Bifidobacteria-Insight into clinical outcomes and mechanisms of its probiotic action.2016-11ReviewMicrobiological Research 192A. SarkarS. MandalPubMed: 27664734DOI: 10.1016/j.micres.2016.07.0014 Insights on Improved Gut HomeostasisImproved Probiotic EfficiencyIncreased Adverse EffectsReduced Pathogen ResistanceModerate evidenceHighly Cited
Exploitation of Leuconostoc mesenteroides strains to improve shelf life, rheological, sensory and functional features of prickly pear (Opuntia ficus-indica L.) fruit puree.2016-10Food Microbiology 59R. Di CagnoP. FilanninoO. VincentiniAlessia LaneraI. CavoskiM. GobbettiPubMed: 27375258DOI: 10.1016/j.fm.2016.06.0093 Insights on Enhanced Tight Junction IntegrityImproved ImmunomodulationReduced Inflammatory StatusLow evidence
Consumption of a Bifidobacterium bifidum Strain for 4 Weeks Modulates Dominant Intestinal Bacterial Taxa and Fecal Butyrate in Healthy Adults2016-10RCTApplied and Environmental Microbiology 82(19)G. GargariValentina TavernitiS. BalzarettiC. FerrarioC. GardanaP. SimonettiS. GuglielmettiPubMed: 27451450DOI: 10.1128/AEM.01753-168 Insights on Increased Butyrate LevelsIncreased Fecal Butyrate LevelsModified Dominant Intestinal Bacterial TaxaChanges in Health Status from Probiotic InterventionAltered Fecal Butyrate LevelsAltered Dominant Intestinal Bacterial CompositionIncreased Rikenellaceae AbundanceModulated Intestinal Microbial TaxaHigh evidenceRigorous Journal
Isolation, characterization and evaluation of probiotic lactic acid bacteria for potential use in animal production.2016-10Research in Veterinary Science 108Yaneisy García-HernándezTania Pérez-SánchezR. BoucourtJ. BalcázarJ. NicoliJoão Moreira-SilvaZ. RodríguezHéctor FuertesOdalys NúñezN. AlbeloN. HalaihelPubMed: 27663381DOI: 10.1016/j.rvsc.2016.08.0092 Insights on Improved Immune ResponseImproved Production EfficiencyLow evidenceHighly Cited
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.2016-10RCT · n = 64Biomedicine & Pharmacotherapy 83Yaser GamallatAbdo MeyiahE. KuugbeeA. HagoGift ChiwalaA. AwadasseidDjibril BambaXin ZhangX. ShangF. LuoY. XinPubMed: 27447122DOI: 10.1016/j.biopha.2016.07.0019 Insights on Reduced Inflammatory ResponseReduced Tumor VolumeReduced InflammationIncreased Expression of Pro-apoptotic ProteinsReduced Tumor IncidenceReduced Tumor MultiplicityReduced Expression of Beta-CateninReduced Inflammatory Protein LevelsIncreased Cellular ApoptosisLow evidenceHighly CitedRigorous JournalAnimal Study
Augmentation of T helper type 1 immune response through intestinal immunity in murine cutaneous herpes simplex virus type 1 infection by probiotic Lactobacillus plantarum strain 06CC2.2016-10Clinical TrialInternational Immunopharmacology 39Tatsuya MatsusakiS. TakedaM. TakeshitaYuo ArimaChuluunbat Tsend-AyushTsendesuren OyunsurenC. SugitaH. YoshidaW. WatanabeM. KurokawaPubMed: 27517518DOI: 10.1016/j.intimp.2016.08.0015 Insights on Enhanced Natural Killer Cell ActivityDelayed Development of Herpetic Skin LesionsReduced Brain Virus YieldsEnhanced DTH Reaction to HSV-1 AntigenIncreased IFN-γ Production by Splenocytes in Response to HSV-1 AntigenLow evidenceRigorous JournalAnimal Study
Effects of dietary live and heat-inactive baker's yeast on growth, gut health, and disease resistance of Nile tilapia under high rearing density.2016-09Fish & Shellfish Immunology 56Chao RanLu HuangJun HuP. TaconSuxu HeZhimin LiYibing WangZhi LiuLi XuYalin YangZhigang ZhouPubMed: 27393237DOI: 10.1016/j.fsi.2016.07.0013 Insights on Enhanced Disease ResistanceImproved Growth RateIncreased Gut Microvilli LengthLow evidence
Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder.2016-09Observational · n = 100Journal of Affective Disorders 202E. AizawaH. TsujiT. AsaharaTakuya TakahashiT. TeraishiS. YoshidaM. OtaNorie KogaK. HattoriH. KunugiPubMed: 27288567DOI: 10.1016/j.jad.2016.05.0386 Insights on Reduced Depression SymptomsIncreased Bifidobacterium LevelsReduced Bifidobacterium CountsReduced Bifidobacterium and Lactobacillus Counts in Patients with MDDReduced Lactobacillus CountsReduced Occurrence of Major Depressive DisorderHigh evidenceHighly Cited
A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infantS (PiPS) trial.2016-08RCT · n = 1,315Health Technology Assessment 20(66)K. CosteloeU. BowlerP. BrocklehurstP. HardyPaul HealE. JuszczakA. KingN. PantonF. StaceyA. WhileyM. WilksM. MillarPubMed: 27594381DOI: 10.3310/hta2066010 Insights on Reduced Colitis-Related MortalityReduced Severity of Necrotizing EnterocolitisReduced Incidence of Clinical SepsisReduced Mortality Rate Before DischargePrevented SepsisPrevention of Necrotising EnterocolitisReduced Necrotising EnterocolitisReduced Mortality RateReduced MortalityPrevented Bloodstream InfectionHigh evidenceLarge Human Trial
Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up.2016-08RCT · n = 28Journal of Periodontology 87(8)Alicia MoralesP. CarvajalNora SilvaMarcela HernándezC. GodoyG. RodríguezR. CabelloJocelyn García-SesnichA. HoareP. DiazJ. GamonalPubMed: 26944407DOI: 10.1902/jop.2016.1506657 Insights on Reduced Need for Periodontitis SurgeryImproved Periodontitis SymptomsImproved Probing DepthReduced Surgical InterventionReduced Probing DepthReduced Periodontal Pocket Depth ≥6 mmReduced Probing Depths in Chronic PeriodontitisHigh evidenceHighly Cited
Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial.2016-08RCT · n = 110Taiwanese Journal of Obstetrics and Gynecology 55(4)M. HoYin-Yi ChangWei-Chun ChangHung-Chih LinMei-Hung WangWu‐Chou LinT. ChiuPubMed: 27590374DOI: 10.1016/j.tjog.2016.06.0031 Insight on Reduced Group B Streptococcus ColonizationHigh evidenceHighly Cited
Mitigation of heat stress-related complications by a yeast fermentate product.2016-08Journal of thermal biology 60Henri Alexandre Giblot DucrayLudmila GlobaOleg PustovyyStuart ReevesLarry RobinsonVitaly VodyanoyIryna SorokulovaPubMed: 27503713DOI: 10.1016/j.jtherbio.2016.06.0025 Insights on Reduced Plasma Lipopolysaccharide LevelsReduced Metabolic EndotoxemiaReduced Intestinal DamageProtected Erythrocyte IntegrityWhite Blood Cell CountLow evidence
Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial.2016-07RCT · n = 30Journal of Dairy Science 99(7)B. Bogovič MatijašićT. ObermajerL. LipoglavšekTjaša SernelI. LocatelliMitja KosA. ŠmidI. RogeljPubMed: 27157575DOI: 10.3168/jds.2015-107431 Insight on Presence of Viable L. acidophilus La-5 Strains in FecesHigh evidenceRigorous Journal
Lactobacillus crispatus as biomarker of the healthy vaginal tract.2016-07Annales de biologie clinique 74(4)J. LepargneurPubMed: 27492695DOI: 10.1684/abc.2016.11692 Insights on Improved Vaginal HealthEnhanced Vaginal HealthLow evidence
Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial2016-07RCTJournal of Pediatric Gastroenterology and Nutrition 63(1)T. OkazakiT. AsaharaA. YamatakaYuki OgasawaraGeoffrey J. LaneK. NomotoS. NagataY. YamashiroPubMed: 26859092DOI: 10.1097/MPG.000000000000114025 Insights on Reduced Faecal pHReduced Enterobacteriaceae CountsIncreased Acetic Acid Levels in FecesReduced Postoperative Infectious ComplicationsElevated Bifidobacterium LevelsIncreased Fecal Acetic Acid ConcentrationReduced Blood Bacterial IncidenceIncreased Fecal Bifidobacteria LevelsIncreased Intestinal Bifidobacteria LevelsReduced Clostridium difficile CountImproved Intestinal MicroenvironmentImproved Intestinal HealthReduced Pseudomonas in FecesReduced Enterobacteriaceae Levels in FecesIncreased Intestinal Bifidobacteria PopulationReduced Bacterial Load in BloodReduced BacteremiaIncreased Bifidobacterium LevelsReduced Bacteremia IncidenceReduced Enterobacteriaceae in IntestinesReduced Clostridium Difficile in IntestinesReduced Bacterial Detection in BloodReduced Fecal Clostridium difficileReduced Bacterial Levels in BloodReduced Clostridium Difficile LevelsHigh evidence
Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial.2016-07RCT · n = 39Applied Physiology, Nutrition, and Metabolism 41(7)D. MichaličkováR. MinićN. DikićM. AndjelkovicMarija Kostic-VucicevicTamara StojmenovicIvan NikolićB. DjordjevicPubMed: 27363733DOI: 10.1139/apnm-2015-054110 Insights on Reduced URTI SymptomsReduced Duration of Upper Respiratory Tract InfectionReduced Duration of Upper Respiratory Tract IllnessReduced Upper Respiratory Tract Infection SymptomsUnchanged Severity of URTIIncreased CD4+/CD8+ RatioImproved Self-Rated VigorImproved CD4+/CD8+ RatioReduced URTI DurationAltered CD4+/CD8+ RatioHigh evidence
The effects of feeding with synbiotic (Pediococcus acidilactici and fructooligosaccharide) enriched adult Artemia on skin mucus immune responses, stress resistance, intestinal microbiota and performance of angelfish (Pterophyllum scalare).2016-07RCTFish & Shellfish Immunology 54Mahmood AzimiradS. MeshkiniN. AhmadifardS. HoseinifarPubMed: 27150050DOI: 10.1016/j.fsi.2016.05.0018 Insights on Improved Gut MicrobiotaIncreased Serum Lysozyme ActivityImproved Growth PerformanceIncreased Immunoglobulin LevelsIncreased Skin Mucus Immune ResponseEnhanced Stress ResistanceIncreased Fecal Lactic Acid Bacteria ConcentrationIncreased Intestinal Lactic Acid Bacteria PopulationHigh evidenceHighly Cited
Lactobacillus reuteri DSM 17938 for the Management of Functional Abdominal Pain in Childhood: A Randomized, Double-Blind, Placebo-Controlled Trial.2016-07RCT · n = 101The Journal of Pediatrics 174Z. WeizmanJaber Abu-AbedM. BinsztokPubMed: 27156182DOI: 10.1016/j.jpeds.2016.04.0032 Insights on Reduced Abdominal Pain FrequencyReduced Abdominal Pain IntensityHigh evidence
Effect of oral administration of Bacillus coagulans B37 and Bacillus pumilus B9 strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model2016-07RCT · n = 36Veterinary World 9(7)Lopamudra HaldarD. N. GandhiPubMed: 27536040DOI: 10.14202/vetworld.2016.766-7724 Insights on Increased Fecal LactobacilliReduced Coliform CountsIncreased Bacillus Spore CountsReduced Fecal Coliform CountLow evidenceAnimal Study
Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.2016-07RCT · n = 50Journal of Dairy Science 99(7)Kozo YamamotoK. YokoyamaTakehisa MatsukawaSayaka KatoS. KatoKazuhisa YamadaTatsuhiko HirotaPubMed: 27108169DOI: 10.3168/jds.2015-1060511 Insights on Improved Immune FunctionImproved Skin SymptomsReduced Subjective SymptomsReduced Lactate Dehydrogenase LevelsIncreased Transforming Growth Factor-β LevelsIncreased IL-12 LevelsReduced Type-2-helper-T-cell-dominant InflammationImproved Atopic Dermatitis SymptomsImproved Atopic Dermatitis SeverityIncreased Interleukin-12 ProductionReduced Scratching FrequencyHigh evidenceRigorous Journal
Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins2016-06Antimicrobial Agents and Chemotherapy 60(6)Gabrielle RipertS. RacedoA. ElieC. JacquotP. BressollierM. UrdaciPubMed: 27001810DOI: 10.1128/AAC.02815-153 Insights on Reduced Cytotoxic EffectsNormalized Expression of rhoB GeneReduced Toxin-induced CytotoxicityLow evidenceHighly Cited
Beneficial effects of Bifidobacterium lactis on lipid profile and cytokines in patients with metabolic syndrome: A randomized trial. Effects of probiotics on metabolic syndrome.2016-06RCT · n = 51Nutrition 32(6)L. J. BerniniA. SimãoD. AlfieriM. A. LozovoyNaiara Lourenço MariC. H. B. de SouzaI. DichiG. N. CostaPubMed: 27126957DOI: 10.1016/j.nut.2015.11.00111 Insights on Reduced Body Mass IndexReduced Total Cholesterol LevelsReduced Low-Density Lipoprotein LevelReduced Tumor Necrosis Factor AlphaReduced Interleukin-6 LevelsReduced Pro-Inflammatory CytokinesReduced LDL CholesterolReduced Low-Density Lipoprotein CholesterolReduced Total CholesterolReduced Tumor Necrosis Factor-α (TNF-α)Reduced Tumor Necrosis Factor-α LevelsHigh evidenceHighly Cited
Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers - Randomized, double blind, placebo-controlled study.2016-06RCT · n = 210Clinical Nutrition 35(3)I. HojsakAna Močić PavićT. KosJ. DumančićS. KolačekPubMed: 26031908DOI: 10.1016/j.clnu.2015.05.0047 Insights on Reduced Gastrointestinal InfectionsReduced Total InfectionsReduced Respiratory InfectionsReduced Day Care Absenteeism Due to InfectionsReduced Antibiotic Use Due to InfectionsReduced Mean Number of Infections per ChildDuration of SymptomsHigh evidence
Does Short-Term High Dose Probiotic Supplementation Containing Lactobacillus casei Attenuate Exertional-Heat Stress Induced Endotoxaemia and Cytokinaemia?2016-06RCT · n = 8International Journal of Sport Nutrition and Exercise Metabolism 26(3)S. GillD. AllertonPaula Ansley-RobsonK. HemmingsMartin CoxR. CostaPubMed: 26568577DOI: 10.1123/ijsnem.2015-01862 Insights on Reduced Exertional Heat Stress-Induced EndotoxemiaReduced Cytokine Response to Exertional Heat StressHigh evidence
A double-blinded randomized trial on growth and feeding tolerance with Saccharomyces boulardii CNCM I-745 in formula-fed preterm infants.2016-05RCT · n = 125Jornal de Pediatria 92(3)Ling-fen XuYun WangYang WangJianhua FuMei SunZhi-qin MaoY. VandenplasPubMed: 26946967DOI: 10.1016/j.jped.2015.08.0134 Insights on Improved Weight GainNo Adverse Health EffectsImproved Feeding ToleranceReduced Time to Full Enteral FeedingHigh evidence
Identification and characterization of Bacillus subtilis from grass carp (Ctenopharynodon idellus) for use as probiotic additives in aquatic feed.2016-05Fish & Shellfish Immunology 52Xia GuoDan-Dan ChenK. PengZheng-Wei CuiXu-Jie ZhangShun LiYong‐An ZhangPubMed: 26988285DOI: 10.1016/j.fsi.2016.03.0173 Insights on Improved Immune ResponseReduced Inflammatory ResponseReduced Inflammation LevelsLow evidenceHighly Cited
Antagonistics against pathogenic Bacillus cereus in milk fermentation by Lactobacillus plantarum ZDY2013 and its anti-adhesion effect on Caco-2 cells against pathogens.2016-04Journal of Dairy Science 99(4)Zhihong ZhangX. TaoN. ShahHua WeiPubMed: 26830743DOI: 10.3168/jds.2015-105872 Insights on Reduced Pathogenic Bacillus Cereus LevelsReduced Enterotoxin-Producing Bacillus Cereus AdhesionLow evidenceRigorous Journal
Effects of dietary Lactobacillus plantarum B1 on growth performance, intestinal microbiota, and short chain fatty acid profiles in broiler chickens.2016-04RCTPoultry Science 95(4)Q. PengX. ZengJinlong ZhuSiyuan WangX. LiuC. HouP. ThackerS. QiaoPubMed: 26772658DOI: 10.3382/ps/pev43518 Insights on Increased Short-Chain Fatty Acid LevelsIncreased Lactic Acid Bacteria LevelsImproved Intestinal MicrobiotaIncreased Secretory IgA LevelImproved Average Daily GainImproved Growth PerformanceReduced E. coli LevelsIncreased SCFA LevelsImproved Gut Microbiota BalanceReduced Harmful Gut BacteriaIncreased Short Chain Fatty AcidsReduced Fecal Escherichia coli LevelsIncreased Short Chain Fatty Acid ProfilesIncreased Secretory Immunoglobulin AImproved Intestinal Microbial CompositionIncreased Average Daily Gain During Finisher PeriodUnchanged Intestinal MorphologyEnhanced SCFA ProductionHigh evidenceHighly CitedRigorous Journal
Fermented milk with probiotic Lactobacillus rhamnosus S1K3 (MTCC5957) protects mice from salmonella by enhancing immune and nonimmune protection mechanisms at intestinal mucosal level.2016-04Clinical TrialThe Journal of Nutritional Biochemistry 30T. S. KemgangS. KapilaV. P. ShanmugamS. ReddiR. KapilaPubMed: 27012622DOI: 10.1016/j.jnutbio.2015.11.01814 Insights on Improved Immune ResponseImproved Intestinal Barrier IntegrityImproved Intestinal Mucosal ImmunityReduced Salmonella Enterica InvasionReduced Salmonella IncidenceIncreased Secretory IgA LevelEnhanced Tight Junction IntegrityImproved Overall Health StatusReduced Pathogen InfectionEnhanced Immune ResponseRegulated Cytokine LevelsIncreased Fecal Secretory IgA LevelsEnhanced Intestinal IntegrityImproved Cytokine LevelsLow evidenceAnimal Study
High-Dose Probiotic Supplementation Containing Lactobacillus casei for 7 Days Does Not Enhance Salivary Antimicrobial Protein Responses to Exertional Heat Stress Compared With Placebo.2016-04RCT · n = 8International Journal of Sport Nutrition and Exercise Metabolism 26(2)S. GillA. TeixeiraF. RosadoMartin CoxR. CostaPubMed: 26479711DOI: 10.1123/ijsnem.2015-01713 Insights on Enhanced Salivary Antimicrobial Protein ResponsesElevated Salivary Antimicrobial Protein Levels Due to Exertional Heat StressImproved Saliva Flow RateHigh evidence