Historical Spice as a Future Drug: Therapeutic Potential of Piperlongumine.2016-08-16Current Pharmaceutical Design 22(27)S. PrasadA. TyagiPubMed: 27262330DOI: 10.2174/13816128226661606011030271 Insight on Increased Chemosensitivity to Drug-Resistant Cancer Cells
Hypolipidemic effects of a new piperine derivative GB-N from Piper longum in high-fat diet-fed rats2012-04-12Pharmaceutical Biology 50(8)L. BaoShiming BaiGereltu BorijihanPubMed: 22494195DOI: 10.3109/13880209.2012.6543953 Insights on Increased Hepatic Lipid Metabolism MarkersIncreased HDL CholesterolReduced Serum Triglyceride Levels
Piper longum L.: A comprehensive review on traditional uses, phytochemistry, pharmacology, and health‐promoting activities2022-10-18Phytotherapy Research 36(12)P. BiswasMimosa GhoraiTulika MishraA. GopalakrishnanDebleena RoyA. ManeA. MundhraN. DasV. M. MohtureM. PatilMd. Habibur RahmanN. JhaG. BatihaS. SahaM. ShekhawatRadhaM. KumarD. PandeyA. DeyPubMed: 36256521DOI: 10.1002/ptr.764919 Insights on Increased Anti-Venom EfficacyReduced Helminth InfectionIncreased Antiangiogenic ActivityEnhanced Antimicrobial ResistanceReduced Mosquito PopulationImproved Asthmatic ConditionReduced Lipid LevelsReduced Inflammatory ActivityImproved Liver FunctionImproved ImmunomodulationImproved Cardioprotective ActivityIncreased Anticancer ActivityReduced Pain IntensityEnhanced Neuropharmacological FunctionReduced Pathogenic LoadReduced Arthritis SymptomsIncreased Antioxidant ActivityReduced Ulcer SymptomsReduced Glucose Levels
Evaluation of the Efficacy & Biochemical Mechanism of Cell Death Induction by Piper longum Extract Selectively in In-Vitro and In-Vivo Models of Human Cancer Cells2014-11-17PLoS ONE 9(11)Pamela OvadjeDennis MaPhillip TremblayAlessia RomaMatthew SteckleJ. GuerreroJ. ArnasonS. PandeyPubMed: 25401766DOI: 10.1371/journal.pone.01132502 Insights on Reduced Colon Cancer Tumor GrowthIncreased Apoptosis in Cancer Cells
Health-Promoting Nature of Lactococcus lactis IBB109 and Lactococcus lactis IBB417 Strains Exhibiting Proliferation Inhibition and Stimulation of Interleukin-18 Expression in Colorectal Cancer Cells2022-05-25Frontiers in Microbiology 13Przemysław SałańskiM. KowalczykJ. BardowskiA. SzczepankowskaPubMed: 35694291DOI: 10.3389/fmicb.2022.8229126 Insights on Improved Intestinal Cell AdhesionReduced Colorectal Cancer Cell ProliferationReduced Cancer Cell ProliferationImproved Survival in Gastrointestinal ConditionsImproved Antibiotic SensitivityIncreased Interleukin-18 Expression
Anti-inflammatory properties of fermented soy milk with Lactococcus lactis subsp. lactis S-SU2 in murine macrophage RAW264.7 cells and DSS-induced IBD model mice.2015-06International Immunopharmacology 26(2)Miho KawaharaMaki NemotoToru NakataSaya KondoHajime TakahashiB. KimuraT. KudaPubMed: 25887264DOI: 10.1016/j.intimp.2015.04.0046 Insights on Enhanced Adhesion to Enterocyte-like CellsImproved Digestive HealthIncreased Bile ResistancePrevention of Inflammatory Bowel Disease CharacteristicsReduced NO Secretion Induced by LPSIncreased Nitric Oxide Secretion
Safety assessment of dairy microorganisms: the Lactococcus genus.2008-09-01International Journal of Food Microbiology 126(3)E. CasaltaM. MontelPubMed: 17976847DOI: 10.1016/J.IJFOODMICRO.2007.08.0132 Insights on Reduced Human InfectionsReduced Incidence of Fish Diseases
Different effects of two newly-isolated probiotic Lactobacillus plantarum 15HN and Lactococcus lactis subsp. Lactis 44Lac strains from traditional dairy products on cancer cell lines.2014-12Anaerobe 30Babak HaghshenasN. AbdullahY. NamiDayang RadiahR. RosliA. KhosroushahiPubMed: 25168457DOI: 10.1016/j.anaerobe.2014.08.0092 Insights on Reduction of Cancer Cell CytotoxicityIncreased Apoptosis in Cancer Cells
A lactose fermentation product produced by Lactococcus lactis subsp. lactis, acetate, inhibits the motility of flagellated pathogenic bacteria.2015-04-01Microbiology 161(4)Shuichi NakamuraYusuke V. MorimotoS. KudoPubMed: 25573770DOI: 10.1099/mic.0.0000314 Insights on Reduced Bacterial MotilityParalysis Due to Salmonella InfectionReduced Intracellular pH of Pathogenic BacteriaReduced Pathogenic Bacterial Motility
Effects of Lactococcus lactis from Cyprinus carpio L. as probiotics on growth performance, innate immune response and disease resistance against Aeromonas hydrophila.2019-10Fish & Shellfish Immunology 93Junchang FengXulu ChangYuru ZhangXiao YanJianxin ZhangG. NiePubMed: 31302283DOI: 10.1016/j.fsi.2019.07.02810 Insights on Increased Anti-inflammatory CytokinesEnhanced Innate Immune FunctionEnhanced Innate Immune ResponseEnhanced Disease ResistanceImproved Growth PerformanceEnhanced Anti-inflammatory ResponseIncreased Plasma Anti-inflammatory Cytokine LevelsRegulated Cytokine ExpressionImproved Cell Survival RatesEnhanced Pro-Inflammatory Cytokine Response
Lactococcus lactis subsp. cremoris strain JFR1 attenuates Salmonella adhesion to human intestinal cells in vitro.2016-12Food Research International 90J. ZhangA. GuriM. CorredigR. Morales-RayasAshraf N. HassanM. GriffithsG. LaPointePubMed: 29195867DOI: 10.1016/j.foodres.2016.10.0093 Insights on Reduced Bacterial Adhesion to Intestinal CellsReduced Salmonella VirulenceReduced Salmonella typhimurium Adhesion
The Effect of Lactococcus lactis subsp. lactis PTCC 1403 on the Growth Performance, Digestive Enzymes Activity, Antioxidative Status, Immune Response, and Disease Resistance of Rainbow Trout (Oncorhynchus mykiss)2021-05-18Probiotics and Antimicrobial Proteins 13(6)Sakineh YeganehMilad AdelAhmad NosratimovafaghMahmoud A. O. DawoodPubMed: 34002350DOI: 10.1007/s12602-021-09787-314 Insights on Enhanced Protein Efficiency RatioEnhanced Digestive Enzyme ActivityReduced Blood Glucose LevelsEnhanced Antioxidant ResponseImproved Immune ResponseIncreased Immunoglobulin MEnhanced Disease ResistanceReduced MortalityImproved Feed Conversion RatioReduced Serum Glucose LevelsImproved Antioxidative ResponseLower Plasma Glucose LevelsImproved Cell Survival RatesIncreased Serum Lysozyme Activity
Lactococcus Lactis Subsp. cremoris Is an Efficacious Beneficial Bacterium that Limits Tissue Injury in the Intestine2019-02iScience 12T. DarbyJoshua A. OwensB. SaeediL. LuoJ. MatthewsB. RobinsonC. NaudinRheinallt M. JonesPubMed: 30739017DOI: 10.1016/j.isci.2019.01.03011 Insights on Reduced Injury-Induced Gut InflammationReduced Colitis InflammationReduced Ileum InflammationReduced Intestinal Tissue DamageProtection Against Radiological DamageProtection Against Gut Tissue DamageReduced Gastric Tissue DamageReduced Radiological Damage in the GutIncreased Cytoprotection Against Tissue DamageReduced Inflammatory InjuryReduced Gut Inflammation
Effect of Potential Probiotic Lactococcus lactis Subsp. lactis on Growth Performance, Intestinal Microbiota, Digestive Enzyme Activities, and Disease Resistance of Litopenaeus vannamei2016-11-07Probiotics and Antimicrobial Proteins 9(2)M. AdelA. El‐SayedS. YeganehMaryam DadarS. GiriPubMed: 27822707DOI: 10.1007/s12602-016-9235-95 Insights on Enhanced Digestive Enzyme ActivityReduced Vibrio Counts in IntestineImproved Microbiota BalanceEnhanced Disease ResistanceImproved Growth Performance
Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18.2012-12International Immunopharmacology 14(4)A. KosakaHuimin YanS. OhashiYayoi GotohAmi SatoH. TsutsuiT. KaishoT. TodaN. TsujiPubMed: 23102661DOI: 10.1016/j.intimp.2012.10.0078 Insights on Improved Cellular ImmunityIncreased Cytokine ProductionImproved Cellular Immune ResponseEnhanced IFN-γ ProductionIncreased IL-10 ProductionEnhanced Interleukin-10 ProductionIncreased Interleukin-12 ProductionEnhanced Interferon Gamma Production
Encapsulated Lactococcus lactis with enhanced gastrointestinal survival for the development of folate enriched functional foods.2015-07Bioresource Technology 188J. DivyaK. NampoothiriPubMed: 25686721DOI: 10.1016/j.biortech.2015.01.0732 Insights on Increased Folate LevelsImproved Gastrointestinal Survival
Analyses of the probiotic property and stress resistance-related genes of Lactococcus lactis subsp. lactis NCDO 2118 through comparative genomics and in vitro assays2017-04-06PLOS ONE 12(4)L. C. OliveiraT. SaraivaW. M. SilvaU. PereiraB. C. CamposL. BenevidesF. RochaH. FigueiredoV. AzevedoS. SoaresPubMed: 28384209DOI: 10.1371/journal.pone.01751161 Insight on Reduced Colitis Symptoms
Effects of Lactococcus lactis subsp. lactis I2 with β-Glucooligosaccharides on Growth, Innate Immunity and Streptococcosis Resistance in Olive Flounder (Paralichthys olivaceus).2018-09-28Journal of Microbiology and Biotechnology 28(9)M. T. HasanW. JangJin Yeong TakBong-Joo LeeK. KimSang-woo HurHyonsob HanBo-Seong KimDo-Huh MinShin-Kwon KimI. KongPubMed: 30176713DOI: 10.4014/jmb.1805.0501114 Insights on Enhanced GrowthEnhanced Innate Immune FunctionImproved Streptococcal ResistanceImproved Innate ImmunityIncreased Pro-inflammatory Cytokine ExpressionImproved Viability of Lactic Acid BacteriaImproved Weight GainImproved Growth PerformanceIncreased Resistance to Group A Streptococcal InfectionsImproved Growth RateImproved Intestinal LAB ViabilityReduced Pro-Inflammatory CytokinesElevated TNF-α Expression LevelEnhanced Protection Against Streptococcal Infection
Effect of Lactobacillus fermentum ZS40 on the NF-κB signaling pathway in an azomethane-dextran sulfate sodium-induced colon cancer mouse model2022-09-26Frontiers in Microbiology 13Jia LiuShuaiqi WangRuokun YiX. LongXin ZhaoPubMed: 36225358DOI: 10.3389/fmicb.2022.9539058 Insights on Reduced Colon Cancer Marker ProteinsReduced Body WeightReduced Inflammatory StimulatorsReduced Incidence of Colon CancerReduced Activation of TLR4/NF-κB Signaling PathwayReduced Abnormal Colonic LesionsInhibited NF-kB Pathway ActivationReduced Inflammation Levels
Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4-17 against Escherichia coli causing urinary tract infection in humans.2019-06Microbial Pathogenesis 131F. FalahA. VasieeB. A. BehbahaniF. T. YazdiS. MoradiS. MortazaviS. RoshanakPubMed: 30974159DOI: 10.1016/j.micpath.2019.04.00611 Insights on Improved Intestinal Cell AdhesionImproved Colon Cell AdhesionIncreased Survival in Adverse Gastrointestinal ConditionsImproved Survival in Gastrointestinal ConditionsReduced Intestinal Cell AdhesionReduced Cellular HydrophobicityIncreased Anti-Adhesive Properties Against Pathogenic BacteriaEnhanced Cell Membrane HydrophobicityReduced Pathogen AdhesionReduced Adhesion of Escherichia coliIncreased Cell Membrane Hydrophobicity
Biofilms of Lactobacillus plantarum and Lactobacillus fermentum: Effect on stress responses, antagonistic effects on pathogen growth and immunomodulatory properties.2016-02Food Microbiology 53N. AoudiaA. RieuR. BriandetJ. DeschampsJ. ChlubaG. JegoC. GarridoJ. GuzzoPubMed: 26611169DOI: 10.1016/j.fm.2015.04.0091 Insight on Reduced TNF Production
Exopolysaccharide from Lactobacillus fermentum Lf2 and its functional characterization as a yogurt additive.2016-11Journal of Dairy Research 83(4)E. C. AleM. PerezlindoP. BurnsEduardo TabacmanJ. ReinheimerA. BinettiPubMed: 27845020DOI: 10.1017/S00220299160005713 Insights on Improved ImmunomodulationReduced Risk of Salmonella InfectionImproved Yogurt Texture
Lactobacillus fermentum strains of dairy-product origin adhere to mucin and survive digestive juices.2019-12-01Journal of Medical Microbiology 68(12)Kanwal AzizArsalan Haseeb ZaidiHafiza Naseem FatimaMuhammad TariqPubMed: 31613203DOI: 10.1099/jmm.0.0010908 Insights on Increased Mucosal AdhesionReduced Mucin AdhesionReduced Cholesterol LevelsIncreased Adhesion to Intestinal MucinImproved Survival in Digestive EnvironmentImproved Safety ProfileEnhanced Oxalate DegradationReduced Total Cholesterol Levels
Consumption of Probiotic Lactobacillus fermentum MTCC: 5898-Fermented Milk Attenuates Dyslipidemia, Oxidative Stress, and Inflammation in Male Rats Fed on Cholesterol-Enriched Diet2018-05-13Probiotics and Antimicrobial Proteins 11(2)R. YadavS. H. KhanS. MadaS. MeenaR. KapilaS. KapilaPubMed: 29754388DOI: 10.1007/s12602-018-9429-410 Insights on Reduced Hepatic Lipid LevelsReduced Serum Total Cholesterol LevelsReduced Low-Density Lipoprotein LevelReduced Risk of Coronary Heart DiseaseImproved Antioxidative Enzyme ActivitiesReduced Inflammatory Cytokines mRNA ExpressionReduced Serum TriacylglycerolsReduced Lipid PeroxidationReduced Atherogenic IndexIncreased High-Density Lipoprotein Cholesterol
Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity2020-05-06Foods 9(5)Won-Young ChoGo-Eun HongHa-Jung LeeSu-Jung YeonH. PaikY. HosakaChi-Ho LeePubMed: 32384659DOI: 10.3390/foods90505942 Insights on Improved Blood Lipid MetabolismReduced Abdominal Fat
Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice2017-05-25Nutrients 9(6)Xiaoyong ChenXin ZhaoHongwei WangZelin YangJian LiHuayi SuoPubMed: 28587089DOI: 10.3390/nu90605454 Insights on Reduced Colonic InflammationReduced Proinflammatory FactorsInhibited IκBα DegradationReduced Inflammatory Pathways
Probiotic Lactobacillus fermentum KU200060 isolated from watery kimchi and its application in probiotic yogurt for oral health.2020-10Microbial Pathogenesis 147Sung-Min LimN. LeeKee-Tae KimH. PaikPubMed: 32758520DOI: 10.1016/j.micpath.2020.10443010 Insights on Enhanced Gut HealthImproved Oral HealthPotential Probiotic BenefitsReduced Mutans Streptococcus CountsImproved Antibacterial ActivitySuitability as a Probiotic Yogurt StarterIncreased Consumer Acceptability of Probiotic YogurtViability as Probiotic Yogurt StarterReduced Streptococcus mutans ActivityReduced Biofilm Formation
Dietary Lactobacillus fermentum and Lactobacillus paracasei improve the intestinal health of broilers challenged with coccidia and Clostridium perfringens2022-12-15Frontiers in Veterinary Science 9Peng LiLiyun ZhengY.Y. QiZhipeng LiuE. DuJintao WeiZ. ZhangShuangshuang GuoB. DingPubMed: 36590818DOI: 10.3389/fvets.2022.10256773 Insights on Improved Intestinal Barrier FunctionNormalization of TGF-β mRNA Level in the SpleenReduced Lesion Severity
Safety Assessment of Potential Probiotic Lactobacillus fermentum MTCC-5898 in Murine Model after Repetitive Dose for 28 Days (Sub-Acute Exposure)2019-03-08Probiotics and Antimicrobial Proteins 12(1)M. SamtiyaM. I. BhatTaruna GuptaS. KapilaR. KapilaPubMed: 30847835DOI: 10.1007/s12602-019-09529-64 Insights on Maintained Gut PermeabilityImproved Immune HomeostasisIncreased Tight Junction Protein Gene ExpressionNo Adverse Health Effects
Lactobacillus fermentum CECT5716 supplementation in rats during pregnancy and lactation affects breast milk composition.2020-04Journal of Dairy Science 103(4)Ignasi Azagra-BoronatA. TresM. Massot-CladeraÀ. FranchM. CastellF. GuardiolaF. Pérez-CanoM. J. Rodríguez-LagunasPubMed: 32008776DOI: 10.3168/jds.2019-1738412 Insights on Improved Milk Fatty Acid ProfileIncreased Polyunsaturated Fatty Acids in MilkIncreased Immunoglobulin A LevelsIncreased Immunoglobulin A Levels in Breast MilkIncreased PUFA Levels in Breast MilkImproved Fatty Acid CompositionIncreased Immunoglobulin Levels in MilkReduced Palmitic Acid Levels in Breast MilkElevated IgA Levels in MilkElevated Immunoglobulin LevelsDecreased Proportion of Palmitic Acid in MilkImproved Fatty Acid Profile