Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Supplement Research Feed

The latest peer-reviewed supplement and nutrition research, newest first — each study linked to the supplements and health outcomes it covers.

Lactobacillus delbrueckii: A Functional Powerhouse in Dairy Fermentation and Emerging Probiotic Applications.
- 2026-02
- Review
- Food science & nutrition 14(2)
- - Yousef Nami
  - Anahita Barghi
  - Mahsa Sadeghi
  - Tara Farhadi
  - Babak Haghshenas
- PubMed: 41710811
- DOI: 10.1002/fsn3.71546
3 Insights on
- Low evidence
Synbiotic intervention with Bifidobacterium bifidum and prebiotics reduces enterohemorrhagic Escherichia coli colonization.
- 2026-02
- Letters in applied microbiology 79(2)
- - Wanqiu Sha
  - Anqi Su
  - Hong Cheng
  - Ning Dong
  - Jia Fu
  - Liang Zhu
  - Guoqing Tao
  - Yunxin Xue
  - Hongwei Cui
  - Dai Wang
- PubMed: 41636800
- DOI: 10.1093/lambio/ovag019
1 Insight on
- Reduced Enterohemorrhagic Escherichia coli Colonization
- Low evidence
Lactobacillus reuteri DSM 17938 Improves Intestinal Motility in Mice With Postoperative Ileus by Modulating Gut Microbiota and Macrophage.
- 2026-02
- Neurogastroenterology and motility 38(2)
- - Jingyi Tang
  - Yingnan Hu
  - Dian Yu
  - Baoqing Liu
  - Wenjun Xu
  - Weihan Zhu
  - Yanting Xia
  - Zhipeng Zheng
  - Wei Zhang
- PubMed: 41672915
- DOI: 10.1111/nmo.70260
2 Insights on
- Reduced Inflammatory Response
- Improved Intestinal Motility
- Low evidence
- Animal Study
Bioactive Phenolic Compounds in Extra Virgin Olive Oil: Implications for Cardiovascular Health.
- 2026-02
- Review
- Food science & nutrition 14(2)
- - Cristina Vázquez-Jiménez
  - Mª Dolores Rodríguez-Pérez
  - Laura Ortega-Hombrados
  - Ana María Sánchez-Tévar
  - José Pedro de la Cruz-Cortés
  - José A Gonzalez-Correa
- PubMed: 41695108
- DOI: 10.1002/fsn3.71441
4 Insights on
- Low evidence
Innovative co-fermentation of Propionibacterium freudenreichii and Rhizopus oryzae enhances vitamin B12, riboflavin, and flavor profile components in sweet fermented glutinous rice.
- 2026-02
- Food chemistry 503
- - Ruoxi Zhang
  - Liye Chen
  - Dongming Zhang
  - Jenni Sihvola
  - Bhawani Chamlagain
  - Miikka Olin
  - Vieno Piironen
  - Pekka Varmanen
- PubMed: 41483792
- DOI: 10.1016/j.foodchem.2025.147815
2 Insights on
- Increased Antioxidant Capacity
- Enhanced Sensory Perception
- Low evidence
Interventions Targeting the Gut Microbiome to Improve Cancer Treatment Outcomes and Their Gastrointestinal Side Effects: A Systematic Review and Meta-analysis.
- 2026-02
- Meta-Analysis · n = 37
- The Journal of nutrition 156(2)
- - Cecilia Morel
  - Ruijie Li
  - Carmen Fiuza Luces
  - Mark Fh Brougham
  - Juan Francisco Pascual-Gazquez
  - Luciana Torquati
  - Raquel Revuelta Iniesta
- PubMed: 41475679
- DOI: 10.1016/j.tjnut.2025.101300
4 Insights on
- High evidence
Clinical effectiveness and safety of total glucosides of paeony as an immunomodulator in patients with refractory oral lichen planus: A multicenter, pragmatic, randomized controlled trial.
- 2026-02
- RCT · n = 448
- Phytomedicine : international journal of phytotherapy and phytopharmacology 151
- - Yiwen Deng
  - Leilei Zhou
  - Na Li
  - Fan Huang
  - Guanhuan Du
  - Yufeng Wang
  - Jian Meng
  - Shijie Chen
  - Xiufeng Wei
  - Wenmei Wang
  - Guoyao Tang
- PubMed: 41539096
- DOI: 10.1016/j.phymed.2026.157770
3 Insights on
- High evidence
- Large Human Trial
Lactobacillus helveticus R0052-derived membrane vesicles ameliorate DSS-induced inflammatory bowel disease by modulating the gut microbiota and activating the cholinergic anti-inflammatory pathway.
- 2026-02
- International immunopharmacology 171
- - Chinasa Valerie Olovo
  - Ying Ji
  - Dickson Kofi Wiredu Ocansey
  - Xinxiang Huang
  - Min Xu
- PubMed: 41512794
- DOI: 10.1016/j.intimp.2025.116058
4 Insights on
- Low evidence
- Animal Study
Effect of vitamin E supplementation on recovery and recurrence prevention in women with lower urinary tract infections: A triple-blind randomized clinical trial.
- 2026-02
- RCT
- Clinical nutrition ESPEN 71
- - Hajar Mafakher
  - Azadeh Ebrahimzadeh
  - Adeleh Sahebnasagh
  - Melika Ramezani
  - Razieh Avan
- PubMed: 41390063
- DOI: 10.1016/j.clnesp.2025.102876
4 Insights on
- High evidence
Oral vaccination via virus-like particles encapsulated in Lactococcus lactis.
- 2026-02
- Clinical Trial
- Fish & shellfish immunology 169
- - Hui Yee Hong
  - Lee Ching Pei Carmen
  - Pin Xuan Chee
  - Lim Xin Ying
  - Zhi Wei Wong
  - Janlin Chan
  - Mookkan Prabakaran
  - Daiwen Yang
- PubMed: 41519596
- DOI: 10.1016/j.fsi.2025.111013
2 Insights on
- Reduced Viral Load
- Improved Specific Antibody Response
- Low evidence
- Animal Study
Hepatoprotective Potential of Indian Medicinal Plants.
- 2026-02
- Review
- Combinatorial chemistry & high throughput screening 29(3)
- - Arti Kumari
  - Nisha Chandila
  - Rubina Bhutani
  - Inderjeet Yadav
- PubMed: 39835553
- DOI: 10.2174/0113862073346295250107070310
1 Insight on
- Reduced Liver Enzyme Levels
- Low evidence
Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.
- 2026-02
- RCT · n = 108
- Journal of cachexia, sarcopenia and muscle 17(1)
- - Ilili Feyesa
  - Jeew Hettiarachchi
  - Robin M Daly
  - Elena S George
  - Ekavi N Georgousopoulou
  - David Scott
  - Brenton J Baguley
  - Gavin Abbott
  - Sze-Yen Tan
- PubMed: 41632974
- DOI: 10.1002/jcsm.70221
2 Insights on
- Improved Five Times Sit-to-Stand Time
- Improved Muscle Power
- High evidence
- Large Human Trial
Streptococcus thermophilus: A next-generation chassis for customizing exopolysaccharide with rare sugar.
- 2026-02
- Review
- Food research international (Ottawa, Ont.) 226
- - Mengshi Xiao
  - Jiuxiang Nie
  - Xiaodan Fu
  - Lin Zhang
  - Haijin Mou
  - Qiuhong Niu
- PubMed: 41539799
- DOI: 10.1016/j.foodres.2025.118150
2 Insights on
- Improved Bioactivity
- Increased Bioactivity
- Low evidence
Bifidobacterium Breve SHMB 8001 Alleviates DSS-Induced Colitis in Mice Via Modulating the Intestinal Barrier and Gut Microbiota.
- 2026-02
- Journal of food science 91(2)
- - Gaojie Liu
  - Xufei Wang
  - Yan Hao
  - Lewen Tu
  - Yongchao Mei
  - Ting Zhang
  - Yizhong Wang
- PubMed: 41645793
- DOI: 10.1111/1750-3841.70903
4 Insights on
- Low evidence
- Rigorous Journal
The Efficacy and Safety of Nutritional Supplements for Cancer Supportive Care: An Umbrella Review and Hierarchical Evidence Synthesis.
- 2026-01
- Systematic Review
- Integrative cancer therapies 25
- - Sarah Benna-Doyle
  - Suzanne Grant
  - Alison Maunder
  - Jing Liu
  - Melik Ibrahim
  - Adele Cave
  - Chhiti Pandey
  - Monica Tang
  - Eng-Siew Koh
  - Geoff Delaney
  - Deep Jyoti Bhuyan
  - Victoria Choi
  - Ki Kwon
  - Maria Gonzalez
  - Susannah Graham
  - Ashanya Malalasekera
  - Carolyn Ee
- PubMed: 41482855
- DOI: 10.1177/15347354251405267
13 Insights on
- High evidence
Efficacy of the herbal product of Cuscuta campestris Yunck. and Polypodium vulgare L. in patients with obsessive-compulsive disorder: A triple-blind clinical trial.
- 2026-01
- RCT · n = 84
- Journal of ethnopharmacology 354
- - Behnaz Bakhshinejad
  - Abdolreza Sabahi
  - Tania Dehesh
  - Zarrin Sarhadynejad
  - Mehrnaz Mehrabani
  - Mahdiyeh Khazaneha
  - Mehrzad Mehrbani
  - Mitra Mehrabani
- PubMed: 40848906
- DOI: 10.1016/j.jep.2025.120452
1 Insight on
- Improved Quality of Life
- High evidence
Streptococcus thermophilus alleviates fatty liver disease by regulating gut microbiota, lipid metabolism, and inflammation.
- 2026-01
- International immunopharmacology 168
- - Junlin Xia
  - Yanbin Cheng
  - Lixuan Sang
  - Qingyu Wei
  - Quansheng Li
  - Bing Chang
- PubMed: 41275833
- DOI: 10.1016/j.intimp.2025.115905
4 Insights on
- Low evidence
Therapeutic Mechanisms of Lactiplantibacillus plantarum NXU0014 Against Chronic Alcohol-Induced Liver Injury Mediated by Gut-Liver Axis Modulation.
- 2026-01
- Molecular nutrition & food research 70(1)
- - Quan Ji
  - Yanhong Wang
  - Longxuan Huo
  - Chen Qiao
  - Fuqi Li
  - Fan Yang
  - Lin Pan
- PubMed: 41543328
- DOI: 10.1002/mnfr.70375
4 Insights on
- Low evidence
- Rigorous Journal
- Animal Study
Efficacy of Topical Betamethasone Valerate and Olive Oil in Preventing Acute Radiation Dermatitis in Breast Cancer: A Randomized Double-Blind Placebo-Controlled Study.
- 2026-01
- RCT · n = 132
- Clinical breast cancer 26(1)
- - Israa K Mohamed
  - Maggie M Abbassi
  - Mohamed R Kelany
  - Samar F Farid
- PubMed: 40973558
- DOI: 10.1016/j.clbc.2025.08.008
4 Insights on
- High evidence
- Large Human Trial
The effect of exercise and soy protein intake on physical frailty score improvement in community-dwelling elderly: a randomized controlled trial.
- 2026-01
- RCT · n = 84
- Experimental gerontology 213
- - Masakazu Imaoka
  - Mitsumasa Hida
  - Misa Nakamura
  - Keiko Sakai
  - Emi Anzai
  - Takashi Ichise
  - Nobuhiko Tachibana
  - Ien Tei
  - Yoshinori Hasegawa
- PubMed: 41386386
- DOI: 10.1016/j.exger.2025.112995
1 Insight on
- Improved Walking Speed
- High evidence
Impact of Sodium Ascorbate High Dose on Quality of Life and Pain in Patients Diagnosed With and Treated for Terminal Cancer (Real-World Data Study).
- 2026-01
- Observational · n = 92
- Integrative cancer therapies 25
- - Hugo Mario Galindo Salom
  - Carlos Alberto Carrillo Bravo
  - Helber Armando Prieto Lozano
  - Paulo Andrés López Posada
- PubMed: 41606996
- DOI: 10.1177/15347354251414640
2 Insights on
- Improved Quality of Life
- Reduced Pain
- Moderate evidence
The effect of riboflavin on the mean attack frequency, severity, and duration of migraine headaches: A systematic review and dose-response meta-analysis of clinical trials.
- 2026-01
- Review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 31(1)
- - Sepide Amini
  - Zahra Heidari
  - Cain C T Clark
  - Mohammad Bagherniya
- PubMed: 41769676
- DOI: 10.4103/jrms.jrms_547_24
2 Insights on
- Reduced Migraine Frequency
- Reduced Migraine Duration
- Low evidence
Gut microbiota and immune regulation by Lactobacillus delbrueckii subsp. bulgaricus LB42: From preclinical safety assessment to clinical evidence.
- 2026-01
- RCT
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 207
- - Jingyan Wang
  - Yinhua Liu
  - Chengsheng Zhu
  - Zhiying Wang
  - Sijia Wang
  - Shuguang Fang
  - Fei Xu
- PubMed: 41241129
- DOI: 10.1016/j.fct.2025.115851
5 Insights on
- High evidence
Programming the Infant Gut: How Maternal and Early Life Nutrition Shape the Infant Microbiome and Long-term Health-A Narrative Review.
- 2026-01
- Review
- Molecular nutrition & food research 70(2)
- - Fanette Fontaine
  - Sondra Turjeman
  - Meriam Haib
  - Maria Carmen Collado
  - Karel Callens
  - Omry Koren
- PubMed: 41555705
- DOI: 10.1002/mnfr.70385
1 Insight on
- Improved Atopic Dermatitis Symptoms
- Moderate evidence
- Rigorous Journal
Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
- 2026-01
- RCT
- The Journal of nutrition 156(1)
- - Christina Diekmann
  - Tim B Schiemann
  - Hannah F Kienēs
  - Carolin Wiechmann
  - Christina Kopp
  - Birgit Stoffel-Wagner
  - Martin Coenen
  - Robert Németh
  - Michael Wagner
  - Sarah Egert
- PubMed: 41232773
- DOI: 10.1016/j.tjnut.2025.11.003
1 Insight on
- Reduced Hunger Ratings
- High evidence
Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.
- 2026-01
- Review · n = 4,755
- Translational sports medicine 2026(1)
- - Marcos D M Drummond
  - Ronaldo A D Silva
  - Nelson Carvas Junior
  - Miércio S Melo
  - Matheus H L Ferreira
- PubMed: 41635649
- DOI: 10.1155/tsm2/5557511
2 Insights on
- Increased Muscle Strength
- Increased Fat-Free Mass
- High evidence
Efficacy of Probiotic Lactobacillus spp. Isolated From Healthy Korean Indigenous Calves.
- 2026-01
- Clinical Trial
- Veterinary medicine and science 12(1)
- - Ji-Yeong Ku
  - Mi-Jin Lee
  - Youngwoo Jung
  - Youngjun Kim
  - Kwang-Man Park
  - Jonghun Baek
  - Byoungsoo Kim
  - Ji-Seon Yoon
  - Jinho Park
- PubMed: 41482829
- DOI: 10.1002/vms3.70742
5 Insights on
- Low evidence
- Animal Study
Comparative effectiveness of Panax notoginseng saponins-related agents and antiplatelet agents in ischemic stroke: A systematic review and network meta-analysis.
- 2026-01
- Systematic Review · n = 424
- Journal of ethnopharmacology 355
- - Hongrui Zhang
  - Luda Feng
  - Xinxing Lai
  - Yonghong Gao
  - Ning Liang
  - Cuilin Que
  - Zixin Cheng
  - Na Li
  - Jiawang Li
  - Ziteng Hu
  - Yannan He
  - Zhenhong Liu
  - Ying Gao
- PubMed: 40769440
- DOI: 10.1016/j.jep.2025.120364
3 Insights on
- High evidence
Comparing the Direct Oral Anticoagulants versus Vitamin K Antagonists in Bioprosthetic Valves: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 2026-01
- Meta-Analysis · n = 3,863
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 32
- - Muhammad Hassan Waseem
  - Zain Ul Abideen
  - Ameer Haider Cheema
  - Kanza Farhan
  - Hafsa Arshad Azam Raja
  - Muhammad Zubair Tahir
  - Fahad Saleem
  - Amna Nadeem
  - Pawan Kumar Thada
- PubMed: 41589822
- DOI: 10.1177/10760296251415375
1 Insight on
- Reduced All-Cause Mortality
- High evidence
The effect of propolis supplementation on blood pressure: a systematic review and meta-analysis of controlled trials.
- 2026-01
- Meta-Analysis · n = 30
- Minerva cardiology and angiology 73(6)
- - Hongyan Qu
  - Li Cao
  - Ziye Wen
  - Chao Li
  - Meihong Xiao
- PubMed: 39846965
- DOI: 10.23736/s2724-5683.24.06656-0
2 Insights on
- Reduced Diastolic Blood Pressure
- Reduced Systolic Blood Pressure
- High evidence