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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effectiveness of L-Carnitine for the Treatment of Erythropoietin-Resistant Renal Anemia: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial.
- 2026-05
- RCT
- Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 36(3)
- - Stephanie E Reuter
  - Alison L Steiber
  - Randall J Faull
  - Allan M Evans
- PubMed: 41644022
- DOI: 10.1053/j.jrn.2026.01.008
1 Insight on
- Reduced Erythropoietin Resistance Index
- High evidence
Gegen Qinlian decoction alleviates bacterial diarrhea via Lactobacillus amylovorus-modulated restoration of colonic water transport through the cAMP/CFTR/AQP3 pathway.
- 2026-05
- Microbial pathogenesis 214
- - Zhen-Ye Luo
  - Zhe Chen
  - Feng-Lin Zhang
  - Chang-Shun Liu
  - Fei-Long Chen
  - Ze-Zhong Zheng
  - Xiao-Mei Tan
- PubMed: 41802655
- DOI: 10.1016/j.micpath.2026.108434
3 Insights on
- Low evidence
- Animal Study
Functional bread containing synbiotic microcapsules loaded with Lactobacillus delbrueckii subsp. bulgaricus and enzymatic levan.
- 2026-05
- Food chemistry 511
- - Pınar Aytar Çelik
  - Dilan Barut Yavaş
  - Benay Çolak
  - Belma Nural Yaman
  - Özlem Erdal Altıntaş
  - Seda Doğan
  - Arzu Akın
  - Ebru Toksoy Öner
  - Ahmet Çabuk
- PubMed: 41812452
- DOI: 10.1016/j.foodchem.2026.148823
1 Insight on
- Increased Butyric Acid Production
- Low evidence
Effect of Vitamin D Supplementation on Total Knee Arthroplasty Outcomes: A Systematic Review.
- 2026-05
- Review · n = 562
- Orthopaedic journal of sports medicine 14(5)
- - Fardis Vosoughi
  - Ariyan Ayati Firoozabadi
  - Amirhossein Amiri
  - Iman Menbari Oskuie
- PubMed: 42212200
- DOI: 10.1177/23259671261432670
8 Insights on
- High evidence
The Effect of Moringa oleifera on Body Weight and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-05
- Review
- Food science & nutrition 14(5)
- - Mahnoush Mehrzad Samarin
  - Fatemeh Sheikhhossein
  - Amir Hossein Khalilkhaneh
  - Shadi Ghaemi
  - Amin Abbasi
  - Hadi Bazyar
  - Farhang Djafari
  - Zahra Dianati
  - Seyed Mojtaba Khodashenas
  - Gholamreza Askari
  - Mohammad Reza Amini
- PubMed: 42254443
- DOI: 10.1002/fsn3.71899
4 Insights on
- Low evidence
Effect of different kefir dosages on inflammation status, metabolic profile, and anthropometric measurements in adults: A systematic review and meta-analysis.
- 2026-05
- Meta-Analysis
- Nutrition, metabolism, and cardiovascular diseases : NMCD 36(5)
- - Mohammed Hamsho
  - Razan Hawari
  - Zehra Yeşil
  - Zeina Dakhel
  - Derya Dursun Saydam
  - Merve Terzi
  - Yazan Ranneh
- PubMed: 41076330
- DOI: 10.1016/j.numecd.2025.104364
10 Insights on
- High evidence
Effects of vitamin D supplementation on patients with systemic lupus erythematosus: A systematic review and meta-analysis.
- 2026-05
- Meta-Analysis · n = 847
- Autoimmunity reviews 25(5)
- - Jiale Lu
  - Qingmiao Zhu
  - Jiaxun Yu
  - Zhuchen Tan
  - Yingxin Kang
  - Qice Sun
  - Ting Zhao
- PubMed: 41951148
- DOI: 10.1016/j.autrev.2026.104057
4 Insights on
- High evidence
Maternal characteristics associated with ovalbumin concentrations in breast milk.
- 2026-05
- RCT · n = 60
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 37(5)
- - Sophie A Hughes
  - Jessica R Metcalfe
  - Sharon L Perrella
  - Donna T Geddes
  - Debra J Palmer
- PubMed: 42129921
- DOI: 10.1111/pai.70365
1 Insight on
- Increased Breast Milk Ovalbumin Level
- High evidence
Unraveling the vaginal microbiota-based etiology of recurrent cystitis: the potential role of Lactobacillus vaginal suppositories.
- 2026-05
- Review
- Therapeutic advances in urology 18
- - Takanori Sekito
  - Hidetada Hirakawa
  - Takuya Sadahira
- PubMed: 42137495
- DOI: 10.1177/17562872261448600
2 Insights on
- Increased Vaginal Lactobacilli Levels
- Reduced Cystitis Episode
- Low evidence
The Effect of Cranberry Consumption on Body Weight and Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-05
- Review
- Food science & nutrition 14(5)
- - Sogand Tavakoli
  - Shadi Ghaemi
  - Mohammad Reza Amini
  - Farhang Djafari
  - Kimia Fathzadeh
  - Mohammadreza Hosseinpour Dogolsar
  - Fatemeh Sheikhhossein
  - Azita Hekmatdoost
- PubMed: 42137440
- DOI: 10.1002/fsn3.71885
6 Insights on
- Low evidence
High versus standard dose folic acid supplementation for miscarriage prevention: systematic review and meta-analysis of randomized controlled trials.
- 2026-05
- Meta-Analysis · n = 5,144
- American journal of obstetrics & gynecology MFM 8(5)
- - Daniele Vinti
  - Alexander Fiore
  - Gianfranco Fornelli
  - Marco Reschini
  - Paola Viganò
  - Edgardo Somigliana
  - Noemi Salmeri
- PubMed: 41825593
- DOI: 10.1016/j.ajogmf.2026.101934
3 Insights on
- High evidence
Advocating gut-retina connection and microbiota mediated pathways in management of age-related macular degeneration: Preclinical to clinical perspective.
- 2026-05
- Review
- Ageing research reviews 117
- - Pramod V Waghmare
  - Kaustubh Ajit Kolekar
  - Bushra Bashir
  - Popat S Kumbhar
  - Kalpana S Patil
  - Gaurav Gupta
  - Parteek Prasher
  - Saurabh Kumar Jha
  - John Disouza
  - Shailendra S Gurav
  - Kamal Dua
  - Sachin Kumar Singh
- PubMed: 41759744
- DOI: 10.1016/j.arr.2026.103071
4 Insights on
- Low evidence
Influence of dietary supplementation with two distinct probiotic strains, Bifidobacterium longum R0175 and Lacticaseibacillus rhamnosus JB-1, on seizure susceptibility and valproate response: Behavioral and biochemical studies in mice.
- 2026-05
- Nutrition (Burbank, Los Angeles County, Calif.) 145
- - Piotr Wlaź
  - Karolina Skonieczna-Żydecka
  - Adrian Wiater
  - Daniel Styburski
  - Małgorzata Majewska
  - Anna Boguszewska-Czubara
  - Elżbieta Wyska
  - Alan González-Ibarra
  - Nikola Gapińska
  - Dorota Luchowska-Kocot
  - Renata Żelazowska
  - Marcin Grąz
  - Katarzyna Socała
- PubMed: 41576857
- DOI: 10.1016/j.nut.2025.113083
1 Insight on
- Increased threshold for myoclonic seizures
- Low evidence
- Animal Study
Structure-activity relationship of Laminaria japonica polysaccharide in promoting acetic acid synthesis by Lactobacillus rhamnosus GG.
- 2026-05
- Food research international (Ottawa, Ont.) 231
- - Jiabin Wu
  - Yaqing Lin
  - Hangyu Huang
  - Lin Wang
  - Yi Zhang
  - Jin Wang
  - Lei Pan
- PubMed: 41819923
- DOI: 10.1016/j.foodres.2026.118756
4 Insights on
- Low evidence
Does previous pregnancy experience improve folic acid supplementation uptake? A systematic review and meta-analysis.
- 2026-05
- Meta-Analysis · n = 855
- BMJ open 16(5)
- - Utibe Ebong
  - Jason J Wilson
  - Joanne Given
  - Frank Casey
  - Maria Loane
  - Helen Dolk
- PubMed: 42082233
- DOI: 10.1136/bmjopen-2025-106205
5 Insights on
- High evidence
Dietary berberine supplementation improves select physiological and psychological responses during exertional heat stress: A pilot study in young adults.
- 2026-05
- RCT
- Physiological reports 14(10)
- - Dante A Van Arman
  - Jacob C Saunders
  - Yaw O Korankyi
  - Emerson P Heckler
  - Ben J Lee
  - Trevor L Gillum
  - Matthew R Kuennen
- PubMed: 42204774
- DOI: 10.14814/phy2.70937
7 Insights on
- High evidence
Saffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review.
- 2026-05
- Systematic Review
- Journal of evidence-based integrative medicine 31
- - Aisha Alshdefat
  - Ahmad Ayed
  - Ibrahim Aqtam
  - Olabisi Ibitoye
  - Sophia Vincent
  - Atiya Al Furqani
- PubMed: 42186868
- DOI: 10.1177/2515690x261455162
5 Insights on
- High evidence
Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation.
- 2026-05
- RCT · n = 19
- Molecular nutrition & food research 70(10)
- - Paige E Jamieson
  - Inah Gu
  - Nicholas J Reichart
  - Claudia S Maier
  - Emily Ho
  - Thomas J Sharpton
  - Thomas O Metz
  - Ryan Bradley
  - Jan F Stevens
- PubMed: 42138225
- DOI: 10.1002/mnfr.70501
3 Insights on
- High evidence
- Rigorous Journal
Probiotic combinations affect characteristics of chickpea yogurt: an investigation on physicochemical, rheological, and organoleptic properties and SCFAs fermentation.
- 2026-05
- Food chemistry 510
- - Haiyang Shi
  - Jing Luo
  - Zhexin Fan
  - Baokun Li
  - Xiaoqian Chen
  - Bingyuan Lei
  - Yingying Qiu
  - Jiancheng Wang
  - Tong Pan
  - Wenwei Lu
  - Zhifeng Fang
- PubMed: 41795525
- DOI: 10.1016/j.foodchem.2026.148756
2 Insights on
- Increased Short-Chain Fatty Acid Production
- Improved Short-Chain Fatty Acid Production
- Low evidence
Vitamin C and postoperative outcomes following mandibular third molar extraction: a randomized split-mouth study.
- 2026-05
- RCT
- Oral surgery, oral medicine, oral pathology and oral radiology 141(5)
- - Merve Demirel
  - Alper Aktas
  - Mevlüde Kizil
  - Nadir Yalcin
- PubMed: 41309404
- DOI: 10.1016/j.oooo.2025.10.011
2 Insights on
- Reduced Pain
- Reduced Facial Swelling
- High evidence
Black tea consumption and the risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.
- 2026-05
- Meta-Analysis · n = 477
- Nutrition, metabolism, and cardiovascular diseases : NMCD 36(5)
- - Ze-Mu Wang
  - Xiao-Qing Lian
  - Qingqing Long
  - Bo Wu
  - Lian-Sheng Wang
- PubMed: 41152040
- DOI: 10.1016/j.numecd.2025.104369
1 Insight on
- Reduced Risk of Coronary Heart Disease
- High evidence
Enhanced flavor and biogenic amine safety of salt-reduced Doubanjiang through co-inoculated fermentation with Pediococcus acidilactici and Zygosaccharomyces rouxii.
- 2026-05
- n = 226
- Food research international (Ottawa, Ont.) 232
- - Shenglan Liao
  - Youming Li
  - Jiayao Lin
  - Xiaoyi Wang
  - Yunhao Lu
  - Weiqin Deng
  - Qiang He
  - Yuanlong Chi
  - Zhenghong Xu
- PubMed: 41895950
- DOI: 10.1016/j.foodres.2026.118871
1 Insight on
- Improved Food Safety
- Moderate evidence
Chemo-immunotherapeutic potential of Lactobacillus rhamnosus GG and its bioengineering for cancer therapy.
- 2026-05
- Biomaterials 328
- - Zhaonan Liu
  - Qing Guan
  - Jianfeng Xin
  - Wei Tang
  - Yu Chen
  - Jiaying Zhang
  - Junjie Chen
  - Shijie Bi
  - Peng Wang
  - Jun Liu
- PubMed: 41237436
- DOI: 10.1016/j.biomaterials.2025.123848
2 Insights on
- Increased Cell Death
- Enhanced Antitumor Immune Response
- Low evidence
Limosilactobacillus fermentum LF61: A multidimensional study on safety and functionality from genomics to clinical application.
- 2026-05
- RCT · n = 49
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 211
- - Manfei Jin
  - Fei Xu
  - Yinhua Liu
  - Zhao Jiang
- PubMed: 41655688
- DOI: 10.1016/j.fct.2026.116002
4 Insights on
- High evidence
Effects of marine-derived Enterococcus durans YQ-6 on growth performance, intestinal health and microbial community of Leizhou black ducks.
- 2026-05
- RCT · n = 180
- Poultry science 105(5)
- - Yufeng Gou
  - Jiang Wu
  - Qiucheng Yao
  - Namula Zhao
  - Haiyan Wu
  - Zhibao Chen
- PubMed: 41691807
- DOI: 10.1016/j.psj.2026.106568
2 Insights on
- Improved Growth Performance
- Improved Intestinal Health
- High evidence
Blueberry consumption enhances vascular function but not cognitive abilities in healthy individuals: a systematic review and meta-analysis.
- 2026-05
- Meta-Analysis · n = 632
- Nutrition research (New York, N.Y.) 149
- - Yu He
  - Jing Yang
  - Shuzhen Zhang
  - Junfan Mai
  - Meiying Li
- PubMed: 41974068
- DOI: 10.1016/j.nutres.2026.03.007
5 Insights on
- High evidence
Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation.
- 2026-04
- Pharmacological research 226
- - Jing Xie
  - Yongzhi Zhang
  - Jiao-Lin Wang
  - Fei He
  - Ke Xu
  - Jianjun Chen
  - Peng Xie
- PubMed: 41825730
- DOI: 10.1016/j.phrs.2026.108158
3 Insights on
- Low evidence
- Animal Study
Synergistic effects of oral inoculation with recombinant Lactobacillus plantarum NC8 Co-expressing interleukin-2, interleukin-17b and interleukin-26 on infectious bronchitis vaccination in chickens.
- 2026-04
- Clinical Trial
- Poultry science 105(4)
- - Junjie Peng
  - Shaohua Guo
  - Yanyan Liu
  - Weiwei Hao
  - Xin Yang
  - Shanshan Zhu
  - Rong Gao
- PubMed: 41633076
- DOI: 10.1016/j.psj.2026.106551
1 Insight on
- Enhanced Immune Response
- Low evidence
- Animal Study
Oral delivery of engineered Lactococcus lactis microcapsules expressing antioxidant enzymes for inflammatory bowel disease: Mechanisms of intestinal barrier repair and microbiota modulation.
- 2026-04
- Materials today. Bio 37
- - Yue Meng
  - Chao Miao
  - Jiaxin Guo
  - Wei Zhang
  - Ling Guo
  - Yu Zhang
  - Yujun Jiang
- PubMed: 41716339
- DOI: 10.1016/j.mtbio.2026.102902
3 Insights on
- Low evidence
Randomized Trial of Milk Oral Immunotherapy: Fixed Low-Dose vs Escalation to Medium-Dose.
- 2026-04
- RCT · n = 32
- The journal of allergy and clinical immunology. In practice 14(4)
- - Ken-Ichi Nagakura
  - Kyohei Takahashi
  - Yoko Miura
  - Kaito Goto
  - Akira Kawai
  - Naoko Fusayasu
  - Kiyotake Ogura
  - Sakura Sato
  - Motohiro Ebisawa
  - Noriyuki Yanagida
- PubMed: 41633410
- DOI: 10.1016/j.jaip.2026.01.025
5 Insights on
- High evidence