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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Dietary berberine supplementation improves select physiological and psychological responses during exertional heat stress: A pilot study in young adults.
- 2026-05
- RCT
- Physiological reports 14(10)
- - Dante A Van Arman
  - Jacob C Saunders
  - Yaw O Korankyi
  - Emerson P Heckler
  - Ben J Lee
  - Trevor L Gillum
  - Matthew R Kuennen
- PubMed: 42204774
- DOI: 10.14814/phy2.70937
7 Insights on
- High evidence
Effect of Vitamin D Supplementation on Total Knee Arthroplasty Outcomes: A Systematic Review.
- 2026-05
- Review · n = 562
- Orthopaedic journal of sports medicine 14(5)
- - Fardis Vosoughi
  - Ariyan Ayati Firoozabadi
  - Amirhossein Amiri
  - Iman Menbari Oskuie
- PubMed: 42212200
- DOI: 10.1177/23259671261432670
8 Insights on
- High evidence
Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis.
- 2026-05
- Meta-Analysis · n = 847
- Autoimmunity reviews 25(5)
- - Jiale Lu
  - Qingmiao Zhu
  - Jiaxun Yu
  - Zhuchen Tan
  - Yingxin Kang
  - Qice Sun
  - Ting Zhao
- PubMed: 41951148
- DOI: 10.1016/j.autrev.2026.104057
4 Insights on
- High evidence
Blueberry consumption enhances vascular function but not cognitive abilities in healthy individuals: a systematic review and meta-analysis.
- 2026-05
- Meta-Analysis · n = 632
- Nutrition research (New York, N.Y.) 149
- - Yu He
  - Jing Yang
  - Shuzhen Zhang
  - Junfan Mai
  - Meiying Li
- PubMed: 41974068
- DOI: 10.1016/j.nutres.2026.03.007
5 Insights on
- High evidence
Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.
- 2026-04
- RCT
- The American journal of clinical nutrition 123(4)
- - Tyler A Churchward-Venne
  - Philippe Jm Pinckaers
  - Joey Sj Smeets
  - Gabriel Nasri Marzuca-Nassr
  - Stefan Hm Gorissen
  - Cas J Fuchs
  - Joan M Senden
  - Joy Pb Goessens
  - Annemie P Gijsen
  - Will Kwh Wodzig
  - Luc Jc van Loon
- PubMed: 41580240
- DOI: 10.1016/j.ajcnut.2026.101205
2 Insights on
- Reduced Muscle Protein Synthesis Rate
- Reduced Quadriceps Muscle Cross-Sectional Area
- High evidence
The role of Lactobacillus in dibutyl phthalate-induced gut and liver injury: Probiotic intervention and multi-omics evidence.
- 2026-04
- Ecotoxicology and environmental safety 314
- - Siming Huo
  - Bo Li
  - Jiayu Du
  - Zheng Cao
- PubMed: 41895142
- DOI: 10.1016/j.ecoenv.2026.120051
2 Insights on
- Improved Intestinal Barrier Function
- Reduced Liver Injury
- Low evidence
- Animal Study
Randomized Trial of Milk Oral Immunotherapy: Fixed Low-Dose vs Escalation to Medium-Dose.
- 2026-04
- RCT · n = 32
- The journal of allergy and clinical immunology. In practice 14(4)
- - Ken-Ichi Nagakura
  - Kyohei Takahashi
  - Yoko Miura
  - Kaito Goto
  - Akira Kawai
  - Naoko Fusayasu
  - Kiyotake Ogura
  - Sakura Sato
  - Motohiro Ebisawa
  - Noriyuki Yanagida
- PubMed: 41633410
- DOI: 10.1016/j.jaip.2026.01.025
5 Insights on
- High evidence
Oral delivery of engineered Lactococcus lactis microcapsules expressing antioxidant enzymes for inflammatory bowel disease: Mechanisms of intestinal barrier repair and microbiota modulation.
- 2026-04
- Materials today. Bio 37
- - Yue Meng
  - Chao Miao
  - Jiaxin Guo
  - Wei Zhang
  - Ling Guo
  - Yu Zhang
  - Yujun Jiang
- PubMed: 41716339
- DOI: 10.1016/j.mtbio.2026.102902
3 Insights on
- Low evidence
Determination of Folate Bioavailability From Brewer's Yeast in a Dual Isotope Randomized Human Intervention Study.
- 2026-04
- RCT
- Molecular nutrition & food research 70(7)
- - Nadine Weber
  - Lisa Striegel
  - Yvonne Methner
  - Beate Brandl
  - Viola Groehn
  - Jean-Pierre Knapp
  - Thomas Skurk
  - Michael Rychlik
- PubMed: 41954190
- DOI: 10.1002/mnfr.70453
1 Insight on
- Increased Folate Bioavailability
- High evidence
- Rigorous Journal
Lactobacillus plantarum Dynamically Changes the Fermentation Characteristics and Active Ingredients of Summer/Autumn Tea Leaves.
- 2026-04
- Food science & nutrition 14(4)
- - Yimei Luo
  - Yuangan Qian
  - Yangwen Ou
  - Shimin Tian
  - Yixiao Xie
  - Yulong Zheng
  - Jun Hao
  - Hong Sun
  - Fuyu Yang
- PubMed: 42005329
- DOI: 10.1002/fsn3.71773
3 Insights on
- Low evidence
Preparation of fermented plant-based beverages using grape seed: Comparison of lactic acid bacteria strains, physicochemical characteristics and flavor profiles.
- 2026-04
- Food chemistry: X 35
- - Ruiguo Cui
  - Yuting Xiao
  - Lixiang Huai
  - Jialin Xue
  - Zheshuo Cui
  - Caihong Cheng
  - Xiaoyu Liu
  - Lijun Song
- PubMed: 42011494
- DOI: 10.1016/j.fochx.2026.103845
2 Insights on
- Increased Antioxidant Activity
- Increased Asparagine Levels
- Low evidence
Alginate alleviates hyperuricemia by modulating the Pediococcus acidilactici LW1-1-butyrate-NLRP3 inflammasome axis.
- 2026-04
- International journal of biological macromolecules 354
- - Yukun Li
  - Rongshuang Han
  - Rong Wang
  - Xiaoyan Zhang
  - Mengchen Shan
  - Tianyu Fu
  - Yupeng Li
  - Xingsi Qi
  - Bin Cao
  - Yi Wang
  - Tao Mao
  - Zibin Tian
- PubMed: 41819315
- DOI: 10.1016/j.ijbiomac.2026.151318
4 Insights on
- Low evidence
- Animal Study
An exopolysaccharide-rich fraction from Bifidobacterium animalis subsp. lactis MG741 ameliorates high-fat diet-induced MASLD by enhancing intestinal barrier function.
- 2026-04
- International journal of biological macromolecules 359
- - Hee-Jin Kim
  - Hee-Kyoung Son
  - Yu Ra Lee
  - Yejin Ahn
  - Hye-Bin Lee
  - Ji-Yeon Lee
  - Miri Park
  - Jae-Ho Park
  - Ho-Young Park
- PubMed: 41937014
- DOI: 10.1016/j.ijbiomac.2026.151802
6 Insights on
- Low evidence
Probiotic and antibacterial properties of recombinant Lactococcus lactis expressing the fusion antimicrobial peptides BMAP18-BSN37 in mice and chickens.
- 2026-04
- Poultry science 105(4)
- - Ruibiao Wang
  - Yukai Lin
  - Yu Xia
  - Suxian Liu
  - Doudou Feng
  - Siyang Li
  - Tengyue Zhou
  - Huarun Sun
  - Jiyuan Shen
  - Bo Wen
  - Minghui Li
  - Chengshui Liao
  - Baoliang Qin
  - Jianhe Hu
  - Yuanfang Ma
  - Ke Ding
  - Lei Wang
- PubMed: 41616534
- DOI: 10.1016/j.psj.2026.106507
4 Insights on
- Low evidence
- Animal Study
High-dose Oral Vitamin C Supplementation and Acute Pain Control Following Laparoscopic Cholecystectomy: A Randomized Controlled Study.
- 2026-04
- RCT · n = 320
- Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 41(2)
- - Yoonyoung Choi
  - Tae Ho Hong
- PubMed: 41042187
- DOI: 10.1016/j.jopan.2025.06.008
5 Insights on
- High evidence
- Large Human Trial
Integrated omics-based analysis reveals the role of ferulic acid activating a co-production of 4-vinyl guaiacol and fumaric acid by Rhizopus oryzae.
- 2026-04
- Bioresource technology 445
- - Xin Li
  - Shanshan Wu
  - Xueyu Tang
- PubMed: 41638588
- DOI: 10.1016/j.biortech.2026.134146
2 Insights on
- Increased Fumaric Acid Production
- Simultaneous 4-Vinyl Guaiacol Production
- Low evidence
Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults.
- 2026-04
- RCT · n = 11
- The American journal of clinical nutrition 123(4)
- - Freyja Ad Haigh
  - Alistair J Monteyne
  - Doaa R Abdelrahman
  - Andrew J Murton
  - Tim Ja Finnigan
  - Hannah E Theobald
  - Francis B Stephens
  - Benjamin T Wall
- PubMed: 41643855
- DOI: 10.1016/j.ajcnut.2026.101231
2 Insights on
- Improved Whole Body Net Protein Balance
- Increased Myofibrillar Protein Synthesis
- High evidence
Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic-Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-04
- Meta-Analysis
- The Journal of nutrition 156(4)
- - Bowen Yu
  - Junyan Liu
  - Fangfang Bu
  - Hongli Yan
  - Chen Chen
  - Yanfei Li
  - Yifei Sun
  - Yaqin Wang
  - Junhua Yuan
- PubMed: 41478593
- DOI: 10.1016/j.tjnut.2025.101314
9 Insights on
- High evidence
Chitosan and sulfated glucan nanoparticles: A novel strategy for cryopreservation of Lactobacillus plantarum.
- 2026-04
- Food research international (Ottawa, Ont.) 230
- - Tingyue Deng
  - Xiaowei Shen
  - Zeyu Han
  - Jing Liu
  - Bolin Zhang
  - Hongfei Zhao
- PubMed: 41794538
- DOI: 10.1016/j.foodres.2026.118549
1 Insight on
- Improved Survival During Cryopreservation
- Low evidence
Legume Intake and Glycemic Control in Individuals With or at Risk of Metabolic Syndrome: Multi-Omics Insights From Both Observational and Interventional Evidence.
- 2026-04
- Observational · n = 82
- Molecular nutrition & food research 70(7)
- - Guoqing Ma
  - Haozhi Niu
  - Junqi Li
  - Nan Yang
  - Xia Liao
  - Hang Yu
  - Haixia Yang
  - Tian Tian
  - Qian Wang
  - Xin Liu
- PubMed: 41954199
- DOI: 10.1002/mnfr.70463
1 Insight on
- Improved Fasting Plasma Glucose
- High evidence
- Rigorous Journal
Effects of Bifidobacterium animalis subsp. lactis IMAU12267 on milk fermentation, subsequent storage, and functional properties.
- 2026-04
- Food chemistry: X 35
- - Xiao Liu
  - Sheng Zhang
  - Lu Li
  - Yongfu Chen
  - Jianli Li
- PubMed: 41971400
- DOI: 10.1016/j.fochx.2026.103791
1 Insight on
- Improved Storage Viability
- Low evidence
Synergistic effects of oral inoculation with recombinant Lactobacillus plantarum NC8 Co-expressing interleukin-2, interleukin-17b and interleukin-26 on infectious bronchitis vaccination in chickens.
- 2026-04
- Clinical Trial
- Poultry science 105(4)
- - Junjie Peng
  - Shaohua Guo
  - Yanyan Liu
  - Weiwei Hao
  - Xin Yang
  - Shanshan Zhu
  - Rong Gao
- PubMed: 41633076
- DOI: 10.1016/j.psj.2026.106551
1 Insight on
- Enhanced Immune Response
- Low evidence
- Animal Study
Bacteriocin gene-mediated ecological adaptation of Bifidobacterium breve in the adult human gut.
- 2026-04
- Clinical Trial
- Cell genomics 6(4)
- - Jingyu Wang
  - Xin Qian
  - Qing Li
  - Zhiying Jin
  - Na Liu
  - Jianxin Zhao
  - Wei Chen
  - Shaopu Wang
  - Peijun Tian
- PubMed: 41421358
- DOI: 10.1016/j.xgen.2025.101106
2 Insights on
- Improved Stability of Gut Microbiota
- Improved Strain-Level Competitive Fitness
- Moderate evidence
Improvement of starch fine structure, physicochemical properties and digestive characteristics of adlay seeds by fermentation with Lactobacillus plantarum and Lactobacillus paracasei.
- 2026-04
- International journal of biological macromolecules 355
- - Shuang Xu
  - Weijie Qi
  - Yaxing Xie
  - Jianjun Cheng
  - Qingfeng Ban
- PubMed: 41861878
- DOI: 10.1016/j.ijbiomac.2026.151547
3 Insights on
- Low evidence
Multi-Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.
- 2026-04
- RCT · n = 80
- Food science & nutrition 14(4)
- - Sijia Zhu
  - Yan Qiao
  - Wenjing He
  - Yaojie Xiao
  - Guiqin Song
  - Kang Liu
  - Shuguang Fang
- PubMed: 41971606
- DOI: 10.1002/fsn3.71735
11 Insights on
- High evidence
Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- 2026-04
- Observational · n = 150
- JGH open : an open access journal of gastroenterology and hepatology 10(4)
- - Amirhesam Mehrara
  - Saba Moradi
  - Masoumeh Dorosti
  - Leila Dehghanian
  - Masoumeh Sadat MirShafaie
  - Mohammadreza Esfahanian
  - Bita Moradi
  - Ali Nouri
  - Sara Khoshdooz
  - Parsa Bahmani
  - Saeid Doaei
  - Maryam Gholamalizadeh
- PubMed: 41994477
- DOI: 10.1002/jgh3.70398
1 Insight on
- Increased Risk of Gastroesophageal Reflux Disease
- High evidence
Fibre manipulation to manage symptom severity and quality of life in patients with functional bowel disorders: A systematic review.
- 2026-04
- Systematic Review
- Clinical nutrition ESPEN 72
- - Rojina Raked
  - Mary Ibrahim
  - Jennifer Utter
  - Shannon Morley
  - Kate Mueller
- PubMed: 41525871
- DOI: 10.1016/j.clnesp.2025.102896
1 Insight on
- Improved Stool Consistency
- High evidence
Development of a propidium monoazide-droplet digital polymerase chain reaction assay for strain-specific quantification of Lactiplantibacillus plantarum YZH81 in fermented milk.
- 2026-04
- Journal of dairy science 109(4)
- - Zhihao Wang
  - Yanrong Liu
  - Zhongfa Tan
  - Chi Zhang
  - Xiaoli Wang
  - Yao Yang
- PubMed: 41485570
- DOI: 10.3168/jds.2025-27317
1 Insight on
- Strain-Specific Lactiplantibacillus Plantarum Quantification
- Low evidence
- Rigorous Journal
- Animal Study
A pilot feasibility study of nurse-led psyllium supplementation for metabolic health in hospitalized patients with schizophrenia.
- 2026-04
- Clinical Trial
- Archives of psychiatric nursing 61
- - Ru-Shin Jang
  - Chin-Chou Yang
  - Wen-Jiuan Yen
  - Mei-Ling Lin
- PubMed: 41956574
- DOI: 10.1016/j.apnu.2026.152072
3 Insights on
- Moderate evidence
Arginine therapy in sickle cell disease: A systematic review and meta-analysis of clinical outcomes.
- 2026-04
- Meta-Analysis · n = 830
- Clinical nutrition ESPEN 72
- - Favour M L Foncha
  - Joseph Y Bena Nnang
  - Samuel G J Fodop
  - Best C I Poudjoum
  - Dimitri S Tcheuko
  - Joel G K Mekontso
- PubMed: 41534622
- DOI: 10.1016/j.clnesp.2025.102898
5 Insights on
- High evidence