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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Metabolic modulation of yogurt fermentation kinetics and acidification by Bifidobacterium-starter culture interactions.
- 2026-01-23
- Frontiers in microbiology 17
- - Zhi Zhao
  - Shaoqi Shi
  - Lele Zhang
  - Meilun An
  - Pengcheng Wen
  - Yue Sang
  - Haihong Feng
  - Baochao Hou
  - Jian He
  - Wei-Lian Hung
  - Baolei Li
  - Liang Zhao
  - Xiaoxia Li
  - Ran Wang
- PubMed: 41657908
- DOI: 10.3389/fmicb.2026.1724590
1 Insight on
- Reduced Postprandial Acidification
- Low evidence
Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial.
- 2026-01-23
- Clinical Trial · n = 130
- Frontiers in nutrition 12
- - Ghanashyam Patel
  - Saumin Shah
  - Christopher R D'Adamo
- PubMed: 41659807
- DOI: 10.3389/fnut.2025.1721748
4 Insights on
- High evidence
Lactiplantibacillus plantarum Q180 supplementation restores high-fat diet-induced gut dysbiosis and intestinal barrier dysfunction in mice.
- 2026-01-23
- Journal of applied microbiology 137(2)
- - Minseo Cho
  - Jaeryang Chu
  - Chae-Won No
  - Yeon-Woo Kim
  - Jiwoo Lee
  - Hyunchae Joung
  - Yoo Jin Kwon
  - Chang Hun Shin
  - Jisu Lee
  - Jung-Heun Ha
- PubMed: 41574946
- DOI: 10.1093/jambio/lxag021
4 Insights on
- Low evidence
- Animal Study
Bifidobacterium Infantis Promotes FOSL1-Mediated Transcriptional Repression of VDR to Accelerate Autoimmune Pancreatitis Progression Through Activation of Oxidative Stress.
- 2026-01-23
- Inflammation 49(1)
- - Jie Tang
  - Qin Li
  - Kai Li
  - Dongyun Hang
  - Danyin Gu
  - Lingmei Feng
  - Guoyu Chen
  - Ming Xu
- PubMed: 41572095
- DOI: 10.1007/s10753-025-02368-4
2 Insights on
- Increased Oxidative Stress
- Accelerated Autoimmune Pancreatitis Progression
- Low evidence
Multi-Strain Probiotic and Common Infections in Early Childhood Education Settings: A Randomised Controlled Trial.
- 2026-01-23
- RCT · n = 118
- Journal of paediatrics and child health 62(3)
- - Hafiz Haris Ahmad
  - Blake Peck
  - Daniel Terry
- PubMed: 41574644
- DOI: 10.1111/jpc.70295
3 Insights on
- High evidence
- Large Human Trial
Integrative Evidence on Sesame Supplementation for Cardiometabolic Risk Factors Relevant to Retinopathy.
- 2026-01-23
- Meta-Analysis · n = 441
- International journal of medical sciences 23(3)
- - Wu-Hsien Kuo
  - Ko-Shih Chang
  - Fu-Hsuan Kuo
  - Kuan-Po Cheng
  - Ru-Yin Tsai
- PubMed: 41799776
- DOI: 10.7150/ijms.123717
1 Insight on
- Reduced Fasting Blood Glucose Levels
- High evidence
Current Evidence from Animal Models on Molecular Changes Underlying Antidepressant Effects of Psychobiotics.
- 2026-01-22
- Review
- Pharmaceutics 18(1)
- - Nevena Todorović Vukotić
  - Neda Đorđević
  - Andrijana Stanisavljević Ilić
  - Svetlana Soković Bajić
  - Ivana Perić
- PubMed: 41599247
- DOI: 10.3390/pharmaceutics18010140
8 Insights on
- Low evidence
Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-01-22
- Review
- Obesity reviews : an official journal of the International Association for the Study of Obesity 27(7)
- - Carmelo Pujia
  - Yvelise Ferro
  - Alberto Castagna
  - Elisa Mazza
  - Samantha Maurotti
  - Francesca Rita Noto
  - Valeria Rizzo
  - Tiziana Montalcini
  - Arturo Pujia
- PubMed: 41572527
- DOI: 10.1111/obr.70094
5 Insights on
- Low evidence
Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T-cell Expansion in Hepatocellular Carcinoma.
- 2026-01-22
- Observational
- Cancer research 86(8)
- - Qianshi Liu
  - Yiqiang Liu
  - Yue Zhou
  - Liang Liang
  - Yejian Wan
  - Ying Wang
  - Ting Huang
  - Ling Zhong
  - Zhaoshen Li
  - Tao Luo
  - Ming Zhao
  - Zhe-Xuan Li
  - Yu-Cong Li
  - Hai-Tao Lan
  - Hong Wu
  - Chuan Xu
  - Jie Chen
- PubMed: 41570324
- DOI: 10.1158/0008-5472.can-25-0346
3 Insights on
- Low evidence
Lactic Acid Bacteria for Fungal Control and Shelf-Life Extension in Fresh Pasta: Mechanistic Insights and Clean-Label Strategies.
- 2026-01-22
- Review
- Molecules (Basel, Switzerland) 31(2)
- - Noor Sehar
  - Roberta Pino
  - Michele Pellegrino
  - Monica Rosa Loizzo
- PubMed: 41599436
- DOI: 10.3390/molecules31020389
3 Insights on
- Low evidence
Extremely oxygen-sensitive next-generation probiotics: can current microcomposite formulations ensure effective colonic delivery?
- 2026-01-22
- Review
- Microsystems & nanoengineering 12(1)
- - L P Ta
  - S Corrigan
  - H Abeysekera
  - R D Horniblow
- PubMed: 41571627
- DOI: 10.1038/s41378-025-01151-7
4 Insights on
- Low evidence
Probiotic bacteria Bifidobacterium bifidum upregulation of intestinal epithelial tight junction barrier is mediated by TLR-2/TLR-6 receptor complex activation of occludin gene.
- 2026-01-21
- NPJ biofilms and microbiomes 12(1)
- - Raz Abdulqadir
  - Rana Al-Sadi
  - Yash Gupta
  - Manmeet Rawat
  - Thomas Ma
- PubMed: 41559082
- DOI: 10.1038/s41522-025-00903-7
1 Insight on
- Improved Intestinal Barrier Function
- Low evidence
Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.
- 2026-01-21
- Review
- International journal of molecular sciences 27(2)
- - Olga Adriana Caliman-Sturdza
  - Josiana A Vaz
  - Ancuta Veronica Lupaescu
  - Andrei Lobiuc
  - Codruta Bran
  - Roxana Elena Gheorghita
- PubMed: 41596722
- DOI: 10.3390/ijms27021079
8 Insights on
- Moderate evidence
- Rigorous Journal
Effect of Vitamin B12 Supplementation on Hematological and Athropometric Parameters in Children With Severe Acute Malnutrition, Aged 1 to 60 Months in Nutritional Rehabilitation Center (RCT).
- 2026-01-21
- RCT
- Clinical pediatrics 65(5)
- - Bhartendu Krishna Pathak
  - Manisha Maurya
  - Nandita Mishra
  - Rajesh Kumar Yadav
  - Anshul Singh
  - Madhu Sonkar
- PubMed: 41566649
- DOI: 10.1177/00099228251415045
2 Insights on
- Improved Height-for-Age Z-Score
- Improved Weight-for-Age Z Score
- High evidence
Evaluating the Quality of Selected Commercial Probiotic Products, Both Dietary Supplements and Foods for Special Medical Purposes.
- 2026-01-20
- Foods (Basel, Switzerland) 15(2)
- - Anna Zawistowska-Rojek
  - Justyna Rybak
  - Paulina Smoleń
  - Agnieszka Kociszewska
  - Paweł Rudnicki-Velasquez
  - Karolina Węgrzyńska
  - Tomasz Zaręba
  - Stefan Tyski
  - Anna Baraniak
- PubMed: 41596971
- DOI: 10.3390/foods15020373
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Exploring the potential for competitive exclusion of commensal probiotic candidates against the insidious swine pathogen Brachyspira hyodysenteriae.
- 2026-01-20
- Animal microbiome 8(1)
- - Samuel Gómez-Martínez
  - Lucía Pérez-Pérez
  - Alejandro Ucero-Carrretón
  - Álvaro López-García
  - Cristina Galisteo
  - Ana Carvajal
  - Héctor Argüello
- PubMed: 41559772
- DOI: 10.1186/s42523-025-00511-y
2 Insights on
- Reduced Brachyspira hyodysenteriae Growth
- Maintained Anti-Pathogen Activity
- Low evidence
Correction: Adjunctive use of Streptococcus salivarius M18 probiotic in the treatment of periodontitis: a randomized controlled trial.
- 2026-01-20
- 3 Biotech 16(2)
- - Wei-Ju Chen
  - Lavanya Ajay Sharma
  - Peng Shao
  - Tia Griffith
  - Robert Love
  - Rohit Jain
  - John Hale
  - Ajay Sharma
- PubMed: 41567852
- DOI: 10.1007/s13205-026-04700-7
1 Insight on
- Improved Periodontal Health
- Low evidence
Whey protein intakes up to 0.4g/kg body mass are well tolerated before a 10km run at 85% of race pace: a clinical trial.
- 2026-01-20
- Clinical Trial
- Journal of the International Society of Sports Nutrition 23(1)
- - Keely Shaw
  - Brynn Lindstrom
  - Amy Moss
  - Jill A Parnell
- PubMed: 41556283
- DOI: 10.1080/15502783.2026.2615270
1 Insight on
- Increased Bloating
- High evidence
Oral health benefits of Heyndrickxia coagulans: a systematic review and meta-analysis of current evidence.
- 2026-01-20
- Review · n = 183
- Frontiers in oral health 6
- - Silvia Cirio
  - Guglielmo Campus
  - Claudia Salerno
  - Aesha Allam
  - Maria Grazia Cagetti
- PubMed: 41641154
- DOI: 10.3389/froh.2025.1733955
1 Insight on
- Reduced Salivary Levels of Mutans Streptococci
- High evidence
The role of fermented foods in healthy longevity: A review of potential anti-aging mechanisms.
- 2026-01-19
- Review
- Current research in food science 12
- - Hongyu Mu
  - Yeyan Yao
  - Yongqiang Gong
  - Tao Yang
- PubMed: 41551173
- DOI: 10.1016/j.crfs.2025.101300
5 Insights on
- Low evidence
Phytotherapeutic Supplementation with Momordica charantia: Beneficial Effects in Patients with Suboptimal Glycemic Control on Double Antidiabetic Therapy-A Real-World Evidence Observational Study.
- 2026-01-19
- Observational · n = 85
- Nutrients 18(2)
- - Cosmin Mihai Vesa
  - Timea Claudia Ghitea
  - Ada Radu
  - Andrei Flavius Radu
  - Teodora Maria Bodog
  - Ruxandra Florina Bodog
  - Roxana Daniela Brata
  - Cristiana Bustea
- PubMed: 41599921
- DOI: 10.3390/nu18020309
2 Insights on
- Improved Fasting Plasma Glucose
- Reduced HbA1c Level
- High evidence
- Rigorous Journal
Antiviral Role of Surface Layer Protein A (SlpA) of Lactobacillus acidophilus.
- 2026-01-19
- Pathogens (Basel, Switzerland) 15(1)
- - Govindaraj Anumanthan
  - Ananta Prasad Arukha
  - Ayalew Mergia
  - Bikash Sahay
- PubMed: 41599087
- DOI: 10.3390/pathogens15010103
1 Insight on
- Reduced Viral Load
- Low evidence
Recent Research on the Role of Lactobacilli Probiotics in Cancer Management.
- 2026-01-17
- Review
- Nutrients 18(2)
- - See-Hyoung Park
- PubMed: 41599910
- DOI: 10.3390/nu18020297
5 Insights on
- Moderate evidence
- Rigorous Journal
Bacillus amyloliquefaciens BA5 Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Mice.
- 2026-01-17
- Nutrients 18(2)
- - Yuanyuan He
  - Feiran Li
  - Yangrui Li
  - Mengen Xu
  - Chuxian Quan
  - Shah Nawaz
  - Md F Kulyar
  - Mudassar Iqbal
  - Jiakui Li
- PubMed: 41599912
- DOI: 10.3390/nu18020298
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Vitamin D and Omega-3 Supplementation for Emotional and Behavioral Dysregulation in Autism Spectrum Disorders: A Systematic Review.
- 2026-01-16
- Review
- Journal of clinical medicine 15(2)
- - Marta Berni
  - Giulia Mutti
  - Raffaella Tancredi
  - Filippo Muratori
  - Sara Calderoni
- PubMed: 41598699
- DOI: 10.3390/jcm15020745
4 Insights on
- Low evidence
Mendelian randomization study of the role of TD CD4+ T cells in the association between Streptococcus thermophilus and esophageal cancer.
- 2026-01-16
- Observational
- Medicine 105(3)
- - Yonglun Zhang
  - Qian Li
- PubMed: 41560008
- DOI: 10.1097/md.0000000000047174
1 Insight on
- Reduced Cancer Risk
- Low evidence
In Vitro Assessment of Gut Microbiota Modulation Through Functional Biscuits Enriched with Almond By-Products.
- 2026-01-15
- Foods (Basel, Switzerland) 15(2)
- - Angela Racioppo
  - Maria Rosaria Corbo
  - Angela Guerrieri
  - Milena Sinigaglia
  - Antonio Bevilacqua
  - Rossella Caporizzi
  - Antonio Derossi
  - Barbara Speranza
- PubMed: 41596911
- DOI: 10.3390/foods15020313
1 Insight on
- Improved Gut Microbiota Composition
- Low evidence
Genome-Based Evaluation of Safety and Probiotic Traits in Infant Feces-Sourced Bifidobacterium animalis subsp. lactis BD1.
- 2026-01-15
- Foods (Basel, Switzerland) 15(2)
- - Meng Tian
  - Zihao Liu
  - Jiahang Li
  - Jialin Wang
  - Dayong Ren
  - Yue Leng
- PubMed: 41596914
- DOI: 10.3390/foods15020316
4 Insights on
- Low evidence
"Attacking" the Gut-Brain Axis with Psychobiotics: An Umbrella Review of Depressive and Anxiety Symptoms.
- 2026-01-15
- Review
- Pharmaceuticals (Basel, Switzerland) 19(1)
- - Alberto Souza Sá Filho
  - Tatiane Bastos Souza
  - José Luís Rodrigues Martins
  - Gunnar P H Dietz
  - Katia Flávia Fernandes
  - Stone de Sá
  - Pedro Augusto Inacio
  - Iransé Oliveira-Silva
  - Gustavo Pedrino
  - Vicente Aprigliano
  - Gaspar R Chiappa
  - James Oluwagbamigbe Fajemiroye
- PubMed: 41599756
- DOI: 10.3390/ph19010156
2 Insights on
- Reduced Depression Symptoms
- Reduced Anxiety
- Low evidence
Preparation of Polylactic Acid/Modified Natto Composite Films and Property Evaluation.
- 2026-01-15
- ACS omega 11(3)
- - Weepol Pramualkijja
  - Kawee Srikulkit
- PubMed: 41626485
- DOI: 10.1021/acsomega.5c06426
1 Insight on
- Improved Mechanical Properties
- Low evidence