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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis.
- 2006-10
- RCT · n = 40
- Microbes and Infection 8(12-13)
- - K. Anukam
  - Emmanuel O. Osazuwa
  - Gibson I. Osemene
  - Felix Ehigiagbe
  - A. Bruce
  - G. Reid
- PubMed: 17045832
- DOI: 10.1016/J.MICINF.2006.08.008
1 Insight on
- Increased Cure Rate of Bacterial Vaginosis
- High evidence
- Highly Cited
Summary of Probiotic Activities of Bifidobacterium lactis HN019
- 2006-10
- Review
- Journal of Clinical Gastroenterology 40(9)
- - M. Sanders
- PubMed: 17016131
- DOI: 10.1097/01.mcg.0000225576.73385.f0
4 Insights on
- Low evidence
Protective effects and mechanisms of a probiotic bacterium Lactobacillus rhamnosus against experimental Edwardsiella tarda infection in tilapia (Oreochromis niloticus).
- 2006-10
- Clinical Trial
- Veterinary Immunology and Immunopathology 113(3-4)
- - N. Pirarat
  - Takeshi Kobayashi
  - T. Katagiri
  - M. Maita
  - M. Endo
- PubMed: 16870266
- DOI: 10.1016/J.VETIMM.2006.06.003
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effects of the probiotic strain Lactobacillus johnsonii strain La1 on autonomic nerves and blood glucose in rats.
- 2006-10
- Clinical Trial
- Life Sciences 79(20)
- - T. Yamano
  - M. Tanida
  - A. Niijima
  - Keiko Maeda
  - Nobuaki Okumura
  - Y. Fukushima
  - K. Nagai
- PubMed: 16893554
- DOI: 10.1016/J.LFS.2006.06.038
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother-child pair.
- 2006-10
- International Journal of Food Microbiology 112(1)
- - R. Martín
  - E. Jiménez
  - M. Olivares
  - M. Marín
  - L. Fernández
  - J. Xaus
  - J. M. Rodríguez
- PubMed: 16843562
- DOI: 10.1016/J.IJFOODMICRO.2006.06.011
3 Insights on
- Low evidence
- Highly Cited
Molecular Identification of Leuconostoc mesenteroides as a Cause of Brain Abscess in an Immunocompromised Patient
- 2006-08
- Case Report · n = 1
- Journal of Clinical Microbiology 44(8)
- - A. Albanese
  - T. Spanu
  - M. Sali
  - F. Novegno
  - T. D'Inzeo
  - R. Santangelo
  - A. Mangiola
  - C. Anile
  - G. Fadda
- PubMed: 16891540
- DOI: 10.1128/JCM.00448-06
1 Insight on
- Reduced Brain Abscess Incidence
- Low evidence
Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 modify carboxylic acid formation in the hindgut of rats given pectin, inulin, and lactitol.
- 2006-08
- Clinical Trial
- The Journal of Nutrition 136(8)
- - U. Nilsson
  - M. Nyman
  - S. Ahrné
  - E. O. Sullivan
  - G. Fitzgerald
- PubMed: 16857837
- DOI: 10.1093/JN/136.8.2175
2 Insights on
- Increased Faecal Carboxylic Acid Concentration
- Reduced Carboxylic Acids Concentration in Distal Colon with Lactitol
- Low evidence
- Animal Study
Immunomodulatory effects of polysaccharides produced by Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1.
- 2006-08
- Clinical Trial
- Journal of Dairy Science 89(8)
- - Seiya Makino
  - Shuji Ikegami
  - Hiroshi Kano
  - T. Sashihara
  - H. Sugano
  - H. Horiuchi
  - Tadao Saito
  - M. Oda
- PubMed: 16840603
- DOI: 10.3168/JDS.S0022-0302(06)72560-7
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Antimicrobial potential of four Lactobacillus strains isolated from breast milk
- 2006-07
- Journal of Applied Microbiology 101(1)
- - M. Olivares
  - M. Díaz-Ropero
  - R. Martín
  - J. M. Rodríguez
  - J. Xaus
- PubMed: 16834593
- DOI: 10.1111/j.1365-2672.2006.02981.x
4 Insights on
- Low evidence
- Highly Cited
Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
- 2006-07
- RCT · n = 362
- The American Journal of Gastroenterology 101(7)
- - P. Whorwell
  - L. Altringer
  - J. Morel
  - Yvonne Bond
  - D. Charbonneau
  - L. O’Mahony
  - B. Kiely
  - F. Shanahan
  - E. Quigley
- PubMed: 16863564
- DOI: 10.1111/j.1572-0241.2006.00734.x
12 Insights on
- High evidence
- Large Human Trial
- Highly Cited
Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice.
- 2006-07
- Clinical Trial
- FEMS Immunology & Medical Microbiology 47(2)
- - M. Rachid
  - C. Matar
  - J. Duarte
  - G. Perdigón
- PubMed: 16831211
- DOI: 10.1111/J.1574-695X.2006.00088.X
5 Insights on
- Low evidence
- Animal Study
Effects of dietary supplementation with Clostridium butyricum on the growth performance and humoral immune response in Miichthys miiuy
- 2006-07
- RCT · n = 150
- Journal of Zhejiang University SCIENCE B 7(7)
- - Zeng-fu Song
  - Tian-Xing Wu
  - L. Cai
  - Li-jing Zhang
  - Xiao-dong Zheng
- PubMed: 16773736
- DOI: 10.1631/jzus.2006.B0596
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Beneficial immunomodulatory activity of Lactobacillus casei in malnourished mice pneumonia: effect on inflammation and coagulation.
- 2006-07
- RCT
- Nutrition 22(7-8)
- - Graciela Agüero
  - J. Villena
  - S. Racedo
  - C. Haro
  - S. Alvarez
- PubMed: 16815495
- DOI: 10.1016/J.NUT.2006.03.013
18 Insights on
- Low evidence
- Animal Study
Short communication: Effects of Lactobacillus helveticus-fermented milk on the differentiation of cultured normal human epidermal keratinocytes.
- 2006-06
- Journal of Dairy Science 89(6)
- - H. Baba
  - A. Masuyama
  - T. Takano
- PubMed: 16702271
- DOI: 10.3168/JDS.S0022-0302(06)72275-5
6 Insights on
- Low evidence
The continuing story of class IIa bacteriocins.
- 2006-06
- Review
- Microbiology and molecular biology reviews : MMBR 70(2)
- - Djamel Drider
  - Gunnar Fimland
  - Yann Héchard
  - Lynn M McMullen
  - Hervé Prévost
- PubMed: 16760314
- DOI: 10.1128/mmbr.00016-05
1 Insight on
- Reduced Pathogenic Bacterial Activity
- Moderate evidence
- Highly Cited
Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial.
- 2006-05
- RCT · n = 125
- Microbes and Infection 8(6)
- - K. Anukam
  - Emmanuel O. Osazuwa
  - I. Ahonkhai
  - M. Ngwu
  - Gibson I. Osemene
  - A. Bruce
  - G. Reid
- PubMed: 16697231
- DOI: 10.1016/J.MICINF.2006.01.003
3 Insights on
- High evidence
- Highly Cited
Effects of a Lactobacillus casei synbiotic on serum lipoprotein, intestinal microflora, and organic acids in rats.
- 2006-05
- Clinical Trial
- Journal of Dairy Science 89(5)
- - M. Liong
  - N. Shah
- PubMed: 16606710
- DOI: 10.3168/JDS.S0022-0302(06)72207-X
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.
- 2006-05
- Observational · n = 944
- The Journal of Nutrition 136(5)
- - Y. Ikeda
  - M. Iki
  - A. Morita
  - E. Kajita
  - S. Kagamimori
  - Y. Kagawa
  - H. Yoneshima
- PubMed: 16614424
- DOI: 10.1093/JN/136.5.1323
2 Insights on
- Reduced Bone Loss
- Increased Total Hip Bone Mineral Density
- High evidence
- Highly Cited
Kinetic analysis of the antibacterial activity of probiotic lactobacilli towards Salmonella enterica serovar Typhimurium reveals a role for lactic acid and other inhibitory compounds.
- 2006-04
- Research in Microbiology 157(3)
- - L. Makras
  - Vagelis Triantafyllou
  - Domitille Fayol-Messaoudi
  - T. Adriany
  - G. Zoumpopoulou
  - E. Tsakalidou
  - A. Servin
  - L. De Vuyst
- PubMed: 16266797
- DOI: 10.1016/J.RESMIC.2005.09.002
1 Insight on
- Reduced Salmonella Enterica Invasion
- Low evidence
- Highly Cited
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression.
- 2006-04
- Biochemical and Biophysical Research Communications 343(1)
- - S. Sougioultzis
  - S. Simeonidis
  - K. Bhaskar
  - Xinhua Chen
  - P. Anton
  - S. Keates
  - C. Pothoulakis
  - C. Kelly
- PubMed: 16529714
- DOI: 10.1016/J.BBRC.2006.02.080
4 Insights on
- Low evidence
- Highly Cited
Oral administration of two probiotic strains, Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711, enhances the intestinal function of healthy adults.
- 2006-03
- RCT · n = 30
- International Journal of Food Microbiology 107(2)
- - M. Olivares
  - M. Díaz-Ropero
  - Nuria Gómez
  - F. Lara‐Villoslada
  - S. Sierra
  - J. Maldonado
  - Rocío Martín
  - E. López-Huertas
  - J. M. Rodríguez
  - J. Xaus
- PubMed: 16271414
- DOI: 10.1016/J.IJFOODMICRO.2005.08.019
5 Insights on
- High evidence
- Highly Cited
Two subpopulations of Listeria monocytogenes occur at subinhibitory concentrations of leucocin 4010 and nisin.
- 2006-02
- Applied and environmental microbiology 72(2)
- - Tina Hornbaek
  - Per B Brockhoff
  - Henrik Siegumfeldt
  - Birgitte Bjørn Budde
- PubMed: 16461719
- DOI: 10.1128/aem.72.2.1631-1638.2006
1 Insight on
- Reduced Antilisterial Activity
- Low evidence
- Rigorous Journal
Effects of a dried Bacillus subtilis culture on egg quality.
- 2006-02
- RCT
- Poultry Science 85(2)
- - L. Li
  - C. L. Xu
  - C. Ji
  - Q. Ma
  - K. Hao
  - Z. Jin
  - K. Li
- PubMed: 16523640
- DOI: 10.1093/PS/85.2.364
7 Insights on
- High evidence
- Highly Cited
Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1
- 2006-02
- RCT · n = 22
- British Journal of Nutrition 95(2)
- - T. Yamano
  - H. Iino
  - Mamiko Takada
  - S. Blum
  - F. Rochat
  - Y. Fukushima
- PubMed: 16469146
- DOI: 10.1079/BJN20051507
5 Insights on
- High evidence
- Highly Cited
Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets
- 2006-01
- RCT · n = 120
- Acta Odontologica Scandinavica 64(5)
- - E. Çaglar
  - Sule Kavaloglu Cildir
  - S. Ergeneli
  - N. Sandalli
  - S. Twetman
- PubMed: 16945898
- DOI: 10.1080/00016350600801709
2 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- Reduced Salivary Lactobacilli Levels
- High evidence
- Highly Cited
Plasma cobalamin and folate and their metabolic markers methylmalonic acid and total homocysteine among Egyptian children before and after nutritional supplementation with the probiotic bacteria Lactobacillus acidophilus in yoghurt matrix
- 2006-01
- RCT
- International Journal of Food Sciences and Nutrition 57(7-8)
- - M. Mohammad
  - A. Molloy
  - J. Scott
  - >Laila Hussein
- PubMed: 17162326
- DOI: 10.1080/09637480600968735
5 Insights on
- High evidence
Effect of regular ingestion of Saccharomyces boulardii plus inulin or Lactobacillus acidophilus LB in children colonized by Helicobacter pylori
- 2005-12
- RCT · n = 2,585
- Acta Paediatrica 94(12)
- - M. Gotteland
  - L. Poliak
  - S. Cruchet
  - O. Brunser
- PubMed: 16421034
- DOI: 10.1111/j.1651-2227.2005.tb01848.x
1 Insight on
- Reduced Helicobacter pylori Colonization
- High evidence
- Large Human Trial
- Highly Cited
Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement.
- 2005-12
- RCT · n = 94
- American Journal of Hypertension 18(12)
- - T. Jauhiainen
  - H. Vapaatalo
  - T. Poussa
  - Sinikka Kyrönpalo
  - M. Rasmussen
  - R. Korpela
- PubMed: 16364832
- DOI: 10.1016/J.AMJHYPER.2005.06.006
4 Insights on
- High evidence
- Highly Cited
The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome--a double blind, placebo-controlled, randomized study.
- 2005-12
- RCT · n = 54
- Clinical Nutrition 24(6)
- - E. Niv
  - T. Naftali
  - Ron Hallak
  - N. Vaisman
- PubMed: 16051399
- DOI: 10.1016/J.CLNU.2005.06.001
4 Insights on
- High evidence
- Highly Cited
Correlation of probiotic Lactobacillus salivarius growth phase with its cell wall-associated proteome.
- 2005-11
- FEMS Microbiology Letters 252(1)
- - P. Kelly
  - Patricia B. Maguire
  - M. Bennett
  - Desmond J. Fitzgerald
  - Richard J. Edwards
  - B. Thiede
  - A. Treumann
  - J. Kevin Collins
  - Gerald C. O'sullivan
  - F. Shanahan
  - C. Dunne
- PubMed: 16214296
- DOI: 10.1016/J.FEMSLE.2005.08.051
2 Insights on
- Reduced Crohn's Disease Symptoms
- Alleviated Symptoms of Mild to Moderate Crohn's Disease
- Low evidence