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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Effects of Irvingia gabonensis Seed Extract Supplementation on Anthropometric and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
- 2019-12-19
- Meta-Analysis
- Journal of the American College of Nutrition 39(5)
- - Jounghee Lee
  - Mei Chung
  - Zhuxuan Fu
  - Jihee Choi
  - Hae-Jeung Lee
- PubMed: 31855111
- DOI: 10.1080/07315724.2019.1691956
8 Insights on
- High evidence
- Rigorous Journal
Are Lactobacillus salivarius G60 and inulin more efficacious to treat patients with oral halitosis and tongue coating than the probiotic alone and placebo? A randomized clinical trial.
- 2019-12-19
- RCT · n = 45
- Journal of Periodontology 91(6)
- - C. R. Mousquer
  - A. D. Bona
  - D. C. Milani
  - S. Callegari-Jacques
  - K. Ishikawa
  - M. Mayer
  - C. Rösing
  - F. Fornari
- PubMed: 31799694
- DOI: 10.1002/jper.19-0089
4 Insights on
- High evidence
L-Citrulline increases nitric oxide and improves control in obese asthmatics.
- 2019-12-19
- RCT · n = 41
- JCI insight 4(24)
- - Fernando Holguin
  - Hartmut Grasemann
  - Sunita Sharma
  - Daniel Winnica
  - Karen Wasil
  - Vong Smith
  - Margaret H Cruse
  - Nancy Perez
  - Erika Coleman
  - Timothy J Scialla
  - Loretta G Que
- PubMed: 31714895
- DOI: 10.1172/jci.insight.131733
4 Insights on
- High evidence
d-Amino Acids and Lactic Acid Bacteria.
- 2019-12-12
- Review
- Microorganisms 7(12)
- - Jyumpei Kobayashi
- PubMed: 31842512
- DOI: 10.3390/microorganisms7120690
2 Insights on
- Improved Gut Health
- No Human Health Outcome Reported
- Low evidence
Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis.
- 2019-12-12
- Meta-Analysis · n = 503
- Phytotherapy research : PTR 34(5)
- - Boxun Zhang
  - Rensong Yue
  - Ying Wang
  - Lizhen Wang
  - Jiawei Chin
  - Xiaoying Huang
  - Yayi Jiang
- PubMed: 31833112
- DOI: 10.1002/ptr.6592
3 Insights on
- High evidence
Effects of the Consumption of Probiotic Yogurt Containing Bifidobacterium lactis Bb12 on the Levels of Streptococcus mutans and Lactobacilli in Saliva of Students with Initial Stages of Dental Caries: A Double-Blind Randomized Controlled Trial
- 2019-12-10
- RCT · n = 66
- Caries Research 54(1)
- - A. Zare Javid
  - Essam Amerian
  - L. Basir
  - A. Ekrami
  - M. Haghighizadeh
  - Leila Maghsoumi-Norouzabad
- PubMed: 31821997
- DOI: 10.1159/000504164
7 Insights on
- High evidence
In vitro Study of Lactobacillus paracasei CNCM I-1518 in Healthy and Clostridioides difficile Colonized Elderly Gut Microbiota
- 2019-12-10
- Frontiers in Nutrition 6
- - Sophie Fehlbaum
  - C. Chassard
  - C. Schwab
  - Maarja Voolaid
  - Candice Fourmestraux
  - M. Derrien
  - C. Lacroix
- PubMed: 31921877
- DOI: 10.3389/fnut.2019.00184
4 Insights on
- Low evidence
Inclusion of the direct-fed microbial Clostridium butyricum in diets for weanling pigs increases growth performance and tends to increase villus height and crypt depth, but does not change intestinal microbial abundance.
- 2019-12-10
- RCT
- Journal of Animal Science 98(1)
- - G. Casas
  - L. Blavi
  - Tzu-Wen L. Cross
  - A. Lee
  - K. Swanson
  - H. Stein
- PubMed: 31820779
- DOI: 10.1093/jas/skz372
4 Insights on
- High evidence
- Rigorous Journal
The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)
- 2019-12-09
- PLOS ONE 14(12)
- - Hongqin Li
  - Ying Zhou
  - Huayun Ling
  - L. Luo
  - D. Qi
  - Lin Feng
- PubMed: 31815958
- DOI: 10.1371/journal.pone.0223428
6 Insights on
- Low evidence
- Rigorous Journal
Lactobacillus rhamnosus GG and Saccharomyces cerevisiae boulardii exert synergistic antipathogenic activity in vitro against enterotoxigenic Escherichia coli.
- 2019-12-09
- Beneficial Microbes 10(8)
- - F. Moens
  - C. Duysburgh
  - P. van den Abbeele
  - M. Morera
  - M. Marzorati
- PubMed: 31965838
- DOI: 10.3920/bm2019.0064
2 Insights on
- Reduced Enterotoxigenic Escherichia coli Abundance
- Reduced ETEC Toxin Levels
- Low evidence
Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review.
- 2019-12-05
- Systematic Review
- International journal of environmental research and public health 16(24)
- - Amiza Hamdan
  - Ruszymah Haji Idrus
  - Mohd Helmy Mokhtar
- PubMed: 31817324
- DOI: 10.3390/ijerph16244911
5 Insights on
- High evidence
A Systematic Review and Meta-Analysis on the Effects of Probiotic Species on Iron Absorption and Iron Status.
- 2019-12-03
- Meta-Analysis · n = 950
- Nutrients 11(12)
- - Susan C Vonderheid
  - Lisa Tussing-Humphreys
  - Chang Park
  - Heather Pauls
  - Nefertiti OjiNjideka Hemphill
  - Bazil LaBomascus
  - Andrew McLeod
  - Mary Dawn Koenig
- PubMed: 31816981
- DOI: 10.3390/nu11122938
3 Insights on
- High evidence
- Rigorous Journal
The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomised, double blind, placebo-controlled trial.
- 2019-12-03
- RCT
- Alimentary pharmacology & therapeutics 51(1)
- - Rita Nocerino
  - Francesca De Filippis
  - Gaetano Cecere
  - Antonio Marino
  - Maria Micillo
  - Carmen Di Scala
  - Carmen de Caro
  - Antonio Calignano
  - Cristina Bruno
  - Lorella Paparo
  - Anna M Iannicelli
  - Linda Cosenza
  - Ylenia Maddalena
  - Giusy Della Gatta
  - Serena Coppola
  - Laura Carucci
  - Danilo Ercolini
  - Roberto Berni Canani
- PubMed: 31797399
- DOI: 10.1111/apt.15561
5 Insights on
- High evidence
- Rigorous Journal
Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta-analysis of clinical trials.
- 2019-12-02
- Meta-Analysis · n = 279
- Phytotherapy research : PTR 34(3)
- - Moloud Payab
  - Shirin Hasani-Ranjbar
  - Nazila Shahbal
  - Mostafa Qorbani
  - Azadeh Aletaha
  - Hamed Haghi-Aminjan
  - Akbar Soltani
  - Fatemeh Khatami
  - Shekoufeh Nikfar
  - Shokoufeh Hassani
  - Mohammad Abdollahi
  - Bagher Larijani
- PubMed: 31793087
- DOI: 10.1002/ptr.6547
4 Insights on
- High evidence
Lactobacillus reuteri Stimulates Intestinal Epithelial Proliferation and Induces Differentiation into Goblet Cells in Young Chickens.
- 2019-12-02
- Clinical Trial · n = 108
- Journal of Agricultural and Food Chemistry 67(49)
- - Shuang Xie
  - Shiyi Zhao
  - Lan Jiang
  - Linhao Lu
  - Qian Yang
  - Qinghua Yu
- PubMed: 31789514
- DOI: 10.1021/acs.jafc.9b06256
4 Insights on
- Low evidence
- Animal Study
Lactobacillus reuteri DSM 17938 feeding of healthy newborn mice regulates immune responses while modulating gut microbiota and boosting beneficial metabolites.
- 2019-12-01
- Clinical Trial
- American Journal of Physiology-Gastrointestinal and Liver Physiology 317(6)
- - Yuying Liu
  - X. Tian
  - Baokun He
  - T. Hoang
  - Christopher M. Taylor
  - Eugene E. Blanchard
  - J. Freeborn
  - Sinyoung Park
  - Meng Luo
  - J. Couturier
  - D. Tran
  - S. Roos
  - Guoyao Wu
  - J. M. Rhoads
- PubMed: 31482733
- DOI: 10.1152/ajpgi.00107.2019
2 Insights on
- Increased Proportion of Intestinal Regulatory T Cells
- Increased Tolerance to Inflammatory Stimuli
- Low evidence
- Animal Study
Lactobacillus fermentum strains of dairy-product origin adhere to mucin and survive digestive juices.
- 2019-12-01
- Journal of Medical Microbiology 68(12)
- - Kanwal Aziz
  - Arsalan Haseeb Zaidi
  - Hafiza Naseem Fatima
  - Muhammad Tariq
- PubMed: 31613203
- DOI: 10.1099/jmm.0.001090
7 Insights on
- Low evidence
Bifidobacteria adolescentis regulated immune responses and gut microbial composition to alleviate DNFB-induced atopic dermatitis in mice
- 2019-11-30
- RCT · n = 9
- European Journal of Nutrition 59(7)
- - Zhifeng Fang
  - Lingzhi Li
  - Jianxian Zhao
  - Hao Zhang
  - Yuan-Kun Lee
  - Wenwei Lu
  - Wei Chen
- PubMed: 31786642
- DOI: 10.1007/s00394-019-02145-8
7 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The usage of a lactobacilli probiotic in the non-surgical therapy of peri-implantitis: A randomized pilot study.
- 2019-11-25
- RCT
- Clinical Oral Implants Research 31(1)
- - I. Laleman
  - M. Pauwels
  - M. Quirynen
  - W. Teughels
- PubMed: 31705683
- DOI: 10.1111/clr.13555
2 Insights on
- Reduced Plaque Levels
- Reduced Bleeding on Probing (BOP)
- High evidence
Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case-Control Study.
- 2019-11-25
- Observational · n = 146
- Headache 60(3)
- - Anthony G Mansour
  - Rechdi Ahdab
  - Yazan Daaboul
  - Serge Korjian
  - Daniel Alexander Morrison
  - Essa Hariri
  - Maher Salem
  - Christelle El Khoury
  - Naji Riachi
  - Sola Aoun Bahous
- PubMed: 31769041
- DOI: 10.1111/head.13715
2 Insights on
- Reduced Arterial Stiffness
- Reduced Vitamin K2 Status
- High evidence
The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review.
- 2019-11-22
- Systematic Review
- Plant foods for human nutrition (Dordrecht, Netherlands) 75(1)
- - Jackson L Williams
  - Julian M Everett
  - Nathan M D'Cunha
  - Domenico Sergi
  - Ekavi N Georgousopoulou
  - Richard J Keegan
  - Andrew J McKune
  - Duane D Mellor
  - Nicola Anstice
  - Nenad Naumovski
- PubMed: 31758301
- DOI: 10.1007/s11130-019-00771-5
2 Insights on
- Reduced Anxiety
- Reduced Stress
- High evidence
Evaluation of a mouthrinse containing guava leaf extract as part of comprehensive oral care regimen- a randomized placebo-controlled clinical trial.
- 2019-11-21
- RCT · n = 20
- BMC complementary and alternative medicine 19(1)
- - Namratha Nayak
  - Jothi Varghese
  - Seema Shetty
  - Vinutha Bhat
  - Tejal Durgekar
  - Richard Lobo
  - Usha Y Nayak
  - Vishwanath U
- PubMed: 31752836
- DOI: 10.1186/s12906-019-2745-8
4 Insights on
- High evidence
Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study
- 2019-11-20
- RCT · n = 359
- Journal of Nutritional Science 5
- - M. Abrahamse-Berkeveld
  - M. Alles
  - E. Franke-Beckmann
  - K. Helm
  - R. Knecht
  - R. Köllges
  - B. Sandner
  - J. Knol
  - K. Ben Amor
  - A. Bufe
- PubMed: 28620469
- DOI: 10.1017/jns.2016.35
9 Insights on
- High evidence
- Large Human Trial
Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis.
- 2019-11-20
- Clinical Trial
- Clinical pharmacology and therapeutics 107(2)
- - Mikihiro Fujiya
  - Nobuhiro Ueno
  - Shin Kashima
  - Kazuyuki Tanaka
  - Aki Sakatani
  - Katsuyoshi Ando
  - Kentaro Moriichi
  - Hiroaki Konishi
  - Naoya Kamiyama
  - Yoshikazu Tasaki
  - Tomohiro Omura
  - Kazuo Matsubara
  - Masaki Taruishi
  - Toshikatsu Okumura
- PubMed: 31513280
- DOI: 10.1002/cpt.1628
2 Insights on
- Maintained Remission in Ulcerative Colitis
- Improved Mucosal Healing
- Moderate evidence
Effect of Lactobacillus plantarum TWK10 on Exercise Physiological Adaptation, Performance, and Body Composition in Healthy Humans
- 2019-11-19
- RCT · n = 54
- Nutrients 11(11)
- - Wen-Ching Huang
  - Mon-Chien Lee
  - Chia-Chia Lee
  - Ker-Sin Ng
  - Y. Hsu
  - Tsung-Yu Tsai
  - S. Young
  - Jin-Seng Lin
  - Chi-Chang Huang
- PubMed: 31752370
- DOI: 10.3390/nu11112836
4 Insights on
- High evidence
Acute effects of combined Bacopa, American ginseng and whole coffee fruit on working memory and cerebral haemodynamic response of the prefrontal cortex: a double-blind, placebo-controlled study.
- 2019-11-18
- RCT
- Nutritional neuroscience 24(11)
- - Talitha Best
  - Chantelle Clarke
  - Nathan Nuzum
  - Wei-Peng Teo
- PubMed: 31736428
- DOI: 10.1080/1028415x.2019.1690288
3 Insights on
- High evidence
Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study
- 2019-11-16
- RCT · n = 131
- European Journal of Nutrition 59(1)
- - I. Lazou Ahrén
  - A. Berggren
  - Cristina Teixeira
  - Titti Martinsson Niskanen
  - N. Larsson
- PubMed: 31734734
- DOI: 10.1007/s00394-019-02137-8
9 Insights on
- High evidence
- Rigorous Journal
Lactobacillus fermentum: a bacterial species with potential for food preservation and biomedical applications
- 2019-11-15
- Critical Reviews in Food Science and Nutrition 60(20)
- - K. Naghmouchi
  - Y. Belguesmia
  - F. Bendali
  - G. Spano
  - B. Seal
  - D. Drider
- PubMed: 31729242
- DOI: 10.1080/10408398.2019.1688250
14 Insights on
- Low evidence
A dual‐strain Lactobacilli reuteri probiotic improves the treatment of residual pockets: A randomized controlled clinical trial
- 2019-11-14
- RCT · n = 39
- Journal of Clinical Periodontology 47(1)
- - I. Laleman
  - M. Pauwels
  - M. Quirynen
  - W. Teughels
- PubMed: 31520543
- DOI: 10.1111/jcpe.13198
3 Insights on
- High evidence
Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update
- 2019-11-14
- Meta-Analysis
- Nutrients 11(11)
- - B. Patro-Gołąb
  - H. Szajewska
- PubMed: 31739457
- DOI: 10.3390/nu11112762
4 Insights on
- High evidence