1 Insight on

• Increased Bifidobacterium spp. DNA in Lymph Nodes

14 Insights on

• Reduced Faecal pH
• Increased Body Weight
• Reduced Faecal Calprotectin
• Increased Fecal Secretory IgA Levels
• Increased Fecal Acetate Levels
• Elevated Fecal Lactate Levels
• Increased Fecal Immunoglobulin A Levels
• Increased Lactate Levels
• Reduced Fecal Calprotectin Levels
• Reduced Fecal Calprotectin
• Increased Fecal Acetate Concentration
• Increased Fecal Lactate Concentration
• Increased Fecal IgA Concentration
• Increased Fecal Lactate Levels

9 Insights on

• Reduced Inflammatory Response
• Reduced Inflammation Levels
• Reduced Induced Innate Immune Response
• Improved Gut Homeostasis
• Reduced Inflammation
• Reduced Baseline IL-8 Secretion
• Reduced Groalpha Secretion
• Enhanced Host-Microbe Balance
• Reduced Apoptosis Induced by Pathogens

2 Insights on

• Improved Immune Response Against Listeria monocytogenes
• Induction of Specific CD8+ T Cells

2 Insights on

• Reduced Symptoms of Allergic Dermatitis
• Reduced Allergen-Induced Skin Inflammation

4 Insights on

• Reduced Staphylococcal Counts
• Resolved Clinical Signs of Mastitis
• Colonization of Breast Milk with Lactobacilli
• Improved Mastitis Symptoms

2 Insights on

• Improved Serum Lipids
• No Change in Serum Lipid Levels

2 Insights on

• Reduced TNF Production
• Reduced MCP-1/CCL2 Levels

1 Insight on

• Restored Normal Microbiota

1 Insight on

• Enhanced Pro-Apoptotic MAPK Signaling

3 Insights on

• Improved Stool Consistency
• Reduced Stool Consistency
• Reduced Radiation-Induced Diarrhea Incidence

7 Insights on

• Increased Serum Lysozyme Activity
• Improved Immune Response
• Reduced Pathogen Growth
• Improved Serum Bactericidal Activity
• Increased Hematocrit Levels
• Improved Resistance to Infections
• Increased Survival Against Pathogens

7 Insights on

• Reduced T Cell Responsiveness
• Reduced Proliferation of CD4(+) T Cells
• Increased Apoptosis in T Cells
• Increased IFN-gamma Secretion from Naïve T Cells
• Reduced IL-4 Secretion from Naïve T Cells
• Modulated Dendritic Cell Function
• Increased Apoptosis of OVA-specific TCR Tg T Cells

6 Insights on

• Altered T Cell Subsets
• Increased CD4+ and CD8+ T Cell Proportion
• Reduced CTLA-4 Induction on CD4 T Cells
• Increased Ileal Enterobacteriaceae Counts
• Increased Interleukin-8 Expression in the Ileum
• Reduced CTLA-4 Expression on CD4 T Cells

4 Insights on

• Reduced Salmonella Enterica Invasion
• Reduced Pathogen Infection
• Enhanced Bile Salt Resistance
• Reduced Salmonella sonnei Infection

4 Insights on

• Improved Intestinal Barrier Integrity
• Maintained Intestinal Barrier Function
• Improved Epithelial Protection
• Protection Against Cellular Damage Induced by Pathogens

3 Insights on

• Reduced Inflammatory Response
• Reduced Baseline IL-8 Secretion
• Improved Barrier Integrity

2 Insights on

• Increased Bifidobacterial Population
• Improved Prebiotic Index

2 Insights on

• Increased CD4 Counts
• Resolved Moderate Diarrhea

5 Insights on

• Improved Antibacterial Activity
• Improved Innate Immune Response
• Enhanced Respiratory Burst Activity
• Increased Granulocyte Count
• Improved Serum Bactericidal Activity

1 Insight on

• Increased Clostridium perfringens Density

3 Insights on

• Reduced Ulcerative Colitis Symptoms
• Increased IL-10 Production
• Reduced Risk of Salmonella Infection

4 Insights on

• Reduced Immunoglobulin E Production
• Reduced Ovalbumin-Specific IgE Production
• Improved Th1/Th2 Balance
• Reduced Histamine Release

1 Insight on

• Reduced Salivary Levels of Mutans Streptococci

7 Insights on

• Reduced Body Weight
• Improved Crypt Hyperplasia
• Reduced Histological Damage
• Reduced Myeloperoxidase Activity
• Decreased Mannitol Flux
• Reduced Mucosal Adherent Citrobacter rodentium
• Maintained Colonic Epithelial Barrier Integrity

2 Insights on

• Increased Interleukin-12 Production
• Improved Immunostimulatory Activity

6 Insights on

• Increased PMN Cell Phagocytic Capacity
• Reduced TNF-α Levels
• Reduced Incidence of Common Infectious Diseases
• Increased Hemoglobin Levels
• Improved Serum Albumin Levels
• Reduced Incidence of Infections

3 Insights on

• Reduced Intestinal Permeability
• Increased Head Circumference
• Increased Counts of Bifidobacteria

5 Insights on

• Improved Epithelial Permeability
• Improved Gut Permeability
• Reduced Visceral Pain
• Reduced Stress-Mediated Visceral Hyperalgesia
• Prevented Visceral Hyperalgesia

20 Insights on

• No Adverse Effects on Body Weight or Food Intake
• Absence of Treatment-Associated Bacterial Translocation
• Significant Bacterial Translocation with Intraperitoneal Administration
• Increased Plasma Serum Alpha-Amyloid Protein
• Nonpathogenic Even at High Doses
• Ensured Safety for Human Consumption
• Reduced Bacterial Translocation
• Absence of Bacteremia
• No Hepatic or Splenic Translocation with Oral Administration
• No Illness or Death Despite Bacterial Translocation
• Nonpathogenic Condition
• No Bacteremia or Translocation of Bacteria to Vital Organs
• Absence of Bacterial Translocation to Liver or Spleen
• No Illness or Death from Bacterial Translocation (Intraperitoneal Administration)
• No Bacteremia
• No Adverse Weight or Intake Effects in Mice
• Nonpathogenic for Mice
• Maintained Body Weight
• No Adverse Effects from Intraperitoneal Administration
• Increased Serum Amyloid Protein