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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Evaluation of the Impact of Probiotic Supplementation on Gingival Inflammation in Subjects Undergoing Orthodontic Treatment with Fixed Appliances or Clear Aligners: A Randomized, Single-Blind Pilot Study.
- 2025-11-10
- RCT
- Dentistry journal 13(11)
- - Jacopo Lanzetti
  - Serena Queirolo
  - Giulia Furini Evans
  - Umberto Gibello
  - Andrea Deregibus
  - Francesco Pera
- PubMed: 41294507
- DOI: 10.3390/dj13110526
2 Insights on
- Reduced Gingival Bleeding
- Reduced Plaque Accumulation
- High evidence
Bioinformatic Analysis of Oxalate-Degrading Enzymes in Probiotics: A Systematic Genome-Scale and Structural Survey.
- 2025-11-08
- Review
- Microorganisms 13(11)
- - Shengda Du
  - Ke Sun
  - Bo Xiao
  - Zhihua Liu
- PubMed: 41304238
- DOI: 10.3390/microorganisms13112553
2 Insights on
- Reduced Kidney Stone Formation
- Increased Oxalate-Degrading Activity
- Low evidence
Effects of Moringa oleifera Lam. Supplementation on Cardiometabolic Outcomes: A Meta-Analysis of Randomized Controlled Trials with GRADE Assessment.
- 2025-11-07
- Meta-Analysis · n = 341
- Nutrients 17(22)
- - Diana Crișan
  - Laura Gavrilaș
  - Ramona Păltinean
  - Oleg Frumuzachi
  - Andrei Mocan
  - Gianina Crișan
- PubMed: 41305552
- DOI: 10.3390/nu17223501
1 Insight on
- Reduced Diastolic Blood Pressure
- High evidence
- Rigorous Journal
Whole-Genome Sequence Analysis and Subtractive Screening of Lactobacilli in the Searching for New Probiotics to Protect the Mammary Glands.
- 2025-11-06
- International journal of molecular sciences 26(21)
- - Dobroslava Bujňáková
  - Tímea Galambošiová
  - Lívia Karahutová
- PubMed: 41226844
- DOI: 10.3390/ijms262110809
1 Insight on
- Reduced Mastitis Risk
- Low evidence
- Rigorous Journal
- Animal Study
Bifidobacterium animalis subsp. lactis BB-12 attenuates diabetic retinopathy through gut microbiota modulation: evidence for the gut-retinal axis.
- 2025-11-06
- Frontiers in cellular and infection microbiology 15
- - Jiayi Lin
  - Yaqi Cheng
  - Yumin Ling
  - Simin Gu
  - Haocheng Zhu
  - Meng Li
  - Huan Yu
  - Jianbing Li
  - Qian Luo
  - Weihua Li
  - Shiqi Ling
- PubMed: 41278472
- DOI: 10.3389/fcimb.2025.1681943
9 Insights on
- Low evidence
- Animal Study
Proteomic study of Akkermansia muciniphila and Bifidobacterium species co-culture under different carbon sources.
- 2025-11-06
- Frontiers in microbiology 16
- - Jordy Evan Sulaiman
  - Yuewei Zhan
  - Shuchen Wang
  - Ka Lun Lai
  - James Ho Wa Li
  - Daniel Ye Yutong
  - Karl Wah Keung Tsim
  - Kenneth King Yip Cheng
  - Yong Lai
  - Henry Lam
- PubMed: 41277960
- DOI: 10.3389/fmicb.2025.1666747
2 Insights on
- Improved Intestinal Barrier Function
- Increased Bifidobacterium Levels
- Low evidence
Certain fermented dairy foods as a source of multibiotics and multimetabolites: a comprehensive review.
- 2025-11-06
- Review
- Frontiers in nutrition 12
- - Duygu Ağagündüz
  - Yasemin Ertaş Öztürk
  - Büşra Ayhan
  - Tuğçe Bulmuş-Tüccar
  - Çiler Özenir
  - Nazlıcan Erdoğan Gövez
  - Yesim Ozogul
  - Tuba Esatbeyoglu
  - Fatih Ozogul
- PubMed: 41280398
- DOI: 10.3389/fnut.2025.1678150
5 Insights on
- Low evidence
The Nutritional Challenges Following Revisional Bariatric Surgery After Sleeve Gastrectomy: A Systematic Review and Meta Analysis.
- 2025-11-05
- Meta-Analysis · n = 49
- Obesity surgery 35(12)
- - Hassan El-Masry
  - Mohamed H Mahmoud
  - Batool Sami Mohamed
  - Dina Elraggal
  - Mostafa H Elkholy
  - Ahmed Abokhozima
- PubMed: 41193797
- DOI: 10.1007/s11695-025-08325-2
7 Insights on
- High evidence
Natural Compounds in Oral Microbiota Modulation and Caries Prevention: A Systematic Review.
- 2025-11-05
- Review · n = 77
- Dentistry journal 13(11)
- - María Del Pilar Angarita-Díaz
  - Lilia J Bernal-Cepeda
  - Jéssica María Sarmiento-Ordoñez
  - Yohan Yañez-Navas
  - Karen Garcia-Plazas
  - Hermann Gutierrez-Reyes
  - Laura Correa-Guataquira
- PubMed: 41294499
- DOI: 10.3390/dj13110518
2 Insights on
- Reduced Streptococcus Mutans Levels
- Reduced Salivary pH
- Moderate evidence
Effects of Whey Protein Supplementation on Body Composition, Muscular Strength, and Cardiometabolic Health in Older Adults: A Systematic Review with Pairwise Meta-Analysis.
- 2025-11-05
- Review · n = 1,454
- Healthcare (Basel, Switzerland) 13(21)
- - Mousa Khalafi
  - Saeid Fatolahi
  - Reihaneh Jafari
  - Sara K Rosenkranz
  - Michael E Symonds
  - Zeinab Abbaszadeh Bidgoli
  - Maria Luz Fernandez
  - Farnaz Dinizadeh
  - Alexios Batrakoulis
- PubMed: 41228181
- DOI: 10.3390/healthcare13212814
3 Insights on
- High evidence
Comparative Evaluation of Functional Properties of Cow, Goat, and Donkey Milks Fermented with Lactic Acid Bacteria.
- 2025-11-05
- Antioxidants (Basel, Switzerland) 14(11)
- - Giusy Rita Caponio
  - Alessandro Annunziato
  - Mirco Vacca
  - Mariasimona Cavaliere
  - Ilenia Ceglie
  - Marianna Ranieri
  - Alessio Di Luca
  - Angela Gabriella D'Alessandro
  - Grazia Tamma
  - Maria De Angelis
- PubMed: 41300487
- DOI: 10.3390/antiox14111331
2 Insights on
- Reduced Oxidative Stress
- Improved Antioxidant Activity
- Low evidence
Probiotic-enhanced chemotherapy: Lactobacillus fermentum synergizes with vincristine to induce apoptosis via dual pathway activation in human cancer cells.
- 2025-11-05
- Cancer cell international 25(1)
- - Abbas Asoudeh-Fard
  - Mohadeseh Asoudeh-Fard
  - Asghar Parsaei
- PubMed: 41194119
- DOI: 10.1186/s12935-025-04032-1
1 Insight on
- Reduced Vincristine Dose Requirement
- Low evidence
Effects of a Scutellaria baicalensis/Crataegus laevigata, magnesium and chromium supplement on stressed individuals: A randomised, double-blind, placebo-controlled, crossover trial.
- 2025-11-05
- RCT
- Journal of psychopharmacology (Oxford, England) 39(12)
- - Fiona Dodd
  - Ramon Weishaupt
  - Philipp K M Katumba
  - Rian Elcoate
  - Emma Wightman
- PubMed: 41194549
- DOI: 10.1177/02698811251381261
6 Insights on
- High evidence
Comparative efficacy of different dietary interventions for cardiopulmonary fitness at high altitude: a systematic review and network meta-analysis.
- 2025-11-04
- Systematic Review · n = 329
- Frontiers in nutrition 12
- - Bin Wang
  - Yanle Xiong
  - Ning Lin
  - Jiaojiao Shi
  - Bo Zou
  - Xin Ma
  - Kaihong Zeng
  - Chao Kang
- PubMed: 41262729
- DOI: 10.3389/fnut.2025.1658950
2 Insights on
- Reduced Heart Rate
- Reduced Hematocrit
- High evidence
Survival and safety evaluation of Bifidobacterium longum subsp. longum ZS-8 in healthy adults, determined using PMAxx-qPCR and amplicon sequencing.
- 2025-11-04
- Clinical Trial
- Microbiology spectrum 13(11)
- - Feng Liu
  - Biao Dong
  - Zhongsun Wang
  - Dan Lin
  - Huan Xu
  - Baisheng Ke
  - Wanying Kang
  - Yang Jin
  - Xiuting Huang
  - Hui Lu
  - Liqing Zhao
  - Yun Qian
  - Liangling Cai
  - Long Xu
  - Zhenjiang Zech Xu
- PubMed: 40981476
- DOI: 10.1128/spectrum.02861-24
3 Insights on
- Moderate evidence
Levodopa Added to Stroke Rehabilitation: The ESTREL Randomized Clinical Trial.
- 2025-11-04
- RCT · n = 610
- JAMA 334(17)
- - Stefan T Engelter
  - Josefin E Kaufmann
  - Annaelle Zietz
  - Andreas R Luft
  - Alexandros Polymeris
  - Valerian L Altersberger
  - Karin Wiesner
  - Martina Wiegert
  - Jeremia P O Held
  - Yannik Rottenberger
  - Anne Schwarz
  - Friedrich Medlin
  - Ettore A Accolla
  - Sandrine Foucras
  - Georg Kägi
  - Gian Marco De Marchis
  - Svetlana Politz
  - Matthias Greulich
  - Alexander A Tarnutzer
  - Rolf Sturzenegger
  - Mira Katan
  - Urs Fischer
  - Krassen Nedeltchev
  - Janine Schär
  - Katrien Van Den Keybus Deglon
  - Pierre-André Rapin
  - Alexander Salerno
  - David J Seiffge
  - Elias Auer
  - Julian Lippert
  - Leo H Bonati
  - Corina Schuster-Amft
  - Szabina Gäumann
  - Joelle N Chabwine
  - Andrea Humm
  - J Carsten Möller
  - Raoul Schweinfurther
  - Bartosz Bujan
  - Piotr Jedrysiak
  - Peter S Sandor
  - Roman Gonzenbach
  - Veit Mylius
  - Dietmar Lutz
  - Carmen Lienert
  - Nils Peters
  - Patrik Michel
  - René M Müri
  - Sabine Schädelin
  - Lars G Hemkens
  - Gary A Ford
  - Philippe A Lyrer
  - Henrik Gensicke
  - Christopher Traenka
- PubMed: 40982270
- DOI: 10.1001/jama.2025.15185
1 Insight on
- Improved Motor Function
- High evidence
- Large Human Trial
- Rigorous Journal
Efficacy of N-Acetylcysteine in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis.
- 2025-11-04
- Meta-Analysis · n = 773
- BMC gastroenterology 25(1)
- - Ahmad Hormati
  - Asma Mousavi
  - Shayan Shojaei
  - Atie Moghtadaei
  - Sanaz Bordbar
  - Hediyeh Alemi
  - Amir Kasaeian
  - Sadaf Sepanlou
- PubMed: 41188701
- DOI: 10.1186/s12876-025-04382-0
2 Insights on
- Reduced Incidence of Post-ERCP Pancreatitis
- Reduced Post-ERCP Pancreatitis Severity
- High evidence
Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial.
- 2025-11-03
- RCT
- The Journal of clinical endocrinology and metabolism 111(5)
- - Trupti N Prasad
  - Rimesh Pal
  - Sanjay K Bhadada
  - Sant Ram
  - Veenu Singla
  - Seema Pulami
- PubMed: 41183496
- DOI: 10.1210/clinem/dgaf589
3 Insights on
- High evidence
Thiamine use and short-term prognosis in critical cerebrovascular disease: a propensity score matched retrospective analysis from the MIMIC-IV database.
- 2025-11-03
- Observational · n = 814
- BMC neurology 25(1)
- - Tianli Zhang
  - Minheng Zhang
  - Haixia Fan
  - Xuan Chen
  - Peng Wei
  - Zhaoxu Yin
  - Xin Li
- PubMed: 41184785
- DOI: 10.1186/s12883-025-04478-w
1 Insight on
- Reduced All-Cause Mortality
- High evidence
Probiotics in Periodontal Diseases: Mechanisms, Evidence Mapping, Limitations, and Future Directions.
- 2025-11-03
- Review
- Cureus 17(11)
- - Hamza Alasbily
  - Huda H Mohamed
  - Adnan Asheibi
  - Manal S Bazina
  - Ali Alkaseh
  - Hana M Ghaith
  - Fardous Ali Fahmi
- PubMed: 41356942
- DOI: 10.7759/cureus.96042
1 Insight on
- Improved Periodontal Health
- Low evidence
Comparative efficacy and safety of anti-osteoporotic therapies for kidney transplant recipients: a systematic review and network meta-analysis.
- 2025-11-03
- Systematic Review · n = 66
- Frontiers in endocrinology 16
- - Xiaopei Liu
  - Xingyao Li
  - Yanhong Zhao
  - Qi Gao
  - Yuan Xue
  - Zhongheng Wu
  - Xingmin Shi
  - Xili Wu
- PubMed: 41255525
- DOI: 10.3389/fendo.2025.1689233
1 Insight on
- Improved Bone Mineral Density
- High evidence
Probiotic Potential of Traditional and Emerging Microbial Strains in Functional Foods: From Characterization to Applications and Health Benefits.
- 2025-11-02
- Review
- Microorganisms 13(11)
- - Chijioke Christopher Uhegwu
  - Christian Kosisochukwu Anumudu
- PubMed: 41304207
- DOI: 10.3390/microorganisms13112521
1 Insight on
- Improved Gastrointestinal Symptoms
- Low evidence
Emerging prospects of Bacillus species in attaining the sustainable development goals.
- 2025-11-01
- Review
- Applied microbiology and biotechnology 109(1)
- - Harsh Kumar
  - Shivani Guleria
  - Kamil Kuča
  - Lukas Peter
  - Arifullah Mohammed
  - Tabarak Malik
  - Nidhi Sethi
  - Daljeet Singh Dhanjal
  - Dinesh Kumar
  - Hasnita Binti Che Harun
- PubMed: 41175226
- DOI: 10.1007/s00253-025-13634-8
2 Insights on
- Improved Gastrointestinal Health
- Improved General Well-Being
- Low evidence
The Effect of Kefir Consumption on Blood Pressure and C-Reactive Protein: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
- 2025-11-01
- Meta-Analysis · n = 385
- Endocrinology, diabetes & metabolism 8(6)
- - Elaheh Rashidbeygi
  - Mahnoush Mehrzad Samarin
  - Fatemeh Sheikhhossein
  - Amir Hossein Khalilkhaneh
  - Masoomeh Gholizadeh
  - Negin Lohrasbi
  - Amin Abbasi
  - Hadi Bazyar
  - Gholamreza Askari
  - Mohammad Reza Amini
- PubMed: 41139305
- DOI: 10.1002/edm2.70124
3 Insights on
- High evidence
Efficacy and Safety of Saccharomyces Boulardii with Standard Quadruple Therapy for Eradication of Helicobacter Pylori in Adults: Meta-Analysis.
- 2025-11-01
- Meta-Analysis · n = 295
- Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 35(11)
- - Fengzhen Ma
  - Heyin Huang
  - Kanglin Tian
  - Wei Wang
- PubMed: 41247686
- DOI: 10.29271/jcpsp.2025.11.1440
1 Insight on
- Increased Helicobacter pylori Eradication Rate
- High evidence
Collagen Supplementation Augments Strength Training-Induced Gains in Tendon Size and Rate of Force Development in Elite Female Master Field Hockey Athletes.
- 2025-11-01
- RCT · n = 12
- International journal of sport nutrition and exercise metabolism 35(6)
- - Christopher D Nulty
  - Robert M Erskine
- PubMed: 40992424
- DOI: 10.1123/ijsnem.2025-0089
5 Insights on
- High evidence
Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation.
- 2025-10-31
- Journal of microbiology (Seoul, Korea) 63(10)
- - Seokcheon Song
  - Jun-Hyeong Kim
  - Sung Jae Jang
  - Eun Jung Jo
  - Sang Kyun Lim
  - GwangPyo Ko
- PubMed: 41164963
- DOI: 10.71150/jm.2509005
3 Insights on
- Low evidence
Dietary probiotic supplementation with Lactococcus lactis and Bacillus velezensis enhances growth performance, meat quality, blood profiles, and cecal and feed microbiota in growing rabbits.
- 2025-10-31
- Animal biotechnology 36(1)
- - Nada Elbaz
  - Elwy A Ashour
  - Samar S Bassiony
  - Ahmed I Elsherbeni
  - Samir A Mahgoub
  - Ali O Osman
  - Islam Sabike
  - Naif A Al-Gabri
  - Mahmoud Moustafa
  - Mohammed Al-Shehri
  - Mohamed E Abd El-Hack
- PubMed: 41173468
- DOI: 10.1080/10495398.2025.2577947
3 Insights on
- Low evidence
- Animal Study
Efficacy of vitamin C in COVID-19 management: a systematic review and meta-analysis.
- 2025-10-31
- Meta-Analysis · n = 19
- BMC infectious diseases 25(1)
- - Shuyi Zhou
  - Shijie Gao
  - Yujie Fang
  - Na Zhang
  - Guansheng Ma
- PubMed: 41174501
- DOI: 10.1186/s12879-025-11891-6
2 Insights on
- Reduced Short-term Mortality
- Reduced In-hospital Mortality
- High evidence
Low-Cost Protocol for Quantitative Measurement of Streptococcus salivarius in Human Saliva.
- 2025-10-31
- Observational
- Life (Basel, Switzerland) 15(11)
- - Flavia-Cristina Al-Akel
  - Lacramioara Eliza Chiperi
  - Krisztina Eszter Vas
  - Edit Szekely
  - Claudia Raluca Mariean
  - Corina Eugenia Budin
  - Anca Bacarea
- PubMed: 41302119
- DOI: 10.3390/life15111695
1 Insight on
- Reduced Streptococcus salivarius Colonization
- Low evidence