Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity, lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance
- 2011-09-07
- RCT · n = 11
- British Journal of Nutrition 107(8)
- - A. Taniguchi-Fukatsu
  - H. Yamanaka-Okumura
  - Yuko Naniwa-Kuroki
  - Yuka Nishida
  - Hironori Yamamoto
  - Y. Taketani
  - E. Takeda
- PubMed: 21899797
- DOI: 10.1017/S0007114511004156
2 Insights on
- Improved Insulin Sensitivity
- Reduced Hepatic Oxidative Stress
- High evidence
In vitro assessment of the immunomodulatory effects of multispecies probiotic formulations for management of allergic diseases.
- 2011-09-01
- Beneficial microbes 2(3)
- - N B M M Rutten
  - I Besseling-Van der Vaart
  - M Klein
  - S De Roock
  - A M Vlieger
  - G T Rijkers
- PubMed: 21986357
- DOI: 10.3920/bm2011.0012
2 Insights on
- Reduced Th2 Cytokine Production
- Enhanced Anti-Inflammatory Cytokine Production
- Low evidence
- Rigorous Journal
Lactococci and lactobacilli as mucosal delivery vectors for therapeutic proteins and DNA vaccines
- 2011-08-30
- Microbial Cell Factories 10(S1)
- - L. Bermúdez-Humarán
  - Pascale Kharrat
  - J. Chatel
  - P. Langella
- PubMed: 21995317
- DOI: 10.1186/1475-2859-10-S1-S4
12 Insights on
- Low evidence
- Highly Cited
Whole-Genome Shotgun Sequencing of an Indian-Origin Lactobacillus helveticus Strain, MTCC 5463, with Probiotic Potential
- 2011-08-15
- Journal of Bacteriology 193(16)
- - J. Prajapati
  - C. Khedkar
  - J. Chitra
  - S. Suja
  - V. Mishra
  - V. Sreeja
  - R. Patel
  - V. B. Ahir
  - V. Bhatt
  - M. Sajnani
  - S. Jakhesara
  - P. Koringa
  - C. Joshi
- PubMed: 21705605
- DOI: 10.1128/JB.05449-11
3 Insights on
- Low evidence
Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.
- 2011-08-15
- PloS one 6(8)
- - Shuichi Segawa
  - Mikihiro Fujiya
  - Hiroaki Konishi
  - Nobuhiro Ueno
  - Naoyuki Kobayashi
  - Tatsuro Shigyo
  - Yutaka Kohgo
- PubMed: 21858054
- DOI: 10.1371/journal.pone.0023278
3 Insights on
- Low evidence
- Highly Cited
Oral ingestion of Streptococcus thermophilus does not affect mucositis severity or tumor progression in the tumor-bearing rat
- 2011-07-15
- RCT · n = 36
- Cancer Biology & Therapy 12(2)
- - K. Tooley
  - G. Howarth
  - K. Lymn
  - A. Lawrence
  - R. Butler
- PubMed: 21508671
- DOI: 10.4161/cbt.12.2.15720
2 Insights on
- Mitigated Chemotherapy-Induced Mucositis
- No Effect on Tumor Progression
- Low evidence
- Animal Study
Strain-dependent release of cytokines modulated by Lactobacillus salivarius human isolates in an in vitro model
- 2011-07-14
- BMC Research Notes 3(1)
- - L. Drago
  - L. Nicola
  - E. Iemoli
  - G. Banfi
  - E. De Vecchi
- PubMed: 20184725
- DOI: 10.1186/1756-0500-3-44
1 Insight on
- Reduced Th2 Cytokine Production
- Low evidence
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
- 2011-07-12
- Lipids in Health and Disease 10(1)
- - H. An
  - Shin‐Young Park
  - Do Kyung Lee
  - Jung Rae Kim
  - M. Cha
  - S. Lee
  - H. Lim
  - K. Kim
  - N. Ha
- PubMed: 21745411
- DOI: 10.1186/1476-511X-10-116
13 Insights on
- Moderate evidence
- Highly Cited
- Rigorous Journal
The immunomodulatory properties of viable Lactobacillus salivarius ssp. salivarius CECT5713 are not restricted to the large intestine
- 2011-06-19
- Clinical Trial
- European Journal of Nutrition 51(3)
- - B. Arribas
  - N. Garrido-Mesa
  - Laura Perán
  - D. Camuesco
  - M. Comalada
  - E. Bailón
  - M. Olivares
  - J. Xaus
  - L. Kruidenier
  - I. Sanderson
  - A. Zarzuelo
  - M. Rodríguez-Cabezas
  - J. Gálvez
- PubMed: 21688122
- DOI: 10.1007/s00394-011-0221-4
7 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Functional Analysis of the p40 and p75 Proteins from Lactobacillus casei BL23
- 2011-06-17
- Microbial Physiology 19(4)
- - Christine Bäuerl
  - G. Pérez-Martínez
  - Fang Yan
  - D. Polk
  - V. Monedero
- PubMed: 21178363
- DOI: 10.1159/000322233
1 Insight on
- Enhanced Intestinal Mucosal Cell Protection
- Low evidence
- Highly Cited
Efficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study
- 2011-06-14
- RCT · n = 50
- Surgical Endoscopy 25(12)
- - K. Agarwal
  - C. D. Tripathi
  - B. Agarwal
  - S. Saluja
- PubMed: 21671126
- DOI: 10.1007/s00464-011-1793-z
3 Insights on
- High evidence
- Highly Cited
Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults
- 2011-06-13
- RCT · n = 100
- Scandinavian Journal of Gastroenterology 46(9)
- - Philip A Waller
  - P. Gopal
  - G. Leyer
  - A. Ouwehand
  - C. Reifer
  - Morgan E Stewart
  - L. Miller
- PubMed: 21663486
- DOI: 10.3109/00365521.2011.584895
7 Insights on
- High evidence
- Highly Cited
Fermented Milk Containing Bifidobacterium lactis DN-173 010 in Childhood Constipation: A Randomized, Double-Blind, Controlled Trial
- 2011-06-01
- RCT · n = 159
- Pediatrics 127(6)
- - M. Tabbers
  - A. Chmielewska
  - M. Roseboom
  - N. Crastes
  - C. Perrin
  - J. Reitsma
  - O. Norbruis
  - H. Szajewska
  - M. Benninga
- PubMed: 21606153
- DOI: 10.1542/peds.2010-2590
1 Insight on
- Increased Stool Frequency
- High evidence
- Highly Cited
Bifidobacterium breve - HT-29 cell line interaction: modulation of TNF-α induced gene expression.
- 2011-06-01
- Beneficial Microbes 2(2)
- - R. Boesten
  - F. Schuren
  - L. Willemsen
  - A. Vriesema
  - J. Knol
  - W. D. de Vos
- PubMed: 21831793
- DOI: 10.3920/BM2011.0005
2 Insights on
- Reduced Inflammatory Response
- Suppressed TNF-α Induced Genes
- Low evidence
The extracellular proteome of Bifidobacterium animalis subsp. lactis BB-12 reveals proteins with putative roles in probiotic effects.
- 2011-05-20
- Proteomics 11(12)
- - Ofir Gilad
  - Birte Svensson
  - Alexander H Viborg
  - Birgitte Stuer-Lauridsen
  - Susanne Jacobsen
- PubMed: 21598393
- DOI: 10.1002/pmic.201000716
2 Insights on
- Induced Immunomodulatory Effects
- Improved Host-Probiotic Interaction
- Low evidence
Development of a fermented goats' milk containing Lactobacillus rhamnosus: in vivo study of health benefits.
- 2011-05-20
- Clinical Trial
- Journal of the Science of Food and Agriculture 91(13)
- - S. Salva
  - M. Núñez
  - J. Villena
  - A. Ramón
  - G. Font
  - S. Alvarez
- PubMed: 21604277
- DOI: 10.1002/jsfa.4467
12 Insights on
- Low evidence
- Highly Cited
- Animal Study
Randomized, placebo-controlled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection.
- 2011-05-15
- RCT · n = 100
- Clinical Infectious Diseases 52(10)
- - A. Stapleton
  - Melissa Au-Yeung
  - T. Hooton
  - D. Fredricks
  - P. Roberts
  - C. Czaja
  - Yuliya Yarova-Yarovaya
  - T. Fiedler
  - Marsha E Cox
  - W. Stamm
- PubMed: 21498386
- DOI: 10.1093/cid/cir183
2 Insights on
- Reduced Recurrence of Urinary Tract Infections
- Reduced Recurrent UTI
- High evidence
- Highly Cited
- Rigorous Journal
Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study.
- 2011-05-05
- RCT · n = 35
- Climacteric : the journal of the International Menopause Society 14(5)
- - M Gossell-Williams
  - C Hyde
  - T Hunter
  - D Simms-Stewart
  - H Fletcher
  - D McGrowder
  - C A Walters
- PubMed: 21545273
- DOI: 10.3109/13697137.2011.563882
6 Insights on
- High evidence
Role of the probiotic strain Lactobacillus paracasei LMGP22043 carried by artichokes in influencing faecal bacteria and biochemical parameters in human subjects
- 2011-04-20
- RCT
- Journal of Applied Microbiology 111(1)
- - F. Valerio
  - S. D. Candia
  - S. L. Lonigro
  - F. Russo
  - G. Riezzo
  - A. Orlando
  - P. Bellis
  - A. Sisto
  - P. Lavermicocca
- PubMed: 21447019
- DOI: 10.1111/j.1365-2672.2011.05019.x
3 Insights on
- High evidence
Interventions for preventing oral mucositis for patients with cancer receiving treatment.
- 2011-04-13
- Meta-Analysis · n = 131
- The Cochrane database of systematic reviews 2021(3)
- - Helen V Worthington
  - Jan E Clarkson
  - Gemma Bryan
  - Susan Furness
  - Anne-Marie Glenny
  - Anne Littlewood
  - Martin G McCabe
  - Stefan Meyer
  - Tasneem Khalid
- PubMed: 21491378
- DOI: 10.1002/14651858.cd000978.pub5
1 Insight on
- Reduced Oral Mucositis Severity
- High evidence
- Highly Cited
A randomised double-blind placebo-controlled trial with Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp. lactis BB-12 for maintenance of remission in ulcerative colitis.
- 2011-04-01
- RCT · n = 32
- Journal of Crohn's and Colitis 5(2)
- - S. Wildt
  - I. Nordgaard
  - U. Hansen
  - E. Brockmann
  - J. Rumessen
- PubMed: 21453880
- DOI: 10.1016/j.crohns.2010.11.004
1 Insight on
- Maintained Remission in Ulcerative Colitis
- High evidence
- Highly Cited
Influence of a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502® on bowel habits of healthy adults
- 2011-03-30
- Letters in Applied Microbiology 52(6)
- - M. Verdenelli
  - S. Silvi
  - C. Cecchini
  - C. Orpianesi
  - A. Cresci
- PubMed: 21395626
- DOI: 10.1111/j.1472-765X.2011.03042.x
3 Insights on
- Low evidence
Influence of a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502® on bowel habits of healthy adults.
- 2011-03-30
- RCT
- Letters in applied microbiology 52(6)
- - M C Verdenelli
  - S Silvi
  - C Cecchini
  - C Orpianesi
  - A Cresci
- PubMed: 21395626
- DOI: 10.1111/j.1472-765x.2011.03042.x
1 Insight on
- Improved Bowel Habits
- High evidence
Bovine milk fermented with Lactobacillus rhamnosus L8020 decreases the oral carriage of mutans streptococci and the burden of periodontal pathogens.
- 2011-03-21
- RCT · n = 50
- Journal of Investigative and Clinical Dentistry 2(3)
- - H. Nikawa
  - Yuta Tomiyama
  - Minako Hiramatsu
  - Kaori Yushita
  - Yuko Takamoto
  - Hitomi Ishi
  - Sumiyo Mimura
  - Aya Hiyama
  - H. Sasahara
  - Kazuko Kawahara
  - S. Makihira
  - T. Satoda
  - T. Takemoto
  - H. Murata
  - Y. Mine
  - T. Taji
- PubMed: 25426790
- DOI: 10.1111/j.2041-1626.2011.00056.x
7 Insights on
- High evidence
Effect of a Probiotic Intake on Oxidant and Antioxidant Parameters in Plasma of Athletes During Intense Exercise Training
- 2011-03-12
- RCT · n = 24
- Current Microbiology 62(6)
- - D. Martarelli
  - M. Verdenelli
  - S. Scuri
  - M. Cocchioni
  - S. Silvi
  - C. Cecchini
  - P. Pompei
- PubMed: 21400082
- DOI: 10.1007/s00284-011-9915-3
3 Insights on
- High evidence
- Highly Cited
Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study
- 2011-03-11
- Observational · n = 1,662
- Osteoporosis International 23(2)
- - Y. Fujita
  - Masayuki Iki
  - J. Tamaki
  - K. Kouda
  - A. Yura
  - E. Kadowaki
  - Yuho Sato
  - Jong-Seong Moon
  - K. Tomioka
  - N. Okamoto
  - N. Kurumatani
- PubMed: 21394493
- DOI: 10.1007/s00198-011-1594-1
3 Insights on
- High evidence
- Rigorous Journal
Safety and persistence of orally administered human Lactobacillus sp. strains in healthy adults.
- 2011-03-01
- Clinical Trial · n = 14
- Beneficial Microbes 2(1)
- - P. Hütt
  - P. Kõll
  - J. Štšepetova
  - Beatriz Álvarez
  - R. Mändar
  - Kasper Krogh-Andersen
  - H. Marcotte
  - Lennart Hammarström
  - M. Mikelsaar
- PubMed: 21831792
- DOI: 10.3920/BM2010.0023
2 Insights on
- Gastrointestinal Tract Persistence
- Absence of Severe Gastrointestinal Adverse Effects
- Moderate evidence
Lactobacillus johnsonii CRL1647, isolated from Apis mellifera L. bee-gut, exhibited a beneficial effect on honeybee colonies.
- 2011-03-01
- Beneficial Microbes 2(1)
- - M. Audisio
  - M. R. Benítez-Ahrendts
- PubMed: 21831787
- DOI: 10.3920/BM2010.0024
4 Insights on
- Low evidence
Review: Functional Properties of Kefir
- 2011-02-28
- Review
- Critical Reviews in Food Science and Nutrition 51(3)
- - Z. Guzel‐Seydim
  - T. Kok-Tas
  - A. Greene
  - A. C. Seydim
- PubMed: 21390946
- DOI: 10.1080/10408390903579029
4 Insights on
- Moderate evidence
- Highly Cited
Evaluation of a probiotics, Bifidobacterium breve BBG-01, for enhancement of immunogenicity of an oral inactivated cholera vaccine and safety: a randomized, double-blind, placebo-controlled trial in Bangladeshi children under 5 years of age.
- 2011-02-24
- RCT
- Vaccine 29(10)
- - F. Matsuda
  - M. Chowdhury
  - A. Saha
  - T. Asahara
  - K. Nomoto
  - A. Tarique
  - T. Ahmed
  - M. Nishibuchi
  - A. Cravioto
  - F. Qadri
- PubMed: 21236234
- DOI: 10.1016/j.vaccine.2010.12.133
13 Insights on
- High evidence