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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Effects of probiotics, prebiotics, and synbiotics on gut microbiota in older adults: a systematic review and meta-analysis of randomized controlled trials.
- 2025-09-29
- Meta-Analysis · n = 633
- Nutrition journal 24(1)
- - Kai Zhuang
  - Huanhuan Luo
  - Muhuang Zeng
  - Sze Chun Leo Chan
  - Meiting Gong
  - Yunhan Wang
- PubMed: 41023690
- DOI: 10.1186/s12937-025-01218-1
10 Insights on
- High evidence
A Synbiotic of Bifidobacterium animalis subsp. lactis BB-12 and 2'-FL Alleviate Infant Diarrhea and Anxiety-like Behaviors via Gut Microbiota Modulation in an EPEC O127 Infection Model.
- 2025-09-29
- Nutrients 17(19)
- - Zhuo Liu
  - Wenxiu Wang
  - Ning Li
  - Jinkuan Chen
  - Qianxu Wang
  - Mengzhen Jia
  - Xiaorui Wang
  - Bo Zhang
  - Nan Sheng
  - Zhigang Liu
- PubMed: 41097176
- DOI: 10.3390/nu17193099
11 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
A prospective study of serum folate levels in patients with solid tumors treated with olaparib.
- 2025-09-27
- RCT
- The oncologist 30(10)
- - Jamile Shammo
  - Laura Owczarzak
  - Nicole K Yun
  - Lois Winkelman
  - Sanjib Basu
  - Ruta Rao
  - Amina Ahmed
  - Summer Dewdney
  - Melody Cobleigh
  - Lydia Usha
- PubMed: 41014151
- DOI: 10.1093/oncolo/oyaf321
2 Insights on
- Increased Hemoglobin Levels
- Normalized Folate Level
- High evidence
Effects of Athletic Nutritional Supplements on the Human Gut Microbiota: A Narrative Review.
- 2025-09-26
- Review
- Nutrients 17(19)
- - Themistoklis Katsimichas
  - Anastasia Xintarakou
  - Charalambos Vlachopoulos
  - Costas Tsioufis
  - George Lazaros
- PubMed: 41097148
- DOI: 10.3390/nu17193071
1 Insight on
- No Human Health Outcome Reported
- Moderate evidence
- Rigorous Journal
Effect of probiotic administration of Bifidobacterium animalis subsp. lactis BB-12 and Lactiplantibacillus plantarum ATCC 14917 on metabolic profiles in an IBS-D rat model: a metabolomic analysis approach.
- 2025-09-26
- n = 20
- Journal of the science of food and agriculture 106(1)
- - Nazila Dardmeh
  - Ali A Moazzami
  - Masoud Yavarmanesh
  - Maryam M Matin
  - Hamid Noorbakhsh
- PubMed: 41002283
- DOI: 10.1002/jsfa.70190
4 Insights on
- Low evidence
Oral lipoteichoic and lipoic acids improve insulin resistance and body composition in porphyria mice on a high-carbohydrate diet.
- 2025-09-26
- n = 6
- Journal of physiology and biochemistry 81(4)
- - Miriam Longo
  - Teresa Rubio
  - Araceli Lamelas
  - Daniel Jericó
  - Andrea Rodenes-Gavidia
  - Jordi Cervero
  - Juan Martínez-Blanch
  - Empar Chenoll
  - Patricia Martorell
  - Erika Paolini
  - Marica Meroni
  - José Ignacio Riezu-Boj
  - Isabel Solares
  - Ana Sampedro
  - Francesco Urigo
  - María Collantes
  - Michele Battistin
  - Stefano Gatti
  - Gemma Quincoces
  - Ivan Peñuelas
  - María Jesús Moreno-Aliaga
  - Matías A Ávila
  - Elena Di Pierro
  - Daniel Ramón
  - Fermín I Milagro
  - Paola Dongiovanni
  - Antonio Fontanellas
- PubMed: 41004024
- DOI: 10.1007/s13105-025-01124-4
3 Insights on
- Low evidence
- Animal Study
Characterization and In Vitro Probiotic Assessment of Alkalihalobacillus wakoensis as New Potent Probiotic Candidate.
- 2025-09-26
- Food science & nutrition 13(10)
- - Ali Zarei
  - Ahmad Gholami
  - Zahra Kanannejad
  - Aydin Berenjian
  - Seyed Hesamodin Nabavizadeh
  - Milad Mohkam
- PubMed: 41019162
- DOI: 10.1002/fsn3.71031
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Lactococcus lactis Strain Plasma Uniquely Induces IFN-α Production via Plasmacytoid Dendritic Cell Activation: A Comparative Study of Postbiotic Products.
- 2025-09-26
- n = 19
- Microorganisms 13(10)
- - Shigeru Fujimura
  - Masato Kawamura
  - Yurina Tamura
- PubMed: 41156721
- DOI: 10.3390/microorganisms13102261
4 Insights on
- Low evidence
Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial.
- 2025-09-26
- RCT · n = 32
- Medicine 104(39)
- - Noura Mohammed Bakr
  - Gihan Adel Balbola
  - Soha Fuad Alqadi
  - Najla Dar-Odeh
  - Shadia Elsayed
  - Nuha Alghamdi
  - Nisreen Nabiel Hassan
  - Sara N Hashem
  - Safaa Ramadan El Sayed
- PubMed: 41029033
- DOI: 10.1097/md.0000000000044827
2 Insights on
- Improved Clinical Success
- Improved Radiographic Success
- High evidence
Red yeast rice with monacolin K for the improvement of hyperlipidemia: A narrative review.
- 2025-09-26
- Review
- World journal of clinical cases 13(27)
- - Kevan English
- PubMed: 40881894
- DOI: 10.12998/wjcc.v13.i27.105415
3 Insights on
- Low evidence
Health benefits of ethnic fermented foods.
- 2025-09-26
- Systematic Review
- Frontiers in nutrition 12
- - Dushica Santa
  - Melanie Huch
  - Dominic A Stoll
  - Hülya Cunedioglu
  - Reimo Priidik
  - Barçın Karakaş-Budak
  - Antonia Matalas
  - Vincenzo Pennone
  - Aiswarya Girija
  - Elena Arranz
  - Michail Syrpas
  - Arghya Mukherjee
  - Paul D Cotter
  - Sandra Mojsova
  - Christophe Chassard
  - Smilja Praćer
  - Guy Vergères
  - Mary-Liis Kütt
- PubMed: 41080174
- DOI: 10.3389/fnut.2025.1677478
1 Insight on
- Improved Gut Health
- High evidence
The comparison of antioxidant and anti-inflammatory potency of native probiotics and paraprobiotics in DSS-induced colitis mice with a normal diet.
- 2025-09-26
- Genes & nutrition 20(1)
- - Niloofar Rezaie
  - Shadi Aghamohammad
  - Elham Haj Agha Gholizadeh Khiavi
  - Malihe Talebi
  - Mohammad Reza Pourshafie
  - Mahdi Rohani
- PubMed: 41013217
- DOI: 10.1186/s12263-025-00774-9
3 Insights on
- Low evidence
Ligilactobacillus salivarius alleviated intestinal damage induced by Salmonella in mice via regulating microbiota.
- 2025-09-25
- BMC microbiology 25(1)
- - Xiaohui Liang
  - Qin He
  - Chang Xu
  - Munwar Ali
  - Linlin Gu
  - Muhammad Safdar
  - Qudratullah
  - Kun Li
- PubMed: 40999333
- DOI: 10.1186/s12866-025-04277-w
1 Insight on
- Reduced Intestinal Damage
- Low evidence
- Animal Study
A network meta-analysis of probiotics in the treatment of childhood asthma.
- 2025-09-25
- Systematic Review · n = 839
- Frontiers in pediatrics 13
- - Jiajia Sun
  - Meiyi Zhu
  - Ying Liu
  - Di Zhang
- PubMed: 41098501
- DOI: 10.3389/fped.2025.1637284
1 Insight on
- Increased FEV1
- High evidence
Effect of carnosine or beta-alanine supplementation therapy for prediabetes or type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.
- 2025-09-25
- Meta-Analysis · n = 377
- BMC endocrine disorders 25(1)
- - Na Li
  - Xueqin Yan
  - Jiayi Lin
  - Meng Wu
  - Xingyu He
  - Jingxian Yang
  - Hongling Li
  - Wenjun Wei
  - Yinlei Zhang
  - Yuting Zhong
  - Guangya Xu
  - Zhonglin Fan
  - Xingrong Hu
  - Yao Wang
  - Zheng Shi
- PubMed: 40999397
- DOI: 10.1186/s12902-025-02016-w
3 Insights on
- High evidence
Dosing strategies for β-alanine supplementation in strength and power performance: a systematic review.
- 2025-09-25
- Systematic Review · n = 197
- Journal of the International Society of Sports Nutrition 22(1)
- - Si-Wei Ong
  - Wei-Ling Chen
  - Kuei-Yu Chien
  - Chih-Wen Hsu
- PubMed: 40995761
- DOI: 10.1080/15502783.2025.2566368
2 Insights on
- Improved Maximal Strength
- Improved Power-Related Outcome
- High evidence
Probiotic-Based Materials as Living Therapeutics.
- 2025-09-25
- Review
- Advanced materials (Deerfield Beach, Fla.) 38(1)
- - Laura Sabio
  - Graham J Day
  - Manuel Salmeron-Sanchez
- PubMed: 40999775
- DOI: 10.1002/adma.202508500
1 Insight on
- Improved Gastrointestinal Symptoms
- Low evidence
Probiotic and aroma-producing Bacillus sp. isolates from teles, a traditional fermented fish from Assam, India: functional characterisation and potential application in fermented foods.
- 2025-09-24
- BMC microbiology 25(1)
- - Debashree Borthakur
  - Bipin Kumar Sharma
  - Vijay Jagdish Upadhye
- PubMed: 40993571
- DOI: 10.1186/s12866-025-04312-w
1 Insight on
- Improved Gastrointestinal Resilience
- Low evidence
- Animal Study
Unlocking the Therapeutic Potential: Selenium and Myo-Inositol Supplementation in Thyroid Disorders-Efficacy and Future Directions.
- 2025-09-24
- Review
- Life (Basel, Switzerland) 15(10)
- - Chinnu George Samuel
  - Parul Singh
  - Hala Abdullahi
  - Ibrahim Ibrahim
- PubMed: 41157173
- DOI: 10.3390/life15101500
4 Insights on
- Low evidence
Probiotics in Pet Food: A Decade of Research, Patents, and Market Trends.
- 2025-09-24
- Review
- Foods (Basel, Switzerland) 14(19)
- - Phatthranit Klinmalai
  - Pitiya Kamonpatana
  - Janenutch Sodsai
  - Atcharawan Srisa
  - Khwanchat Promhuad
  - Yeyen Laorenza
  - Attawit Kovitvadhi
  - Sathita Areerat
  - Anusorn Seubsai
  - Massalin Nakphaichit
  - Nathdanai Harnkarnsujarit
- PubMed: 41097477
- DOI: 10.3390/foods14193307
4 Insights on
- Low evidence
Effects of vitamin D supplements on bone metabolism in kidney transplant recipients: a systematic review and meta-analysis.
- 2025-09-24
- Meta-Analysis · n = 985
- Systematic reviews 14(1)
- - Peishan Cai
  - Zhou Shu
  - Taotao Zhou
  - Jie Li
  - Wei Chen
  - Xianpeng Zeng
  - Fang Zeng
- PubMed: 40993781
- DOI: 10.1186/s13643-025-02828-w
13 Insights on
- High evidence
A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease.
- 2025-09-24
- NPJ biofilms and microbiomes 11(1)
- - Aline Ovalle
  - Estefanía López
  - Jimena Sierralta
  - Nuria Paricio
  - Daniel Garrido
- PubMed: 40993130
- DOI: 10.1038/s41522-025-00797-5
3 Insights on
- Low evidence
- Animal Study
Synbiotics in Alzheimer's disease: mechanisms, clinical evidence, and therapeutic prospects.
- 2025-09-24
- Review
- Journal of translational medicine 23(1)
- - Yuhua Lin
  - Rongping Weng
  - Huayang Pan
  - Yangbo Hou
  - Yipeng Sun
  - Junkai Wen
- PubMed: 40993787
- DOI: 10.1186/s12967-025-07064-3
5 Insights on
- Low evidence
Bifidobacterium treatment for chronic low back pain in patients with Modic changes: study protocol for a multicenter, randomized, placebo-controlled trial.
- 2025-09-24
- RCT
- Trials 26(1)
- - Sunqi Nian
  - Chengjin Li
  - Na Li
  - Fei Chen
  - Caiwang Zhao
  - Guangyao Zhang
  - Sheng Lu
  - Jiayu Chen
- PubMed: 40993700
- DOI: 10.1186/s13063-025-09084-2
5 Insights on
- High evidence
Flaxseed in Diabetes Management: Nutritional and Therapeutic Insights.
- 2025-09-24
- Review
- Current nutrition reports 14(1)
- - Preedhi Kapoor
  - Zubair Ahmad Parrey
  - Bilal Ahmad Mir
  - Ab Waheed Wani
  - Ritu Kumari
  - Gurseen Rakhra
  - Ridhi Joshi
  - Gurmeen Rakhra
  - Wajid Aslam Khan
  - Kasim Sakran Abass
  - Bodour S Rajab
  - Arshad Farid
  - Saad Alghamdi
- PubMed: 40991096
- DOI: 10.1007/s13668-025-00696-3
4 Insights on
- Low evidence
Effect of Probiotics Containing Lactobacillus plantarum on Blood Lipids: Systematic Review, Meta-Analysis, and Network Pharmacological Analysis.
- 2025-09-23
- Review · n = 2,104
- Foods (Basel, Switzerland) 14(19)
- - Jinshi Zuo
  - Dan Huang
  - Jie Liu
  - Zidan Wang
  - Yuerong Ren
  - Yang Su
  - Yuxia Ma
- PubMed: 41097469
- DOI: 10.3390/foods14193300
6 Insights on
- High evidence
Probiotics as Adjuvants to Standard Helicobacter pylori Treatment: Evidence for the Use of Lacidofil®, an Established Blend of Thoroughly Characterized Strains.
- 2025-09-23
- Review
- Microorganisms 13(10)
- - Noémie Auclair-Ouellet
  - Annie Tremblay
  - Ola Kassem
  - Sara E Caballero-Calero
  - Stéphane Bronner
  - Sylvie Binda
- PubMed: 41156685
- DOI: 10.3390/microorganisms13102223
3 Insights on
- Low evidence
Efficacy of dietary supplements on sports performance outcomes: a systematic review of evidence in elite athletes.
- 2025-09-22
- Systematic Review · n = 928
- Frontiers in nutrition 12
- - Tongwu Yu
  - Chuanwei Ding
- PubMed: 41058995
- DOI: 10.3389/fnut.2025.1675654
1 Insight on
- Improved Athletic Performance
- High evidence
Performance-enhancing effects of caffeine and L-Theanine among Iranian elite wrestlers: a focus on cognitive and specific physical performance.
- 2025-09-22
- RCT
- Journal of the International Society of Sports Nutrition 22(1)
- - Rouzbeh Razazan
  - Mohammad Hemmatinafar
  - Babak Imanian
  - Nima Jahaniboushehri
  - Rasoul Rezaei
  - Gholamhossein Nazemzadegan
- PubMed: 40977612
- DOI: 10.1080/15502783.2025.2564238
9 Insights on
- High evidence
Curcumin Versus Corticosteroids for Symptomatic Oral Lichen Planus: A Systematic Review and Meta-Analysis.
- 2025-09-22
- Meta-Analysis
- Clinical and experimental dental research 11(5)
- - Sadeq A Al-Maweri
  - Gamilah Al-Qadhi
  - Ahmed Yaseen Alqutaibi
  - Nadhem M Sallam
  - Mounzer Assad
  - Mahfoudh A Abdulghani
  - Marwan Mansoor Ali Mohammed
- PubMed: 40977174
- DOI: 10.1002/cre2.70227
2 Insights on
- Reduced Pain
- Improved Clinical Lesion Score
- High evidence