April 2018 Supplement Research Papers

• April 1

  • Metabolic and Performance Effects of Yerba Mate on Well-trained Cyclists.

    • 2018-04-01
    • RCT · n = 9
    • Medicine and science in sports and exercise 50(4)
    • • Jose L Areta
      • Ingvild Austarheim
      • Helle Wangensteen
      • Carlo Capelli

    • PubMed: 29117073
    • DOI: 10.1249/mss.0000000000001482

    9 Insights on

    • Reduced Heart Rate
    • Reduced Respiratory Exchange Ratio
    • Increased Fat Utilization
    • Reduced Time Trial Completion Time
    • Increased Power Output
    • Increased Oxygen Consumption
    • Reduced Rate of Perceived Exertion
    • Improved Gross Efficiency
    • Improved Pacing

    • High evidence
• April 6

  • Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema

    • 2018-04-06
    • RCT
    • Pediatric Allergy and Immunology 29(3)
    • • K. Wickens
      • C. Barthow
      • E. Mitchell
      • T. Stanley
      • G. Purdie
      • Judy Rowden
      • Janice Kang
      • Fiona Hood
      • L. V. D. van den Elsen
      • Elizabeth E Forbes-Blom
      • I. Franklin
      • Phillipa Barnes
      • P. Fitzharris
      • Robyn M. Maude
      • P. Stone
      • P. Abels
      • R. Murphy
      • J. Crane

    • PubMed: 29415330
    • DOI: 10.1111/pai.12874

    7 Insights on

    • Reduced Eczema Prevalence
    • Reduced Prevalence of Atopic Sensitization
    • Reduced IgE-Associated Eczema in Infants
    • Reduced Infant Eczema
    • Reduced Infant Wheeze
    • Reduced Wheeze
    • Reduced SCORAD Score

    • High evidence
    • Rigorous Journal
• April 12

  • Effects of Lactobacillus reuteri LR1 on the growth performance, intestinal morphology, and intestinal barrier function in weaned pigs.

    • 2018-04-12
    • RCT · n = 144
    • Journal of Animal Science 96(6)
    • • H. Yi
      • Li Wang
      • Yunxia Xiong
      • XiaoLu Wen
      • Zhilin Wang
      • Xuefen Yang
      • K. Gao
      • Zong-yong Jiang

    • PubMed: 29659876
    • DOI: 10.1093/jas/sky129

    6 Insights on

    • Improved Intestinal Barrier Function
    • Improved Intestinal Morphology
    • Improved Immune Response
    • Improved Growth Performance
    • Enhanced Immune Response
    • Increased Serum Immunoglobulin A (IgA) Levels

    • Low evidence
    • Rigorous Journal
    • Animal Study
• April 16

  • Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin‐induced diabetic rats

    • 2018-04-16
    • Clinical Trial
    • Pathogens and Disease 76(4)
    • • Ling Zhang
      • Qianqian Qin
      • Manni Liu
      • Xiangling Zhang
      • F. He
      • Guoqing Wang

    • PubMed: 29668928
    • DOI: 10.1093/femspd/fty028

    13 Insights on

    • Reduced Tumor Necrosis Factor Alpha
    • Reduced Hepatic Oxidative Stress
    • Improved Liver Function
    • Reduced Serum Malondialdehyde Levels
    • Reduced Plasma Lipopolysaccharide Levels
    • Reduced Inflammation
    • Reduced Glucotoxicity
    • Normalized Intestinal Microbiota
    • Increased Blood Concentration of HDL
    • Reduced Hepatic Glycogen Levels
    • Reduced Serum Plasminogen Activator Inhibitor-1
    • Reduced Total Glucagon-Like Peptide-1 Levels
    • Improved Gut Microbial Alpha Diversity

    • Low evidence
    • Highly Cited
    • Animal Study
• April 19

  • Role of Lactobacillus reuteri in Human Health and Diseases

    • 2018-04-19
    • Frontiers in Microbiology 9
    • • Qinghui Mu
      • Vincent J. Tavella
      • Xin M. Luo

    • PubMed: 29725324
    • DOI: 10.3389/fmicb.2018.00757

    17 Insights on

    • Improved Intestinal Barrier Function
    • Reduced Pro-Inflammatory Cytokines
    • Enhanced Immune System Function
    • Reduced Pro-inflammatory Cytokine Release
    • Reduced Inflammation Levels
    • Reduced Pro-inflammatory Cytokine Levels
    • Enhanced Antimicrobial Resistance
    • Reduced Proinflammatory Cytokine Production
    • Modulated Immune Response
    • Reduced Colony Colonization by Pathogenic Organisms
    • Inhibited Pathogenic Microbes
    • Enhanced Intestinal Barrier Function
    • Prevention and Treatment of Inflammatory Diseases
    • Enhanced Regulatory T Cell Development
    • Reduced Inflammatory Diseases
    • Reduced Microbial Translocation
    • Reduced Inflammatory Bowel Disease Symptoms

    • Low evidence
    • Highly Cited
• April 25

  • Elucidation of the anti-hyperammonemic mechanism of Lactobacillus amylovorus JBD401 by comparative genomic analysis

    • 2018-04-25
    • BMC Genomics 19(1)
    • • Parul Singh
      • Hea-Jong Chung
      • In-Ah Lee
      • Roshan D’Souza
      • Hyeon-Jin Kim
      • Seong-Tshool Hong

    • PubMed: 29695242
    • DOI: 10.1186/s12864-018-4672-3

    1 Insight on

    • Reduced Blood Ammonia Levels

    • Low evidence
    • Rigorous Journal
• April 26

  • New lactic acid bacteria for skin health via oral intake of heat‐killed or live cells

    • 2018-04-26
    • Animal Science Journal 89(6)
    • • H. Kimoto-Nira

    • PubMed: 29696746
    • DOI: 10.1111/asj.13017

    2 Insights on

    • Improved Skin Condition
    • Improved Skin Health

    • Low evidence

  • Effects of active dry yeast on ruminal pH characteristics and energy partitioning of finishing steers under thermoneutral or heat-stressed environment.

    • 2018-04-26
    • RCT
    • Journal of Animal Science 96(7)
    • • W. Crossland
      • A. Norris
      • L. Tedeschi
      • T. Callaway

    • PubMed: 29701773
    • DOI: 10.1093/jas/sky165

    2 Insights on

    • Increased Digestible Energy
    • Increased Metabolizable Energy

    • High evidence
• April 27

  • The effects of Bifidobacterium animalis ssp. lactis B94 on gastrointestinal wellness in adults with Prader–Willi syndrome: study protocol for a randomized controlled trial

    • 2018-04-27
    • RCT · n = 36
    • Trials 19(1)
    • • Z. Alyousif
      • Jennifer L Miller
      • Mariana Sandoval
      • Chad W. MacPherson
      • Varuni Nagulesapillai
      • W. Dahl

    • PubMed: 29703235
    • DOI: 10.1186/s13063-018-2648-x

    2 Insights on

    • Reduced Constipation
    • Improved Gastrointestinal Symptoms

    • High evidence
• Undated – 8 supplement studies

  • The addition of inulin and Lactobacillus casei 01 in sheep milk ice cream.

    • 2018-04
    • Food Chemistry 246
    • • C. Balthazar
      • H. Silva
      • E. Esmerino
      • R. Rocha
      • J. Moraes
      • Mariana A V Carmo
      • L. Azevedo
      • I. Camps
      • Yuri K D Abud
      • C. Sant’Anna
      • R. Franco
      • M. Q. Freitas
      • M. C. Silva
      • R. Raices
      • G. B. Escher
      • D. Granato
      • C. Senaka Ranadheera
      • Filomena Nazarro
      • A. Cruz

    • PubMed: 29291874
    • DOI: 10.1016/j.foodchem.2017.12.002

    7 Insights on

    • Increased ACE Inhibitor Activity
    • Increased Antioxidant Activity
    • Improved Antioxidant Activity
    • Maintenance of Therapeutic Probiotic Levels
    • Improved Bioavailability
    • No Change in Gastrointestinal Survival
    • Unchanged Gastrointestinal Resistance

    • Low evidence
    • Highly Cited

  • Antiobesity effect of Lactobacillus reuteri 263 associated with energy metabolism remodeling of white adipose tissue in high-energy-diet-fed rats.

    • 2018-04
    • The Journal of Nutritional Biochemistry 54
    • • Li-Han Chen
      • Yi-Hsing Chen
      • Kuan-Chen Cheng
      • Ting-Yi Chien
      • Ching‐Hung Chan
      • Shu-Ping Tsao
      • Hui-Yu Huang

    • PubMed: 29329013
    • DOI: 10.1016/j.jnutbio.2017.11.004

    11 Insights on

    • Reduced Obesity
    • Improved Lipid Metabolism
    • Reduced Inflammation Levels
    • Improved Energy Metabolism in White Adipose Tissue
    • Enhanced Thermogenesis in White Adipose Tissue
    • Induction of Browning of White Adipose Tissue
    • Improved Obesity Parameters
    • Increased Oxygen Consumption in White Adipose Tissue
    • Enhanced Thermogenesis
    • Improved Thermogenesis
    • Improved Glucose Metabolism

    • Low evidence

  • Randomized double-blind controlled clinical trial of the blood pressure-lowering effect of fermented milk with Lactococcus lactis: A pilot study.

    • 2018-04
    • RCT · n = 18
    • Journal of Dairy Science 101(4)
    • • L. M. Beltrán-Barrientos
      • A. F. González-Córdova
      • A. Hernández-Mendoza
      • Eduardo H. Torres-Inguanzo
      • H. Astiazarán-García
      • J. Esparza-Romero
      • B. Vallejo‐Cordoba

    • PubMed: 29428751
    • DOI: 10.3168/jds.2017-13189

    5 Insights on

    • Reduced Diastolic Blood Pressure
    • Reduced Low-Density Lipoprotein Level
    • Reduced Systolic Blood Pressure
    • Reduced Triglyceride Levels
    • Reduced Serum Total Cholesterol Levels

    • High evidence
    • Rigorous Journal

  • Functional characterization of Lactobacillus plantarum ITEM 17215: A potential biocontrol agent of fungi with plant growth promoting traits, able to enhance the nutritional value of cereal products.

    • 2018-04
    • Food Research International 106
    • • M. Quattrini
      • C. Bernardi
      • M. Stuknytė
      • F. Masotti
      • A. Passera
      • G. Ricci
      • L. Vallone
      • I. De Noni
      • M. Brasca
      • M. G. Fortina

    • PubMed: 29580007
    • DOI: 10.1016/j.foodres.2018.01.074

    7 Insights on

    • Improved Gut Health
    • Reduced Pathogenic Fungal Activity
    • Reduced Mycotoxin Bioavailability
    • Increased Production of Antifungal Compounds
    • Reduced Phytate Levels
    • Enhanced Plant Growth
    • Reduced Fungal Growth

    • Low evidence

  • L-carnosine as an add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double-blind, randomized placebo-controlled trial.

    • 2018-04
    • RCT
    • Psychiatry research 262
    • • Alireza Ghajar
      • Mohammad-Reza Khoaie-Ardakani
      • Zahara Shahmoradi
      • Amir-Reza Alavi
      • Mohsen Afarideh
      • Mohammad-Reza Shalbafan
      • Maryam Ghazizadeh-Hashemi
      • Shahin Akhondzadeh

    • PubMed: 29427913
    • DOI: 10.1016/j.psychres.2018.02.012

    7 Insights on

    • Reduced Depression Symptoms
    • Reduced Positive Symptom
    • Improved Negative Symptom
    • Reduced Total PANSS Score
    • Reduced Negative Symptom Score
    • Reduced Extrapyramidal Symptoms
    • Reduced Positive Symptom Score

    • High evidence

  • Lactobacillus crispatus represses vaginolysin expression by BV associated Gardnerella vaginalis and reduces cell cytotoxicity.

    • 2018-04
    • Anaerobe 50
    • • J. Castro
      • A. Martins
      • M. E. Rodrigues
      • N. Cerca

    • PubMed: 29427630
    • DOI: 10.1016/j.anaerobe.2018.01.014

    2 Insights on

    • Reduced Cytotoxicity
    • Reduced Cytotoxicity Induced by Gardnerella Vaginalis

    • Low evidence

  • Efficacy of species-specific probiotic Pediococcus acidilactici FT28 on blood biochemical profile, carcass traits and physicochemical properties of meat in fattening pigs.

    • 2018-04
    • RCT · n = 36
    • Research in Veterinary Science 117
    • • Runjun Dowarah
      • A. Verma
      • N. Agarwal
      • Putan Singh

    • PubMed: 29179030
    • DOI: 10.1016/j.rvsc.2017.11.011

    12 Insights on

    • Increased Serum Albumin Levels
    • Reduced Triglyceride Levels
    • Reduced Serum Triglycerides
    • Increased Serum Total Protein Levels
    • Elevated Serum Globulin Levels
    • Increased Blood Glucose Levels
    • Increased Weight of Ham
    • Improved TBARS Levels
    • Improved Ether Extract Levels
    • Improved Meat pH Level
    • Reduced TBARS Levels
    • Improved Ether Extract Value

    • Low evidence
    • Animal Study

  • Efficacy and safety of Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham for menopausal women: A systematic review of clinical trials and the way forward.

    • 2018-04
    • Systematic Review
    • Journal of ethnopharmacology 216
    • • Chuenjid Kongkaew
      • Norman C Scholfield
      • Teerapon Dhippayom
      • Piyameth Dilokthornsakul
      • Surasak Saokaew
      • Nathorn Chaiyakunapruk

    • PubMed: 29409850
    • DOI: 10.1016/j.jep.2018.01.028

    4 Insights on

    • Increased Vaginal Lactobacilli Levels
    • Reduced Alkaline Phosphatase Level
    • Reduced Climacteric Symptom Score
    • Improved Urogenital Tract Symptoms

    • High evidence