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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota.
- 2023-09
- Clinical Trial · n = 20
- Minerva Obstetrics and Gynecology 75(5)
- - V. de Leo
  - Elisa Lazzeri
  - L. Governini
  - A. M. Cuppone
  - Lorenzo Colombini
  - Lucia Teodori
  - G. Ciprandi
  - F. Iannelli
  - G. Pozzi
- PubMed: 35686637
- DOI: 10.23736/S2724-606X.22.05087-4
1 Insight on
- Reduced Vaginal Colonization of Pathogenic Bacteria
- Moderate evidence
Assessment of virgin coconut oil in a balanced diet on indicators of cardiovascular health in non-obese volunteers: A human metabolic study.
- 2023-09
- Observational · n = 22
- Diabetes & metabolic syndrome 17(9)
- - Shanmugam Murugaiha Jeyakumar
  - Korrapati Damayanti
  - Laxmi Rajkumar Ponday
  - Vani Acharya
  - Swarupa Rani Koppala
  - Uday Kumar Putcha
  - Balakrishna Nagalla
  - Ayyalasomayajula Vajreswari
- PubMed: 37591045
- DOI: 10.1016/j.dsx.2023.102844
8 Insights on
- Low evidence
Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha.
- 2023-09
- Case Report
- Federal practitioner : for the health care professionals of the VA, DoD, and PHS 40(9)
- - Sondra Vazirani
  - Amit Kothari
  - Jeffrey Fujimoto
  - Mariana Gomez
- PubMed: 38562158
- DOI: 10.12788/fp.0409
1 Insight on
- Reduced Cholestatic Pattern of Liver Injury
- Low evidence
Limosilactobacillus reuteri consumption significantly reduces the total cholesterol concentration without affecting other cardiovascular disease risk factors in adults: A systematic review and meta-analysis.
- 2023-09
- Meta-Analysis · n = 512
- Nutrition research (New York, N.Y.) 117
- - Jinshu Liu
  - Ruiting Zhu
  - Jinping Song
  - Muhammad Sohaib
  - Saikun Wang
  - Jing Mao
  - Jiahe Qi
  - Xuance Xiong
  - Wei Zhou
  - Lirong Guo
- PubMed: 37419064
- DOI: 10.1016/j.nutres.2023.06.004
7 Insights on
- High evidence
Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial.
- 2023-08
- RCT · n = 350
- Clinical nutrition (Edinburgh, Scotland) 42(8)
- - Xudong Yan
  - Xiaoyu Pan
  - Lu Ding
  - Yiheng Dai
  - Jun Chen
  - Yong Yang
  - Yuefeng Li
  - Hu Hao
  - Huixian Qiu
  - Zhenzhi Ye
  - René Liang Shen
  - Yanqi Li
  - Christian Ritz
  - Yueming Peng
  - Ping Zhou
  - Fei Gao
  - Ping-Ping Jiang
  - Hung-Chih Lin
  - Gitte Zachariassen
  - Per Torp Sangild
  - Benqing Wu
- PubMed: 37437359
- DOI: 10.1016/j.clnu.2023.06.024
3 Insights on
- High evidence
- Large Human Trial
Comparative effectiveness of six herbs in the management of glycemic status of type 2 diabetes mellitus patients: A systematic review and network meta-analysis of randomized controlled trials.
- 2023-08
- Systematic Review · n = 3,130
- Diabetes & metabolic syndrome 17(8)
- - Subodh Kumar
  - Suresh K Sharma
  - Shiv Kumar Mudgal
  - Rakhi Gaur
  - Rajat Agarwal
  - Harminder Singh
  - Sanjay Kalra
- PubMed: 37451111
- DOI: 10.1016/j.dsx.2023.102826
2 Insights on
- Reduced Hemoglobin A1c
- Reduced Fasting Blood Glucose Levels
- High evidence
Effect of Tomato (Solanum lycopersicum) Extract in Patients with Primary Insomnia: A Double-blind Randomized Study.
- 2023-08
- RCT · n = 70
- Central nervous system agents in medicinal chemistry 23(2)
- - Parvin Dehnavi
  - Hassan Rakhshandeh
  - Elham Bakhtiari
  - Hadi Asadpour
  - Seyed Mostafa Moshirian Farahi
  - Fatemeh Forouzanfar
- PubMed: 37475550
- DOI: 10.2174/1871524923666230720155754
4 Insights on
- High evidence
The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women: A randomized controlled trial.
- 2023-08
- Review · n = 15
- Complementary therapies in clinical practice 52
- - Ilknur Sirkeci
  - Ozlem Cagan
  - Sevgi Koc
- PubMed: 37054616
- DOI: 10.1016/j.ctcp.2023.101748
2 Insights on
- Reduced Anxiety
- Reduced Labor Pain
- Low evidence
Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis.
- 2023-08
- Meta-Analysis · n = 244
- The American journal of clinical nutrition 118(2)
- - Stine Smedegaard
  - Ulla Kampmann
  - Per G Ovesen
  - Henrik Støvring
  - Nikolaj Rittig
- PubMed: 37536867
- DOI: 10.1016/j.ajcnut.2023.05.012
5 Insights on
- High evidence
Chili pepper intake and all-cause and disease-specific mortality.
- 2023-08
- Meta-Analysis · n = 564
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 93(4)
- - Lili Yang
  - Jiahong Sun
  - Min Zhao
  - Bo Xi
- PubMed: 35038885
- DOI: 10.1024/0300-9831/a000746
3 Insights on
- High evidence
Limosilactobacillus mucosae and Lactobacillus amylovorus Protect Against Experimental Colitis via Upregulation of Colonic 5-Hydroxytryptamine Receptor 4 and Transforming Growth Factor-β2.
- 2023-08
- The Journal of nutrition 153(8)
- - Youling Hao
  - Lili Jiang
  - Dandan Han
  - Dayong Si
  - Zhiyuan Sun
  - Zhenlong Wu
  - Zhaolai Dai
- PubMed: 37356501
- DOI: 10.1016/j.tjnut.2023.06.031
1 Insight on
- Reduced Colonic Inflammation
- Low evidence
- Animal Study
Postprandial Metabolic Mesponses to High-fat Feeding in Healthy Adults Following Ingestion of Oolong Tea-Derived Polymerized Polyphenols: A Randomized, Double-blinded, Placebo-controlled Crossover Study.
- 2023-07
- RCT · n = 16
- The American journal of clinical nutrition 118(1)
- - Oliver J Perkin
  - Yung-Chih Chen
  - Drusus A Johnson
  - Joel E Thomas
  - Greg Atkinson
  - James A Betts
  - Javier T Gonzalez
- PubMed: 37080462
- DOI: 10.1016/j.ajcnut.2023.04.020
14 Insights on
- High evidence
Role of Alternate Therapies to Improve the Quality of Life in Menopausal Women: A Systematic Review.
- 2023-07
- Review
- Journal of mid-life health 14(3)
- - P Aarshageetha
  - P R Rani Janci
  - N Devi Tharani
- PubMed: 38312763
- DOI: 10.4103/jmh.jmh_222_22
2 Insights on
- Managed Vasomotor Symptoms
- Reduced Sexual Dysfunction
- Low evidence
Bifidobacterium lactis TY-S01 protects against alcoholic liver injury in mice by regulating intestinal barrier function and gut microbiota.
- 2023-07
- Heliyon 9(7)
- - Xi Shu
  - Jing Wang
  - Liang Zhao
  - Jian Wang
  - Pengjie Wang
  - Feng Zhang
  - Ran Wang
- PubMed: 37539263
- DOI: 10.1016/j.heliyon.2023.e17878
1 Insight on
- Reduced Alcohol-Induced Liver Injury
- Low evidence
l-theanine adjunct to sertraline for major depressive disorder: A randomized, double-blind, placebo-controlled clinical trial.
- 2023-07
- RCT · n = 50
- Journal of affective disorders 333
- - Ahmad Shamabadi
  - Farnaz Kafi
  - Melika Arab Bafrani
  - Hassan Asadigandomani
  - Fatemeh A Basti
  - Shahin Akhondzadeh
- PubMed: 37084960
- DOI: 10.1016/j.jad.2023.04.029
3 Insights on
- High evidence
Benefits of fermented synbiotic soymilk containing Lactobacillus acidophilus, Bifidobacterium lactis, and inulin towards lead toxicity alleviation.
- 2023-06
- Heliyon 9(6)
- - Maryamsadat Riasatian
  - Seyed Mohammad Mazloomi
  - Afsane Ahmadi
  - Zahra Derakhshan
  - Saeed Rajabi
- PubMed: 37408889
- DOI: 10.1016/j.heliyon.2023.e17518
1 Insight on
- Reduced Serum Lead Levels
- Low evidence
Probiotics and their postbiotics for the control of opportunistic fungal pathogens: A review.
- 2023-06
- Review
- Biotechnology reports (Amsterdam, Netherlands) 38
- - S Divyashree
  - B Shruthi
  - P R Vanitha
  - M Y Sreenivasa
- PubMed: 37215743
- DOI: 10.1016/j.btre.2023.e00800
1 Insight on
- Reduced Opportunistic Pathogens
- Low evidence
Bromelain supplementation and inflammatory markers: A systematic review of clinical trials.
- 2023-06
- Systematic Review
- Clinical nutrition ESPEN 55
- - Irislene Costa Pereira
  - Eduardo Emanuel Sátiro Vieira
  - Lucillia Rabelo de Oliveira Torres
  - Felipe Cavalcanti Carneiro da Silva
  - João Marcelo de Castro E Sousa
  - Francisco Leonardo Torres-Leal
- PubMed: 37202035
- DOI: 10.1016/j.clnesp.2023.02.028
2 Insights on
- Reduced Interleukin-1β Levels
- Reduced Prostaglandin E2 Level
- High evidence
Phytotherapy in paediatric skin disorders - A systematic literature review.
- 2023-06
- Systematic Review · n = 2,358
- Complementary therapies in medicine 74
- - Evelyne Kloter
  - Fiorella Albanese
  - Reka Schweighoffer
  - Ursula Wolf
- PubMed: 36958415
- DOI: 10.1016/j.ctim.2023.102942
1 Insight on
- Improved Wound Healing
- High evidence
Effects of dietary supplementation of Pediococcus pentosaceus strains from kimchi in weaned piglet challenged with Escherichia coli and Salmonella enterica
- 2023-05
- RCT
- Journal of Animal Science and Technology 65(3)
- - D. Song
  - Jihwan Lee
  - Kangheun Kim
  - H. Oh
  - J. An
  - Seyeon Chang
  - Hyunah Cho
  - Seh-Young Park
  - K. Jeon
  - Y. Yoon
  - Yoonjeong Yoo
  - Y. Cho
  - Ji-Hun Cho
- PubMed: 37332280
- DOI: 10.5187/jast.2023.e31
4 Insights on
- Low evidence
- Animal Study
Impact of Saccharomyces boulardii on jaundice in premature infants undergoing phototherapy.
- 2023-05
- RCT · n = 55
- Jornal de pediatria 99(3)
- - Di Hu
  - Ying Wang
  - Suyan Yang
  - Huijuan Zhang
- PubMed: 36574954
- DOI: 10.1016/j.jped.2022.10.010
6 Insights on
- High evidence
Effects of Kefir Consumption on Cardiometabolic Risk Factors: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- 2023-05
- Meta-Analysis · n = 314
- Current drug targets 24(7)
- - Farveh Yahyapoor
  - Neda Haghighat
  - Zahra Sohrabi
  - Omid Asbaghi
  - Mohammad Bagherniya
  - Tannaz Jamialahmadi
  - Amirhossein Sahebkar
- PubMed: 37102491
- DOI: 10.2174/1389450124666230427095742
9 Insights on
- High evidence
l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study.
- 2023-04
- RCT
- Physiological reports 11(8)
- - Zeinab Noormohammadi
  - Hana Arghavani
  - Mohammadhasan Javanbakht
  - Maryam Daneshpazhooh
  - Mahmood Jalili
- PubMed: 37078370
- DOI: 10.14814/phy2.15657
6 Insights on
- High evidence
Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy.
- 2023-04
- RCT · n = 23
- International dental journal 73(2)
- - Evelina Alkimavičienė
  - Rasa Pušinskaitė
  - Nomeda Basevičienė
  - Rasa Banienė
  - Nijolė Savickienė
  - Ingrida Marija Pacauskienė
- PubMed: 36167610
- DOI: 10.1016/j.identj.2022.08.006
6 Insights on
- High evidence
Safety and efficacy of a feed additive consisting of Lactiplantibacillus plantarum DSM 11520 for horses, dogs, cats and pet rabbits (Animal Probiotics Sweden AB)
- 2023-04
- EFSA Journal 21(4)
- - V. Bampidis
  - G. Azimonti
  - M. Bastos
  - Henrik Christensen
  - B. Dusemund
  - M. Durjava
  - M. Kouba
  - M. López-Alonso
  - Secundino López Puente
  - F. Marcon
  - B. Mayo
  - A. Pechová
  - M. Petkova
  - F. Ramos
  - Yolanda Sanz
  - R. Villa
  - R. Woutersen
  - M. Anguita
  - Rosella Brozzi
  - J. Galobart
  - M. Innocenti
  - Y. García‐Cazorla
- PubMed: 37089175
- DOI: 10.2903/j.efsa.2023.7974
3 Insights on
- Low evidence
A systematic review and meta-analysis of almond effect on C-reactive protein and interleukin-6 in adults.
- 2023-03
- Meta-Analysis
- Complementary therapies in medicine 72
- - Mitra Hariri
  - Bahareh Amirkalali
  - Hamid Reza Baradaran
  - Ali Gholami
- PubMed: 36535459
- DOI: 10.1016/j.ctim.2022.102911
2 Insights on
- Reduced Interleukin-6 Levels
- Reduced C-Reactive Protein Levels
- High evidence
Antidiabetic properties of mango in animal models and humans: A systematic review.
- 2023-03
- Systematic Review
- Nutrition research (New York, N.Y.) 111
- - Sepideh Alasvand Zarasvand
  - Amy P Mullins
  - Bahram Arjmandi
  - Vivian Haley-Zitlin
- PubMed: 36841190
- DOI: 10.1016/j.nutres.2023.01.003
1 Insight on
- Reduced Blood Glucose Levels
- High evidence
Infant blood concentrations of folate markers and catabolites are modified by 5,10-methylenetetrahydrofolate reductase C677T genotype and dietary folate source.
- 2023-03
- RCT · n = 182
- The American journal of clinical nutrition 117(3)
- - Rima Obeid
  - Ines Warnke
  - Anja Wittke
  - Igor Bendik
  - Barbara Troesch
  - Rotraut Schoop
  - Christina Hecht
  - Johann Demmelmair
  - Berthold Koletzko
- PubMed: 36872017
- DOI: 10.1016/j.ajcnut.2022.09.002
2 Insights on
- Increased Red Blood Cell Count
- Increased Parabenzoylaminobenzoic Acid Concentration
- High evidence
- Large Human Trial
Long-Term Consumption of Nuts (Including Peanuts, Peanut Butter, Walnuts, and Other Nuts) in Relation to Risk of Frailty in Older Women: Evidence from a Cohort Study.
- 2023-03
- Observational · n = 704
- The Journal of nutrition 153(3)
- - Ruibin Wang
  - Marian T Hannan
  - Molin Wang
  - Andrea W Schwartz
  - Esther Lopez-Garcia
  - Francine Grodstein
- PubMed: 36931754
- DOI: 10.1016/j.tjnut.2023.01.003
1 Insight on
- Reduced Frailty Incidence
- High evidence
Acetyl-L-carnitine for the prevention of taxane-induced neuropathy in patients with breast cancer: a systematic review and meta-analysis.
- 2023-03
- Review
- Research in pharmaceutical sciences 18(2)
- - Mahnaz Momenzadeh
  - Amir Aria
  - Keyvan Ghadimi
  - Azadeh Moghaddas
- PubMed: 36873277
- DOI: 10.4103/1735-5362.367791
1 Insight on
- Reduced Taxane-Induced Neuropathy
- Low evidence