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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Ylang-ylang and lavender aromatherapy for paediatric dental anxiety: A randomized control trial in first restorative appointment.
- 2025-10-31
- RCT
- Bioinformation 21(10)
- - Amol N Patil
  - Sneha N Kamble
  - Pranali Shelke
  - Priya Telang
  - Aishwarya Shelar
  - Mrunalini Kadam
- PubMed: 41623781
- DOI: 10.6026/973206300213686
2 Insights on
- Reduced Anxiety
- Reduced Pulse Rate
- High evidence
A Retrospective Study of the Association between Low Vitamin B1 in the Blood and Cognitive Impairment in Patients with Alzheimer's Disease.
- 2025-10-31
- Observational
- Journal of nutritional science and vitaminology 71(5)
- - Yuji Higaki
  - Yu Kobayashi
- PubMed: 41183968
- DOI: 10.3177/jnsv.71.421
1 Insight on
- Reduced Cognitive Function
- Low evidence
The Effect of Maternal Folic Acid Supplementation on Neurodevelopmental Disorders in Offspring: An Umbrella Review of Systematic Reviews and Meta-Analyses.
- 2025-10-31
- Systematic Review · n = 23
- Nutrients 17(21)
- - Miao Yu
  - Yiming Hu
  - Lei Hou
  - Xiaomin Wu
  - Xiangxin Chen
  - Ruohan Yan
  - Jie Dong
  - Jing Wu
- PubMed: 41228512
- DOI: 10.3390/nu17213443
9 Insights on
- High evidence
- Rigorous Journal
Berries derived Polyphenols and Bone Health: A Systematic Review.
- 2025-10-31
- Systematic Review
- Nutrients 17(21)
- - Simone Perna
  - Giorgia F Ruina
  - Asmita Acharya
  - Giuseppe Mazzola
  - Mariangela Rondanelli
  - Patrizia Riso
- PubMed: 41228518
- DOI: 10.3390/nu17213440
3 Insights on
- High evidence
- Rigorous Journal
Natural Products in Alzheimer's Disease: A Systematic Review of Clinical Trials and Underlying Molecular Mechanisms.
- 2025-10-31
- Systematic Review · n = 3,582
- International journal of molecular sciences 26(21)
- - Maria T Bayo Jimenez
  - Lorenzo Rivas-García
  - Cristina Sánchez-González
  - Giuseppe Grosso
  - Vivian Lipari
  - Laura Vera-Ramírez
  - Maurizio Battino
  - Francesca Giampieri
  - José L Quiles
  - Tamara Y Forbes-Hernández
- PubMed: 41226670
- DOI: 10.3390/ijms262110631
1 Insight on
- Improved Cognitive Function
- High evidence
- Rigorous Journal
Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation.
- 2025-10-31
- Journal of microbiology (Seoul, Korea) 63(10)
- - Seokcheon Song
  - Jun-Hyeong Kim
  - Sung Jae Jang
  - Eun Jung Jo
  - Sang Kyun Lim
  - GwangPyo Ko
- PubMed: 41164963
- DOI: 10.71150/jm.2509005
3 Insights on
- Low evidence
Dietary probiotic supplementation with Lactococcus lactis and Bacillus velezensis enhances growth performance, meat quality, blood profiles, and cecal and feed microbiota in growing rabbits.
- 2025-10-31
- Animal biotechnology 36(1)
- - Nada Elbaz
  - Elwy A Ashour
  - Samar S Bassiony
  - Ahmed I Elsherbeni
  - Samir A Mahgoub
  - Ali O Osman
  - Islam Sabike
  - Naif A Al-Gabri
  - Mahmoud Moustafa
  - Mohammed Al-Shehri
  - Mohamed E Abd El-Hack
- PubMed: 41173468
- DOI: 10.1080/10495398.2025.2577947
3 Insights on
- Low evidence
- Animal Study
Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.
- 2025-10-30
- Review
- Journal of clinical medicine 14(21)
- - Rebeka Olga Mátyus
  - Zsóka Szikora
  - Diána Bodó
  - Bettina Vargáné Szabó
  - Éva Csupor
  - Dezső Csupor
  - Barbara Tóth
- PubMed: 41227106
- DOI: 10.3390/jcm14217710
3 Insights on
- Low evidence
In Vitro Detoxification of Fumonisin B1 (FB1) into Hydrolyzed Fumonisin B1 (HFB1) by Lactobacillus spp. Isolated from Pig Caecum.
- 2025-10-30
- International journal of molecular sciences 26(21)
- - Huu Anh Dang
  - Attila Zsolnai
  - Mariam Kachlek
  - Veronika Halas
  - Diana Giannuzzi
  - Stefano Schiavon
  - Isaac Hyeladi Malgwi
- PubMed: 41226597
- DOI: 10.3390/ijms262110557
2 Insights on
- Reduced Fumonisin B1 Levels
- Increased Hydrolyzed Fumonisin B1 Conversion
- Low evidence
- Rigorous Journal
- Animal Study
Unraveling the Effects of Melissa officinalis L. on Cognition and Sleep Quality: A Narrative Review.
- 2025-10-30
- Review
- International journal of molecular sciences 26(21)
- - Maria Vitória Barroso Oliveira
  - Júlia Aparecida Garguerra
  - Caroline Barbalho Lamas
  - Lucas Fornari Laurindo
  - Victória Dogani Rodrigues
  - Kátia Portero Sloan
  - Lance Alan Sloan
  - Eduardo Federighi Baisi Chagas
  - Elen Landgraf Guiguer
  - Claudia Rucco Penteado Detregiachi
  - Maria Angélica Miglino
  - Eliana de Souza Bastos Mazuqueli Pereira
  - Vítor Engrácia Valenti
  - Luís R Silva
  - Sandra Maria Barbalho
- PubMed: 41226605
- DOI: 10.3390/ijms262110566
3 Insights on
- Moderate evidence
- Rigorous Journal
Latilactobacillus sakei CNTA 173 Reduces Fat Mass by Modulating Sphingolipid Metabolism in Diet-Induced Obese Wistar Rats.
- 2025-10-30
- Journal of agricultural and food chemistry 73(45)
- - Ignacio Goyache
  - Lorena Valdes-Varela
  - Raquel Virto
  - Iñigo Clemente-Larramendi
  - Miguel López-Yoldi
  - Ana Romo-Hualde
  - Ana Gloria Gil
  - Fermín I Milagro
  - Paula Aranaz
- PubMed: 41166528
- DOI: 10.1021/acs.jafc.5c10238
5 Insights on
- Low evidence
- Rigorous Journal
Effects of nicotinamide supplementation in normal-tension glaucoma: a crossover placebo-controlled randomised clinical trial.
- 2025-10-30
- RCT
- The British journal of ophthalmology 110(4)
- - Ahnul Ha
  - Young Kook Kim
  - Chang Kyu Lee
  - Pete A Williams
  - James E Morgan
  - Young In Shin
  - Eunsol Kim
  - Myungjin Kim
  - Seungsoo Rho
- PubMed: 41167798
- DOI: 10.1136/bjo-2025-328096
2 Insights on
- Improved Photopic Negative Response Amplitude
- Improved B-wave Amplitude
- High evidence
Microbiome-targeted nanoplatforms and engineering approaches in breast cancer therapy.
- 2025-10-30
- Review
- Molecular cancer 24(1)
- - Zufa Sabeel
  - Zhao Yang
- PubMed: 41168838
- DOI: 10.1186/s12943-025-02456-x
1 Insight on
- Increased Abundance of Bifidobacterium
- Low evidence
Impact of astaxanthin on oxidative markers, uric acid, and clinical symptoms in heart failure: a randomized clinical trial.
- 2025-10-29
- RCT · n = 80
- BMC cardiovascular disorders 25(1)
- - Shirin Ghotboddin Mohammadi
  - Davood Shafie
  - Awat Feizi
  - Mohammad Bagherniya
  - Ali-Reza Ahmadi
  - Marzieh Kafeshani
- PubMed: 41162864
- DOI: 10.1186/s12872-025-05260-z
7 Insights on
- High evidence
Microbial Transformation of Dietary Glycerol Contributes to Intestinal Acrolein Formation and Urinary Excretion.
- 2025-10-29
- Observational · n = 20
- Molecular nutrition & food research 69(24)
- - Clarissa Schwab
  - Hanna Lang
  - Simone Stegmüller
  - Jiri Hosek
  - Angeliki Marietou
  - Lucia Huertas-Díaz
  - Qing Li
  - Asta Petrine Smedgaard Krings
  - Andrea Zander
  - Ulrik Kræmer Sundekilde
  - Elke Richling
- PubMed: 41159664
- DOI: 10.1002/mnfr.70289
2 Insights on
- Increased Endogenous Acrolein Formation
- Increased Urinary Acrolein Biomarkers
- Moderate evidence
- Rigorous Journal
Effects of Acute Fish Oil Supplementation on Muscle Function and Soreness After Eccentric Contraction-Induced Muscle Damage.
- 2025-10-29
- RCT
- Nutrients 17(21)
- - Sang-Rok Lee
  - Dean Directo
  - Yangmi Kang
  - Joshua Stein
  - Mason Calvert
  - Yong Woo An
  - Do-Houn Kim
- PubMed: 41228481
- DOI: 10.3390/nu17213408
4 Insights on
- High evidence
- Rigorous Journal
Lychee Fermented by Mixed Probiotic Strains Alleviates D-Galactose-Induced Skeletal Muscle and Intestinal Aging in Mice.
- 2025-10-29
- Foods (Basel, Switzerland) 14(21)
- - Huixian Han
  - Jin Tao
  - Xiaoyue Bai
  - Yizhi Jing
  - Zhengyuan Zhai
  - Junjie Luo
  - Wanxiang Zhang
  - Dan Gan
  - Yanling Hao
- PubMed: 41227656
- DOI: 10.3390/foods14213684
7 Insights on
- Low evidence
Harnessing Probiotics to Combat Candidiasis: Mechanisms, Evidence, and Future Directions.
- 2025-10-29
- Review
- Journal of fungi (Basel, Switzerland) 11(11)
- - Emma Wright
  - Nisha Valand
  - Umakhanth Venkatraman Girija
- PubMed: 41295160
- DOI: 10.3390/jof11110779
4 Insights on
- Low evidence
Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review).
- 2025-10-29
- Review
- Molecular medicine reports 33(1)
- - Yanhua Han
  - Yuchao Jia
  - Lili Chen
  - Mingyao Zhang
- PubMed: 41170726
- DOI: 10.3892/mmr.2025.13731
1 Insight on
- Reduced Upper Respiratory Infections
- Low evidence
Probiotics Decrease C-Reactive Protein Levels in Depression Depending on Metabolic Syndrome Presence or Antidepressant Treatment - Secondary Results of a Randomized Clinical Trial.
- 2025-10-29
- RCT · n = 88
- Current neuropharmacology 23
- - Oliwia Gawlik Kotelnicka
  - Adam Wysokinski
  - Agata Gajewska
  - Karolina Czarnecka-Chrebelska
  - Karolina Kopacz
  - Anna Skowrońska
  - Ewa Pikus
  - Ewa Brzeziańska-Lasota
  - Dominik Strzelecki
- PubMed: 41177800
- DOI: 10.2174/011570159x371175251002220658
5 Insights on
- High evidence
An oral M-cell targeted Lactococcus lactis vaccine against Echinococcus multilocularis infection.
- 2025-10-28
- Frontiers in immunology 16
- - Yang Xiao
  - Zhao-Hui Luo
  - Shun-Juan Wang
  - Yao Dai
  - Jia-Yu Chen
  - Jia-Yong Cui
  - Run-Le Li
  - Feng Tang
- PubMed: 41229421
- DOI: 10.3389/fimmu.2025.1683003
4 Insights on
- Low evidence
- Animal Study
Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging.
- 2025-10-28
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(4)
- - Zheng Cao
  - Cui Zhang
  - Hehua Lei
  - Weichuan Lin
  - Wenkai Yu
  - Xin Gao
  - Yanmeng He
  - Xinzhi Li
  - Qingwei Xiang
  - Zhiwen Zhang
  - Weifei Luo
  - Andrew D Patterson
  - Limin Zhang
  - Gang Chen
- PubMed: 41147383
- DOI: 10.1002/advs.202515794
5 Insights on
- Low evidence
The Effect of Yacon Consumption on Glycemic Control and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
- 2025-10-28
- Meta-Analysis · n = 239
- Endocrinology, diabetes & metabolism 8(6)
- - Maryam Nilghaz
  - Fatemeh Sheikhhossein
  - Mahnoush Mehrzad Samarin
  - Mohammad Reza Amini
  - Mahsa Elahikhah
  - Moharam Jalalzadeh
  - Maryam Khakbaz
  - Negin Lohrasbi
  - Sajjad Etesamnia
  - Fatemeh Torkizadeh
  - Azita Hekmatdoost
- PubMed: 41152200
- DOI: 10.1002/edm2.70121
7 Insights on
- High evidence
Probiotic Combination of Bifidobacterium adolescentis and Bifidobacterium bifidum Enhances Lipophagy in MAFLD Rats.
- 2025-10-28
- MicrobiologyOpen 14(6)
- - Mahtab Mehboodi
  - Mohammad Mehdi Alinaghi
  - Maryam Behmanesh
  - Mohammad Hosein Kolahkaj
  - Milad Pour Mohammad Ali Namdari
  - Hadis Khanbabaie
  - Arezoo Harsjian
  - Narges Namavar
  - Saman Rabiei
  - Maryam Sadat Pishva
  - Payam Baziyar
  - Sara Rashki Ghaleno
  - Mohammad Hasan Maleki
- PubMed: 41157845
- DOI: 10.1002/mbo3.70100
6 Insights on
- Low evidence
- Animal Study
Probiotic Supplementation Enhances the Effects of a Nutritional Intervention on Quality of Life in Women with Hashimoto's Thyroiditis-A Double-Blind Randomised Study.
- 2025-10-28
- RCT · n = 32
- Nutrients 17(21)
- - Karolina Osowiecka
  - Damian Skrypnik
  - Joanna Myszkowska-Ryciak
- PubMed: 41228460
- DOI: 10.3390/nu17213387
4 Insights on
- High evidence
- Rigorous Journal
The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis.
- 2025-10-27
- Review
- BJPsych open 11(6)
- - Mattia Marchi
  - Pietro Grenzi
  - Antonio Travascio
  - Daniele Uberti
  - Edoardo De Micheli
  - Fabio Quartaroli
  - Giuseppe Laquatra
  - Luca Pingani
  - Silvia Ferrari
  - Gian M Galeazzi
- PubMed: 41140145
- DOI: 10.1192/bjo.2025.10885
4 Insights on
- Low evidence
Effect of egg consumption on circulating choline, betaine, and trimethylamine n-oxide in adults: a systematic review and meta-analysis of randomized controlled trials.
- 2025-10-27
- Meta-Analysis · n = 6
- Nutrition journal 24(1)
- - Naheed Aryaeian
  - Azadeh Heydarian
  - Negin Tahvilian
  - Hossein Hosseini
  - Amirhossein Ramezani Ahmadi
  - Seyedeh Hajar Davarpanah
- PubMed: 41146117
- DOI: 10.1186/s12937-025-01227-0
3 Insights on
- High evidence
Anticancer Potential of Whey Proteins-A Systematic Review of Bioactivity and Functional Mechanisms.
- 2025-10-26
- Systematic Review
- International journal of molecular sciences 26(21)
- - Selin Elmas
  - Meliha Fındık
  - Ramazan Kıyak
  - Gökhan Taşkın
  - Daniela Cîrțînă
  - Rodica Dîrnu
  - Natalia Guță
  - Roxana-Maria Mecu
  - Monica-Delia Bîcă
- PubMed: 41226446
- DOI: 10.3390/ijms262110406
3 Insights on
- High evidence
- Rigorous Journal
Exploring the Anticancer Potential of the Multistrain Probiotic Formulation OxxySlab in Bladder Cancer Cell Lines.
- 2025-10-26
- Antioxidants (Basel, Switzerland) 14(11)
- - Valeria Ciummo
  - Alessia Ciafarone
  - Serena Altamura
  - Francesca Lombardi
  - Marcella Reale
  - Maria Grazia Cifone
  - Benedetta Cinque
  - Paola Palumbo
- PubMed: 41300439
- DOI: 10.3390/antiox14111282
4 Insights on
- Low evidence
Functional and Compositional Changes in Ileal Microbiota in Piglets During the Nursing Period Revealed by 16s rRNA Gene and Metagenomics.
- 2025-10-25
- Animals : an open access journal from MDPI 15(21)
- - Boxuan Yang
  - Pengfei Shen
  - Zhijian Xu
  - Jianbo Yang
  - Bo Song
  - Hui Jiang
  - Jianmin Chai
  - Jiangchao Zhao
  - Feilong Deng
  - Ying Li
- PubMed: 41227433
- DOI: 10.3390/ani15213102
1 Insight on
- No Direct Health Outcome Reported
- Low evidence