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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Enhanced Immunomodulatory Activity and Stability in Simulated Digestive Juices of Lactobacillus plantarum L-137 by Heat Treatment
- 2012-05-23
- Bioscience, Biotechnology, and Biochemistry 76(5)
- - Takashi Fujiki
  - Y. Hirose
  - Yoshihiro Yamamoto
  - S. Murosaki
- PubMed: 22738959
- DOI: 10.1271/bbb.110919
2 Insights on
- Improved Cytokine Production
- Protection Against Colitis
- Low evidence
Randomized Trial of Probiotics and Calcium on Diarrhea and Respiratory Tract Infections in Indonesian Children
- 2012-05-01
- RCT · n = 494
- Pediatrics 129(5)
- - R. Agustina
  - F. Kok
  - O. van de Rest
  - U. Fahmida
  - A. Firmansyah
  - W. Lukito
  - E. Feskens
  - E. G. van den Heuvel
  - R. Albers
  - I. Bovee-Oudenhoven
- PubMed: 22492764
- DOI: 10.1542/peds.2011-1379
1 Insight on
- Reduced Diarrhea Incidence
- High evidence
- Large Human Trial
- Highly Cited
Suitability of ivy extract for the treatment of paediatric cough.
- 2012-04-25
- Clinical Trial
- Phytotherapy research : PTR 26(12)
- - M Schmidt
  - M Thomsen
  - U Schmidt
- PubMed: 22532491
- DOI: 10.1002/ptr.4671
3 Insights on
- Moderate evidence
Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial.
- 2012-04-23
- Clinical Trial
- Phytotherapy research : PTR 27(2)
- - Andreas Suter
  - Reinhard Saller
  - Eugen Riedi
  - Michael Heinrich
- PubMed: 22522969
- DOI: 10.1002/ptr.4696
3 Insights on
- Moderate evidence
Whey protein coating bead improves the survival of the probiotic Lactobacillus rhamnosus CRL 1505 to low pH.
- 2012-04-20
- Letters in applied microbiology 54(6)
- - C L Gerez
  - G Font de Valdez
  - M L Gigante
  - C R F Grosso
- PubMed: 22448978
- DOI: 10.1111/j.1472-765x.2012.03247.x
1 Insight on
- Improved Survival of Probiotic Bacteria
- Low evidence
Hypolipidemic effects of a new piperine derivative GB-N from Piper longum in high-fat diet-fed rats
- 2012-04-12
- Clinical Trial
- Pharmaceutical Biology 50(8)
- - L. Bao
  - Shiming Bai
  - Gereltu Borijihan
- PubMed: 22494195
- DOI: 10.3109/13880209.2012.654395
3 Insights on
- Low evidence
- Animal Study
Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs
- 2012-04-02
- RCT · n = 16
- Immunopharmacology and Immunotoxicology 34(6)
- - Yojiro Arimori
  - R. Nakamura
  - Y. Hirose
  - S. Murosaki
  - Yoshihiro Yamamoto
  - O. Shidara
  - H. Ichikawa
  - Y. Yoshikai
- PubMed: 22468623
- DOI: 10.3109/08923973.2012.672425
1 Insight on
- Increased Type I Interferon Production
- High evidence
Lactobacillus plantarum 299v does not reduce enteric bacteria or bacterial translocation in patients undergoing colon resection.
- 2012-03-21
- RCT
- Digestive diseases and sciences 57(7)
- - Peter Mangell
  - Henrik Thorlacius
  - Ingvar Syk
  - Siv Ahrné
  - Göran Molin
  - Crister Olsson
  - Bengt Jeppsson
- PubMed: 22434095
- DOI: 10.1007/s10620-012-2102-y
3 Insights on
- High evidence
- Rigorous Journal
Pro-apoptotic effects of Paecilomyces hepiali, a Cordyceps sinensis extract on human lung adenocarcinoma A549 cells in vitro.
- 2012-03-20
- Journal of Cancer Research and Therapeutics 7(4)
- - Asmitananda Thakur
  - Ren Hui
  - Hongyan Zhang
  - Yang Tian
  - Tian-jun Chen
  - Mingwei Chen
- PubMed: 22269403
- DOI: 10.4103/0973-1482.92007
1 Insight on
- Induced Apoptosis
- Low evidence
Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-κB signaling in the intestine.
- 2012-03-15
- Clinical Trial
- American Journal of Physiology-Gastrointestinal and Liver Physiology 302(6)
- - Yuying Liu
  - Nicole Y. Fatheree
  - Nisha Mangalat
  - J. M. Rhoads
- PubMed: 22207578
- DOI: 10.1152/ajpgi.00266.2011
10 Insights on
- Low evidence
- Highly Cited
- Animal Study
Herbs in exercise and sports.
- 2012-03-08
- Review
- Journal of physiological anthropology 31
- - Chee Keong Chen
  - Ayu Suzailiana Muhamad
  - Foong Kiew Ooi
- PubMed: 22738233
- DOI: 10.1186/1880-6805-31-4
2 Insights on
- Improved Cycling Endurance
- Improved Running Endurance
- Low evidence
Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon.
- 2012-03-01
- RCT · n = 45
- Journal of Medical Microbiology 61(3)
- - Jin-Hee Chang
  - Y. Shim
  - S. Cha
  - M. Reaney
  - K. Chee
- PubMed: 22034161
- DOI: 10.1099/jmm.0.035154-0
13 Insights on
- Low evidence
- Animal Study
Pregnancy outcome after exposure to the probiotic Lactobacillus in early pregnancy
- 2012-02-28
- Observational · n = 304
- Journal of Obstetrics and Gynaecology 32(3)
- - J. E. Lee
  - J. .. Han
  - J. Choi
  - H. Ahn
  - S. W. Lee
  - M. H. Kim
  - H. Ryu
  - J. H. Yang
  - A. Nava-Ocampo
  - G. Koren
- PubMed: 22369393
- DOI: 10.3109/01443615.2011.641621
4 Insights on
- High evidence
Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling
- 2012-02-22
- PLoS ONE 7(2)
- - Carissa M. Thomas
  - T. Hong
  - Jan-Peter van Pijkeren
  - P. Hemarajata
  - D. V. Trinh
  - Weidong Hu
  - R. Britton
  - M. Kalkum
  - J. Versalovic
- PubMed: 22384111
- DOI: 10.1371/journal.pone.0031951
1 Insight on
- Reduced TNF Production
- Low evidence
- Highly Cited
Lactobacillus acidophilus Induces Cytokine and Chemokine Production via NF-κB and p38 Mitogen-Activated Protein Kinase Signaling Pathways in Intestinal Epithelial Cells
- 2012-02-22
- Clinical and Vaccine Immunology 19(4)
- - Yujun Jiang
  - Xuena Lü
  - C. Man
  - Linlin Han
  - Yi Shan
  - X. Qu
  - Y. Liu
  - Shiqin Yang
  - Yuqing Xue
  - Yinghua Zhang
- PubMed: 22357649
- DOI: 10.1128/CVI.05617-11
2 Insights on
- Activated Immune Response
- Enhanced Cytokine Production
- Low evidence
The Obesity and Fatty Liver Are Reduced by Plant-Derived Pediococcus pentosaceus LP28 in High Fat Diet-Induced Obese Mice
- 2012-02-17
- RCT · n = 6
- PLoS ONE 7(2)
- - Xingrong Zhao
  - Fumiko Higashikawa
  - M. Noda
  - Yusuke Kawamura
  - Y. Matoba
  - T. Kumagai
  - M. Sugiyama
- PubMed: 22363472
- DOI: 10.1371/journal.pone.0030696
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effect of Lactobacillus salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota
- 2012-02-17
- Clinical Trial
- PLoS ONE 7(2)
- - Eliette Riboulet-Bisson
  - M. Sturme
  - I. Jeffery
  - M. M. O’Donnell
  - M. M. O’Donnell
  - B. Neville
  - B. Forde
  - M. Claesson
  - H. Harris
  - G. Gardiner
  - P. G. Casey
  - P. Lawlor
  - P. O’Toole
  - R. Ross
- PubMed: 22363561
- DOI: 10.1371/journal.pone.0031113
2 Insights on
- Altered Spirochaetes Abundance in Pig Microbiota
- Reduced Impact of Gram-negative Microorganisms
- Low evidence
- Highly Cited
- Animal Study
Effect of a Synbiotic Yogurt on Levels of Fecal Bifidobacteria, Clostridia, and Enterobacteria
- 2012-02-15
- RCT · n = 46
- Applied and Environmental Microbiology 78(4)
- - Amritanshu Palaria
  - I. Johnson-Kanda
  - D. O'sullivan
- PubMed: 22101054
- DOI: 10.1128/AEM.05848-11
6 Insights on
- High evidence
- Rigorous Journal
Dietary supplements for established atopic eczema.
- 2012-02-15
- Meta-Analysis · n = 596
- The Cochrane database of systematic reviews 2015(5)
- - Fiona J Bath-Hextall
  - Claire Jenkinson
  - Rosemary Humphreys
  - Hywel C Williams
- PubMed: 22336810
- DOI: 10.1002/14651858.cd005205.pub3
1 Insight on
- Improved Eczema Severity
- High evidence
Herbal medicines for the management of irritable bowel syndrome: a comprehensive review.
- 2012-02-01
- Systematic Review
- World journal of gastroenterology 18(7)
- - Roja Rahimi
  - Mohammad Abdollahi
- PubMed: 22363129
- DOI: 10.3748/wjg.v18.i7.589
1 Insight on
- Improved IBS Symptom Score
- High evidence
Impact of enterococcus on immunocompetent and immunosuppressed patients with perforation of the small or large bowel.
- 2012-02-01
- Observational · n = 473
- Technology and Health Care 20(1)
- - M. Kaffarnik
  - M. Urban
  - U. Hopt
  - S. Utzolino
- PubMed: 22297712
- DOI: 10.3233/THC-2011-0654
1 Insight on
- Increased Mortality Rate
- High evidence
Probiotic potential of Lactobacillus spp. isolated from Brazilian regional ovine cheese
- 2012-01-17
- Journal of Dairy Research 79(1)
- - S. M. M. Meira
  - V. E. Helfer
  - R. V. Velho
  - F. C. Lopes
  - A. Brandelli
- PubMed: 23171587
- DOI: 10.1017/S0022029911000884
4 Insights on
- Low evidence
Carbohydrate Metabolism Is Essential for the Colonization of Streptococcus thermophilus in the Digestive Tract of Gnotobiotic Rats
- 2011-12-22
- Clinical Trial
- PLoS ONE 6(12)
- - Muriel Thomas
  - Laura Wrzosek
  - L. Ben-Yahia
  - Marie‐Louise Noordine
  - C. Gitton
  - D. Chevret
  - P. Langella
  - C. Mayeur
  - C. Cherbuy
  - F. Rul
- PubMed: 22216112
- DOI: 10.1371/journal.pone.0028789
4 Insights on
- Low evidence
- Animal Study
Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine
- 2011-12-15
- Clinical Trial
- Pediatric Research 71(1)
- - Y. Ohtsuka
  - T. Ikegami
  - H. Izumi
  - M. Namura
  - Tomomi Ikeda
  - T. Ikuse
  - Y. Baba
  - T. Kudo
  - Ryuyo Suzuki
  - Toshiaki Shimizu
- PubMed: 22289850
- DOI: 10.1038/pr.2011.11
1 Insight on
- Increased CD3d Expression in Colon During Weaning
- Low evidence
- Rigorous Journal
- Animal Study
Production of Multiple Bacteriocins from a Single Locus by Gastrointestinal Strains of Lactobacillus salivarius
- 2011-12-15
- Journal of Bacteriology 193(24)
- - Eileen F. O'Shea
  - P. O’Connor
  - Emma J. Raftis
  - P. O’Toole
  - C. Stanton
  - P. Cotter
  - R. Ross
  - C. Hill
- PubMed: 21984788
- DOI: 10.1128/JB.06221-11
1 Insight on
- Reduced Risk of Listeria Monocytogenes Infection
- Low evidence
A comprehensive post-market review of studies on a probiotic product containing Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011.
- 2011-12-01
- Review
- Beneficial Microbes 2(4)
- - Lauren Foster
  - T. Tompkins
  - Wendy J. Dahl
- PubMed: 22146691
- DOI: 10.3920/BM2011.0032
16 Insights on
- Low evidence
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders
- 2011-11-11
- Review
- Therapeutic Advances in Gastroenterology 5(2)
- - T. Kelesidis
  - C. Pothoulakis
- PubMed: 22423260
- DOI: 10.1177/1756283X11428502
1 Insight on
- Enhanced Gut Health
- High evidence
- Highly Cited
- Rigorous Journal
Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice
- 2011-11-10
- Gut Pathogens 3(1)
- - L. Fitzpatrick
  - Jeffrey S. Small
  - W. Greene
  - Kelly Karpa
  - D. Keller
- PubMed: 22014083
- DOI: 10.1186/1757-4749-3-16
3 Insights on
- Low evidence
Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults
- 2011-11-09
- RCT · n = 114
- British Journal of Nutrition 107(10)
- - M. Jones
  - C. Martoni
  - Mathieu Parent
  - S. Prakash
- PubMed: 22067612
- DOI: 10.1017/S0007114511004703
5 Insights on
- High evidence
- Highly Cited
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication
- 2011-10-11
- Clinical Trial
- Neurogastroenterology & Motility 23(12)
- - P. Bercik
  - A. Park
  - D. Sinclair
  - A. Khoshdel
  - J. Lu
  - X. Huang
  - Y. Deng
  - P. Blennerhassett
  - M. Fahnestock
  - D. Moine
  - B. Berger
  - J. Huizinga
  - W. Kunze
  - P. McLean
  - G. Bergonzelli
  - S. Collins
  - Eduardo Verdu
- PubMed: 21988661
- DOI: 10.1111/j.1365-2982.2011.01796.x
6 Insights on
- Low evidence
- Highly Cited
- Animal Study