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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

The Herbal Alternatives for Menopause (HALT) Study: background and study design.
- 2005-10
- RCT
- Maturitas 52(2)
- - Katherine M Newton
  - Susan D Reed
  - Lou Grothaus
  - Kelly Ehrlich
  - Jane Guiltinan
  - Evette Ludman
  - Andrea Z Lacroix
- PubMed: 16186076
- DOI: 10.1016/j.maturitas.2005.01.007
1 Insight on
- Improved Menopause Symptom
- High evidence
E1 enzyme of the pyruvate dehydrogenase complex in Corynebacterium glutamicum: molecular analysis of the gene and phylogenetic aspects.
- 2005-09
- Journal of bacteriology 187(17)
- - Mark E Schreiner
  - Diana Fiur
  - Jirí Holátko
  - Miroslav Pátek
  - Bernhard J Eikmanns
- PubMed: 16109942
- DOI: 10.1128/jb.187.17.6005-6018.2005
1 Insight on
- No Human Health Outcome Reported
- Low evidence
Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis
- 2005-09
- RCT · n = 6
- European Journal of Gastroenterology & Hepatology 17(9)
- - S. Caro
  - H. Tao
  - A. Grillo
  - F. Franceschi
  - C. Elia
  - M. Zocco
  - G. Gasbarrini
  - A. Sepulveda
  - A. Gasbarrini
- PubMed: 16093873
- DOI: 10.1097/00042737-200509000-00011
4 Insights on
- High evidence
- Rigorous Journal
Radio-detoxified endotoxin activates natural immunity: a review.
- 2005-09
- Review
- Pathophysiology 12(2)
- - L. Bertók
- PubMed: 16023558
- DOI: 10.1016/J.PATHOPHYS.2005.02.004
4 Insights on
- Low evidence
Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
- 2005-09
- Review
- Alimentary Pharmacology & Therapeutics 22(6)
- - C. Picard
  - J. Fioramonti
  - A. François
  - T. Robinson
  - F. Neant
  - C. Matuchansky
- PubMed: 16167966
- DOI: 10.1111/j.1365-2036.2005.02615.x
3 Insights on
- Moderate evidence
- Highly Cited
Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: a double blind, randomized, controlled trial.
- 2005-08
- RCT · n = 122
- Clinical Nutrition 24(4)
- - M. de Vrese
  - P. Winkler
  - P. Rautenberg
  - T. Harder
  - C. Noah
  - C. Laue
  - S. Ott
  - J. Hampe
  - S. Schreiber
  - K. Heller
  - J. Schrezenmeir
- PubMed: 16054520
- DOI: 10.1016/J.CLNU.2005.02.006
18 Insights on
- High evidence
- Highly Cited
Colonization of the rectum by Lactobacillus species and decreased risk of bacterial vaginosis.
- 2005-08
- Observational · n = 531
- The Journal of Infectious Diseases 192(3)
- - M. Antonio
  - L. Rabe
  - S. Hillier
- PubMed: 15995952
- DOI: 10.1086/430926
2 Insights on
- Reduced Risk of Bacterial Vaginosis
- Reduced Prevalence of Bacterial Vaginosis
- High evidence
- Highly Cited
Dietary administration of Lactobacillus delbrüeckii and Bacillus subtilis, single or combined, on gilthead seabream cellular innate immune responses.
- 2005-07
- RCT
- Fish & Shellfish Immunology 19(1)
- - I. Salinas
  - A. Cuesta
  - M. Esteban
  - J. Meseguer
- PubMed: 15722232
- DOI: 10.1016/J.FSI.2004.11.007
3 Insights on
- High evidence
- Highly Cited
Modulation of the fecal microbiota by the intake of a Lactobacillus johnsonii La1-containing product in human volunteers.
- 2005-07
- Clinical Trial · n = 8
- FEMS Microbiology Letters 248(2)
- - Daniel Garrido
  - A. Suau
  - P. Pochart
  - S. Cruchet
  - M. Gotteland
- PubMed: 15970400
- DOI: 10.1016/J.FEMSLE.2005.05.045
6 Insights on
- Moderate evidence
Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice.
- 2005-06
- RCT
- The Journal of Nutrition 135(6)
- - J. Villena
  - S. Racedo
  - Graciela Agüero
  - E. Bru
  - M. Medina
  - S. Alvarez
- PubMed: 15930453
- DOI: 10.1093/JN/135.6.1462
18 Insights on
- Low evidence
- Highly Cited
- Animal Study
A Randomized Formula Controlled Trial of Bifidobacterium lactis and Streptococcus thermophilus for Prevention of Antibiotic-Associated Diarrhea in Infants
- 2005-05
- RCT · n = 80
- Journal of Clinical Gastroenterology 39(5)
- - N. Corrêa
  - L. A. Péret Filho
  - F. J. Penna
  - Fátima M L S Lima
  - J. Nicoli
- PubMed: 15815206
- DOI: 10.1097/01.mcg.0000159217.47419.5b
1 Insight on
- Reduced Antibiotic-Associated Diarrhea
- High evidence
- Highly Cited
Safety evaluation of Lactobacillus delbrueckii subsp. lactis UO 004, a probiotic bacterium.
- 2005-03
- Research in Microbiology 156(2)
- - M. F. Fernández
  - S. Boris
  - C. Barbés
- PubMed: 15748979
- DOI: 10.1016/J.RESMIC.2004.09.006
3 Insights on
- Low evidence
Rhizopus oryzae Adheres to, Is Phagocytosed by, and Damages Endothelial Cells In Vitro
- 2005-02
- Infection and Immunity 73(2)
- - A. Ibrahim
  - B. Spellberg
  - Valentina Avanessian
  - Yue Fu
  - J. Edwards
- PubMed: 15664916
- DOI: 10.1128/IAI.73.2.778-783.2005
3 Insights on
- Low evidence
- Highly Cited
Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice.
- 2005-02
- Clinical Trial
- FEMS Immunology & Medical Microbiology 43(2)
- - I. Castagliuolo
  - F. Galeazzi
  - S. Ferrari
  - M. Elli
  - P. Brun
  - A. Cavaggioni
  - D. Tormen
  - G. Sturniolo
  - L. Morelli
  - G. Palù
- PubMed: 15681150
- DOI: 10.1016/J.FEMSIM.2004.08.011
5 Insights on
- Low evidence
- Highly Cited
- Animal Study
Clinical effects of Lactobacillus acidophilus strain L-92 on perennial allergic rhinitis: a double-blind, placebo-controlled study.
- 2005-02
- RCT · n = 49
- Journal of Dairy Science 88(2)
- - Y. Ishida
  - F. Nakamura
  - H. Kanzato
  - D. Sawada
  - H. Hirata
  - A. Nishimura
  - O. Kajimoto
  - S. Fujiwara
- PubMed: 15653517
- DOI: 10.3168/JDS.S0022-0302(05)72714-4
2 Insights on
- Improved Nasal Symptoms in Perennial Allergic Rhinitis
- Improved Ocular Symptoms
- High evidence
- Highly Cited
Lactobacillus johnsonii La1 Antagonizes Giardia intestinalis In Vivo
- 2005-02
- Clinical Trial
- Infection and Immunity 73(2)
- - M. Humen
  - G. D. De Antoni
  - J. Benyacoub
  - M. E. Costas
  - M. I. Cardozo
  - L. Kozubsky
  - K. Saudan
  - Angele Boenzli-Bruand
  - S. Blum
  - E. Schiffrin
  - P. Pérez
- PubMed: 15664978
- DOI: 10.1128/IAI.73.2.1265-1269.2005
6 Insights on
- Low evidence
- Highly Cited
- Animal Study
Effect of Milk Fermented with Lactobacillus acidophilus Strain L-92 on Symptoms of Japanese Cedar Pollen Allergy: A Randomized Placebo-Controlled Trial
- 2005-01
- RCT · n = 23
- Bioscience, Biotechnology, and Biochemistry 69(9)
- - Y. Ishida
  - F. Nakamura
  - H. Kanzato
  - D. Sawada
  - N. Yamamoto
  - H. Kagata
  - M. Oh-Ida
  - Haruo Takeuchi
  - S. Fujiwara
- PubMed: 16195581
- DOI: 10.1271/bbb.69.1652
3 Insights on
- High evidence
- Highly Cited
Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients.
- 2005-01
- Clinical Trial
- Journal of Renal Nutrition 15(1)
- - Kentaro Taki
  - F. Takayama
  - T. Niwa
- PubMed: 15648012
- DOI: 10.1053/J.JRN.2004.09.028
5 Insights on
- High evidence
- Highly Cited
The control of hypertension by use of coconut water and mauby: two tropical food drinks.
- 2005-01
- Clinical Trial
- The West Indian medical journal 54(1)
- - T Alleyne
  - S Roache
  - C Thomas
  - A Shirley
- PubMed: 15892382
- DOI: 10.1590/s0043-31442005000100002
3 Insights on
- Moderate evidence
Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.
- 2004-12
- Clinical Trial
- Journal of the American Academy of Dermatology 51(6)
- - Maritza A Middelkamp-Hup
  - Madhu A Pathak
  - Concepcion Parrado
  - David Goukassian
  - Francisca Rius-Díaz
  - Martín C Mihm
  - Thomas B Fitzpatrick
  - Salvador González
- PubMed: 15583582
- DOI: 10.1016/j.jaad.2004.06.027
6 Insights on
- Moderate evidence
Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function.
- 2004-12
- The American Journal of Clinical Nutrition 80(6)
- - H. Braat
  - Jan M. H. Van den Brande
  - E. V. van Tol
  - D. Hommes
  - M. Peppelenbosch
  - S. V. van Deventer
- PubMed: 15585777
- DOI: 10.1093/AJCN/80.6.1618
7 Insights on
- Low evidence
- Highly Cited
Increased Poliovirus-Specific Intestinal Antibody Response Coincides with Promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial
- 2004-11
- RCT · n = 30
- Pediatric Research 56(5)
- - C. Mullié
  - A. Yazourh
  - H. Thibault
  - M. Odou
  - E. Singer
  - N. Kalach
  - O. Kremp
  - M. Romond
- PubMed: 15347767
- DOI: 10.1203/01.PDR.0000141955.47550.A0
8 Insights on
- High evidence
- Highly Cited
Lactobacillus gasseri: effects on mouse intestinal flora enzyme activity and isoflavonoids in the caecum and plasma
- 2004-11
- RCT
- British Journal of Nutrition 92(5)
- - M. Tamura
  - M. Ohnishi-Kameyama
  - K. Shinohara
- PubMed: 15533265
- DOI: 10.1079/BJN20041267
3 Insights on
- High evidence
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
- 2004-10
- Applied and Environmental Microbiology 70(10)
- - S. Duncan
  - P. Louis
  - H. Flint
- PubMed: 15466518
- DOI: 10.1128/AEM.70.10.5810-5817.2004
2 Insights on
- Increased Butyrate Production
- Reduced Lactate Accumulation
- Low evidence
- Highly Cited
Lactobacillus paracasei normalizes muscle hypercontractility in a murine model of postinfective gut dysfunction.
- 2004-09
- Clinical Trial
- Gastroenterology 127(3)
- - E. Verdú
  - P. Bercik
  - G. Bergonzelli
  - Xian-xi Huang
  - P. Blennerhasset
  - F. Rochat
  - M. Fiaux
  - R. Mansourian
  - I. Corthésy-theulaz
  - S. Collins
- PubMed: 15362038
- DOI: 10.1053/J.GASTRO.2004.06.007
9 Insights on
- Low evidence
- Highly Cited
- Animal Study
Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci.
- 2004-09
- RCT
- International Journal of Food Microbiology 95(2)
- - H. Nikawa
  - S. Makihira
  - Hidefumi Fukushima
  - H. Nishimura
  - Yoshie Ozaki
  - K. Ishida
  - S. Darmawan
  - T. Hamada
  - K. Hara
  - A. Matsumoto
  - T. Takemoto
  - R. Aimi
- PubMed: 15282133
- DOI: 10.1016/J.IJFOODMICRO.2004.03.006
2 Insights on
- Reduced Salivary Levels of Mutans Streptococci
- Reduced Oral Carriage of Mutans Streptococci
- Low evidence
- Highly Cited
- Animal Study
Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation.
- 2004-07
- RCT · n = 21
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 93(1)
- - Robert D Gray
  - Kay Haggart
  - Daniel K C Lee
  - Steven Cull
  - Brian J Lipworth
- PubMed: 15281472
- DOI: 10.1016/s1081-1206(10)61447-0
4 Insights on
- High evidence
Effects of Lactobacilli and an acidophilic fungus on the production performance and immune responses in broiler chickens.
- 2004-05
- Clinical Trial
- Poultry Science 83(5)
- - M. Huang
  - Y. Choi
  - R. Houde
  - J. Lee
  - B. Lee
  - Xin Zhao
- PubMed: 15141837
- DOI: 10.1093/PS/83.5.788
2 Insights on
- Reduced Body Weight Gain
- Improved Serum KLH-specific IgA Levels
- Low evidence
- Highly Cited
- Animal Study
The Influence of Lactobacillus brevis on Ornithine Decarboxylase Activity and Polyamine Profiles in Helicobacter pylori‐Infected Gastric Mucosa
- 2004-04
- Helicobacter 9(2)
- - M. Linsalata
  - F. Russo
  - P. Berloco
  - M. Caruso
  - G. Matteo
  - M. Cifone
  - C. Simone
  - E. Ierardi
  - A. Leo
- PubMed: 15068419
- DOI: 10.1111/j.1083-4389.2004.00214.x
5 Insights on
- Low evidence
- Highly Cited
Probiotic Bifidobacteria Protect Mice from Lethal Infection with Shiga Toxin-Producing Escherichia coli O157:H7
- 2004-04
- Clinical Trial
- Infection and Immunity 72(4)
- - T. Asahara
  - K. Shimizu
  - K. Nomoto
  - T. Hamabata
  - A. Ozawa
  - Y. Takeda
- PubMed: 15039348
- DOI: 10.1128/IAI.72.4.2240-2247.2004
3 Insights on
- Low evidence
- Highly Cited
- Animal Study