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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of sour soup on silage fermentation performance and bacterial community of Broussonetia papyrifera.
- 2025-11-18
- BMC microbiology 25(1)
- - Qiming Cheng
  - Meiling Hou
  - Maoya Li
  - Yao Lei
  - Jiachuhan Wang
  - Yulian Chen
  - Yinghao Liu
  - Dianpeng Liu
  - Xiaoqing Zhang
  - Haoran Yu
- PubMed: 41254562
- DOI: 10.1186/s12866-025-04410-9
1 Insight on
- Increased Betaine Content
- Low evidence
Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes.
- 2025-11-18
- Clinical Trial
- Frontiers in nutrition 12
- - Anissa Lasfar
  - Sanne L M van Stratum
  - Maria Imperatrice
  - Colin A J van Kalkeren
  - Jean L J M Scheijen
  - Casper G Schalkwijk
  - Danique La Torre
  - Freddy J Troost
- PubMed: 41340653
- DOI: 10.3389/fnut.2025.1670194
2 Insights on
- Reduced Pore Number
- Reduced Surface Skewness
- High evidence
Probiotic Blend of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis ssp. Lactis BB-12 in Non-constipated Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial.
- 2025-11-18
- RCT
- Journal of gastroenterology and hepatology 41(1)
- - Uday C Ghoshal
  - B S Ramakrishna
  - Pravin M Rathi
  - Akash Shukla
  - Manas Kumar Panigrahi
  - Shubham Jain
  - Indraneel Saha
  - Karmabir Chakravartty
  - Madhuri Singh
  - Uzma Mustafa
  - Shikha Sahu
  - Ujjala Ghoshal
  - Sanjay Chandnani
  - Mahesh K Goenka
  - Monjori Mitra
- PubMed: 41255078
- DOI: 10.1111/jgh.70137
6 Insights on
- High evidence
Effects of Probiotic Short-Term Regiment on Oral Health Parameters in Children: A Pilot Randomized Controlled Trial.
- 2025-11-18
- RCT · n = 40
- Nutrients 17(22)
- - Edouard Starck
  - Vanessa Machado
  - João Botelho
  - Luís Proença
  - Helena Barroso
  - Carla Ascenso
  - Cecília Rozan
- PubMed: 41305654
- DOI: 10.3390/nu17223604
6 Insights on
- High evidence
- Rigorous Journal
Probiotics Attenuate Food Allergy via Short-Chain Fatty Acids-Mediated Immune Modulation and Gut Barrier Restoration.
- 2025-11-18
- Foods (Basel, Switzerland) 14(22)
- - Xue Feng
  - Liuying Li
  - Li Yan
  - Zhencong Yan
  - Zhoujin Xu
  - Yuting Fan
  - Philippe Madjirebaye
  - Xuli Wu
- PubMed: 41300111
- DOI: 10.3390/foods14223953
5 Insights on
- Low evidence
Bifidobacterium infantis modulates intestinal microecology to inhibit the spread of antimicrobial resistance.
- 2025-11-18
- mSystems 10(11)
- - Ziyun Li
  - Jiamin Hu
  - Yingmiao Pan
  - Yaxuan Xi
  - Lei Zhang
- PubMed: 41171056
- DOI: 10.1128/msystems.00728-25
2 Insights on
- No Reduction in Antibiotic-Resistant Organism Colonization
- Improved Gut Microbiota Balance
- Low evidence
- Rigorous Journal
Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer.
- 2025-11-18
- Review
- Exploration of targeted anti-tumor therapy 6
- - Ger T Rijkers
  - Yonah Langcauon
  - Pippe van Leersum
  - Lara Popović
  - Frans J van Overveld
- PubMed: 41281468
- DOI: 10.37349/etat.2025.1002348
1 Insight on
- Improved Response to Immune Checkpoint Inhibitor Therapy
- Low evidence
Lactobacilli-Derived Microbe-Associated Molecular Patterns (MAMPs) in Host Immune Modulation.
- 2025-11-17
- Review
- Biomolecules 15(11)
- - Salvatore Furnari
  - Ruben Ciantia
  - Adriana Garozzo
  - Pio Maria Furneri
  - Virginia Fuochi
- PubMed: 41301527
- DOI: 10.3390/biom15111609
4 Insights on
- Low evidence
An Integrated Engineering Approach to Creating Health-Modulating Postbiotics.
- 2025-11-17
- Review
- Molecular nutrition & food research 70(1)
- - Michael Leonidas Chikindas
  - Diana E Roopchand
  - Santosh Kumar Tiwari
  - Liubov S Sichel
  - Mukund V Karwe
  - Nitin Nitin
  - Vitor Luis Fagundes
  - Igor V Popov
  - John R Tagg
  - Xuanxuan Lu
  - Svetoslav Dimitrov Todorov
- PubMed: 41251175
- DOI: 10.1002/mnfr.70326
6 Insights on
- Moderate evidence
- Rigorous Journal
Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
- 2025-11-17
- RCT · n = 15
- Scientific reports 15(1)
- - Aref Basereh
  - Karen Khoramipour
  - Najmeh Hosseini
  - Mahdieh HajHosseini
  - Adeleh Khodabakhshi
  - Ladan Amirkhosravi
  - Kayvan Khoramipour
- PubMed: 41249265
- DOI: 10.1038/s41598-025-23914-y
11 Insights on
- High evidence
- Rigorous Journal
Strain-specific qPCR assay to track the vaginal colonization of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 strain orally administered.
- 2025-11-17
- Clinical Trial
- BMC microbiology 25(1)
- - Amanda Vaccalluzzo
  - Alessandra Pino
  - Georgiana Bosco
  - Cinzia Caggia
  - Cinzia Lucia Randazzo
- PubMed: 41249926
- DOI: 10.1186/s12866-025-04470-x
2 Insights on
- Increased Vaginal Colonization
- Detected Vaginal Colonization by Probiotic Strain
- Moderate evidence
Navigating Measles Treatment in 2025: A Review on Vaccines, Medications, and Supplements.
- 2025-11-17
- Review
- Pediatric allergy, immunology, and pulmonology 38(4)
- - Misty M Oldham
  - Sandra Benavides
  - Paul M Boylan
- PubMed: 41248922
- DOI: 10.1177/2151321x251397927
1 Insight on
- Reduced Measles Mortality
- Low evidence
Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach.
- 2025-11-17
- Review
- Nutrients 17(22)
- - Ioanna Aggeletopoulou
  - Katerina Karaivazoglou
  - Maria Kalafateli
  - Christos Triantos
- PubMed: 41305645
- DOI: 10.3390/nu17223595
1 Insight on
- Reduced Irritable Bowel Syndrome Symptom Severity
- Moderate evidence
- Rigorous Journal
The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial.
- 2025-11-16
- RCT
- Nutrients 17(22)
- - Anna Koperska
  - Ewa Miller-Kasprzak
  - Agnieszka Seraszek-Jaros
  - Katarzyna Musialik
  - Paweł Bogdański
  - Monika Szulińska
- PubMed: 41305635
- DOI: 10.3390/nu17223585
8 Insights on
- High evidence
- Rigorous Journal
Correction to "Lactobacillus rhamnosus LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes".
- 2025-11-15
- World journal of diabetes 16(11)
- - Lin Geng
  - Ting-Ting Sun
  - Wen-Bo Xia
  - Ying Qin
  - Di Huo
  - Guang-Jin Qu
- PubMed: 41278440
- DOI: 10.4239/wjd.v16.i11.114013
1 Insight on
- Improved Glycemia
- Low evidence
Harnessing CRISPR-Cas9 for Lactobacillus improvement in silage production: current knowledge and future perspectives.
- 2025-11-15
- Review
- Journal of animal science and biotechnology 16(1)
- - Jing Ma
  - Jiao Zhang
  - Xusheng Guo
- PubMed: 41239469
- DOI: 10.1186/s40104-025-01282-x
1 Insight on
- No Improvement in Allergy Symptoms
- Low evidence
Essential amino acid supplementation for pressure ulcers: pathophysiological rationale and results from a pilot study.
- 2025-11-14
- Clinical Trial
- Amino acids 57(1)
- - Maciej Świątkiewicz
  - Andrzej Lejczak
  - Piotr Foltyński
  - Paweł Grieb
- PubMed: 41236568
- DOI: 10.1007/s00726-025-03489-8
1 Insight on
- Reduced Pressure Ulcer Area
- Moderate evidence
Aeronutrient Therapy: A New Frontier in Systemic Drug Delivery.
- 2025-11-14
- Review
- Biomedicines 13(11)
- - Stephen R Robinson
  - Malav S Trivedi
  - Flávia Fayet-Moore
- PubMed: 41301881
- DOI: 10.3390/biomedicines13112788
2 Insights on
- Resolved Pernicious Anemia Symptoms
- Restored Retinol Level
- Low evidence
Lactic acid bacteria in the meat industry: flavor, function, and food safety.
- 2025-11-13
- Review
- Frontiers in microbiology 16
- - Bhagavathi Sundaram Sivamaruthi
  - Periyanaina Kesika
  - Safreena Barwin Syed Rafeek
  - Kasthuri Sivakumar
  - Shanmuga Priya Ramasamy
  - Chaiyavat Chaiaysut
  - Pranom Fukngoen
  - Karthikeyan Alagarsamy
- PubMed: 41321821
- DOI: 10.3389/fmicb.2025.1703213
1 Insight on
- Improved Lactose Digestion
- Low evidence
The effect of postbiotics supplementation on obesity and metabolic health: a systematic review and meta-analysis of randomized control trials.
- 2025-11-13
- Meta-Analysis
- Nutrition & metabolism 22(1)
- - Shuwen Li
  - Mohammad Hassan Sohouli
  - Zeli Li
- PubMed: 41233893
- DOI: 10.1186/s12986-025-01037-5
4 Insights on
- High evidence
Probiotics and Phytoantioxidants Target Coronary Endothelial Dysfunction in Irregular Sleep- and Obesity-Associated Cardiometabolic Syndrome.
- 2025-11-12
- Review
- Life (Basel, Switzerland) 15(11)
- - Chi-Nan Tseng
  - Yen Chu
- PubMed: 41302164
- DOI: 10.3390/life15111740
3 Insights on
- Low evidence
Cardioprotective Effect of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Is Mediated by Sarcolemmal but Not Mitochondrial ATP-Sensitive Potassium Channels in Rats with Systemic Inflammation.
- 2025-11-12
- International journal of molecular sciences 26(22)
- - Yury Yu Borshchev
  - Inessa Yu Burovenko
  - Alena B Karaseva
  - Sarkis M Minasian
  - Alexey D Gordeev
  - Victor Yu Borshchev
  - Dmitry Yu Butko
  - Olga V Borshcheva
  - Alexander N Suvorov
  - Michael M Galagudza
- PubMed: 41303419
- DOI: 10.3390/ijms262210935
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Oral Probiotic Containing Streptococcus salivarius K12 and Lactobacillus brevis CD2 for Preventing Bacterial Pneumonia in Severe COVID-19: Randomized Clinical Trial.
- 2025-11-12
- RCT · n = 60
- The journal of contemporary dental practice 26(10)
- - Jonathan R Lauxen
  - Sidia M Callegari-Jacques
  - Augusto S Mombelli
  - Amanda Prando
  - Tiago T Simon
  - Fernando Fornari
- PubMed: 41526312
- DOI: 10.5005/jp-journals-10024-3954
3 Insights on
- High evidence
Correlation of probiotic consumption with plaque index, salivary pH, and streptococcus mutans: A clinical experimental study.
- 2025-11-11
- Clinical Trial · n = 40
- The Saudi dental journal 37(10-12)
- - Rista Lewiyonah
  - Heriandi Sutadi
  - Eva Fauziah
- PubMed: 41214230
- DOI: 10.1007/s44445-025-00010-5
4 Insights on
- High evidence
Nutritional and Supplemental Interventions for Prevention and Treatment of Oral Mucositis in Pediatric Oncology.
- 2025-11-11
- Systematic Review
- Nutrients 17(22)
- - Razvan Mihai Horhat
  - Alexandru Alexandru
  - Cristiana-Smaranda Ivan
  - Norberth-Istvan Varga
  - Madalina-Ianca Suba
  - Elena Ciurariu
  - Monica Susan
  - Razvan Susan
  - Adrian Cote
- PubMed: 41305573
- DOI: 10.3390/nu17223521
4 Insights on
- High evidence
- Rigorous Journal
Dietary Glycerol Monolaurate Effect on Growth Performance, Intestinal Barrier Function, and Gut Microbiota in Weaned Piglets Challenged by Lipopolysaccharide.
- 2025-11-11
- RCT
- Animals : an open access journal from MDPI 15(22)
- - Huakai Wang
  - Ruiyu Ma
  - Renrong Qi
  - Zhen Liu
  - Yinghao Li
  - Xudong Wu
  - Chunfang Zhao
  - Qiugang Ma
  - Kai Zhan
- PubMed: 41301971
- DOI: 10.3390/ani15223263
1 Insight on
- Improved Gut Microbiota Composition
- High evidence
Evaluation of the Impact of Probiotic Supplementation on Gingival Inflammation in Subjects Undergoing Orthodontic Treatment with Fixed Appliances or Clear Aligners: A Randomized, Single-Blind Pilot Study.
- 2025-11-10
- RCT
- Dentistry journal 13(11)
- - Jacopo Lanzetti
  - Serena Queirolo
  - Giulia Furini Evans
  - Umberto Gibello
  - Andrea Deregibus
  - Francesco Pera
- PubMed: 41294507
- DOI: 10.3390/dj13110526
2 Insights on
- Reduced Gingival Bleeding
- Reduced Plaque Accumulation
- High evidence
A phase II clinical trial of Bifidobacterium longum subsp. longum BL21 for preventing acute radiation enteritis among pelvic radiotherapy patients.
- 2025-11-10
- Clinical Trial · n = 52
- Frontiers in nutrition 12
- - Yinyin Yang
  - Xuhao Gu
  - Chang Liu
  - Li Zou
  - Liwei Xie
  - Yulong Liu
  - Peifeng Zhao
  - Ye Tian
  - Shang Cai
- PubMed: 41293184
- DOI: 10.3389/fnut.2025.1626169
3 Insights on
- High evidence
Progress and prospects of gut microbiota-targeted therapy for primary biliary cholangitis.
- 2025-11-10
- Review
- Gut pathogens 17(1)
- - Xuan Tang
  - Xin You
- PubMed: 41214728
- DOI: 10.1186/s13099-025-00753-w
4 Insights on
- Low evidence
Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions.
- 2025-11-10
- Review
- Frontiers in pharmacology 16
- - Xinyu Liu
  - Wenfeng Zhang
  - Xiao Miao
  - Yinghua Hu
- PubMed: 41293245
- DOI: 10.3389/fphar.2025.1656751
2 Insights on
- Improved Cardiac Function
- Improved Heart Failure Symptom
- Low evidence