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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

N-Acetyl Cysteine in Rodenticide Poisoning: A Systematic Review and Meta-Analysis.
- 2022-11
- Meta-Analysis · n = 492
- Current reviews in clinical and experimental pharmacology 17(3)
- - Muhammed Rashid
  - Viji Pulikkel Chandran
  - Sreedharan Nair
  - Deepa Sudalai Muthu
  - Jemima Pappuraj
  - Krupa Ann Jacob
  - Balaji Sridhar
  - Karen Mark
  - Shabnam Hyder
  - Sohil Khan
  - Girish Thunga
- PubMed: 34455951
- DOI: 10.2174/2772432816666210825102726
4 Insights on
- High evidence
Effects of Bacillus coagulans GBI-30, 6086 as an adjunct starter culture on the production of yogurt.
- 2022-10
- Food research international (Ottawa, Ont.) 160
- - Jiang Cao
  - Zhiming Yu
  - Qingsong Zhang
  - Leilei Yu
  - Jianxin Zhao
  - Hao Zhang
  - Wei Chen
  - Qixiao Zhai
- PubMed: 36076366
- DOI: 10.1016/j.foodres.2022.111398
1 Insight on
- Improved Survival of Probiotic Bacteria
- Low evidence
Effect of macular pigment carotenoids on cognitive functions: A systematic review.
- 2022-10
- Systematic Review
- Physiology & behavior 254
- - Marta-C García-Romera
  - María-Carmen Silva-Viguera
  - Inmaculada López-Izquierdo
  - Alfredo López-Muñoz
  - Raúl Capote-Puente
  - Beatriz Gargallo-Martínez
- PubMed: 35752349
- DOI: 10.1016/j.physbeh.2022.113891
7 Insights on
- High evidence
Isolation, characterization and anti-UVB irradiation activity of an extracellular polysaccharide produced by Lacticaseibacillus rhamnosus VHPriobi O17.
- 2022-10
- Heliyon 8(10)
- - Shudong Peng
  - Chaoqun Guo
  - Songjie Wu
  - Zhi Duan
- PubMed: 36299523
- DOI: 10.1016/j.heliyon.2022.e11125
4 Insights on
- Low evidence
Acetyl-L-carnitine Slows the Progression from Prefrailty to Frailty in Older Subjects: A Randomized Interventional Clinical Trial.
- 2022-10
- RCT · n = 92
- Current pharmaceutical design 28(38)
- - Giulia Malaguarnera
  - Vito Emanuele Catania
  - Gaetano Bertino
  - Laura Maria Chisari
  - Maria Castorina
  - Claudia Bonfiglio
  - Omar Cauli
  - Michele Malaguarnera
- PubMed: 36043711
- DOI: 10.2174/1381612828666220830092815
4 Insights on
- High evidence
Effects of milk protein concentrate supplementation on metabolic parameters, adipocytokines and body composition in obese women under weight-loss diet: study protocol for a randomised controlled trial.
- 2022-10
- RCT
- BMJ open 12(10)
- - Fatemeh Haidari
  - Mahsa Elahikhah
  - Sheikh Mohammed Shariful Islam
  - Majid Mohammadshahi
  - Hajieh Shahbazian
  - Vahideh Aghamohammadi
- PubMed: 36202586
- DOI: 10.1136/bmjopen-2022-064727
8 Insights on
- High evidence
Effect of cocoa (Theobroma cacao L.) on platelet function testing profiles in patients with coronary artery disease: ECLAIR pilot study.
- 2022-09
- Clinical Trial · n = 20
- Open heart 9(2)
- - Naveen Anand Seecheran
  - Darin Sukha
  - Kathryn Grimaldos
  - Gabriella Grimaldos
  - Srivane Richard
  - Aleena Ishmael
  - Ceylon Gomes
  - Lirmala Kampradi
  - Rajeev Seecheran
  - Valmiki Seecheran
  - Lakshmipathi Peram
  - Darren Dookeeram
  - Stanley Giddings
  - Sherry Sandy
  - Anil Ramlackhansingh
  - Sadi Raza
  - Pathmanathan Umaharan
  - Antonio Tello-Montoliu
  - David Schneider
- PubMed: 36100318
- DOI: 10.1136/openhrt-2022-002066
2 Insights on
- Increased Platelet Count
- Reduced Platelet Reactivity
- Moderate evidence
The beneficial effect of tart cherry on plasma levels of inflammatory mediators (not recovery after exercise): A systematic review and meta-analysis on randomized clinical trials.
- 2022-09
- Meta-Analysis
- Complementary therapies in medicine 68
- - Ali Gholami
  - Bahareh Amirkalali
  - Hamid Reza Baradaran
  - Mitra Hariri
- PubMed: 35653966
- DOI: 10.1016/j.ctim.2022.102842
3 Insights on
- High evidence
Clinical Evidence for the Effectiveness of Herbal Medicines in the Treatment of an Obsessive- Compulsive Disorder: A Review Study.
- 2022-09
- Review · n = 37
- Current drug discovery technologies 19(5)
- - Maryam Hosseini Abrishami
  - Mohamad Reza Noras
  - Atefeh Soltanifar
  - Roshanak Salari
  - Lida Jarahi
  - Hamideh Khorram Pazhouh
- PubMed: 35713134
- DOI: 10.2174/1570163819666220616122543
1 Insight on
- Reduced Obsessive-Compulsive Disorder Symptoms
- Moderate evidence
Consumption of oils and anthocyanins may positively modulate PPAR-γ expression in chronic noncommunicable diseases: A systematic review.
- 2022-09
- Systematic Review · n = 346
- Nutrition research (New York, N.Y.) 105
- - Isabela de Souza da Costa Brum
  - Denise Mafra
  - Laís de Souza Gouveia Moreira
  - Karla Thaís Resende Teixeira
  - Milena Barcza Stockler-Pinto
  - Ludmila Ferreira Medeiros de França Cardozo
  - Natalia Alvarenga Borges
- PubMed: 35905655
- DOI: 10.1016/j.nutres.2022.06.004
1 Insight on
- Improved Peroxisome Proliferator-Activated Receptor Gamma Expression
- High evidence
Characterization of autochthonous lactobacilli from goat dairy products with probiotic potential for metabolic diseases.
- 2022-09
- Heliyon 8(9)
- - Antonela Marquez
  - Estefanía Andrada
  - Matias Russo
  - María Lujan Bolondi
  - Emanuel Fabersani
  - Roxana Medina
  - Paola Gauffin-Cano
- PubMed: 36091951
- DOI: 10.1016/j.heliyon.2022.e10462
4 Insights on
- Low evidence
Safety and efficacy of a feed additive consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32264 as a feed additive for cats (NBF Lanes s.r.l.)
- 2022-08
- EFSA Journal 20(8)
- - V. Bampidis
  - G. Azimonti
  - M. Bastos
  - Henrik Christensen
  - Birgit Dusemund
  - Mojca Fašmon Durjava
  - M. Kouba
  - M. López-Alonso
  - Secundino López Puente
  - F. Marcon
  - B. Mayo
  - A. Pechová
  - M. Petkova
  - F. Ramos
  - Yolanda Sanz
  - R. Villa
  - R. Woutersen
  - G. Martelli
  - M. Anguita
  - J. Galobart
  - J. Ortuño
  - J. Revez
  - Rosella Brozzi
- PubMed: 35949936
- DOI: 10.2903/j.efsa.2022.7437
2 Insights on
- Improved Stool Consistency
- Increased Constipation Risk
- Low evidence
Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers.
- 2022-08
- RCT
- Acta tropica 232
- - Hai Ha Pham Thi
  - Tuong Vi Phan Thi
  - Ninh Pham Huynh
  - Vinh Doan
  - Satoru Onoda
  - Thanh Luan Nguyen
- PubMed: 35623400
- DOI: 10.1016/j.actatropica.2022.106537
3 Insights on
- Low evidence
- Animal Study
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature.
- 2022-08
- Review
- Phytotherapy research : PTR 36(10)
- - Giuseppe Derosa
  - Angela D'Angelo
  - Pamela Maffioli
- PubMed: 35912631
- DOI: 10.1002/ptr.7564
4 Insights on
- Low evidence
Effect of Cardamom Inhalation Therapy on Intra-and Postoperative Nausea and Vomiting of Mothers Undergoing Spinal Anesthesia for Elective Cesarean Section.
- 2022-08
- RCT
- Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 37(4)
- - Mahnaz Khatiban
  - Masoumeh Mirzaie
  - Akbar Fazeli
  - Leili Tapak
  - Zahra Khalili
- PubMed: 35581106
- DOI: 10.1016/j.jopan.2021.09.008
4 Insights on
- High evidence
Effect of the addition of the probiotic Bifidobacterium animalis subsp. Lactis (BB-12) in free and microencapsulated form and the prebiotic inulin to synbiotic dry coppa.
- 2022-08
- Food research international (Ottawa, Ont.) 158
- - Talita Aparecida Ferreira de Campos
  - Annecler Rech de Marins
  - Natallya Marques da Silva
  - Marcos Antonio Matiucci
  - Iza Catarini Dos Santos
  - Claudete Regina Alcalde
  - Maria Luiza Rodrigues de Souza
  - Raquel Guttierres Gomes
  - Andresa Carla Feihrmann
- PubMed: 35840239
- DOI: 10.1016/j.foodres.2022.111544
3 Insights on
- Low evidence
Assessment of the efficacy of a feed additive consisting of Limosilactobacillus reuteri (formerly Lactobacillus reuteri) DSM 32203 for dogs (NBF LANES)
- 2022-07
- EFSA Journal 20(7)
- - V. Bampidis
  - G. Azimonti
  - M. Bastos
  - Henrik Christensen
  - B. Dusemund
  - Mojca Fašmon Durjava
  - M. Kouba
  - M. López-Alonso
  - Secundino López Puente
  - F. Marcon
  - B. Mayo
  - A. Pechová
  - M. Petkova
  - F. Ramos
  - Yolanda Sanz
  - R. Villa
  - R. Woutersen
  - G. Martelli
  - M. Anguita
  - Rosella Brozzi
  - J. Galobart
  - J. Ortuño
  - J. Revez
- PubMed: 35865118
- DOI: 10.2903/j.efsa.2022.7436
2 Insights on
- Improved Stool Consistency
- Increased Constipation Risk
- Low evidence
N-acetyl cysteine in the treatment of cannabis use disorder: A systematic review of clinical trials.
- 2022-06
- Systematic Review
- Addictive behaviors 129
- - Rishi Sharma
  - Sai Krishna Tikka
  - Ashish Ramesh Bhute
  - Binaya Kumar Bastia
- PubMed: 35189496
- DOI: 10.1016/j.addbeh.2022.107283
3 Insights on
- High evidence
Effects of Pueraria mirifica on vaginal artery vascularization in postmenopausal women with genitourinary syndrome of menopause.
- 2022-06
- RCT
- Maturitas 160
- - Patsira Warinsiriruk
  - Chananya Tantitham
  - Wichai Cherdshewasart
  - S Abbas Shobeiri
  - Jittima Manonai
- PubMed: 35550707
- DOI: 10.1016/j.maturitas.2022.01.005
4 Insights on
- High evidence
Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial.
- 2022-06
- RCT · n = 60
- Clinical nutrition ESPEN 49
- - Mohsen Taghizadeh
  - Azam Mohammad Zadeh
  - Zatollah Asemi
  - Amir Hosein Farrokhnezhad
  - Mohammad Reza Memarzadeh
  - Zarin Banikazemi
  - Mohammad Shariat
  - Rana Shafabakhsh
- PubMed: 35623877
- DOI: 10.1016/j.clnesp.2022.03.027
10 Insights on
- High evidence
Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs.
- 2022-06
- Meta-Analysis · n = 83
- RMD open 8(2)
- - James M Gwinnutt
  - Maud Wieczorek
  - Javier Rodríguez-Carrio
  - Andra Balanescu
  - Heike A Bischoff-Ferrari
  - Annelies Boonen
  - Giulio Cavalli
  - Savia de Souza
  - Annette de Thurah
  - Thomas E Dorner
  - Rikke Helene Moe
  - Polina Putrik
  - Lucía Silva-Fernández
  - Tanja Stamm
  - Karen Walker-Bone
  - Joep Welling
  - Mirjana Zlatković-Švenda
  - Francis Guillemin
  - Suzanne M M Verstappen
- PubMed: 35654458
- DOI: 10.1136/rmdopen-2021-002167
2 Insights on
- Reduced Pain
- Improved Function
- High evidence
The effect of the probiotic consortia on SARS-CoV-2 infection in ferrets and on human immune cell response in vitro.
- 2022-06
- iScience 25(6)
- - Markus J Lehtinen
  - Ritesh Kumar
  - Bryan Zabel
  - Sanna M Mäkelä
  - Derek Nedveck
  - Peipei Tang
  - Sinikka Latvala
  - Sebastien Guery
  - Charles R Budinoff
- PubMed: 35634575
- DOI: 10.1016/j.isci.2022.104445
2 Insights on
- Reduced Viral Load
- Modulated Immune Response
- Low evidence
Habitual Green Kiwifruit Consumption Is Associated with a Reduction in Upper Gastrointestinal Symptoms: A Systematic Scoping Review.
- 2022-05
- Systematic Review · n = 661
- Advances in nutrition (Bethesda, Md.) 13(3)
- - Simone B Bayer
  - Chris M Frampton
  - Richard B Gearry
  - Giovanni Barbara
- PubMed: 35266507
- DOI: 10.1093/advances/nmac025
3 Insights on
- High evidence
Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial.
- 2022-05
- RCT · n = 523
- Nutrition (Burbank, Los Angeles County, Calif.) 97
- - Dan Xu
  - AnXiu Yang
  - Ruijun Ren
  - Zhong Shan
  - Yuan Ming Li
  - Jing Tan
- PubMed: 35203045
- DOI: 10.1016/j.nut.2022.111608
4 Insights on
- High evidence
- Large Human Trial
Acid stress responses of Lactobacillus amylovorus and Candida kefyr isolated from fermented sorghum gruel and their application in food fermentation.
- 2022-04
- Canadian Journal of Microbiology 68(4)
- - Oluwaseun Adeola Adewara
  - S. Ogunbanwo
- PubMed: 35038286
- DOI: 10.1139/cjm-2021-0118
2 Insights on
- Reduced Antinutrient Levels
- Improved Nutritional Value
- Low evidence
Intake of Bifidobacterium lactis Probio-M8 fermented milk protects against alcoholic liver disease.
- 2022-04
- Journal of dairy science 105(4)
- - Qiuwen He
  - Chengcong Yang
  - Xiaohong Kang
  - Yongfu Chen
  - Tao Zhang
  - Heping Zhang
  - Lai-Yu Kwok
- PubMed: 35086715
- DOI: 10.3168/jds.2021-21265
1 Insight on
- Reduced Liver Disease Symptoms
- Low evidence
- Animal Study
Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/or Lactobacillus reuteri DSM 17938: a multicentre, randomised, controlled, factorial trial in Botswana
- 2022-04
- RCT · n = 272
- BMJ Global Health 7(4)
- - J. Pernica
  - T. Arscott-Mills
  - A. Steenhoff
  - M. Mokomane
  - Banno Moorad
  - Mbabi Bapabi
  - K. Lechiile
  - Oarabile Mangwegape
  - Boswa Batisani
  - Norah Mawoko
  - Charles Muthoga
  - T. Vanniyasingam
  - Joycelyne E Ewusie
  - Amy Lowe
  - Janice M Bonsu
  - Alemayehu Mekonnen Gezmu
  - M. Smieja
  - L. Mazhani
  - K. Størdal
  - L. Thabane
  - M. Kelly
  - D. Goldfarb
- PubMed: 35418412
- DOI: 10.1136/bmjgh-2021-007826
3 Insights on
- High evidence
- Rigorous Journal
A randomised controlled trial of a probiotic and a prebiotic examining metabolic and mental health outcomes in adults with pre-diabetes
- 2022-03
- RCT · n = 153
- BMJ Open 12(3)
- - C. Barthow
  - Fiona Hood
  - Julian Crane
  - Mark Huthwaite
  - M. Weatherall
  - A. Parry-Strong
  - J. Krebs
- PubMed: 35332040
- DOI: 10.1136/bmjopen-2021-055214
3 Insights on
- High evidence
- Rigorous Journal
Fermentation of kiwifruit juice from two cultivars by probiotic bacteria: Bioactive phenolics, antioxidant activities and flavor volatiles.
- 2022-03
- Food chemistry 373
- - Zining Wang
  - Yunzi Feng
  - Nana Yang
  - Tian Jiang
  - Huaide Xu
  - Hongjie Lei
- PubMed: 34731808
- DOI: 10.1016/j.foodchem.2021.131455
2 Insights on
- Increased Antioxidant Capacity
- Improved Flavor Perception
- Low evidence
L-Citrulline supplementation attenuates aortic pulse pressure and wave reflection responses to cold stress in older adults.
- 2022-03
- RCT
- Experimental gerontology 159
- - Salvador J Jaime
  - Jessica Nagel
  - Arun Maharaj
  - Stephen M Fischer
  - Elizabeth Schwab
  - Christopher Martinson
  - Kim Radtke
  - Richard P Mikat
  - Arturo Figueroa
- PubMed: 34990772
- DOI: 10.1016/j.exger.2021.111685
8 Insights on
- High evidence