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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Wheat-durum pasta added of inactivated Bifidobacterium animalis decreases glucose and total cholesterol levels and modulates gut microbiota in healthy rats
- 2021-01-24
- RCT · n = 21
- International Journal of Food Sciences and Nutrition 72(6)
- - C. N. Almada
  - Carine N. Almada-Érix
  - Whyara K A Costa
  - Juliana Silva
  - Lucélia Cabral
  - M. F. Noronha
  - A. E. S. S. Gonçalves
  - Andrey Santos
  - P. Lollo
  - M. Magnani
  - A. Sant’Ana
- PubMed: 33487082
- DOI: 10.1080/09637486.2021.1877261
5 Insights on
- Low evidence
- Animal Study
Lactobacillus Plantarum 299v Changes miRNA Expression in the Intestines of Piglets and Leads to Downregulation of LITAF by Regulating ssc-miR-450a.
- 2021-01-24
- Probiotics and antimicrobial proteins 13(4)
- - Qi Wang
  - Qian Sun
  - Jing Wang
  - Xiaoyu Qiu
  - Renli Qi
  - Jinxiu Huang
- PubMed: 33486700
- DOI: 10.1007/s12602-021-09743-1
2 Insights on
- Reduced Intestinal Proinflammatory Cytokine Levels
- Improved Intestinal Cytokine Function
- Low evidence
- Rigorous Journal
- Animal Study
Protocol for probiotic therapy vs placebo for preterm prelabour rupture of membranes to prolong pregnancy duration (Pro-PPROM) trial.
- 2021-01-23
- RCT
- The Australian & New Zealand journal of obstetrics & gynaecology 61(2)
- - Jonathan Sandeford
  - Tanya Nippita
  - Tushar Bhuta
  - Jillian Patterson
  - Jonathan Morris
  - Sean Seeho
- PubMed: 33484479
- DOI: 10.1111/ajo.13313
1 Insight on
- Prolonged Pregnancy Duration
- High evidence
Does Vancomycin Resistance Increase Mortality? Clinical Outcomes and Predictive Factors for Mortality in Patients with Enterococcus faecium Infections
- 2021-01-22
- Observational · n = 145
- Antibiotics 10(2)
- - Jatapat Hemapanpairoa
  - Dhitiwat Changpradub
  - S. Thunyaharn
  - W. Santimaleeworagun
- PubMed: 33499102
- DOI: 10.3390/antibiotics10020105
2 Insights on
- Increased Mortality Rate with Vancomycin Resistance
- Increased Length of Hospitalization Due to Vancomycin Resistance
- High evidence
Effect of Microencapsulation on Survival at Simulated Gastrointestinal Conditions and Heat Treatment of a Non Probiotic Strain, Lactiplantibacillus plantarum 48M, and the Probiotic Strain Limosilactobacillus reuteri DSM 17938
- 2021-01-21
- Foods 10(2)
- - C. Malmo
  - I. Giordano
  - G. Mauriello
- PubMed: 33494235
- DOI: 10.3390/foods10020217
1 Insight on
- Improved Gut Microbial Persistence
- Low evidence
- Rigorous Journal
Cissus Quadrangularis enhances UCP1 mRNA, indicative of white adipocyte browning and decreases central obesity in humans in a randomized trial.
- 2021-01-21
- RCT
- Scientific reports 11(1)
- - Saimai Chatree
  - Chantacha Sitticharoon
  - Pailin Maikaew
  - Kitchaya Pongwattanapakin
  - Issarawan Keadkraichaiwat
  - Malika Churintaraphan
  - Chanakarn Sripong
  - Rungnapa Sririwichitchai
  - Sompol Tapechum
- PubMed: 33479386
- DOI: 10.1038/s41598-021-81606-9
3 Insights on
- High evidence
- Rigorous Journal
Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01
- 2021-01-19
- Clinical Trial · n = 2
- Applied Microbiology and Biotechnology 105(4)
- - Jiafeng Xia
  - Shiman Jiang
  - L. Lv
  - Wen-rui Wu
  - Qiangqiang Wang
  - Qiaomai Xu
  - Jianzhong Ye
  - D. Fang
  - Yating Li
  - Jingjing Wu
  - Xiaoyuan Bian
  - Liya Yang
  - Huiyong Jiang
  - Kaicen Wang
  - Ren Yan
  - Lanjuan Li
- PubMed: 33507355
- DOI: 10.1007/s00253-021-11099-z
11 Insights on
- Low evidence
- Animal Study
The Probiotic Lactobacillus fermentum Biocenol CCM 7514 Moderates Campylobacter jejuni-Induced Body Weight Impairment by Improving Gut Morphometry and Regulating Cecal Cytokine Abundance in Broiler Chickens
- 2021-01-19
- RCT · n = 72
- Animals 11(1)
- - M. Šefcová
  - Marco Larrea-Álvarez
  - C. Larrea-Álvarez
  - V. Karaffová
  - D. Ortega-Paredes
  - Christian Vinueza-Burgos
  - Z. Ševčíková
  - M. Levkut
  - R. Herich
  - V. Révajová
- PubMed: 33477806
- DOI: 10.3390/ani11010235
3 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The efficacy and safety of Serenoa repens extract for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome: a multicenter, randomized, double-blind, placebo-controlled trial.
- 2021-01-16
- RCT · n = 226
- World journal of urology 39(9)
- - Kai Zhang
  - Run-Qi Guo
  - Shan-Wen Chen
  - Bin Chen
  - Xin-Bo Xue
  - Shan Chen
  - Jian Huang
  - Ming Liu
  - Ye Tian
  - Li Zuo
  - Ming Chen
  - Li-Qun Zhou
- PubMed: 33452912
- DOI: 10.1007/s00345-020-03577-2
5 Insights on
- High evidence
- Large Human Trial
Dietary Supplementation With Bacillus subtilis Promotes Growth and Gut Health of Weaned Piglets
- 2021-01-15
- RCT · n = 160
- Frontiers in Veterinary Science 7
- - Zhilong Tian
  - Xiaodan Wang
  - Y. Duan
  - Yue Zhao
  - Wenming Zhang
  - M. Azad
  - Zhanbin Wang
  - F. Blachier
  - X. Kong
- PubMed: 33521080
- DOI: 10.3389/fvets.2020.600772
8 Insights on
- Low evidence
- Animal Study
Intake of dairy products and associations with major atherosclerotic cardiovascular diseases: a systematic review and meta-analysis of cohort studies.
- 2021-01-14
- Meta-Analysis
- Scientific reports 11(1)
- - Marianne Uhre Jakobsen
  - Ellen Trolle
  - Malene Outzen
  - Heddie Mejborn
  - Manja G Grønberg
  - Christian Bøge Lyndgaard
  - Anders Stockmarr
  - Stine K Venø
  - Anette Bysted
- PubMed: 33446728
- DOI: 10.1038/s41598-020-79708-x
1 Insight on
- Reduced Ischemic Stroke
- High evidence
- Rigorous Journal
Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial
- 2021-01-14
- RCT
- Obesity Surgery 31(5)
- - Marília Rizzon Zaparolli Ramos
  - Lígia de Oliveira Carlos
  - Nathalia Ramori Farinha Wagner
  - I. Felicidade
  - Magda Rosa Ramos da Cruz
  - C. Taconeli
  - R. Fernandes
  - A. J. Filho
  - A. Campos
- PubMed: 33443719
- DOI: 10.1007/s11695-021-05222-2
6 Insights on
- High evidence
- Rigorous Journal
Bifidobacterium animalis subsp. lactis BB-12 Improves the State Anxiety and Sports Performance of Young Divers Under Stress Situations: A Single-Arm, Prospective Proof-of-Concept Study.
- 2021-01-13
- Clinical Trial
- Frontiers in psychology 11
- - Weizhong Dong
  - Ying Wang
  - Shuaixiong Liao
  - Wei Tang
  - Li Peng
  - Gang Song
- PubMed: 33519585
- DOI: 10.3389/fpsyg.2020.570298
3 Insights on
- Moderate evidence
Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial
- 2021-01-13
- RCT · n = 348
- Nutrients 13(1)
- - Yutao Chen
  - Jun Lu
  - K. Wickens
  - T. Stanley
  - Robyn M. Maude
  - P. Stone
  - C. Barthow
  - J. Crane
  - E. Mitchell
  - F. Merien
  - R. Murphy
- PubMed: 33450885
- DOI: 10.3390/nu13010209
7 Insights on
- High evidence
- Large Human Trial
Lactobacillus rhamnosus AD3 as a Promising Alternative for Probiotic Products
- 2021-01-13
- Biomolecules 11(1)
- - A. Stivala
  - G. Carota
  - V. Fuochi
  - P. Furneri
- PubMed: 33450875
- DOI: 10.3390/biom11010094
2 Insights on
- Reduced Risk of Genital Infections
- Reduced Urogenital Pathogen Activity
- Low evidence
Immunomodulation of J774A.1 Murine Macrophages by Lactiplantibacillus plantarum Strains Isolated From the Human Gastrointestinal Tract and Fermented Foods
- 2021-01-12
- Frontiers in Microbiology 11
- - N. Garcia-Gonzalez
  - M. A. Nuñez-Sanchez
  - Miguel Villoria Recio
  - N. Battista
  - C. Gahan
  - A. Corsetti
- PubMed: 33510712
- DOI: 10.3389/fmicb.2020.557143
1 Insight on
- Modulated Immune Response
- Low evidence
Impact of 18-Month Soy Protein Supplementation on Steroid Hormones and Serum Biomarkers of Angiogenesis, Apoptosis, and the Growth Hormone/IGF-1 Axis: Results of a Randomized, Placebo-Controlled Trial in Males Following Prostatectomy.
- 2021-01-12
- RCT
- Nutrition and cancer 74(1)
- - Maarten C Bosland
  - Jonathan Huang
  - Michael J Schlicht
  - Erika Enk
  - Hui Xie
  - Ikuko Kato
- PubMed: 33432829
- DOI: 10.1080/01635581.2020.1870706
17 Insights on
- High evidence
Investigating the anti‐inflammatory effects of high molecular weight secretions from Limosilactobacillus reuteri PTCC 1655 on LPS‐stimulated PMA‐differentiated THP‐1 cells
- 2021-01-11
- Journal of Applied Microbiology 131(2)
- - Behrooz Johari
  - Faezeh Maghsood
  - H. Madanchi
  - M. Moradi
  - M. Kadivar
- PubMed: 33377567
- DOI: 10.1111/jam.14984
1 Insight on
- Reduced Inflammation Levels
- Low evidence
Risk Factors for the Acquisition of Enterococcus faecium Infection and Mortality in Patients with Enterococcal Bacteremia: A 5-Year Retrospective Analysis in a Tertiary Care University Hospital
- 2021-01-11
- Observational · n = 186
- Antibiotics 10(1)
- - Atsushi Uda
  - K. Shigemura
  - K. Kitagawa
  - Kayo Osawa
  - Kenichiro Onuma
  - Yonmin Yan
  - Tatsuya Nishioka
  - M. Fujisawa
  - I. Yano
  - T. Miyara
- PubMed: 33440660
- DOI: 10.3390/antibiotics10010064
3 Insights on
- High evidence
Interventions for treating leg ulcers in people with sickle cell disease.
- 2021-01-09
- Systematic Review · n = 198
- The Cochrane database of systematic reviews 2021(1)
- - Arturo J Martí-Carvajal
  - Jennifer M Knight-Madden
  - Maria José Martinez-Zapata
- PubMed: 34559425
- DOI: 10.1002/14651858.cd008394.pub4
2 Insights on
- Reduced Ulcer Size
- Improved Leg Ulcer Healing
- High evidence
Effect of Oral Administration with Lactobacillus plantarum CAM6 Strain on Sows during Gestation-Lactation and the Derived Impact on Their Progeny Performance
- 2021-01-08
- RCT · n = 20
- Mediators of Inflammation 2021
- - C. Betancur
  - Y. Martínez
  - G. Téllez-Isaías
  - Rogel Castillo
  - Xinghua Ding
- PubMed: 33505214
- DOI: 10.1155/2021/6615960
8 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
The In Vitro Adsorption Ability of Lactobacillus acidophilus NCFM to Benzo(a)pyrene in PM2.5
- 2021-01-07
- Journal of Toxicology 2021
- - L. Fu
  - Y. Ning
  - Hongfei Zhao
  - Junfeng Fan
  - Bolin Zhang
- PubMed: 33505465
- DOI: 10.1155/2021/6290524
1 Insight on
- Reduced Benzo(a)pyrene Levels
- Low evidence
- Rigorous Journal
Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults
- 2021-01-07
- RCT · n = 60
- World Journal of Gastroenterology 27(1)
- - E. Rahayu
  - M. Mariyatun
  - Nancy Eka Putri Manurung
  - P. N. Hasan
  - Phatthanaphong Therdtatha
  - Riko Mishima
  - Husnita Komalasari
  - N. A. Mahfuzah
  - F. H. Pamungkaningtyas
  - Wahyu Krisna Yoga
  - Dina Aulia Nurfiana
  - Stefanie Yolanda Liwan
  - M. Juffrie
  - A. Nugroho
  - T. Utami
- PubMed: 33505154
- DOI: 10.3748/wjg.v27.i1.107
3 Insights on
- High evidence
- Rigorous Journal
Effects of intragastric administration of L-tryptophan on the glycaemic response to a nutrient drink in men with type 2 diabetes - impacts on gastric emptying, glucoregulatory hormones and glucose absorption.
- 2021-01-05
- RCT
- Nutrition & diabetes 11(1)
- - Maryam Hajishafiee
  - Rachel A Elovaris
  - Karen L Jones
  - Leonie K Heilbronn
  - Michael Horowitz
  - Sally D Poppitt
  - Christine Feinle-Bisset
- PubMed: 33414406
- DOI: 10.1038/s41387-020-00146-9
11 Insights on
- High evidence
Exercise associated or not to the intake of Eurycoma longifolia improves strength and cardiorespiratory fitness in men with androgen deficiency.
- 2021-01-05
- RCT · n = 12
- Complementary therapies in clinical practice 42
- - Alice Erwig Leitão
  - Melissa de Carvalho Souza Vieira
  - Diogo Almeida Gomes
  - Leonessa Boing
  - Andreia Pelegrini
  - Edson Luiz
  - Adriana Coutinho de Azevedo Guimarães
- PubMed: 33445146
- DOI: 10.1016/j.ctcp.2020.101301
3 Insights on
- High evidence
Prophylactic effect of Lactobacillus plantarum KSFY06 on HCl/ethanol-induced gastric injury in mice.
- 2021-01-04
- Food & Function 11(3)
- - Ranran Wang
  - Xiaofei Zeng
  - Bihui Liu
  - Ruokun Yi
  - Xianrong Zhou
  - Jianfei Mu
  - Xin Zhao
- PubMed: 32162630
- DOI: 10.1039/c9fo02474c
5 Insights on
- Low evidence
A 5-year longitudinal association between dietary fermented soya bean (natto) intake and tooth loss through bone mineral density in postmenopausal women: The Yokogoshi cohort study.
- 2021-01-04
- Observational · n = 435
- Gerodontology 38(3)
- - M. Iwasaki
  - Misuzu Sato
  - A. Yoshihara
  - Toshiko Saito
  - K. Kitamura
  - T. Ansai
  - Kazutoshi Nakamura
- PubMed: 33393717
- DOI: 10.1111/ger.12523
1 Insight on
- Reduced Tooth Loss
- High evidence
An Exopolysaccharide Produced by Bifidobacterium longum 35624® Inhibits Osteoclast Formation via a TLR2-Dependent Mechanism
- 2021-01-03
- Calcified Tissue International 108(5)
- - A. Wallimann
  - M. Hildebrand
  - D. Groeger
  - B. Stanić
  - C. Akdis
  - S. Zeiter
  - R. G. Richards
  - T. F. Moriarty
  - L. O’Mahony
  - K. Thompson
- PubMed: 33388801
- DOI: 10.1007/s00223-020-00790-4
3 Insights on
- Low evidence
- Rigorous Journal
Broad Spectrum Polyphenol Supplementation from Tart Cherry Extract on Markers of Recovery from Intense Resistance Exercise.
- 2021-01-02
- RCT
- Journal of the International Society of Sports Nutrition 18(1)
- - D R Hooper
  - T Orange
  - M T Gruber
  - A A Darakjian
  - K L Conway
  - H A Hausenblas
- PubMed: 34126996
- DOI: 10.1186/s12970-021-00449-x
6 Insights on
- High evidence
Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review.
- 2021-01-01
- Systematic Review · n = 749
- Journal of evidence-based integrative medicine 26
- - Wiraphol Phimarn
  - Bunleu Sungthong
  - Hiroyuki Itabe
- PubMed: 33886393
- DOI: 10.1177/2515690x211011038
7 Insights on
- High evidence