys
  - L. Pla-Pagà
  - L. Calderón-Pérez
  - E. Llauradó
  - R. Solà
  - A. Pedret
  - R. Valls
- PubMed: 32277831
- DOI: 10.1093/advances/nmaa030
3 Insights on
- High evidence
- Highly Cited
Dietary Bacillus amyloliquefaciens enhance survival of white spot syndrome virus infected crayfish.
- 2020-07
- Clinical Trial
- Fish & Shellfish Immunology 102
- - Y. Lai
  - M. Luo
  - Fei Zhu
- PubMed: 32325213
- DOI: 10.1016/j.fsi.2020.04.033
6 Insights on
- Low evidence
- Animal Study
Arrhythmogenic foods - A growing medical problem.
- 2020-07
- Review
- Trends in cardiovascular medicine 30(5)
- - Raymond L Woosley
- PubMed: 31477495
- DOI: 10.1016/j.tcm.2019.08.007
1 Insight on
- Increased QTc Interval
- Low evidence
Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial.
- 2020-07
- RCT · n = 443
- The Lancet Gastroenterology & Hepatology 5(7)
- - V. Andresen
  - J. Gschossmann
  - P. Layer
- PubMed: 32277872
- DOI: 10.1016/S2468-1253(20)30056-X
10 Insights on
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
Tribulus Terrestris for Female Sexual Dysfunction: A Systematic Review.
- 2020-07
- Systematic Review · n = 279
- Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 42(07)
- - Ana Luiza Cabrera Martimbianco
  - Rafael Leite Pacheco
  - Rafael Leite Pacheco
  - Fábia Lima Vilarino
  - Carolina de Oliveira Cruz Latorraca
  - Maria Regina Torloni
  - Rachel Riera
- PubMed: 32736394
- DOI: 10.1055/s-0040-1712123
2 Insights on
- Increased Testosterone Level
- Improved Sexual Function
- High evidence
Enhancing immunity in viral infections, with special emphasis on COVID-19: A review.
- 2020-07
- Systematic Review · n = 640
- Diabetes & metabolic syndrome 14(4)
- - Ranil Jayawardena
  - Piumika Sooriyaarachchi
  - Michail Chourdakis
  - Chandima Jeewandara
  - Priyanga Ranasinghe
- PubMed: 32334392
- DOI: 10.1016/j.dsx.2020.04.015
2 Insights on
- Improved Immune Function
- Improved Respiratory Infection Resistance
- High evidence
- Highly Cited
Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation
- 2020-07
- RCT · n = 76
- BMJ Open Diabetes Research & Care 8(1)
- - Fanny Perraudeau
  - Paul J. McMurdie
  - James H. Bullard
  - Andrew Cheng
  - Colleen Cutcliffe
  - Achal Deo
  - J. Eid
  - Jessica Gines
  - Mohan Iyer
  - N. Justice
  - Wesley T Loo
  - Madeleine Nemchek
  - M. Schicklberger
  - Michael Souza
  - B. Stoneburner
  - Surabhi Tyagi
  - O. Kolterman
- PubMed: 32675291
- DOI: 10.1136/bmjdrc-2020-001319
1 Insight on
- Improved Postprandial Glucose Levels
- High evidence
- Rigorous Journal
Effects of supplementing yeast fermentate in the feed or drinking water on stress susceptibility, plasma chemistry, cytokine levels, antioxidant status, and stress- and immune-related gene expression of broiler chickens.
- 2020-07
- RCT
- Poultry science 99(7)
- - Jill R Nelson
  - Eric B Sobotik
  - Giridhar Athrey
  - Gregory S Archer
- PubMed: 32616224
- DOI: 10.1016/j.psj.2020.03.037
3 Insights on
- Low evidence
- Animal Study
Echinacea can help with Azithromycin in prevention of recurrent tonsillitis in children.
- 2020-07
- RCT · n = 100
- American journal of otolaryngology 41(4)
- - Osama G Abdel-Naby Awad
- PubMed: 32487336
- DOI: 10.1016/j.amjoto.2019.102344
2 Insights on
- Reduced Tonsillitis Attack Frequency
- Reduced Tonsillitis Severity
- High evidence
- Large Human Trial
Effects of single or conjoint administration of lactic acid bacteria as potential probiotics on growth, immune response and disease resistance of snakehead fish (Channa argus).
- 2020-07
- RCT · n = 720
- Fish & Shellfish Immunology 102
- - Yi‐di Kong
  - Chunshan Gao
  - Xiaoyan Du
  - J. Zhao
  - Min Li
  - Xiaofeng Shan
  - Guiqin Wang
- PubMed: 32387561
- DOI: 10.1016/j.fsi.2020.05.003
2 Insights on
- Improved Immune Response
- Enhanced Disease Resistance
- Low evidence
- Animal Study
Preventive effect of Lactobacillus reuteri on melanoma.
- 2020-06
- Clinical Trial
- Biomedicine & Pharmacotherapy 126
- - Meng Luo
  - Miaomiao Hu
  - Xu Feng
  - W. Xiaoli
  - Degang Dong
  - Wanchun Wang
- PubMed: 32126498
- DOI: 10.1016/j.biopha.2020.109929
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Unexpected effect of probiotics by Lactococcus lactis subsp. lactis against colitis induced by dextran sulfate sodium in mice.
- 2020-06
- Clinical Trial
- Journal of Infection and Chemotherapy 26(6)
- - Shinichirou Komaki
  - A. Haque
  - H. Miyazaki
  - Tetsuya Matsumoto
  - Shigeki Nakamura
- PubMed: 32122783
- DOI: 10.1016/j.jiac.2020.01.006
3 Insights on
- Low evidence
- Animal Study
Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil.
- 2020-06
- Clinical Trial
- Journal of Dairy Science 103(6)
- - Miaomiao Hu
  - Xiaoli Wu
  - Meng Luo
  - Hua Wei
  - Di Xu
  - Feng Xu
- PubMed: 32229117
- DOI: 10.3168/jds.2019-17836
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study