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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Daily intake of heat-killed Lactobacillus plantarum L-137 augments acquired immunity in healthy adults.
- 2006-12
- RCT · n = 60
- The Journal of Nutrition 136(12)
- - Y. Hirose
  - S. Murosaki
  - Yoshihiro Yamamoto
  - Y. Yoshikai
  - T. Tsuru
- PubMed: 17116721
- DOI: 10.1093/JN/136.12.3069
6 Insights on
- High evidence
- Highly Cited
Effect of Lactobacillus fermentum on serum lipids in subjects with elevated serum cholesterol.
- 2006-12
- RCT · n = 46
- Nutrition, Metabolism and Cardiovascular Diseases 16(8)
- - L. Simons
  - Sarah G. Amansec
  - P. Conway
- PubMed: 17126768
- DOI: 10.1016/J.NUMECD.2005.10.009
6 Insights on
- High evidence
- Highly Cited
Lactobacillus paracasei A survives gastrointestinal passage and affects the fecal microbiota of healthy infants.
- 2006-11
- RCT · n = 26
- Research in Microbiology 157(9)
- - M. Marzotto
  - C. Maffeis
  - T. Paternoster
  - R. Ferrario
  - L. Rizzotti
  - M. Pellegrino
  - F. Dellaglio
  - S. Torriani
- PubMed: 16934438
- DOI: 10.1016/J.RESMIC.2006.06.007
14 Insights on
- High evidence
Adherence of Lactobacillus crispatus to vaginal epithelial cells from women with or without a history of recurrent urinary tract infection.
- 2006-11
- Journal of Urology 176(5)
- - L. Kwok
  - A. Stapleton
  - W. Stamm
  - S. Hillier
  - Cheryl L. Wobbe
  - K. Gupta
- PubMed: 17070251
- DOI: 10.1016/J.JURO.2006.07.014
3 Insights on
- Low evidence
Effects of Bifidobacterium lactis Bb12 Supplementation on Intestinal Microbiota of Preterm Infants: a Double-Blind, Placebo-Controlled, Randomized Study
- 2006-11
- RCT · n = 69
- Journal of Clinical Microbiology 44(11)
- - R. Mohan
  - C. Koebnick
  - J. Schildt
  - S. Schmidt
  - M. Mueller
  - M. Possner
  - M. Radke
  - M. Blaut
- PubMed: 16971641
- DOI: 10.1128/JCM.00767-06
11 Insights on
- High evidence
- Highly Cited
Effects of the probiotic strain Lactobacillus johnsonii strain La1 on autonomic nerves and blood glucose in rats.
- 2006-10
- Clinical Trial
- Life Sciences 79(20)
- - T. Yamano
  - M. Tanida
  - A. Niijima
  - Keiko Maeda
  - Nobuaki Okumura
  - Y. Fukushima
  - K. Nagai
- PubMed: 16893554
- DOI: 10.1016/J.LFS.2006.06.038
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis.
- 2006-10
- RCT · n = 40
- Microbes and Infection 8(12-13)
- - K. Anukam
  - Emmanuel O. Osazuwa
  - Gibson I. Osemene
  - Felix Ehigiagbe
  - A. Bruce
  - G. Reid
- PubMed: 17045832
- DOI: 10.1016/J.MICINF.2006.08.008
1 Insight on
- Increased Cure Rate of Bacterial Vaginosis
- High evidence
- Highly Cited
Lactobacillus salivarius CECT 5713, a potential probiotic strain isolated from infant feces and breast milk of a mother-child pair.
- 2006-10
- International Journal of Food Microbiology 112(1)
- - R. Martín
  - E. Jiménez
  - M. Olivares
  - M. Marín
  - L. Fernández
  - J. Xaus
  - J. M. Rodríguez
- PubMed: 16843562
- DOI: 10.1016/J.IJFOODMICRO.2006.06.011
3 Insights on
- Low evidence
- Highly Cited
Summary of Probiotic Activities of Bifidobacterium lactis HN019
- 2006-10
- Review
- Journal of Clinical Gastroenterology 40(9)
- - M. Sanders
- PubMed: 17016131
- DOI: 10.1097/01.mcg.0000225576.73385.f0
4 Insights on
- Low evidence
Protective effects and mechanisms of a probiotic bacterium Lactobacillus rhamnosus against experimental Edwardsiella tarda infection in tilapia (Oreochromis niloticus).
- 2006-10
- Clinical Trial
- Veterinary Immunology and Immunopathology 113(3-4)
- - N. Pirarat
  - Takeshi Kobayashi
  - T. Katagiri
  - M. Maita
  - M. Endo
- PubMed: 16870266
- DOI: 10.1016/J.VETIMM.2006.06.003
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 modify carboxylic acid formation in the hindgut of rats given pectin, inulin, and lactitol.
- 2006-08
- Clinical Trial
- The Journal of Nutrition 136(8)
- - U. Nilsson
  - M. Nyman
  - S. Ahrné
  - E. O. Sullivan
  - G. Fitzgerald
- PubMed: 16857837
- DOI: 10.1093/JN/136.8.2175
2 Insights on
- Increased Faecal Carboxylic Acid Concentration
- Reduced Carboxylic Acids Concentration in Distal Colon with Lactitol
- Low evidence
- Animal Study
Immunomodulatory effects of polysaccharides produced by Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1.
- 2006-08
- Clinical Trial
- Journal of Dairy Science 89(8)
- - Seiya Makino
  - Shuji Ikegami
  - Hiroshi Kano
  - T. Sashihara
  - H. Sugano
  - H. Horiuchi
  - Tadao Saito
  - M. Oda
- PubMed: 16840603
- DOI: 10.3168/JDS.S0022-0302(06)72560-7
3 Insights on
- Low evidence
- Highly Cited
- Animal Study
Molecular Identification of Leuconostoc mesenteroides as a Cause of Brain Abscess in an Immunocompromised Patient
- 2006-08
- Case Report · n = 1
- Journal of Clinical Microbiology 44(8)
- - A. Albanese
  - T. Spanu
  - M. Sali
  - F. Novegno
  - T. D'Inzeo
  - R. Santangelo
  - A. Mangiola
  - C. Anile
  - G. Fadda
- PubMed: 16891540
- DOI: 10.1128/JCM.00448-06
1 Insight on
- Reduced Brain Abscess Incidence
- Low evidence
Effects of dietary supplementation with Clostridium butyricum on the growth performance and humoral immune response in Miichthys miiuy
- 2006-07
- RCT · n = 150
- Journal of Zhejiang University SCIENCE B 7(7)
- - Zeng-fu Song
  - Tian-Xing Wu
  - L. Cai
  - Li-jing Zhang
  - Xiao-dong Zheng
- PubMed: 16773736
- DOI: 10.1631/jzus.2006.B0596
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Beneficial immunomodulatory activity of Lactobacillus casei in malnourished mice pneumonia: effect on inflammation and coagulation.
- 2006-07
- RCT
- Nutrition 22(7-8)
- - Graciela Agüero
  - J. Villena
  - S. Racedo
  - C. Haro
  - S. Alvarez
- PubMed: 16815495
- DOI: 10.1016/J.NUT.2006.03.013
18 Insights on
- Low evidence
- Animal Study
Effect of milk fermented with a Lactobacillus helveticus R389(+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice.
- 2006-07
- Clinical Trial
- FEMS Immunology & Medical Microbiology 47(2)
- - M. Rachid
  - C. Matar
  - J. Duarte
  - G. Perdigón
- PubMed: 16831211
- DOI: 10.1111/J.1574-695X.2006.00088.X
5 Insights on
- Low evidence
- Animal Study
Antimicrobial potential of four Lactobacillus strains isolated from breast milk
- 2006-07
- Journal of Applied Microbiology 101(1)
- - M. Olivares
  - M. Díaz-Ropero
  - R. Martín
  - J. M. Rodríguez
  - J. Xaus
- PubMed: 16834593
- DOI: 10.1111/j.1365-2672.2006.02981.x
4 Insights on
- Low evidence
- Highly Cited
Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome
- 2006-07
- RCT · n = 362
- The American Journal of Gastroenterology 101(7)
- - P. Whorwell
  - L. Altringer
  - J. Morel
  - Yvonne Bond
  - D. Charbonneau
  - L. O’Mahony
  - B. Kiely
  - F. Shanahan
  - E. Quigley
- PubMed: 16863564
- DOI: 10.1111/j.1572-0241.2006.00734.x
12 Insights on
- High evidence
- Large Human Trial
- Highly Cited
Short communication: Effects of Lactobacillus helveticus-fermented milk on the differentiation of cultured normal human epidermal keratinocytes.
- 2006-06
- Journal of Dairy Science 89(6)
- - H. Baba
  - A. Masuyama
  - T. Takano
- PubMed: 16702271
- DOI: 10.3168/JDS.S0022-0302(06)72275-5
6 Insights on
- Low evidence
The continuing story of class IIa bacteriocins.
- 2006-06
- Review
- Microbiology and molecular biology reviews : MMBR 70(2)
- - Djamel Drider
  - Gunnar Fimland
  - Yann Héchard
  - Lynn M McMullen
  - Hervé Prévost
- PubMed: 16760314
- DOI: 10.1128/mmbr.00016-05
1 Insight on
- Reduced Pathogenic Bacterial Activity
- Moderate evidence
- Highly Cited
Effects of a Lactobacillus casei synbiotic on serum lipoprotein, intestinal microflora, and organic acids in rats.
- 2006-05
- Clinical Trial
- Journal of Dairy Science 89(5)
- - M. Liong
  - N. Shah
- PubMed: 16606710
- DOI: 10.3168/JDS.S0022-0302(06)72207-X
4 Insights on
- Low evidence
- Highly Cited
- Animal Study
Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial.
- 2006-05
- RCT · n = 125
- Microbes and Infection 8(6)
- - K. Anukam
  - Emmanuel O. Osazuwa
  - I. Ahonkhai
  - M. Ngwu
  - Gibson I. Osemene
  - A. Bruce
  - G. Reid
- PubMed: 16697231
- DOI: 10.1016/J.MICINF.2006.01.003
3 Insights on
- High evidence
- Highly Cited
Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.
- 2006-05
- Observational · n = 944
- The Journal of Nutrition 136(5)
- - Y. Ikeda
  - M. Iki
  - A. Morita
  - E. Kajita
  - S. Kagamimori
  - Y. Kagawa
  - H. Yoneshima
- PubMed: 16614424
- DOI: 10.1093/JN/136.5.1323
2 Insights on
- Reduced Bone Loss
- Increased Total Hip Bone Mineral Density
- High evidence
- Highly Cited
Kinetic analysis of the antibacterial activity of probiotic lactobacilli towards Salmonella enterica serovar Typhimurium reveals a role for lactic acid and other inhibitory compounds.
- 2006-04
- Research in Microbiology 157(3)
- - L. Makras
  - Vagelis Triantafyllou
  - Domitille Fayol-Messaoudi
  - T. Adriany
  - G. Zoumpopoulou
  - E. Tsakalidou
  - A. Servin
  - L. De Vuyst
- PubMed: 16266797
- DOI: 10.1016/J.RESMIC.2005.09.002
1 Insight on
- Reduced Salmonella Enterica Invasion
- Low evidence
- Highly Cited
Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression.
- 2006-04
- Biochemical and Biophysical Research Communications 343(1)
- - S. Sougioultzis
  - S. Simeonidis
  - K. Bhaskar
  - Xinhua Chen
  - P. Anton
  - S. Keates
  - C. Pothoulakis
  - C. Kelly
- PubMed: 16529714
- DOI: 10.1016/J.BBRC.2006.02.080
4 Insights on
- Low evidence
- Highly Cited
Oral administration of two probiotic strains, Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711, enhances the intestinal function of healthy adults.
- 2006-03
- RCT · n = 30
- International Journal of Food Microbiology 107(2)
- - M. Olivares
  - M. Díaz-Ropero
  - Nuria Gómez
  - F. Lara‐Villoslada
  - S. Sierra
  - J. Maldonado
  - Rocío Martín
  - E. López-Huertas
  - J. M. Rodríguez
  - J. Xaus
- PubMed: 16271414
- DOI: 10.1016/J.IJFOODMICRO.2005.08.019
5 Insights on
- High evidence
- Highly Cited
Two subpopulations of Listeria monocytogenes occur at subinhibitory concentrations of leucocin 4010 and nisin.
- 2006-02
- Applied and environmental microbiology 72(2)
- - Tina Hornbaek
  - Per B Brockhoff
  - Henrik Siegumfeldt
  - Birgitte Bjørn Budde
- PubMed: 16461719
- DOI: 10.1128/aem.72.2.1631-1638.2006
1 Insight on
- Reduced Antilisterial Activity
- Low evidence
- Rigorous Journal
Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsoniiLa1
- 2006-02
- RCT · n = 22
- British Journal of Nutrition 95(2)
- - T. Yamano
  - H. Iino
  - Mamiko Takada
  - S. Blum
  - F. Rochat
  - Y. Fukushima
- PubMed: 16469146
- DOI: 10.1079/BJN20051507
5 Insights on
- High evidence
- Highly Cited
Effects of a dried Bacillus subtilis culture on egg quality.
- 2006-02
- RCT
- Poultry Science 85(2)
- - L. Li
  - C. L. Xu
  - C. Ji
  - Q. Ma
  - K. Hao
  - Z. Jin
  - K. Li
- PubMed: 16523640
- DOI: 10.1093/PS/85.2.364
7 Insights on
- High evidence
- Highly Cited
Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets
- 2006-01
- RCT · n = 120
- Acta Odontologica Scandinavica 64(5)
- - E. Çaglar
  - Sule Kavaloglu Cildir
  - S. Ergeneli
  - N. Sandalli
  - S. Twetman
- PubMed: 16945898
- DOI: 10.1080/00016350600801709
2 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- Reduced Salivary Lactobacilli Levels
- High evidence
- Highly Cited