The Big One Plus

5 (6 reviews)

In Stock

Supplement Ingredients
Ingredients	Amount Per Serving
Vitamin A Vitamin A	2,400 mcg RAE
Beta Carotene Vitamin A	-
Palmitate Palmitic Acid	-
Vitamin C Vitamin C	125 mg
Ascorbic Acid Vitamin C	-
Ascorbyl Palmitate Ascorbyl Palmitate	-
Vitamin D-3 Vitamin D3	50 mcg
Cholecalciferol Vitamin D	2,000 IU
Vitamin E Vitamin E	67 mg
d-alpha Tocopheryl Acid Succinate Vitamin E	100 IU
Mixed Tocopherols	100 IU
Vitamin K1 Vitamin K1	85 mcg
thiamine Vitamin B1	25 mg
thiamine mononitrate Vitamin B1	-
riboflavin Vitamin B2	25 mg
riboflavin 5' phosphate Vitamin B2	-
niacin Vitamin B3	100 mg
niacinamide Vitamin B3	-
Vitamin B-6 Vitamin B6	25 mg
Pyridoxal 5-Phosphate Vitamin B6	-
folate Vitamin B9	667 mcg DFE
L-5-Methylfolate, calcium salt	400 mcg
Vitamin B-12 Vitamin B12	100 mcg
Methylcobalamin Vitamin B12	-
biotin Vitamin B7	200 mcg
Pantothenic Acid Vitamin B5	100 mg
Calcium D-Pantothenate Vitamin B5	-
Iodine Iodine	100 mcg
Potassium Iodide Iodine	-
Zinc Zinc	15 mg
Zinc Citrate Zinc	-
selenium Selenium	100 mcg
L-selenomethionine Selenium	-
copper Copper	1 mg
copper gluconate Copper	-
manganese Manganese	5 mg
manganese glycinate	-
chromium Chromium	100 mcg
chromium polynicotinate Chromium	-
molybdenum Molybdenum	50 mcg
molybdenum glycinate Molybdenum	-
betaine HCL	25 mg
boron Boron	1 mg
boron citrate Boron	-
Vanadium Vanadium	50 mcg
Vanadyl Sulfate Vanadium	-
Vitamin K2 Vitamin K2	15 mcg
K2 MK-7 Vitamin K2	-

Ingredient Research

Vitamin B1
- Very lowReduced Mortality Risk3 studies
- Very lowImproved Left Ventricular Ejection Fraction3 studies
Vitamin B12
- LowReduced Vitamin B12 Level6 studies
- LowImproved Cognitive Function3 studies
Vitamin B2
- ModerateReduced Migraine Frequency4 studies
- LowReduced Migraine Duration3 studies
Vitamin B6
- LowReduced Anxiety3 studies
Vitamin B9
- HighReduced Homocysteine Level7 studies
- LowImproved Cognitive Function3 studies
- LowIncreased Folate Level3 studies
Vitamin C
- ModerateReduced Pain8 studies
- ModerateReduced Interleukin-6 Levels7 studies
- ModerateReduced Systolic Blood Pressure4 studies
Vitamin D
- HighIncreased 25-hydroxyvitamin D Level16 studies
- HighReduced Inflammation6 studies
- ModerateImproved Insulin Sensitivity9 studies
Vitamin E
- ModerateReduced Aspartate Aminotransferase Level5 studies
- ModerateReduced Alanine Aminotransferase Level4 studies
- ModerateReduced Inflammation3 studies
Vitamin K1
- LowReduced International Normalized Ratio3 studies
Selenium
- HighReduced Thyroid Peroxidase Antibody Level5 studies
- LowReduced Thyroglobulin Antibody Level4 studies
- LowIncreased Serum Free Thyroxine Levels3 studies
Zinc
- LowReduced Zinc Level4 studies
- LowIncreased Hemoglobin Levels3 studies

Research Evidence

How this product's ingredient doses compare to doses studied in research.

Vitamin C125 mg
Studies used 12–1,200 mg/day (median 500) across 19 studies
Low end of studied doses
Vitamin E67 mg
Studies used 5–1,200 mg/day (median 300) across 10 studies
Low end of studied doses
Vitamin B125 mg
Studies used 0–1,200 mg/day (median 100) across 8 studies
Low end of studied doses
Vitamin B225 mg
Studies used 20–1,200 mg/day (median 100) across 5 studies
Low end of studied doses
Vitamin B3100 mg
Studies used 100–3,000 mg/day (median 1,000) across 11 studies
Low end of studied doses
Vitamin B625 mg
Studies used 19–1,200 mg/day (median 80) across 6 studies
Low end of studied doses
Vitamin B12100 mcg
Studies used 250–1,000 mcg/day (median 1,000) across 3 studies
Below studied range
Vitamin B7200 mcg
Studies used 10,000 mcg/day (median 10,000) across 1 study
Below studied range
Zinc15 mg
Studies used 10–100 mg/day (median 55) across 2 studies
Low end of studied doses
Chromium100 mcg
Studies used 200–400 mcg/day (median 300) across 2 studies
Below studied range
Vitamin K215 mcg
Studies used 180–360 mcg/day (median 360) across 6 studies
Below studied range

Research-supported combinations

Ingredient pairs in this product that have synthesised research evidence together.

Moderate evidenceVitamin E + Vitamin Cfor Reduced Pain· 3 studies
Across 3 studies, all reported beneficial effects of the combination of vitamin E and vitamin C on pain reduction, with effect sizes ranging from small to moderate (predominantly small). The median study duration was 60 days. The combination shows similar effects to vitamin E or vitamin C alone based on solo syntheses, but all studies tested the combination as part of a multi-ingredient formulation, precluding isolation of the specific contribution of these two vitamins.

Product Description

Supports overall health and well-being with a balanced blend of essential vitamins and minerals.
Boosts immune system function with Vitamin C and Zinc.
Promotes strong bones through the inclusion of Vitamin D-3 and Calcium.
Enhances cognitive function and energy levels with B-Vitamins like B-6, B-12, and thiamine.
Aids cardiovascular health with mixed tocopherols and Vitamin E.
Improves tissue repair and wound healing supported by Vitamin A and selenium.
Maintains thyroid function with Iodine.
Encourages hormone regulation with Vitamin K1 and K2.
Vegetarian-friendly and completely free of gluten, dairy, and eggs, ensuring it suits various dietary needs.

Formulated by Metabolic Maintenance, The Big One Plus is designed to provide comprehensive health support in a convenient daily capsule. The perfect blend of vitamins, minerals, and key nutrients ensures an optimal balance for enhanced vitality.